4'-methoxyisoflavones - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	4'-methoxyisoflavones	go back to main search page
Accession:	CHEBI:133959	browse the term
Definition:	Any methoxyisoflavone which has a methoxy group at the 4-position of the phenyl substituent.
Synonyms:	related_synonym:	Formula=C16H3O3R9; SMILES=C12=C(C(=C(C(=C2C(C(=C(O1))C=3C(=C(C(=C(C3))OC)))=O))))*; a 4'-methoxyisoflavone

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Genes (206)

afrormosin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

affects activity

afromosin affects the activity of ABCC1 protein

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

biochanin A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

biochanin A inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; biochanin A inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; biochanin A promotes the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; biochanin A promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

decreases activity

biochanin A results in decreased activity of ABCC1 protein

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

multiple interactions

biochanin A inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

acetylcholinesterase

multiple interactions

[[sodium arsenite results in increased abundance of Arsenic] which co-treated with biochanin A] results in increased activity of ACHE protein; [coenzyme Q10 co-treated with biochanin A co-treated with Phloretin] inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of ACHE protein]; biochanin A inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of ACHE protein]

PMID:33410021 PMID:35547012

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

agrin

decreases expression

biochanin A results in decreased expression of AGRN mRNA

NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003

G

aryl hydrocarbon receptor

multiple interactions
increases activity
affects binding

AHR protein affects the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene promotes the reaction [AHR protein binds to CYP1A1 promoter]]; biochanin A promotes the reaction [AHR protein binds to CYP1A1 promoter]
biochanin A results in increased activity of AHR protein
biochanin A binds to AHR protein

PMID:16903077 PMID:28985473 PMID:31621310

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldehyde dehydrogenase 7 family, member A1

decreases expression

biochanin A results in decreased expression of ALDH7A1 mRNA

NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193

G

AT-rich interaction domain 5B

increases expression

biochanin A results in increased expression of ARID5B mRNA

NCBI chr20:20,307,731...20,490,746
Ensembl chr20:20,307,731...20,487,433

G

BRISC and BRCA1 A complex member 2

increases expression

biochanin A results in increased expression of BABAM2 mRNA

NCBI chr 6:24,369,021...24,788,416
Ensembl chr 6:24,369,022...24,833,951

G

butyrylcholinesterase

multiple interactions

[coenzyme Q10 co-treated with biochanin A co-treated with Phloretin] inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of BCHE protein]; biochanin A inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of BCHE protein]

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

decreases expression

biochanin A results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

biochanin A results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

caspase 3

increases activity
multiple interactions

biochanin A results in increased activity of CASP3 protein
biochanin A inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]

PMID:12791511 PMID:38648921

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

biochanin A inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cadherin 2

decreases expression

biochanin A results in decreased expression of CDH2 mRNA

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase inhibitor 1A

decreases expression

biochanin A results in decreased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

creatine kinase B

increases activity

biochanin A results in increased activity of CKB protein

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

claudin 1

multiple interactions

biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of CLDN1 protein]

NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
decreases expression
decreases activity

[Genistein co-treated with biochanin A co-treated with daidzein] results in decreased activity of CYP19A1 protein; [Genistein co-treated with biochanin A co-treated with daidzein] results in decreased expression of CYP19A1 mRNA; biochanin A binds to and results in decreased activity of CYP19A1 protein
biochanin A results in decreased expression of CYP19A1 mRNA
biochanin A results in decreased activity of CYP19A1 protein

PMID:9435150 PMID:16965912

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases hydroxylation
decreases methylation
increases expression
increases activity

AHR protein affects the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene promotes the reaction [AHR protein binds to CYP1A1 promoter]]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1A1 protein]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; biochanin A promotes the reaction [AHR protein binds to CYP1A1 promoter]; Fulvestrant promotes the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1A1 mRNA]
CYP1A1 protein results in increased hydroxylation of biochanin A
CYP1A1 protein results in decreased methylation of biochanin A
biochanin A results in increased activity of CYP1A1 protein

PMID:15479032 PMID:16903077 PMID:28985473 PMID:31621310

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases metabolic processing
decreases activity

CYP1A2 protein results in increased metabolism of biochanin A
biochanin A results in decreased activity of CYP1A2 protein

PMID:12814970 PMID:26278343

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases methylation
multiple interactions
increases expression

CYP1B1 protein results in decreased methylation of biochanin A
Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]
AHR protein affects the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; Butyric Acid promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; sodium propionate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]

PMID:15479032 PMID:28985473 PMID:31621310

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 27, subfamily b, polypeptide 1

affects activity
increases activity
increases expression
affects expression

biochanin A affects the activity of CYP27B1 protein
biochanin A analog results in increased activity of CYP27B1 protein; biochanin A results in increased activity of CYP27B1 protein
biochanin A analog results in increased expression of CYP27B1 mRNA; biochanin A results in increased expression of CYP27B1 mRNA
biochanin A affects the expression of CYP27B1 mRNA; biochanin A analog affects the expression of CYP27B1 mRNA

PMID:15795327 PMID:17659868

NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241

G

deoxyribose-phosphate aldolase

decreases expression

biochanin A results in decreased expression of DERA mRNA

NCBI chr 4:170,663,689...170,742,469
Ensembl chr 4:170,663,665...170,758,865

G

eukaryotic translation initiation factor 5

decreases expression

biochanin A results in decreased expression of EIF5 mRNA

NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656

G

ectonucleotide pyrophosphatase/phosphodiesterase family member 5

decreases expression

biochanin A results in decreased expression of ENPP5 mRNA

NCBI chr 9:16,910,187...16,917,633
Ensembl chr 9:16,910,831...16,917,480

G

epidermal growth factor receptor pathway substrate 15

decreases expression

biochanin A results in decreased expression of EPS15 mRNA

NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221

G

estrogen receptor 1

multiple interactions
decreases expression
affects binding

biochanin A binds to and results in increased activity of ESR1 protein; biochanin A inhibits the reaction [Estradiol binds to ESR1 protein]
biochanin A results in decreased expression of ESR1 protein
[Fulvestrant co-treated with biochanin A] results in decreased expression of ESR1 protein; [Fulvestrant co-treated with biochanin A] results in increased expression of ESR1 mRNA
biochanin A binds to ESR1 protein

PMID:9751507 PMID:12598185 PMID:14579009 PMID:16076101 PMID:19913605 More...

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions
increases expression
decreases expression
affects binding

biochanin A binds to and results in increased activity of ESR2 protein; biochanin A inhibits the reaction [Estradiol binds to ESR2 protein]
[Fulvestrant co-treated with biochanin A] results in increased expression of ESR2 mRNA; Fulvestrant inhibits the reaction [biochanin A results in decreased expression of ESR2 protein]
biochanin A results in increased expression of ESR2 mRNA
biochanin A binds to ESR2 protein

PMID:9751507 PMID:12224631 PMID:16076101 PMID:16566672 PMID:19913605 More...

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

estrogen related receptor, alpha

multiple interactions
affects binding

biochanin A binds to and results in increased activity of ESRRA protein; biochanin A promotes the reaction [ESRRA protein binds to PNRC1 protein]
biochanin A binds to ESRRA protein mutant form

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

G

estrogen-related receptor beta

multiple interactions

biochanin A binds to and results in increased activity of ESRRB protein; biochanin A promotes the reaction [ESRRB protein binds to PNRC1 protein]

NCBI chr 6:106,007,701...106,163,136
Ensembl chr 6:106,008,095...106,160,791

G

estrogen-related receptor gamma

multiple interactions

biochanin A promotes the reaction [ESRRG protein binds to PNRC1 protein]

NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397

G

fibrillarin

increases expression

biochanin A results in increased expression of FBL mRNA

NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:83,469,832...83,478,932

G

folate receptor alpha

decreases expression

biochanin A results in decreased expression of FOLR1 mRNA

NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667

G

glucose-6-phosphate dehydrogenase

affects binding
decreases activity
decreases expression

biochanin A binds to G6PD protein
biochanin A results in decreased activity of G6PD protein
biochanin A results in decreased expression of G6PD mRNA

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

ganglioside GM2 activator

decreases expression

biochanin A results in decreased expression of GM2A mRNA

NCBI chr10:39,219,221...39,231,756
Ensembl chr10:39,219,243...39,231,757

G

G protein subunit alpha i3

decreases expression

biochanin A results in decreased expression of GNAI3 mRNA

NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742

G

glutathione peroxidase 1

decreases expression

biochanin A results in decreased expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

intercellular adhesion molecule 1

multiple interactions

biochanin A inhibits the reaction [CXCL8 protein results in increased expression of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

insulin-like growth factor 1

multiple interactions

[Fulvestrant co-treated with biochanin A] results in decreased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 10

multiple interactions

biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 17A

multiple interactions

biochanin A promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 1 beta

multiple interactions

biochanin A inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

increases expression

biochanin A results in increased expression of IL4 mRNA; biochanin A results in increased expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions

biochanin A inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

LCK proto-oncogene, Src family tyrosine kinase

multiple interactions

biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of LCK protein]

NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794

G

low density lipoprotein receptor class A domain containing 4

decreases expression

biochanin A results in decreased expression of LDLRAD4 mRNA

NCBI chr18:61,519,253...61,848,403
Ensembl chr18:61,521,428...61,843,238

G

latexin

increases expression

biochanin A results in increased expression of LXN mRNA

NCBI chr 2:151,727,556...151,733,426
Ensembl chr 2:151,727,102...151,733,460

G

marker of proliferation Ki-67

multiple interactions

biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of MKI67 protein]

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 14

decreases expression

biochanin A results in decreased expression of MMP14 protein

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 2

decreases activity
decreases expression

biochanin A results in decreased activity of MMP2 protein
biochanin A results in decreased expression of MMP2 mRNA

PMID:16598420 PMID:38266663

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases activity
decreases expression

biochanin A results in decreased activity of MMP9 protein
biochanin A results in decreased expression of MMP9 mRNA

PMID:16598420 PMID:38266663

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

biochanin A inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

metallothionein 2A

increases expression

biochanin A results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

mechanistic target of rapamycin kinase

multiple interactions

biochanin A inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MTOR protein]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

mucin 2, oligomeric mucus/gel-forming

multiple interactions

biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of MUC2 protein]

NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756

G

nuclear receptor coactivator 1

multiple interactions

biochanin A promotes the reaction [RORC protein binds to NCOA1 protein]

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

NADH:ubiquinone oxidoreductase subunit A5

decreases expression

biochanin A results in decreased expression of NDUFA5 mRNA

NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
Ensembl chr 5:52,995,546...53,005,598

G

NFE2 like bZIP transcription factor 2

multiple interactions

[[sodium arsenite results in increased abundance of Arsenic] which co-treated with biochanin A] results in increased expression of NFE2L2 mRNA

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; biochanin A inhibits the reaction [pervanadate results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

non-POU domain containing, octamer-binding

decreases expression

biochanin A results in decreased expression of NONO mRNA

NCBI chr X:66,554,131...66,571,992
Ensembl chr X:66,554,098...66,571,952

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

biochanin A inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

biochanin A binds to and results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

occludin

multiple interactions

biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of OCLN protein]

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

purinergic receptor P2Y14

decreases expression
multiple interactions

biochanin A results in decreased expression of P2RY14 mRNA
Fulvestrant inhibits the reaction [biochanin A results in decreased expression of P2RY14 mRNA]

NCBI chr 2:143,372,697...143,413,213
Ensembl chr 2:143,372,697...143,413,141

G

poly (ADP-ribose) polymerase 1

increases cleavage

biochanin A results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

proliferating cell nuclear antigen

multiple interactions

biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of PCNA protein]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

prefoldin subunit 5

decreases expression

biochanin A results in decreased expression of PFDN5 mRNA

NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516

G

progesterone receptor

affects binding
multiple interactions
increases expression

biochanin A binds to PGR protein
Fulvestrant inhibits the reaction [biochanin A results in increased expression of PGR mRNA]
biochanin A inhibits the reaction [Progesterone binds to PGR protein]

PMID:14579009 PMID:16076101 PMID:34848279

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

plasminogen activator, urokinase receptor

decreases expression

biochanin A results in decreased expression of PLAUR protein

NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595

G

proline-rich nuclear receptor coactivator 1

multiple interactions

biochanin A promotes the reaction [ESRRA protein binds to PNRC1 protein]; biochanin A promotes the reaction [ESRRB protein binds to PNRC1 protein]; biochanin A promotes the reaction [ESRRG protein binds to PNRC1 protein]

NCBI chr 5:47,647,070...47,657,832
Ensembl chr 5:47,647,071...47,650,161

G

peroxisome proliferator-activated receptor gamma

multiple interactions

biochanin A binds to and results in increased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

biochanin A inhibits the reaction [Dextran Sulfate results in decreased phosphorylation of PRKAA1 protein]

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

prostaglandin-endoperoxide synthase 2

multiple interactions

biochanin A inhibits the reaction [CXCL8 protein results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RAB, member RAS oncogene family-like 6

decreases expression

biochanin A results in decreased expression of RABL6 mRNA

NCBI chr 3:8,402,666...8,428,588
Ensembl chr 3:8,402,672...8,428,611

G

RELA proto-oncogene, NF-kB subunit

decreases expression

biochanin A results in decreased expression of RELA mRNA

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

replication timing regulatory factor 1

decreases expression

biochanin A results in decreased expression of RIF1 mRNA

NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617

G

RAR-related orphan receptor C

multiple interactions

biochanin A promotes the reaction [RORC protein binds to NCOA1 protein]

NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907

G

RNA pseudouridine synthase D3

decreases expression

biochanin A results in decreased expression of RPUSD3 mRNA

NCBI chr 4:146,553,743...146,562,789
Ensembl chr 4:146,558,562...146,562,794

G

SH3 domain containing GRB2 like 1, endophilin A2

increases expression

biochanin A results in increased expression of SH3GL1 mRNA

NCBI chr 9:842,285...869,753
Ensembl chr 9:842,288...869,716

G

solute carrier family 16 member 1

multiple interactions

[biochanin A results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate

NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611

G

solute carrier family 25 member 3

decreases expression

biochanin A results in decreased expression of SLC25A3 mRNA

NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:25,586,725...25,667,727

G

solute carrier organic anion transporter family, member 1c1

decreases activity
multiple interactions

biochanin A results in decreased activity of SLCO1B1 protein
[biochanin A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [biochanin A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate

NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289

G

sequestosome 1

multiple interactions

biochanin A inhibits the reaction [Dextran Sulfate results in increased expression of SQSTM1 protein]

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

serine and arginine rich splicing factor 1

decreases expression

biochanin A results in decreased expression of SRSF1 mRNA

NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336

G

sulfotransferase family 1A member 1

increases expression

biochanin A results in increased expression of SULT1A1 mRNA; biochanin A results in increased expression of SULT1A1 protein

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 1E member 1

increases expression

biochanin A results in increased expression of SULT1E1 mRNA; biochanin A results in increased expression of SULT1E1 protein

NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275

G

sulfotransferase family 2A member 1

increases expression

biochanin A results in increased expression of SULT2A1 mRNA; biochanin A results in increased expression of SULT2A1 protein

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

G

sushi domain containing 6

increases expression

biochanin A results in increased expression of SUSD6 mRNA

NCBI chr 6:100,437,834...100,531,621
Ensembl chr 6:100,437,642...100,531,606

G

spleen associated tyrosine kinase

multiple interactions

biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of SYK protein]

NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410

G

thyroid hormone receptor beta

multiple interactions

biochanin A binds to and results in increased activity of THRB protein

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

tight junction protein 1

multiple interactions

biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of TJP1 protein]

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

tumor necrosis factor

multiple interactions

biochanin A inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
biochanin A inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]

PMID:16735947 PMID:38648921

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 21

decreases expression

biochanin A results in decreased expression of TNFRSF21 mRNA

NCBI chr 9:17,879,156...17,954,085
Ensembl chr 9:17,879,156...17,954,085

G

tubulin, beta 5 class I

increases expression

biochanin A results in increased expression of TUBB mRNA

NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940

G

tyrosinase

increases expression

biochanin A results in increased expression of TYR mRNA

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

G

ubiquitin-conjugating enzyme E2D 2

decreases expression

biochanin A results in decreased expression of UBE2D2 mRNA

NCBI chr18:27,364,325...27,406,322
Ensembl chr18:27,364,303...27,406,181

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation
increases expression

UGT1A1 protein results in increased glucuronidation of biochanin A
biochanin A results in increased expression of UGT1A1 mRNA

PMID:14557274 PMID:31621310

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of biochanin A

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

unc-51 like autophagy activating kinase 1

multiple interactions

biochanin A inhibits the reaction [Dextran Sulfate results in decreased phosphorylation of ULK1 protein]

NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966

G

vascular cell adhesion molecule 1

multiple interactions
decreases expression

biochanin A inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Fulvestrant inhibits the reaction [biochanin A results in decreased expression of VCAM1 protein]

PMID:16223672 PMID:16735947

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

WD repeat domain 74

decreases expression

biochanin A results in decreased expression of WDR74 mRNA

NCBI chr 1:205,631,769...205,636,558
Ensembl chr 1:205,631,824...205,636,563

G

WW and C2 domain containing 2

decreases expression

biochanin A results in decreased expression of WWC2 mRNA

NCBI chr16:44,258,372...44,421,815
Ensembl chr16:44,258,372...44,421,812

calycosin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

abhydrolase domain containing 14b

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of ABHD14B protein

NCBI chr 8:107,087,157...107,092,122
Ensembl chr 8:107,088,069...107,092,119

G

acetylcholinesterase

increases expression
multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of ACHE mRNA
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of and results in increased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

advanced glycosylation end product-specific receptor

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased expression of AGER protein]

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

amyloid beta precursor protein

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased expression of APP protein]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

ATP synthase F1 subunit alpha

increases expression
multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of ATP5F1A mRNA
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A protein]
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]]

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

G

beta-secretase 1

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased expression of BACE1 protein]

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

biliverdin reductase B

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of BLVRB protein

NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375

G

caspase 3

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased expression of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cyclin B1

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D3

decreases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CCND3 mRNA

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin G1

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

cyclin-dependent kinase 7

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of CDK7 mRNA

NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383

G

cyclin-dependent kinase inhibitor 1A

decreases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1C

decreases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CDKN1C mRNA

NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048

G

cyclin dependent kinase inhibitor 2D

decreases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CDKN2D mRNA

NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674

G

erythropoietin

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of EPO mRNA

PMID:21309574 PMID:37348668

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

endoplasmic reticulum protein 29

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of ERP29 protein

NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376

G

glycogen synthase kinase 3 beta

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in decreased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased degradation of and results in increased expression of HIF1A protein modified form; 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of and results in decreased degradation of HIF1A protein
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of HIF1A mRNA; 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of HIF1A protein

PMID:21309574 PMID:37348668

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

high mobility group box 1

decreases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of HMGB1 protein

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

interleukin 1 beta

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor-like 1

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL1RL1 mRNA]

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 33

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL33 mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL33 protein]

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

G

interleukin 6

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

keratin 1

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of KRT1 protein

NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844

G

LIM and SH3 protein 1

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of LASP1 protein

NCBI chr10:82,795,177...82,835,659
Ensembl chr10:82,795,137...82,943,292

G

mitogen activated protein kinase 1

increases phosphorylation

7,3'-dihydroxy-4'-methoxyisoflavone results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

7,3'-dihydroxy-4'-methoxyisoflavone results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein tau

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased phosphorylation of MAPT protein]

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

minichromosome maintenance complex component 5

decreases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of MCM5 mRNA

NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389

G

minichromosome maintenance complex component 6

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of MCM6 mRNA

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

G

NADH:ubiquinone oxidoreductase subunit B8

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]]

NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817

G

NFE2 like bZIP transcription factor 2

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NME/NM23 nucleoside diphosphate kinase 1

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of NME1 protein

NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408

G

nuclear respiratory factor 1

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of and affects the localization of NRF1 protein]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NRF1 mRNA]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A protein]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB protein]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NRF1 mRNA]]

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

G

phosphatidylethanolamine binding protein 1

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PEBP1 protein

NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862

G

phosphoglycerate mutase 1

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PGAM1 protein

NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452

G

pyridoxamine 5'-phosphate oxidase

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PNPO protein

NCBI chr10:81,924,584...81,930,844
Ensembl chr10:81,924,569...81,930,871

G

PPARG coactivator 1 alpha

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in decreased expression of PPARGC1A protein]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in increased acetylation of and affects the localization of PPARGC1A protein]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in increased acetylation of PPARGC1A protein]]

PMID:36195188 PMID:36436616

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

peroxiredoxin 1

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PRDX1 protein

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

peroxiredoxin 2

decreases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of PRDX2 protein

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

proline rich membrane anchor 1

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PRIMA1 mRNA

NCBI chr 6:122,338,365...122,390,955
Ensembl chr 6:122,338,370...122,389,921

G

prostaglandin reductase 1

increases expression

[Calycosin cotreated with gallic acid] increases expression of PTGR1 mRNA in hepatocellular carcinoma cells

RGD

NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666

G

RAD9 checkpoint clamp component A

decreases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of RAD9A mRNA

NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608

G

ring-box 1

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of RBX1 mRNA

NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

succinate dehydrogenase complex iron sulfur subunit B

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB protein]
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB mRNA]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB mRNA]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB protein]]

NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293

G

sirtuin 1

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SIRT1 protein]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

S-phase kinase-associated protein 1

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of SKP1 mRNA

NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388

G

S-phase kinase associated protein 2

decreases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of SKP2 mRNA

NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338

G

stress-induced phosphoprotein 1

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of STIP1 protein

NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476

G

transgelin 2

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of TAGLN2 protein

NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972

G

transcription factor A, mitochondrial

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in decreased expression of TFAM protein]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of TFAM mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of TFAM protein]

PMID:36195188 PMID:36436616

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

transforming growth factor, beta 1

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

troponin I3, cardiac type

multiple interactions

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in increased expression of TNNI3 protein]

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

G

ubiquitin protein ligase E3A

increases expression

7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of UBE3A mRNA

NCBI chr 1:110,070,260...110,161,675
Ensembl chr 1:110,070,480...110,157,250

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

UGT1A3 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member B7

increases glucuronidation

UGT2B7 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

G

ubiquinol cytochrome c reductase core protein 2

multiple interactions
increases expression

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 protein]
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 protein]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 protein]]
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of UQCRC2 mRNA

NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453

calycosin-7-O-beta-D-glucoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of BAX mRNA]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of BAX protein]
calycosin-7-O-beta-D-glucoside results in increased expression of BAX mRNA; calycosin-7-O-beta-D-glucoside results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 mRNA]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 protein]
calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 mRNA; calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

increases cleavage
increases expression
multiple interactions

calycosin-7-O-beta-D-glucoside results in increased cleavage of CASP3 protein
calycosin-7-O-beta-D-glucoside results in increased expression of CASP3 mRNA
TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased cleavage of CASP3 protein]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of CASP3 mRNA]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

decreases expression

calycosin-7-O-beta-D-glucoside results in decreased expression of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

erythropoietin

increases expression

calycosin-7-O-beta-D-glucoside results in increased expression of EPO mRNA

PMID:21309574 PMID:37348668

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

glutamic--pyruvic transaminase

decreases expression

calycosin-7-O-beta-D-glucoside results in decreased expression of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

calycosin-7-O-beta-D-glucoside results in decreased degradation of and results in increased expression of HIF1A protein modified form; calycosin-7-O-beta-D-glucoside results in increased expression of and results in decreased degradation of HIF1A protein
calycosin-7-O-beta-D-glucoside results in increased expression of HIF1A mRNA; calycosin-7-O-beta-D-glucoside results in increased expression of HIF1A protein

PMID:21309574 PMID:37348668

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

thioredoxin 1

multiple interactions
decreases expression

TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 mRNA]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 protein]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased cleavage of CASP3 protein]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of BAX mRNA]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of BAX protein]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of CASP3 mRNA]
calycosin-7-O-beta-D-glucoside results in decreased expression of TXN mRNA; calycosin-7-O-beta-D-glucoside results in decreased expression of TXN protein

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

formononetin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases activity
increases expression
affects activity

Acetylcysteine inhibits the reaction [formononetin results in increased expression of ABCB1 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCB1 mRNA]; formononetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]
formononetin results in decreased activity of ABCB1 protein
formononetin affects the activity of ABCB1 protein

PMID:15796199 PMID:23867903 PMID:27996361 PMID:34217736

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

affects activity
decreases expression
multiple interactions

formononetin affects the activity of ABCC1 protein
formononetin results in decreased expression of ABCC1 mRNA
Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC1 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC1 mRNA]

PMID:15796199 PMID:23867903

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC2 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC2 mRNA]
formononetin promotes the reaction [Cisplatin results in increased expression of ABCC2 mRNA]

PMID:23867903 PMID:28414026

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 4

multiple interactions

formononetin promotes the reaction [Cisplatin results in increased expression of ABCC4 mRNA]

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

acid phosphatase 5, tartrate resistant

multiple interactions

formononetin inhibits the reaction [Streptozocin results in increased activity of ACP5 protein]; formononetin inhibits the reaction [Streptozocin results in increased expression of ACP5 mRNA]

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

aryl hydrocarbon receptor

multiple interactions
increases activity

fulvestrant promotes the reaction [formononetin results in increased activity of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldo-keto reductase family 1 member B10

increases expression

formononetin results in increased expression of AKR1B10 mRNA

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

formononetin promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]]
formononetin decreases phosphorylation of AKT1 protein in lung

CTD
RGD

PMID:34077701 PMID:32276600

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

BCL2 associated X, apoptosis regulator

multiple interactions

formononetin promotes the reaction [Epirubicin results in increased expression of BAX mRNA]
formononetin inhibits the reaction [Cisplatin results in increased expression of BAX protein]

PMID:23867903 PMID:28414026

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

formononetin results in decreased expression of BCL2 mRNA
formononetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]
formononetin promotes the reaction [Cisplatin results in increased expression of BCL2 protein]

PMID:23867903 PMID:28414026 PMID:34077701

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions
increases activity
increases expression

Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP3 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP3 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP3 mRNA]; formononetin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; formononetin promotes the reaction [Epirubicin results in increased activity of CASP3 protein]; formononetin promotes the reaction [Epirubicin results in increased expression of CASP3 mRNA]
formononetin increases activity of CASP3 protein in lung
formononetin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]

CTD
RGD

PMID:23867903 PMID:28414026 PMID:34077701 PMID:32276600

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

formononetin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions
increases expression
increases activity

Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP8 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP8 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP8 mRNA]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases expression
increases activity

Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP9 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP9 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP9 mRNA]; formononetin promotes the reaction [Epirubicin results in increased activity of CASP9 protein]; formononetin promotes the reaction [Epirubicin results in increased expression of CASP9 mRNA]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cyclin B1

increases expression
multiple interactions

formononetin results in increased expression of CCNB1 protein
XI-006 inhibits the reaction [formononetin results in increased expression of CCNB1 protein]

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

increases expression
multiple interactions

formononetin results in increased expression of CCND1 protein
XI-006 inhibits the reaction [formononetin results in increased expression of CCND1 protein]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

carnitine palmitoyltransferase 1A

increases expression

formononetin results in increased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

cathepsin K

multiple interactions

formononetin inhibits the reaction [Streptozocin results in increased expression of CTSK mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of CTSK protein]

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases hydroxylation
increases expression
multiple interactions
decreases methylation

CYP1A1 protein results in increased hydroxylation of formononetin
formononetin results in increased expression of CYP1A1 mRNA
fulvestrant promotes the reaction [formononetin results in increased expression of CYP1A1 mRNA]
CYP1A1 protein results in decreased methylation of formononetin

PMID:15479032 PMID:28985473 PMID:37793997

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

formononetin results in decreased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases methylation
increases expression

CYP1B1 protein results in decreased methylation of formononetin
formononetin results in increased expression of CYP1B1 mRNA

PMID:15479032 PMID:28985473

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

formononetin results in decreased activity of CYP2D6 protein

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

epidermal growth factor receptor

decreases phosphorylation

formononetin decreases phosphorylation of EGFR protein in lung

RGD

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

erythropoietin

increases expression

formononetin results in increased expression of EPO mRNA

PMID:21309574 PMID:37348668

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

estrogen receptor 1

affects binding
multiple interactions

formononetin binds to ESR1 protein
[Lipopolysaccharides co-treated with formononetin] results in increased expression of ESR1 protein
formononetin binds to and results in increased activity of ESR1 protein

PMID:9751507 PMID:16076101 PMID:16773531 PMID:37269934

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions
affects binding

formononetin binds to and results in increased activity of ESR2 protein
formononetin binds to ESR2 protein

PMID:9751507 PMID:12224631 PMID:16076101 PMID:16773531 PMID:19913605

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

formononetin inhibits the reaction [Streptozocin results in increased expression of FOS mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glutamate cysteine ligase, modifier subunit

multiple interactions

[formononetin co-treated with Hydrogen Peroxide] results in increased expression of GCLM protein; formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]]

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

hepatitis A virus cellular receptor 1

multiple interactions

formononetin inhibits the reaction [Cisplatin results in increased expression of HAVCR1 mRNA]

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

hypoxia inducible factor 1 subunit alpha

increases expression
multiple interactions

formononetin results in increased expression of HIF1A mRNA; formononetin results in increased expression of HIF1A protein
formononetin results in decreased degradation of and results in increased expression of HIF1A protein modified form; formononetin results in increased expression of and results in decreased degradation of HIF1A protein

PMID:21309574 PMID:37348668

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

multiple interactions

[formononetin co-treated with Hydrogen Peroxide] results in increased expression of HMOX1 protein; formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]
formononetin inhibits the reaction [Glucose results in decreased expression of HMOX1 mRNA]

PMID:34077701 PMID:37944786

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interleukin 17A

multiple interactions

formononetin promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 4

increases expression

formononetin results in increased expression of IL4 mRNA; formononetin results in increased expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions

formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

formononetin inhibits the reaction [Streptozocin results in increased expression of JUN mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

mitogen activated protein kinase 1

multiple interactions

formononetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

formononetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

formononetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

matrilin 3

decreases expression

formononetin results in decreased expression of MATN3 mRNA

NCBI chr 6:31,748,517...31,768,564
Ensembl chr 6:31,748,474...31,768,101

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

formononetin decreases expression of MCL1 protein in lung

RGD

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

MDM2 proto-oncogene

increases expression

formononetin results in increased expression of MDM2 protein

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

MDM4 regulator of p53

increases expression

formononetin results in increased expression of MDM4 protein

NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226

G

matrix metallopeptidase 9

multiple interactions

formononetin inhibits the reaction [Streptozocin results in increased expression of MMP9 mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

nuclear factor of activated T-cells 1

multiple interactions

formononetin inhibits the reaction [Streptozocin results in increased expression of NFATC1 mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of NFATC1 protein]

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

NFE2 like bZIP transcription factor 2

multiple interactions

[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NFE2L2 mRNA; formononetin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]]
formononetin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]

PMID:34077701 PMID:37269934

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

formononetin inhibits the reaction [CXCL8 protein results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nerve growth factor

multiple interactions

formononetin inhibits the reaction [Glucose results in decreased expression of NGF mRNA]; formononetin inhibits the reaction [Glucose results in decreased secretion of and results in decreased expression of NGF protein]

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

NLR family, pyrin domain containing 3

multiple interactions

formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 3

increases expression
multiple interactions

formononetin results in increased expression of NOS3 mRNA
formononetin results in increased phosphorylation of and results in increased activity of NOS3 protein

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA; [formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA]; Wortmannin inhibits the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

progastricsin

decreases expression

formononetin results in decreased expression of PGC mRNA

NCBI chr 9:13,257,462...13,265,682
Ensembl chr 9:13,257,462...13,265,682

G

PPARG coactivator 1 alpha

multiple interactions

formononetin inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein kinase AMP-activated catalytic subunit alpha 1

increases phosphorylation
multiple interactions

formononetin results in increased phosphorylation of PRKAA1 protein
Lipopolysaccharides promotes the reaction [formononetin results in increased phosphorylation of PRKAA1 protein]

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions
increases phosphorylation

Lipopolysaccharides promotes the reaction [formononetin results in increased phosphorylation of PRKAA2 protein]

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

protein kinase cAMP-activated catalytic subunit beta

multiple interactions

[Lipopolysaccharides co-treated with formononetin] results in increased phosphorylation of PRKACB protein

NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198

G

prostaglandin reductase 1

increases expression

[Formononetin cotreated with gallic acid] increases expression of PTGR1 mRNA in hepatocellular carcinoma cells

RGD

NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666

G

prostaglandin-endoperoxide synthase 2

multiple interactions

formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

sirtuin 1

multiple interactions

formononetin inhibits the reaction [Glucose results in decreased expression of SIRT1 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

sirtuin 3

affects binding
multiple interactions

formononetin binds to SIRT3 protein
formononetin inhibits the reaction [Glucose results in decreased expression of SIRT3 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SIRT3 protein]

NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808

G

solute carrier family 22 member 2

decreases expression

formononetin results in decreased expression of SLC22A2 mRNA

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 6 member 14

decreases expression

formononetin results in decreased expression of SLC6A14 mRNA

NCBI chr X:112,314,643...112,375,412
Ensembl chr X:112,314,691...112,375,096

G

superoxide dismutase 1

multiple interactions

formononetin inhibits the reaction [Glucose results in decreased expression of SOD1 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions

formononetin inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SOD2 protein]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

serine/threonine kinase 11

multiple interactions

[Lipopolysaccharides co-treated with formononetin] results in increased phosphorylation of STK11 protein

NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315

G

transgelin

decreases expression

formononetin results in decreased expression of TAGLN mRNA

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

transcription factor A, mitochondrial

multiple interactions

formononetin inhibits the reaction [Glucose results in decreased expression of TFAM mRNA]

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

transcription factor B2, mitochondrial

multiple interactions

formononetin inhibits the reaction [Glucose results in decreased expression of TFB2M mRNA]

NCBI chr13:91,278,889...91,296,709
Ensembl chr13:91,278,898...91,296,657

G

toll-like receptor 4

multiple interactions

formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor protein p53

multiple interactions
decreases expression

formononetin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]
formononetin results in decreased expression of TP53 protein
XI-006 inhibits the reaction [formononetin results in decreased expression of TP53 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

transient receptor potential cation channel, subfamily V, member 5

multiple interactions

formononetin inhibits the reaction [Streptozocin results in decreased expression of TRPV5 mRNA]

NCBI chr 4:70,536,432...70,562,743
Ensembl chr 4:70,536,440...70,562,745

G

transient receptor potential cation channel, subfamily V, member 6

multiple interactions

formononetin inhibits the reaction [Streptozocin results in decreased expression of TRPV6 mRNA]

NCBI chr 4:70,507,347...70,523,013
Ensembl chr 4:70,507,348...70,523,017

G

thioredoxin interacting protein

increases expression

formononetin results in increased expression of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

thioredoxin reductase 1

multiple interactions

[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA; [formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 protein; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA]; Wortmannin inhibits the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA]

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation
increases expression

UGT1A1 protein results in increased glucuronidation of formononetin
formononetin results in increased expression of UGT1A1 mRNA

PMID:14557274 PMID:37793997

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of formononetin

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

irigenin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aggrecan

multiple interactions

irigenin inhibits the reaction [TNF protein results in decreased expression of ACAN mRNA]; irigenin inhibits the reaction [TNF protein results in decreased expression of ACAN protein]

NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627

G

caspase 3

multiple interactions

irigenin inhibits the reaction [TNF protein results in increased activity of and results in increased cleavage of CASP3 protein]; irigenin inhibits the reaction [TNF protein results in increased expression of CASP3 mRNA]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

collagen type II alpha 1 chain

multiple interactions

irigenin inhibits the reaction [TNF protein results in decreased expression of COL2A1 mRNA]; irigenin inhibits the reaction [TNF protein results in decreased expression of COL2A1 protein]

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

matrix metallopeptidase 13

multiple interactions

irigenin inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP13 protein]

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 2

multiple interactions

irigenin inhibits the reaction [TNF protein results in increased expression of MMP2 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

multiple interactions

irigenin inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP3 protein]

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

multiple interactions

irigenin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

tumor necrosis factor

multiple interactions

irigenin inhibits the reaction [TNF protein results in decreased expression of ACAN mRNA]; irigenin inhibits the reaction [TNF protein results in decreased expression of ACAN protein]; irigenin inhibits the reaction [TNF protein results in decreased expression of COL2A1 mRNA]; irigenin inhibits the reaction [TNF protein results in decreased expression of COL2A1 protein]; irigenin inhibits the reaction [TNF protein results in increased activity of and results in increased cleavage of CASP3 protein]; irigenin inhibits the reaction [TNF protein results in increased expression of CASP3 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP2 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP2 protein]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP3 protein]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; irigenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Irisflorentin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
increases activity

4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [irisflorentin results in increased activity of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19867
chemical entity	19865
atom	19865
nonmetal atom	19787
oxygen atom	19527
oxygen molecular entity	19527
organooxygen compound	19189
ether	17310
methoxyisoflavone	312
4'-methoxyisoflavones	206
2'-hydroxybiochanin A	0
2'-hydroxyformononetin	0
3-(3,4-dimethoxy-5-phenylmethoxyphenyl)-5-hydroxy-6-methoxy-7-phenylmethoxy-1-benzopyran-4-one	0
3-(3,4-dimethoxyphenyl)-5,7-dihydroxy-2-methyl-1-benzopyran-4-one	0
3-(3,4-dimethoxyphenyl)-7-hydroxy-2-methyl-8-[(2-methyl-1-piperidinyl)methyl]-1-benzopyran-4-one	0
4'-O-methylisoflavone	0
5,6,7,4'-tetramethoxyisoflavone	0
5,6,7-trimethoxy-3-(3,4,5-trimethoxyphenyl)-1-benzopyran-4-one	0
5,7,8-trimethoxy-3-(4-methoxyphenyl)-1-benzopyran-4-one	0
5-[[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxy-2-oxanyl)oxy]-2-oxanyl]oxy]-7,8-dimethoxy-3-(4-methoxyphenyl)-1-benzopyran-4-one	0
5-hydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-7-phenylmethoxy-1-benzopyran-4-one	0
7-hydroxy-2',4',5'-trimethoxyisoflavone	0
7-hydroxy-3-(3-hydroxy-2,4-dimethoxyphenyl)-1-benzopyran-4-one	0
7-hydroxy-8-methoxy-3-(4-methoxyphenyl)-1-benzopyran-4-one	0
Irisflorentin	1
Irisolidone	0
Texasin	0
acetic acid [5-acetyloxy-3-(4-methoxyphenyl)-4-oxo-1-benzopyran-7-yl] ester	0
afrormosin	1
biochanin A +	103
biochanin A 7-O-(6-O-malonyl-beta-D-glucoside)	0
biochanin A 7-O-beta-D-glucoside	0
calycosin +	67
calycosin-7-O-beta-D-glucoside	8
dalnigrein	0
dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside	0
erylatissin A	0
formononetin +	75
formononetin 7-O-glucoside-6''-O-malonate	0
formononetin 7-O-rutinoside	0
iridin	0
irigenin +	8
licoricone	0
ononin	0
pratensein	0
Path 2
Term	Annotations
CHEBI ontology	19867
subatomic particle	19865
composite particle	19865
hadron	19865
baryon	19865
nucleon	19865
atomic nucleus	19865
atom	19865
main group element atom	19803
p-block element atom	19803
carbon group element atom	19744
carbon atom	19740
organic molecular entity	19740
organic molecule	19692
organic cyclic compound	19482
organic heterocyclic compound	18872
oxacycle	17903
benzopyran	11976
1-benzopyran	11730
isoflavonoid	3827
isoflavones	3808
methoxyisoflavone	312
4'-methoxyisoflavones	206
2'-hydroxybiochanin A	0
2'-hydroxyformononetin	0
3-(3,4-dimethoxy-5-phenylmethoxyphenyl)-5-hydroxy-6-methoxy-7-phenylmethoxy-1-benzopyran-4-one	0
3-(3,4-dimethoxyphenyl)-5,7-dihydroxy-2-methyl-1-benzopyran-4-one	0
3-(3,4-dimethoxyphenyl)-7-hydroxy-2-methyl-8-[(2-methyl-1-piperidinyl)methyl]-1-benzopyran-4-one	0
4'-O-methylisoflavone	0
5,6,7,4'-tetramethoxyisoflavone	0
5,6,7-trimethoxy-3-(3,4,5-trimethoxyphenyl)-1-benzopyran-4-one	0
5,7,8-trimethoxy-3-(4-methoxyphenyl)-1-benzopyran-4-one	0
5-[[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxy-2-oxanyl)oxy]-2-oxanyl]oxy]-7,8-dimethoxy-3-(4-methoxyphenyl)-1-benzopyran-4-one	0
5-hydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-7-phenylmethoxy-1-benzopyran-4-one	0
7-hydroxy-2',4',5'-trimethoxyisoflavone	0
7-hydroxy-3-(3-hydroxy-2,4-dimethoxyphenyl)-1-benzopyran-4-one	0
7-hydroxy-8-methoxy-3-(4-methoxyphenyl)-1-benzopyran-4-one	0
Irisflorentin	1
Irisolidone	0
Texasin	0
acetic acid [5-acetyloxy-3-(4-methoxyphenyl)-4-oxo-1-benzopyran-7-yl] ester	0
afrormosin	1
biochanin A +	103
biochanin A 7-O-(6-O-malonyl-beta-D-glucoside)	0
biochanin A 7-O-beta-D-glucoside	0
calycosin +	67
calycosin-7-O-beta-D-glucoside	8
dalnigrein	0
dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside	0
erylatissin A	0
formononetin +	75
formononetin 7-O-glucoside-6''-O-malonate	0
formononetin 7-O-rutinoside	0
iridin	0
irigenin +	8
licoricone	0
ononin	0
pratensein	0

paths to the root