thymol sulfate(1-) - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	thymol sulfate(1-)	go back to main search page
Accession:	CHEBI:133663	browse the term
Definition:	A phenyl sulfate oxoanion that is the conjugate base of thymol sulfate, obtained by deprotonation of the sulfate group; major species at pH 7.3.
Synonyms:	exact_synonym:	5-methyl-2-(propan-2-yl)phenyl sulfate
	related_synonym:	Formula=C10H13O4S; InChI=1S/C10H14O4S/c1-7(2)9-5-4-8(3)6-10(9)14-15(11,12)13/h4-7H,1-3H3,(H,11,12,13)/p-1; InChIKey=NODSEPOUFZPJEQ-UHFFFAOYSA-M; SMILES=C1(=C(C=C(C)C=C1)OS([O-])(=O)=O)C(C)C; thymol sulfate
	xref:	CAS:89-83-8; KEGG:C09908
	xref_mesh:	MESH:D013943
	cyclic_relationship:	is_conjugate_base_of CHEBI:82911

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Genes (54)

thymol sulfate(1-)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acid phosphatase 5, tartrate resistant

multiple interactions

Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of ACP5 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of ACP5 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

aryl hydrocarbon receptor

multiple interactions
increases activity

[4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] results in increased activity of AHR protein; [4-cymene co-treated with gamma-terpinene co-treated with Thymol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol] results in increased activity of AHR protein; Thymol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
Thymol results in increased activity of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

apoptosis inducing factor, mitochondria associated 1

affects localization

Thymol affects the localization of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Thymol results in increased expression of BAX protein
Thymol inhibits the reaction [imidacloprid results in increased expression of BAX mRNA]
Thymol results in increased expression of BAX mRNA

PMID:21640085 PMID:34171690

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Thymol results in decreased expression of BCL2 protein
Thymol inhibits the reaction [imidacloprid results in decreased expression of BCL2 mRNA]

PMID:21640085 PMID:34171690

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

Thymol inhibits the reaction [Isoproterenol results in decreased expression of BCL2L1 mRNA]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

carbonic anhydrase 2

multiple interactions

Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

caspase 3

increases activity
multiple interactions

Thymol results in increased activity of CASP3 protein
Thymol inhibits the reaction [imidacloprid results in increased expression of CASP3 mRNA]; Thymol inhibits the reaction [imidacloprid results in increased expression of CASP3 protein]

PMID:21640085 PMID:34171690

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity
multiple interactions

Thymol results in increased activity of CASP8 protein
Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA]

PMID:21640085 PMID:26996544

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases activity

Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP9 mRNA]
Thymol results in increased activity of CASP9 protein

PMID:21640085 PMID:26996544

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

Thymol inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]
Thymol inhibits the reaction [Diethylhexyl Phthalate results in increased activity of CAT protein]
Thymol inhibits the reaction [imidacloprid results in decreased activity of CAT protein]; Thymol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]

PMID:26680107 PMID:26721194 PMID:34171690 PMID:35521929

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cathepsin K

multiple interactions

Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of CTSK protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

Thymol inhibits the reaction [imidacloprid results in decreased expression of CYP11A1 mRNA]

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions

Thymol inhibits the reaction [imidacloprid results in decreased expression of CYP17A1 mRNA]

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

Thymol inhibits the reaction [imidacloprid results in decreased expression of CYP19A1 mRNA]

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

Thymol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Thymol results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

dendrocyte expressed seven transmembrane protein

multiple interactions

Thymol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]

NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078

G

diacylglycerol O-acyltransferase 2

multiple interactions

Thymol inhibits the reaction [Ethanol results in increased expression of DGAT2 mRNA]

NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428

G

Fas cell surface death receptor

multiple interactions

Thymol inhibits the reaction [Isoproterenol results in increased expression of FAS mRNA]

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Thymol promotes the reaction [Lipopolysaccharides results in decreased expression of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

follicle stimulating hormone subunit beta

multiple interactions

Thymol inhibits the reaction [imidacloprid results in increased expression of FSHB protein]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

GRB2-associated binding protein 2

multiple interactions

Thymol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA]

NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions

Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit beta 2

multiple interactions

Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]

NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251

G

gamma-aminobutyric acid type A receptor subunit gamma 2

multiple interactions

Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]

NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346

G

glutathione-disulfide reductase

multiple interactions

Thymol inhibits the reaction [Dietary Fats results in decreased activity of GSR protein]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

hydroxysteroid (17-beta) dehydrogenase 3

multiple interactions

Thymol inhibits the reaction [imidacloprid results in decreased expression of HSD17B3 mRNA]

NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554

G

heat shock protein family A (Hsp70) member 8

multiple interactions

Chloroquine inhibits the reaction [Thymol inhibits the reaction [Ethanol results in decreased expression of HSPA8 protein]]; Thymol inhibits the reaction [Ethanol results in decreased expression of HSPA8 protein]

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

5-hydroxytryptamine receptor 3A

increases activity

Thymol results in increased activity of HTR3A protein

NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389

G

interleukin 10

multiple interactions

[Thymol co-treated with Fluorouracil] results in increased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions

Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
Thymol inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]

PMID:26801986 PMID:30048646

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

Thymol inhibits the reaction [Fluorouracil results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

luteinizing hormone subunit beta

multiple interactions

Thymol inhibits the reaction [imidacloprid results in increased expression of LHB protein]

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

microtubule-associated protein 1 light chain 3 alpha

increases expression
multiple interactions

Thymol results in increased expression of MAP1LC3A protein
Thymol inhibits the reaction [Ethanol results in increased expression of MAP1LC3A protein]

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

G

melanocyte inducing transcription factor

multiple interactions

Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MITF mRNA]

NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145

G

matrix metallopeptidase 9

multiple interactions

Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MYC mRNA]

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

nuclear factor of activated T-cells 1

multiple interactions

Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of NFATC1 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

oxoglutarate dehydrogenase

multiple interactions

Thymol inhibits the reaction [Isoproterenol results in decreased activity of OGDH protein]

NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479

G

proliferating cell nuclear antigen

multiple interactions

Thymol inhibits the reaction [imidacloprid results in decreased expression of PCNA protein]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Thymol inhibits the reaction [Fluorouracil results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Thymol inhibits the reaction [Fluorouracil results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

sequestosome 1

multiple interactions

Thymol inhibits the reaction [Ethanol results in increased expression of SQSTM1 protein]

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

Thymol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

sterol regulatory element binding transcription factor 1

multiple interactions

Thymol inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

steroidogenic acute regulatory protein

multiple interactions

Thymol inhibits the reaction [imidacloprid results in decreased expression of STAR mRNA]

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

transforming growth factor, beta 1

multiple interactions

Thymol inhibits the reaction [Dietary Fats results in increased expression of TGFB1 protein]
Thymol inhibits the reaction [Fluorouracil results in increased expression of TGFB1 mRNA]; Thymol inhibits the reaction [Fluorouracil results in increased expression of TGFB1 protein]

PMID:26680107 PMID:34665902

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Thymol inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]
Thymol inhibits the reaction [Fluorouracil results in increased expression of TNF mRNA]; Thymol inhibits the reaction [Fluorouracil results in increased expression of TNF protein]

PMID:26801986 PMID:30048646 PMID:34665902

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 11A

multiple interactions

Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF11A mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF11A protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA]

NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695

G

TNF superfamily member 11

multiple interactions

Thymol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MITF mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MYC mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA]

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

transient receptor potential cation channel, subfamily V, member 3

increases activity

Thymol results in increased activity of TRPV3 protein

NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of Thymol

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of Thymol

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

vascular endothelial growth factor A

multiple interactions

Thymol inhibits the reaction [Dietary Fats results in increased expression of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19874
role	19844
biological role	19842
biochemical role	19549
volatile oil component	7791
thymol	54
thymol sulfate(1-)	54
Path 2
Term	Annotations
CHEBI ontology	19874
subatomic particle	19872
composite particle	19872
hadron	19872
baryon	19872
nucleon	19872
atomic nucleus	19872
atom	19872
main group element atom	19811
p-block element atom	19811
chalcogen	19563
oxygen atom	19535
oxygen molecular entity	19535
oxide	12868
oxoanion	10448
chalcogen oxoanion	659
sulfur oxoanion	657
sulfate	520
organosulfate oxoanion	520
aryl sulfate oxoanion	54
phenyl sulfate oxoanion	54
thymol sulfate(1-)	54

paths to the root