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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-(methylamino)isobutyric acid
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Accession:CHEBI:134261 term browser browse the term
Definition:A non-proteinogenic alpha-amino acid that is isobutyric acid in which the alpha-hydrogen has been replaced by a methylamino group.
Synonyms:exact_synonym: N,2-dimethylalanine
 related_synonym: 2-(Methylamino)isobutyric acid;   Formula=C5H11NO2;   InChI=1S/C5H11NO2/c1-5(2,6-3)4(7)8/h6H,1-3H3,(H,7,8);   InChIKey=DLAMVQGYEVKIRE-UHFFFAOYSA-N;   SMILES=OC(=O)C(NC)(C)C
 xref: CAS:2566-34-9;   Chemspider:68242
 xref_mesh: MESH:C017911
 xref: PMID:15243140;   PMID:15774260;   PMID:16202926;   PMID:16373326;   PMID:17003038;   PMID:17050538;   PMID:17504964;   PMID:21055620;   PMID:26346312;   PMID:8338132;   Reaxys:1746984
 cyclic_relationship: is_tautomer_of CHEBI:192077


show annotations for term's descendants           Sort by:
alpha-(methylamino)isobutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO 2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased expression of DDIT3 mRNA] CTD PMID:22215663 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO 2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased expression of HSPA5 mRNA] CTD PMID:22215663 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Igf1 insulin-like growth factor 1 increases uptake
multiple interactions		 EXP IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid
oxophenylarsine inhibits the reaction [IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid]		 CTD PMID:1928324 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Ins1 insulin 1 increases uptake
multiple interactions
increases transport		 EXP INS1 protein results in increased uptake of 2-(methylamino)isobutyric acid
Wortmannin inhibits the reaction [INS1 protein results in increased uptake of 2-(methylamino)isobutyric acid]
INS1 protein results in increased transport of 2-(methylamino)isobutyric acid		 CTD PMID:1847587 PMID:9877156 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO 2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein] CTD PMID:22215663 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions ISO SLC38A2 mutant form inhibits the reaction [arsenite results in increased transport of 2-(methylamino)isobutyric acid] CTD PMID:22215663 NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          volatile oil component 7791
            isobutyric acid 3104
              alpha-(methylamino)isobutyric acid 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbon oxoacid 18658
                                    carboxylic acid 18655
                                      monocarboxylic acid 18004
                                        fatty acid 16838
                                          saturated fatty acid 16560
                                            propionic acid 3874
                                              alanine 115
                                                alanine derivative 113
                                                  alpha-(methylamino)isobutyric acid 6
paths to the root