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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trelagliptin
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Accession:CHEBI:134715 term browser browse the term
Synonyms:related_synonym: Formula=C18H20FN5O2;   InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1;   InChIKey=IWYJYHUNXVAVAA-OAHLLOKOSA-N;   SMILES=C1(=CC=C(C=C1CN2C(N(C(C=C2N3CCC[C@H](C3)N)=O)C)=O)F)C#N;   SYR-472;   SYR111472;   trelagliptin succinate;   zafatek
 xref: CAS:865759-25-7;   Drug_Central:5013
 xref_mesh: MESH:C000595449


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trelagliptin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpt glutamic--pyruvic transaminase decreases expression ISO trelagliptin results in decreased expression of GPT protein CTD PMID:33421258 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO trelagliptin inhibits the reaction [Dietary Fats results in increased expression of IL1B protein] CTD PMID:33421258 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO trelagliptin inhibits the reaction [Dietary Fats results in increased expression of IL6 protein] CTD PMID:33421258 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO trelagliptin inhibits the reaction [Dietary Fats results in increased expression of INS1 protein] CTD PMID:33421258 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO trelagliptin inhibits the reaction [Dietary Fats results in increased phosphorylation of NFKBIA protein] CTD PMID:33421258 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO trelagliptin inhibits the reaction [Dietary Fats results in increased expression of RELA protein] CTD PMID:33421258 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO trelagliptin inhibits the reaction [Dietary Fats results in increased expression of TNF protein]
trelagliptin results in decreased expression of TNF protein		 CTD PMID:33421258 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      group 19831
        pseudohalo group 4581
          cyano group 4581
            nitrile 4581
              trelagliptin 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                carbocyclic compound 18584
                                  benzenoid aromatic compound 18008
                                    benzenes 17873
                                      trelagliptin 7
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