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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:guggulsterone
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Accession:CHEBI:135338 term browser browse the term
Synonyms:related_synonym: Z/E-Guggulsterone
 xref: CAS:95975-55-6
 xref_mesh: MESH:C023617
 xref: drugcentral:3953
 chemrof_formula: C21H28O2
 chemrof_inchi: InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/t15-,17+,18+,20+,21-/m1/s1
 chemrof_inchikey: WDXRGPWQVHZTQJ-NRJJLHBYSA-N
 chemrof_smiles: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=CC)C(=O)C[C@@]21[H]


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guggulsterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
increases expression 		ISO
EXP 		[pregna-4,17-diene-3,16-dione co-treated with Chenodeoxycholic Acid] results in increased expression of ABCB11 mRNA; [pregna-4,17-diene-3,16-dione co-treated with GW 4064] results in increased expression of ABCB11 mRNA; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of ABCB11 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Bile Acids and Salts results in increased expression of ABCB11 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [GW 4064 results in increased expression of ABCB11 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [NR1H4 protein results in increased expression of ABCB11 mRNA]
pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [[1-Naphthylisothiocyanate co-treated with gamma-sitosterol] results in increased expression of ABCB11 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of ABCB11 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]]; pregna-4,17-diene-3,16-dione promotes the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; pregna-4,17-diene-3,16-dione promotes the reaction [Oleanolic Acid results in decreased expression of ABCB11 mRNA]
pregna-4,17-diene-3,16-dione results in increased expression of ABCB11 mRNA
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Abcb11 protein in liver]] 		CTD
RGD		 PMID:12525500 PMID:12705905 PMID:25278094 PMID:25655198 PMID:26040663 More... RGD:15036816 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB4 mRNA]] CTD PMID:25655198 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [[1-Naphthylisothiocyanate co-treated with gamma-sitosterol] results in increased expression of ABCC2 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]]; pregna-4,17-diene-3,16-dione promotes the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]; pregna-4,17-diene-3,16-dione promotes the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA] CTD PMID:25655198 PMID:26040663 PMID:39030772 PMID:39947414 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression
multiple interactions 		ISO pregna-4,17-diene-3,16-dione results in decreased expression of ABCG5 mRNA
GW 4064 inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased expression of ABCG5 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of ABCG5 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [GW 4064 results in increased expression of ABCG5 mRNA] 		CTD PMID:34767876 PMID:35523117 NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of ABCG8 protein] CTD PMID:35523117 NCBI chr 6:15,698,448...15,717,730
Ensembl chr 6:15,698,448...15,717,730 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACACA protein]] CTD PMID:27773935 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888 		JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of ACADS mRNA]] CTD PMID:27773935 NCBI chr12:47,154,259...47,163,580
Ensembl chr12:47,154,276...47,164,103 		JBrowse link
G Acly ATP citrate lyase multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [Palmitic Acid results in increased expression of ACLY mRNA] CTD PMID:31421115 NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,912,402...85,963,631 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [Oxygen deficiency results in increased expression of ACTA2 protein]
pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]] 		CTD PMID:35123992 PMID:37573684 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased activity of ALPL protein]] CTD PMID:37573684 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA] CTD PMID:15322087 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA] CTD PMID:15322087 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890 		JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO pregna-4,17-diene-3,16-dione results in increased cleavage of BID protein CTD PMID:17475222 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions
decreases expression 		ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]
Guggulsterone decreases expression of BIRC2 protein in colon cancer cells 		CTD
RGD		 PMID:15322087 PMID:19232820 RGD:152998981 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO Guggulsterone decreases expression of BIRC3 protein in colon cancer cells RGD PMID:19232820 RGD:152998981 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BIRC5 mRNA] CTD PMID:15322087 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Casp3 caspase 3 increases activity ISO pregna-4,17-diene-3,16-dione results in increased activity of CASP3 protein CTD PMID:17475222 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 increases activity ISO pregna-4,17-diene-3,16-dione results in increased activity of CASP8 protein CTD PMID:17475222 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 increases activity ISO pregna-4,17-diene-3,16-dione results in increased activity of CASP9 protein CTD PMID:17475222 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cbr3 carbonyl reductase 3 increases expression ISO pregna-4,17-diene-3,16-dione results in increased expression of CBR3 mRNA CTD PMID:20806931 NCBI chr11:46,478,295...46,486,555
Ensembl chr11:46,478,274...46,486,558 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CCNB1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of CCNB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCNB1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCNB1 protein]] CTD PMID:25278094 PMID:29660435 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions 		ISO pregna-4,17-diene-3,16-dione results in decreased expression of CCND1 protein
pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]
pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CCND1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of CCND1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCND1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCND1 protein]] 		CTD PMID:15322087 PMID:17475222 PMID:25278094 PMID:29660435 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO pregna-4,17-diene-3,16-dione results in decreased expression of CDK1 protein CTD PMID:17475222 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO pregna-4,17-diene-3,16-dione results in increased expression of CDKN1A protein CTD PMID:17475222 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO pregna-4,17-diene-3,16-dione results in increased expression of CDKN1B protein CTD PMID:17475222 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA] CTD PMID:15322087 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]] CTD PMID:37573684 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased secretion of COL3A1 protein]] CTD PMID:37573684 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO
EXP 		pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of CPT1A mRNA]]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of CPT1a mRNA and protein in liver]] 		CTD
RGD		 PMID:27773935 PMID:27939985 RGD:15036816 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326 		JBrowse link
G Cyc1 cytochrome c-1 affects localization ISO pregna-4,17-diene-3,16-dione affects the localization of CYC1 protein CTD PMID:17475222 NCBI chr 7:109,947,750...109,950,142
Ensembl chr 7:109,947,766...109,950,657 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of CYP27A1 protein] CTD PMID:35523117 NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects expression ISO pregna-4,17-diene-3,16-dione affects the expression of CYP2B10 mRNA CTD PMID:15833898 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO pregna-4,17-diene-3,16-dione results in increased expression of CYP3A4 mRNA CTD PMID:15075359 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO
EXP 		pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in decreased expression of CYP7A1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [NR1I2 protein results in increased expression of CYP7A1 mRNA]
pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [Ethinyl Estradiol results in decreased expression of CYP7A1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [Ethinyl Estradiol results in decreased expression of CYP7A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Cyp7a1 protein in liver]] 		CTD
RGD		 PMID:12705905 PMID:25655198 PMID:26040663 PMID:29660435 PMID:35523117 More... RGD:15036816 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of CYP7B1 protein] CTD PMID:35523117 NCBI chr 2:102,419,011...102,586,047
Ensembl chr 2:102,419,011...102,451,804 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [Ethinyl Estradiol results in decreased expression of CYP8B1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [Ethinyl Estradiol results in decreased expression of CYP8B1 mRNA]
pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in decreased expression of CYP8B1 protein] 		CTD PMID:25655198 PMID:26040663 PMID:35523117 NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO pregna-4,17-diene-3,16-dione results in decreased expression of DNMT1 mRNA; pregna-4,17-diene-3,16-dione results in decreased expression of DNMT1 protein CTD PMID:23593078 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases expression ISO pregna-4,17-diene-3,16-dione results in decreased expression of DNMT3A mRNA CTD PMID:23593078 NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO pregna-4,17-diene-3,16-dione results in decreased expression of DNMT3B mRNA CTD PMID:23593078 NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:162,604,037...162,629,313 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
decreases expression 		ISO Calcitriol promotes the reaction [pregna-4,17-diene-3,16-dione results in decreased expression of FABP4 protein]; pregna-4,17-diene-3,16-dione promotes the reaction [Calcitriol results in decreased expression of FABP4 protein] CTD PMID:17959142 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Fas mRNA and protein in liver]] RGD PMID:27939985 RGD:15036816 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FASN protein]] CTD PMID:27773935 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions EXP Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of FGF19 protein in liver and intestine]] RGD PMID:27939985 RGD:15036816 NCBI chr 1:209,485,813...209,490,267
Ensembl chr 1:209,485,813...209,490,267 		JBrowse link
G Foxm1 forkhead box M1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of FOXM1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 protein]] CTD PMID:25278094 PMID:29660435 NCBI chr 4:163,325,628...163,338,100
Ensembl chr 4:163,325,614...163,337,172 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO pregna-4,17-diene-3,16-dione results in increased expression of GCLC mRNA CTD PMID:22851183 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO pregna-4,17-diene-3,16-dione results in increased expression of GCLM mRNA CTD PMID:22851183 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased activity of GOT1 protein]] CTD PMID:37573684 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [gamma-sitosterol inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]] CTD PMID:37573684 PMID:39947414 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO pregna-4,17-diene-3,16-dione results in decreased expression of HDAC1 protein CTD PMID:23593078 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [IL1B protein results in increased activity of RELA protein]
pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]]; pregna-4,17-diene-3,16-dione promotes the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA] 		CTD PMID:15322087 PMID:29660435 PMID:37573684 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]] CTD PMID:37573684 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Kl Klotho multiple interactions ISO KL protein affects the reaction [pregna-4,17-diene-3,16-dione inhibits the reaction [Oxygen deficiency results in increased expression of TP53 protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [Oxygen deficiency results in decreased expression of KL protein] CTD PMID:35123992 NCBI chr12:5,326,003...5,367,016
Ensembl chr12:5,325,959...5,367,015 		JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of LPL mRNA]] CTD PMID:27773935 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107 		JBrowse link
G Lrp2 LDL receptor related protein 2 multiple interactions
increases expression 		ISO NR1H4 protein promotes the reaction [pregna-4,17-diene-3,16-dione results in increased expression of LRP2 protein] CTD PMID:15375181 NCBI chr 3:74,597,148...74,754,535
Ensembl chr 3:74,597,148...74,754,535 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO pregna-4,17-diene-3,16-dione results in increased activity of MAPK8 protein CTD PMID:17475222 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mecp2 methyl CpG binding protein 2 decreases expression ISO pregna-4,17-diene-3,16-dione results in decreased expression of MECP2 protein CTD PMID:23593078 NCBI chr  X:156,932,481...156,995,981
Ensembl chr  X:156,941,234...156,943,560 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA] CTD PMID:15322087 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of MYC mRNA] CTD PMID:15322087 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]; pregna-4,17-diene-3,16-dione promotes the reaction [NR1I2 protein binds to NCOA1 protein] CTD PMID:15833898 NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:10,618,722...10,852,776 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects response to substance
multiple interactions 		ISO NFE2L2 protein affects the susceptibility to pregna-4,17-diene-3,16-dione
pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 mRNA]] 		CTD PMID:22851183 PMID:37573684 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP 		pregna-4,17-diene-3,16-dione inhibits the reaction [Hydrogen Peroxide results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Okadaic Acid results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Z-guggulsterone prevents the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Nf-kB protein in liver]] 		CTD
RGD		 PMID:15322087 PMID:27939985 RGD:15036816 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP 		pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Nfkbia protein in liver]] 		CTD
RGD		 PMID:15322087 PMID:27939985 RGD:15036816 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Nrlp3 protein in liver]] RGD PMID:27939985 RGD:15036816 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO pregna-4,17-diene-3,16-dione results in increased expression of NQO1 mRNA CTD PMID:22851183 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO
EXP 		pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of NR0B2 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Imatinib Mesylate results in increased expression of NR0B2 mRNA]
pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [Ethinyl Estradiol results in increased expression of NR0B2 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of NR0B2 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [Ethinyl Estradiol results in increased expression of NR0B2 mRNA]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Nr0b2 protein in liver and intestine]] 		CTD
RGD		 PMID:22414727 PMID:25278094 PMID:25655198 PMID:26040663 PMID:35523117 More... RGD:15036816 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO pregna-4,17-diene-3,16-dione promotes the reaction [Palmitic Acid results in decreased expression of NR1H2 mRNA] CTD PMID:31421115 NCBI chr 1:104,178,483...104,183,863
Ensembl chr 1:104,178,234...104,183,863 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases activity
decreases expression 		ISO
EXP 		2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; 22,23-dihydroavermectin B(1)a inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; abamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Albendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; albendazole sulfoxide inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; alvocidib inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Apigenin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; benidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Benomyl inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; bifenthrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; biochanin A inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Bortezomib inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; carbendazim inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; chrysin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; ciclobendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; cilnidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Colchicine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; cyfluthrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; cyhalothrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; cypermethrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Dactinomycin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Daunorubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; decamethrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Digoxin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; diphenadione inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Dipyridamole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Docetaxel inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; doramectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Doxorubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; emamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Emetine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; enzastaurin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Epirubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Estradiol inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Ethacridine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Ethinyl Estradiol inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Ethylestrenol inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Fenbendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; fenvalerate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; flucythrinate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; fluvalinate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Fulvestrant inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Genistein inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Griseofulvin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Idarubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Isotretinoin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; kadethrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; lacidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; lercanidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Lithocholic Acid inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; manidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Mebendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; methoxy-morpholinyl-doxorubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Mitomycin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; moxidectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Nicardipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Nifedipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Nimodipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Nisoldipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Nocodazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; NR1H4 protein promotes the reaction [pregna-4,17-diene-3,16-dione results in increased abundance of Lipids]; oxfendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; oxibendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; parbendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; phenothrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; picropodophyllin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; pirarubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Podophyllotoxin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of NR1H4 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [Imatinib Mesylate results in increased activity of NR1H4 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [NR1H4 protein results in increased expression of ABCB11 mRNA]; Proflavine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; selamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Simendan inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; ST 1481 inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; surinabant inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Tretinoin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Ursodeoxycholic Acid inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Vinblastine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Vincristine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Vinorelbine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
NR1H4 protein promotes the reaction [pregna-4,17-diene-3,16-dione results in increased expression of LRP2 protein]; pregna-4,17-diene-3,16-dione binds to and results in decreased activity of NR1H4 protein; pregna-4,17-diene-3,16-dione inhibits the reaction [[gamma-sitosterol co-treated with 1-Naphthylisothiocyanate] results in increased expression of NR1H4 mRNA]; pregna-4,17-diene-3,16-dione promotes the reaction [Palmitic Acid results in decreased expression of NR1H4 mRNA]
guggulsterone decreases expression of nr1h4 mRNA in rat embryonic liver cells
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Nr1h4 mRNA and protein in liver and liver cell nuclei and intestine]] 		CTD
RGD		 PMID:12705905 PMID:15375181 PMID:20079722 PMID:22414727 PMID:25257666 More... RGD:15042872, RGD:15036816 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
decreases activity
increases activity
decreases expression 		ISO pregna-4,17-diene-3,16-dione inhibits the reaction [NR1I2 protein results in increased expression of CYP7A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [Thapsigargin results in decreased expression of NR1I2 mRNA]
pregna-4,17-diene-3,16-dione results in decreased activity of NR1I2 protein
pregna-4,17-diene-3,16-dione promotes the reaction [NR1I2 protein binds to NCOA1 protein]
pregna-4,17-diene-3,16-dione results in increased activity of NR1I2 protein
pregna-4,17-diene-3,16-dione results in decreased expression of NR1I2 mRNA 		CTD PMID:12705905 PMID:15075359 PMID:15833898 PMID:25616597 PMID:29933105 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO pregna-4,17-diene-3,16-dione binds to and results in decreased activity of NR1I3 protein; pregna-4,17-diene-3,16-dione inhibits the reaction [NR1I3 protein binds to NCOA1 protein] CTD PMID:15833898 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO
EXP 		pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of PPARA mRNA]]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Ppara mRNA and protein in liver]] 		CTD
RGD		 PMID:27773935 PMID:27939985 RGD:15036816 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA] CTD PMID:15322087 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [Hydrogen Peroxide results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [IL1B protein results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Okadaic Acid results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]
pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA mRNA]]; pregna-4,17-diene-3,16-dione promotes the reaction [1-Naphthylisothiocyanate results in increased expression of RELA mRNA] 		CTD PMID:15322087 PMID:29660435 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SCD1 protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [Palmitic Acid results in increased expression of SCD1 mRNA] CTD PMID:27773935 PMID:31421115 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO
EXP 		pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [[1-Naphthylisothiocyanate co-treated with gamma-sitosterol] results in decreased expression of SLC10A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Slc10a1 protein in liver]] 		CTD
RGD		 PMID:25655198 PMID:26040663 PMID:29660435 PMID:39947414 PMID:27939985 RGD:15036816 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO
EXP 		pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 protein]]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Srebf1 mRNA and protein in liver]] 		CTD
RGD		 PMID:27773935 PMID:27939985 RGD:15036816 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [Oxygen deficiency results in increased expression of TGFB1 protein] CTD PMID:35123992 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases activity 		ISO
EXP 		pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BIRC5 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of MYC mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
pregna-4,17-diene-3,16-dione results in increased activity of TNF protein
pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF mRNA]]; pregna-4,17-diene-3,16-dione promotes the reaction [1-Naphthylisothiocyanate results in increased expression of TNF mRNA]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Tnf protein in liver]] 		CTD
RGD		 PMID:15322087 PMID:29660435 PMID:27939985 RGD:15036816 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO KL protein affects the reaction [pregna-4,17-diene-3,16-dione inhibits the reaction [Oxygen deficiency results in increased expression of TP53 protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [Oxygen deficiency results in increased expression of TP53 protein] CTD PMID:35123992 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA] CTD PMID:15322087 NCBI chr 3:38,607,707...38,639,641
Ensembl chr 3:38,619,506...38,636,264 		JBrowse link
G Vdr vitamin D receptor multiple interactions ISO pregna-4,17-diene-3,16-dione promotes the reaction [Calcitriol results in increased expression of VDR protein] CTD PMID:17959142 NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:130,866,745...130,916,757 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA] CTD PMID:15322087 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of XIAP mRNA] CTD PMID:15322087 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        molecular messenger 19151
          hormone 19098
            sex hormone 19066
              androgen 5743
                guggulsterone 83
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic polycyclic compound 17588
                                  steroid 15237
                                    hydroxy steroid 14970
                                      3-hydroxy steroid 13526
                                        guggulsterone 83
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