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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:desmethylnaproxen
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Accession:CHEBI:133474 term browser browse the term
Definition:A member of the class of naphthols that is naproxen in which the 6-methoxy group has been demethylated.
Synonyms:exact_synonym: (2S)-2-(6-hydroxynaphthalen-2-yl)propanoic acid
 related_synonym: (S)-2-(6-hydroxy-2-naphthyl)propionic acid;   (S)-2-(6-hydroxynaphthalen-2-yl)propanoic acid;   (S)-6-Hydroxy-alpha-methyl-2-naphthaleneacetic acid;   6-O-Demethylnaproxen;   Formula=C13H12O3;   InChI=1S/C13H12O3/c1-8(13(15)16)9-2-3-11-7-12(14)5-4-10(11)6-9/h2-8,14H,1H3,(H,15,16)/t8-/m0/s1;   InChIKey=XWJUDDGELKXYNO-QMMMGPOBSA-N;   SMILES=C1=CC(=CC2=C1C=C(C=C2)[C@@H](C(=O)O)C)O
 xref: CAS:52079-10-4
 xref_mesh: MESH:C034451
 xref: PMID:1400763;   PMID:1400768;   PMID:1400803;   PMID:16187975;   PMID:16305588;   PMID:20006341;   PMID:2438972;   PMID:2566468;   PMID:3558575;   PMID:7086653;   PMID:712339;   PMID:8218967;   PMID:8512758;   Reaxys:8838512
 cyclic_relationship: is_conjugate_acid_of CHEBI:133481


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desmethylnaproxen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpo myeloperoxidase multiple interactions ISO [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to desmethylnaproxen; desmethylnaproxen promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; desmethylnaproxen promotes the reaction [Hydrogen Peroxide results in increased activity of MPO protein] CTD PMID:28754375 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
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  CHEBI ontology 19917
    role 19887
      chemical role 19514
        environmental contaminant 18886
          desmethylnaproxen 1
Path 2
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  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19774
                        carbon atom 19790
                          organic molecular entity 19790
                            organic molecule 19743
                              organic cyclic compound 19533
                                carbocyclic compound 18614
                                  carbopolycyclic compound 17190
                                    carbobicyclic compound 5895
                                      naphthalenes 3860
                                        hydroxynaphthalene 282
                                          naphthols 252
                                            desmethylnaproxen 1
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