CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: picrotoxin
Accession: CHEBI:134126
browse the term
Definition: A mixture consisting of equimolar amounts of picrotoxinin and picrotin found in the climbing plant Anamirta cocculus.
Synonyms: exact_synonym: (1R,3R,5S,8S,9R,12S,13R,14R)-1-hydroxy-13-methyl-14-(prop-1-en-2-yl)-4,7,10-trioxapentacyclo[6.4.1.1(9,12).0(3,5).0(5,13)]tetradecane-6,11-dione -- (1R,3R,5S,8S,9R,12S,13R,14S)-1-hydroxy-14-(2-hydroxypropan-2-yl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.1(9,12).0(3,5).0(5,13)]tetradecane-6,11-dione (1:1)
related_synonym: Cocculin; Cocculus; Coques du levant; picrotoxine; picrotoxinin - picrotin (1:1)
xref: CAS:124-87-8; HMDB:HMDB0014609
xref_mesh: MESH:D010852
xref: Reaxys:21526388; Wikipedia:Picrotoxin
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Abcc8
ATP binding cassette subfamily C member 8
increases expression decreases expression
EXP
Picrotoxin results in increased expression of ABCC8 mRNA; Picrotoxin results in increased expression of ABCC8 protein Picrotoxin results in decreased expression of ABCC8 mRNA
CTD
PMID:18021373
NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
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Acsl5
acyl-CoA synthetase long-chain family member 5
decreases expression
EXP
Picrotoxin results in decreased expression of ACSL5 mRNA
CTD
PMID:15170462
NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
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Acsl6
acyl-CoA synthetase long-chain family member 6
decreases expression
EXP
Picrotoxin results in decreased expression of ACSL6 mRNA
CTD
PMID:15170462
NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757
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Adcy4
adenylate cyclase 4
increases expression
EXP
Picrotoxin results in increased expression of ADCY4 mRNA
CTD
PMID:15170462
NCBI chr15:29,266,280...29,282,153
Ensembl chr15:29,266,287...29,282,108
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Adra1b
adrenoceptor alpha 1B
increases expression
EXP
Picrotoxin results in increased expression of ADRA1B mRNA
CTD
PMID:15170462
NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
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Adra2a
adrenoceptor alpha 2A
increases expression
EXP
Picrotoxin results in increased expression of ADRA2A mRNA
CTD
PMID:15170462
NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
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Adrb2
adrenoceptor beta 2
increases expression
EXP
Picrotoxin results in increased expression of ADRB2 mRNA
CTD
PMID:15170462
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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Agtr1a
angiotensin II receptor, type 1a
increases expression
EXP
Picrotoxin results in increased expression of AGTR1A mRNA
CTD
PMID:15170462
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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Agtr2
angiotensin II receptor, type 2
decreases expression
EXP
Picrotoxin results in decreased expression of AGTR2 mRNA
CTD
PMID:15170462
NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
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Alad
aminolevulinate dehydratase
decreases activity multiple interactions
ISO
Picrotoxin results in decreased activity of ALAD protein carvacryl acetate inhibits the reaction [Picrotoxin results in decreased activity of ALAD protein]
CTD
PMID:25490531
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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Aldob
aldolase, fructose-bisphosphate B
increases expression
EXP
Picrotoxin results in increased expression of ALDOB mRNA
CTD
PMID:15170462
NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
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Alox12
arachidonate 12-lipoxygenase, 12S type
increases expression
EXP
Picrotoxin results in increased expression of ALOX12 mRNA
CTD
PMID:15170462
NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
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Alox5ap
arachidonate 5-lipoxygenase activating protein
increases expression
EXP
Picrotoxin results in increased expression of ALOX5AP mRNA
CTD
PMID:15170462
NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
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Atp5f1d
ATP synthase F1 subunit delta
decreases expression
EXP
Picrotoxin results in decreased expression of ATP5F1D mRNA
CTD
PMID:15170462
NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929
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Atp5po
ATP synthase peripheral stalk subunit OSCP
decreases expression
EXP
Picrotoxin results in decreased expression of ATP5PO mRNA
CTD
PMID:15170462
NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592
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Bcl2l1
Bcl2-like 1
decreases expression
EXP
Picrotoxin results in decreased expression of BCL2L1 mRNA
CTD
PMID:15170462
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bdnf
brain-derived neurotrophic factor
increases expression decreases methylation
ISO EXP
Picrotoxin results in increased expression of BDNF mRNA Picrotoxin results in increased expression of BDNF protein Picrotoxin results in decreased methylation of BDNF promoter
CTD
PMID:11279263 PMID:18184782
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Calb1
calbindin 1
decreases expression
EXP
Picrotoxin results in decreased expression of CALB1 protein
CTD
PMID:15382257
NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431
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Calb2
calbindin 2
decreases expression
EXP
Picrotoxin results in decreased expression of CALB2 protein
CTD
PMID:15382257
NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438
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Casp2
caspase 2
increases expression
EXP
Picrotoxin results in increased expression of CASP2 mRNA
CTD
PMID:15170462
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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Cckar
cholecystokinin A receptor
increases expression
EXP
Picrotoxin results in increased expression of CCKAR mRNA
CTD
PMID:15170462
NCBI chr14:57,292,397...57,300,747
Ensembl chr14:57,292,397...57,300,747
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Cckbr
cholecystokinin B receptor
increases expression
EXP
Picrotoxin results in increased expression of CCKBR mRNA
CTD
PMID:15170462
NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
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Ccnd2
cyclin D2
decreases expression
EXP
Picrotoxin results in decreased expression of CCND2 mRNA
CTD
PMID:15170462
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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Ccnd3
cyclin D3
increases expression
EXP
Picrotoxin results in increased expression of CCND3 mRNA
CTD
PMID:15170462
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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Ccr2
C-C motif chemokine receptor 2
increases expression
EXP
Picrotoxin results in increased expression of CCR2 mRNA
CTD
PMID:15170462
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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Chrm1
cholinergic receptor, muscarinic 1
increases expression
EXP
Picrotoxin results in increased expression of CHRM1 mRNA
CTD
PMID:15170462
NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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Chrm2
cholinergic receptor, muscarinic 2
increases expression
EXP
Picrotoxin results in increased expression of CHRM2 mRNA
CTD
PMID:15170462
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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Chrm3
cholinergic receptor, muscarinic 3
increases expression
EXP
Picrotoxin results in increased expression of CHRM3 mRNA
CTD
PMID:15170462
NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
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Cpt1a
carnitine palmitoyltransferase 1A
increases expression
EXP
Picrotoxin results in increased expression of CPT1A mRNA
CTD
PMID:15170462
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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Cpt1b
carnitine palmitoyltransferase 1B
increases expression
EXP
Picrotoxin results in increased expression of CPT1B mRNA
CTD
PMID:15170462
NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
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Cxcr4
C-X-C motif chemokine receptor 4
increases expression
EXP
Picrotoxin results in increased expression of CXCR4 mRNA
CTD
PMID:15170462
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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Decr1
2,4-dienoyl-CoA reductase 1
decreases expression
EXP
Picrotoxin results in decreased expression of DECR1 mRNA
CTD
PMID:15170462
NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
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Dhcr7
7-dehydrocholesterol reductase
decreases expression
EXP
Picrotoxin results in decreased expression of DHCR7 mRNA
CTD
PMID:15170462
NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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Drd4
dopamine receptor D4
increases expression
EXP
Picrotoxin results in increased expression of DRD4 mRNA
CTD
PMID:15170462
NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
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Edn1
endothelin 1
multiple interactions
EXP
Picrotoxin inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]
CTD
PMID:12184995
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Edn3
endothelin 3
multiple interactions
EXP
Picrotoxin inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine]
CTD
PMID:12184995
NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093
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Ednrb
endothelin receptor type B
decreases expression
EXP
Picrotoxin results in decreased expression of EDNRB mRNA
CTD
PMID:15170462
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP
Picrotoxin results in increased expression of FOS; Picrotoxin results in increased expression of FOS mRNA
CTD
PMID:1380685 PMID:9500968
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Fosl1
FOS like 1, AP-1 transcription factor subunit
increases expression
EXP
Picrotoxin results in increased expression of FOSL1 mRNA
CTD
PMID:15170462
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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Fshr
follicle stimulating hormone receptor
increases expression
EXP
Picrotoxin results in increased expression of FSHR mRNA
CTD
PMID:15170462
NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
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Fzd2
frizzled class receptor 2
increases expression
EXP
Picrotoxin results in increased expression of FZD2 mRNA
CTD
PMID:15170462
NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334
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Gabbr2
gamma-aminobutyric acid type B receptor subunit 2
multiple interactions
EXP
1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea inhibits the reaction [Picrotoxin affects the localization of GABBR2 protein]; Picrotoxin results in decreased expression of and affects the localization of GABBR2 protein
CTD
PMID:24482233
NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104
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Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
multiple interactions
ISO EXP
delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD
PMID:9316872 PMID:14637376 PMID:17054655
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
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Gabra2
gamma-aminobutyric acid type A receptor subunit alpha 2
multiple interactions
ISO
Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein]]
CTD
PMID:10683198 PMID:14637376
NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944
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Gabrb1
gamma-aminobutyric acid type A receptor subunit beta1
multiple interactions
ISO
Picrotoxin inhibits the reaction [Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein]]
CTD
PMID:10683198
NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948
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Gabrb2
gamma-aminobutyric acid type A receptor subunit beta 2
multiple interactions
ISO EXP
Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD
PMID:14637376 PMID:17054655
NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
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Gabrb3
gamma-aminobutyric acid type A receptor subunit beta 3
multiple interactions
ISO
delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
CTD
PMID:9316872
NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961
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Gabrg2
gamma-aminobutyric acid type A receptor subunit gamma 2
multiple interactions
ISO EXP
delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD
PMID:9316872 PMID:14637376 PMID:17054655
NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
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Gad1
glutamate decarboxylase 1
increases expression
EXP
Picrotoxin results in increased expression of GAD1 mRNA
CTD
PMID:15170462
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
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Gad2
glutamate decarboxylase 2
increases response to substance increases expression
ISO EXP
GAD2 gene mutant form results in increased susceptibility to Picrotoxin Picrotoxin results in increased expression of GAD2 mRNA; Picrotoxin results in increased expression of GAD2 protein
CTD
PMID:8954991 PMID:15170462 PMID:15382257
NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
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Glra1
glycine receptor, alpha 1
multiple interactions
ISO
Picrotoxin binds to and results in decreased activity of GLRA1 protein
CTD
PMID:15081878
NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162
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Gnai1
G protein subunit alpha i1
decreases expression
EXP
Picrotoxin results in decreased expression of GNAI1 mRNA
CTD
PMID:15170462
NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
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Gnai2
G protein subunit alpha i2
decreases expression
EXP
Picrotoxin results in decreased expression of GNAI2 mRNA
CTD
PMID:15170462
NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
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Gng8
G protein subunit gamma 8
increases expression
EXP
Picrotoxin results in increased expression of GNG8 mRNA
CTD
PMID:15170462
NCBI chr 1:77,564,512...77,568,371
Ensembl chr 1:77,564,515...77,568,371
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Gnrhr
gonadotropin releasing hormone receptor
increases expression
EXP
Picrotoxin results in increased expression of GNRHR mRNA
CTD
PMID:15170462
NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861
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Gpd1
glycerol-3-phosphate dehydrogenase 1
decreases expression
EXP
Picrotoxin results in decreased expression of GPD1 mRNA
CTD
PMID:15170462
NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
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Hadhb
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
decreases expression
EXP
Picrotoxin results in decreased expression of HADHB mRNA
CTD
PMID:15170462
NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
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Htr5b
5-hydroxytryptamine (serotonin) receptor 5B
increases expression
EXP
Picrotoxin results in increased expression of HTR5B mRNA
CTD
PMID:15170462
NCBI chr13:32,686,911...32,699,835
Ensembl chr13:32,687,042...32,699,835
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Htr6
5-hydroxytryptamine receptor 6
increases expression
EXP
Picrotoxin results in increased expression of HTR6 mRNA
CTD
PMID:15170462
NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912
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Idi1
isopentenyl-diphosphate delta isomerase 1
decreases expression
EXP
Picrotoxin results in decreased expression of IDI1 mRNA
CTD
PMID:15170462
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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Kcnj11
potassium inwardly-rectifying channel, subfamily J, member 11
decreases expression increases expression
EXP
Picrotoxin results in decreased expression of KCNJ11 mRNA; Picrotoxin results in decreased expression of KCNJ11 protein Picrotoxin results in increased expression of KCNJ11 mRNA; Picrotoxin results in increased expression of KCNJ11 protein
CTD
PMID:18021373
NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082
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Kras
KRAS proto-oncogene, GTPase
decreases expression
EXP
Picrotoxin results in decreased expression of KRAS mRNA
CTD
PMID:15170462
NCBI chr 4:178,185,418...178,218,484
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Ldhb
lactate dehydrogenase B
decreases expression
EXP
Picrotoxin results in decreased expression of LDHB mRNA
CTD
PMID:15170462
NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
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Ldhc
lactate dehydrogenase C
increases expression
EXP
Picrotoxin results in increased expression of LDHC mRNA
CTD
PMID:15170462
NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378
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Lhcgr
luteinizing hormone/choriogonadotropin receptor
increases expression
EXP
Picrotoxin results in increased expression of LHCGR mRNA
CTD
PMID:15170462
NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
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Lpl
lipoprotein lipase
decreases expression
EXP
Picrotoxin results in decreased expression of LPL mRNA
CTD
PMID:15170462
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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Lta4h
leukotriene A4 hydrolase
increases expression
EXP
Picrotoxin results in increased expression of LTA4H mRNA
CTD
PMID:15170462
NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
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Mapk1
mitogen activated protein kinase 1
multiple interactions increases phosphorylation
EXP
[Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK1 protein; Dieldrin promotes the reaction [[Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK1 protein] Picrotoxin results in increased phosphorylation of MAPK1 protein
CTD
PMID:35137321
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions increases phosphorylation
EXP
[Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK3 protein; Dieldrin promotes the reaction [[Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK3 protein] Picrotoxin results in increased phosphorylation of MAPK3 protein
CTD
PMID:35137321
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mc4r
melanocortin 4 receptor
increases expression
EXP
Picrotoxin results in increased expression of MC4R mRNA
CTD
PMID:15170462
NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
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Mvk
mevalonate kinase
increases expression
EXP
Picrotoxin results in increased expression of MVK mRNA
CTD
PMID:15170462
NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882
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Ndufs6
NADH:ubiquinone oxidoreductase subunit S6
decreases expression
EXP
Picrotoxin results in decreased expression of NDUFS6 mRNA
CTD
PMID:15170462
NCBI chr 1:29,968,833...29,977,423
Ensembl chr 1:29,968,842...29,977,467
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Npy1r
neuropeptide Y receptor Y1
increases expression
EXP
Picrotoxin results in increased expression of NPY1R mRNA
CTD
PMID:15170462
NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759
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Oprk1
opioid receptor, kappa 1
increases expression
EXP
Picrotoxin results in increased expression of OPRK1 mRNA
CTD
PMID:15170462
NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
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Oprm1
opioid receptor, mu 1
increases expression
EXP
Picrotoxin results in increased expression of OPRM1 mRNA
CTD
PMID:15170462
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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Pde4d
phosphodiesterase 4D
increases expression
EXP
Picrotoxin results in increased expression of PDE4D mRNA
CTD
PMID:15170462
NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884
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Pfkp
phosphofructokinase, platelet
decreases expression
EXP
Picrotoxin results in decreased expression of PFKP mRNA
CTD
PMID:15170462
NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018
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Pgam1
phosphoglycerate mutase 1
decreases expression
EXP
Picrotoxin results in decreased expression of PGAM1 mRNA
CTD
PMID:15170462
NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452
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Pgam2
phosphoglycerate mutase 2
increases expression
EXP
Picrotoxin results in increased expression of PGAM2 mRNA
CTD
PMID:15170462
NCBI chr14:80,681,796...80,683,907
Ensembl chr14:80,681,776...80,683,940
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Prkcd
protein kinase C, delta
decreases expression
EXP
Picrotoxin results in decreased expression of PRKCD mRNA
CTD
PMID:15170462
NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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Prkce
protein kinase C, epsilon
decreases expression
EXP
Picrotoxin results in decreased expression of PRKCE mRNA
CTD
PMID:15170462
NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
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Psma3
proteasome 20S subunit alpha 3
decreases expression
EXP
Picrotoxin results in decreased expression of PSMA3 mRNA
CTD
PMID:15170462
NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965
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Psma4
proteasome 20S subunit alpha 4
decreases expression
EXP
Picrotoxin results in decreased expression of PSMA4 mRNA
CTD
PMID:15170462
NCBI chr 8:55,340,431...55,347,893
Ensembl chr 8:55,340,386...55,347,890
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Psmb8
proteasome 20S subunit beta 8
increases expression
EXP
Picrotoxin results in increased expression of PSMB8 mRNA
CTD
PMID:15170462
NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283
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Psmc3
proteasome 26S subunit, ATPase 3
decreases expression
EXP
Picrotoxin results in decreased expression of PSMC3 mRNA
CTD
PMID:15170462
NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358
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Pvalb
parvalbumin
decreases expression
EXP
Picrotoxin results in decreased expression of PVALB protein
CTD
PMID:15382257
NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
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Ryr2
ryanodine receptor 2
increases expression
EXP
Picrotoxin results in increased expression of RYR2 mRNA
CTD
PMID:21113126
NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
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Smad1
SMAD family member 1
decreases expression
EXP
Picrotoxin results in decreased expression of SMAD1 mRNA
CTD
PMID:15170462
NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
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Smad3
SMAD family member 3
increases expression
EXP
Picrotoxin results in increased expression of SMAD3 mRNA
CTD
PMID:15170462
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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Smad7
SMAD family member 7
decreases expression
EXP
Picrotoxin results in decreased expression of SMAD7 mRNA
CTD
PMID:15170462
NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
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Sqle
squalene epoxidase
decreases expression
EXP
Picrotoxin results in decreased expression of SQLE mRNA
CTD
PMID:15170462
NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
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Sstr2
somatostatin receptor 2
increases expression
EXP
Picrotoxin results in increased expression of SSTR2 mRNA
CTD
PMID:15170462
NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351
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Tgfbr3
transforming growth factor beta receptor 3
increases expression
EXP
Picrotoxin results in increased expression of TGFBR3 mRNA
CTD
PMID:15170462
NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341
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Trhr
thyrotropin releasing hormone receptor
decreases expression
EXP
Picrotoxin results in decreased expression of TRHR mRNA
CTD
PMID:15170462
NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309
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Tshr
thyroid stimulating hormone receptor
increases expression
EXP
Picrotoxin results in increased expression of TSHR mRNA
CTD
PMID:15170462
NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538
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Ucp2
uncoupling protein 2
increases expression
EXP
Picrotoxin results in increased expression of UCP2 mRNA
CTD
PMID:15170462
NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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Ucp3
uncoupling protein 3
increases expression
EXP
Picrotoxin results in increased expression of UCP3 mRNA
CTD
PMID:15170462
NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
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