farnesoid X receptor agonist - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	farnesoid X receptor agonist	go back to main search page
Accession:	CHEBI:132972	browse the term
Definition:	An agonist that binds to and activates farnesoid X receptors
Synonyms:	related_synonym:	BAR agonist; BAR agonists; FXR agonist; FXR agonists; bile acid receptor agonist; bile acid receptor agonists; farnesoid X receptor agonists
	xref:	Wikipedia:Farnesoid_X_receptor

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Rat (291) Mouse (291) Human (310) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (291)

obeticholic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

decreases expression

obeticholic acid results in decreased expression of A2M mRNA

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

ATP binding cassette subfamily A member 1

decreases expression

obeticholic acid results in decreased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 11

multiple interactions
increases expression

obeticholic acid promotes the reaction [PRMT1 protein binds to ABCB11 promoter]
obeticholic acid results in increased expression of ABCB11 mRNA
obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of ABCB11 mRNA]; obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCB11 mRNA]
[obeticholic acid co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCB11 protein; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of ABCB11 protein]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 protein]
Obeticholic acid inhibits the reaction [ethanol decreases expression of Abcb11 protein in liver]

CTD
RGD

PMID:15644430 PMID:15911693 PMID:27255380 PMID:27939613 PMID:29660435 More...

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 4

multiple interactions
increases expression

obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCB4 mRNA]
obeticholic acid results in increased expression of ABCB4 mRNA

PMID:15644430 PMID:27255380 PMID:27939613

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 2

multiple interactions
increases expression

obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCC2 mRNA]
obeticholic acid results in increased expression of ABCC2 mRNA
[obeticholic acid co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC2 protein; [triptolide co-treated with Lipopolysaccharides co-treated with obeticholic acid] results in increased expression of ABCC2 mRNA; NR1H4 promotes the reaction [obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 protein]

PMID:15644430 PMID:27255380 PMID:29660435 PMID:36328986 PMID:36787806

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

multiple interactions

obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of ABCC3 mRNA]
[obeticholic acid co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC3 protein

PMID:32673658 PMID:36787806

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

multiple interactions

[obeticholic acid co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC4 protein

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily G member 1

decreases expression

obeticholic acid results in decreased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

acetyl-CoA acyltransferase 1A

increases expression

obeticholic acid results in increased expression of ACAA1 mRNA

NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624

G

acetyl-CoA acyltransferase 2

increases expression

obeticholic acid results in increased expression of ACAA2 mRNA

NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249

G

acetyl-CoA carboxylase alpha

decreases expression

obeticholic acid results in decreased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acyl-CoA thioesterase 9

increases expression

obeticholic acid results in increased expression of ACOT9 mRNA

NCBI chr X:40,073,197...40,123,573
Ensembl chr X:40,064,810...40,123,559

G

acyl-CoA oxidase 1

increases expression

obeticholic acid results in increased expression of ACOX1 mRNA

PMID:26655953 PMID:27939613

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

acyl-CoA oxidase 2

increases expression

obeticholic acid results in increased expression of ACOX2 mRNA

NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160

G

acyl-CoA oxidase 3, pristanoyl

increases expression

obeticholic acid results in increased expression of ACOX3 mRNA

NCBI chr14:75,133,986...75,176,767
Ensembl chr14:75,094,676...75,176,205

G

acyl-CoA synthetase long-chain family member 1

decreases expression

obeticholic acid results in decreased expression of ACSL1 mRNA

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

acyl-CoA synthetase long-chain family member 4

increases expression

obeticholic acid results in increased expression of ACSL4 mRNA

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

acyl-CoA synthetase long-chain family member 5

increases expression

obeticholic acid results in increased expression of ACSL5 mRNA

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

G

acyl-CoA synthetase long-chain family member 6

increases expression

obeticholic acid results in increased expression of ACSL6 mRNA

NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757

G

ADAMTS-like 2

decreases expression

obeticholic acid results in decreased expression of ADAMTSL2 mRNA

NCBI chr 3:10,397,774...10,434,557
Ensembl chr 3:10,404,626...10,434,554

G

adenylate cyclase 1

increases expression

obeticholic acid results in increased expression of ADCY1 mRNA

NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

decreases expression

obeticholic acid results in decreased expression of ADH1C mRNA

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

1-acylglycerol-3-phosphate O-acyltransferase 2

decreases expression

obeticholic acid results in decreased expression of AGPAT2 mRNA

NCBI chr 3:9,416,837...9,428,567
Ensembl chr 3:9,416,843...9,428,371

G

1-acylglycerol-3-phosphate O-acyltransferase 5

decreases expression

obeticholic acid results in decreased expression of AGPAT5 mRNA

NCBI chr16:70,939,480...70,985,745
Ensembl chr16:70,943,135...70,985,560

G

aldo-keto reductase family 1, member D1

decreases expression

obeticholic acid results in decreased expression of AKR1D1 mRNA

NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372

G

AKT serine/threonine kinase 1

multiple interactions
decreases expression
decreases phosphorylation

obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of AKT1 protein]; obeticholic acid promotes the reaction [Dietary Fats results in decreased phosphorylation of AKT1 protein]
obeticholic acid results in decreased expression of AKT1 mRNA
obeticholic acid results in decreased phosphorylation of AKT1 protein

PMID:27865854 PMID:27939613 PMID:35267068

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

decreases expression

obeticholic acid results in decreased expression of AKT2 mRNA

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

albumin

decreases expression
multiple interactions

obeticholic acid results in decreased expression of ALB mRNA
[Dietary Fats co-treated with obeticholic acid] results in decreased expression of ALB mRNA; [Dietary Fats co-treated with obeticholic acid] results in decreased expression of ALB protein

PMID:27939613 PMID:35267068

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldolase, fructose-bisphosphate A

decreases expression

obeticholic acid results in decreased expression of ALDOA mRNA

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

aldolase, fructose-bisphosphate B

decreases expression

obeticholic acid results in decreased expression of ALDOB mRNA

NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116

G

aldolase, fructose-bisphosphate C

increases expression

obeticholic acid results in increased expression of ALDOC mRNA

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

amnion associated transmembrane protein

decreases expression

obeticholic acid results in decreased expression of AMN mRNA

NCBI chr 6:130,311,372...130,318,815
Ensembl chr 6:130,311,372...130,318,815

G

apolipoprotein A1

decreases expression

obeticholic acid results in decreased expression of APOA1 mRNA

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein A2

increases expression

obeticholic acid results in increased expression of APOA2 mRNA

NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355

G

apolipoprotein B

increases expression

obeticholic acid results in increased expression of APOB mRNA

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

apolipoprotein C2

increases expression

obeticholic acid results in increased expression of APOC2 mRNA

NCBI chr 1:79,329,429...79,334,397
Ensembl chr 1:79,329,428...79,334,476

G

apolipoprotein C3

decreases expression

obeticholic acid results in decreased expression of APOC3 mRNA

NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583

G

apolipoprotein E

decreases expression

obeticholic acid results in decreased expression of APOE mRNA

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

asparaginase

decreases expression

obeticholic acid results in decreased expression of ASPG mRNA

NCBI chr 6:131,176,727...131,196,268
Ensembl chr 6:131,176,874...131,196,268

G

autophagy related 5

multiple interactions

obeticholic acid inhibits the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in decreased expression of ATG5 mRNA]

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

BCL2-associated agonist of cell death

decreases expression

obeticholic acid results in decreased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2, apoptosis regulator

increases expression
multiple interactions

obeticholic acid results in increased expression of BCL2 mRNA
[Dietary Fats co-treated with obeticholic acid] results in decreased expression of BCL2 protein

PMID:27939613 PMID:35267068

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BH3 interacting domain death agonist

decreases expression

obeticholic acid results in decreased expression of BID mRNA

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 3

decreases expression

obeticholic acid results in decreased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

complement C5a receptor 2

decreases expression

obeticholic acid results in decreased expression of C5AR2 mRNA

NCBI chr 1:76,930,381...76,945,432
Ensembl chr 1:76,930,383...76,959,517

G

carbonic anhydrase 14

increases expression

obeticholic acid results in increased expression of CA14 mRNA

NCBI chr 2:183,442,263...183,449,231
Ensembl chr 2:183,441,667...183,449,693

G

caspase 3

multiple interactions

obeticholic acid promotes the reaction [Cycloheximide results in increased activity of CASP3 protein]
obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of CASP3 protein]

PMID:15860571 PMID:26655953

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

multiple interactions

obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of CASP4 protein]

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 8

increases expression

obeticholic acid results in increased expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

C-C motif chemokine ligand 2

multiple interactions

obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin B1

multiple interactions

obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCNB1 protein]

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

multiple interactions

obeticholic acid inhibits the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in decreased expression of CCND1 protein]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCND1 protein]

PMID:29660435 PMID:35439472

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

copper chaperone for superoxide dismutase

decreases expression

obeticholic acid results in decreased expression of CCS mRNA

NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915

G

CD14 molecule

decreases expression

obeticholic acid results in decreased expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

claudin 5

multiple interactions

obeticholic acid inhibits the reaction [Methamphetamine results in decreased expression of CLDN5 protein]

NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992

G

chloride intracellular channel 4

increases expression

obeticholic acid results in increased expression of CLIC4 mRNA

NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452

G

collagen type I alpha 1 chain

decreases expression
multiple interactions

obeticholic acid results in decreased expression of COL1A1 mRNA; obeticholic acid results in decreased expression of COL1A1 protein
obeticholic acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
obeticholic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]

PMID:15860571 PMID:15980055 PMID:27939613 PMID:30745416

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

carnitine palmitoyltransferase 1A

multiple interactions
increases expression

obeticholic acid promotes the reaction [Palmitic Acid results in increased expression of CPT1A mRNA]
obeticholic acid results in increased expression of CPT1A mRNA
obeticholic acid inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]
Obeticholic acid inhibits the reaction [ethanol decreases expression of CPT1a mRNA and protein in liver]
obeticholic acid results in increased expression of CPT1A protein

CTD
RGD

PMID:26655953 PMID:27939613 PMID:27939985 PMID:32738331 PMID:27939985

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

carnitine palmitoyltransferase 2

increases expression

obeticholic acid results in increased expression of CPT2 mRNA

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

G

cysteine-rich C-terminal 1

decreases expression

obeticholic acid results in decreased expression of CRCT1 mRNA

NCBI chr 2:178,633,789...178,635,274
Ensembl chr 2:178,634,092...178,634,394

G

cAMP responsive element binding protein 3-like 1

decreases expression

obeticholic acid results in decreased expression of CREB3L1 mRNA

NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456

G

cAMP responsive element binding protein 3-like 3

increases expression

obeticholic acid results in increased expression of CREB3L3 mRNA

NCBI chr 7:8,622,614...8,631,053
Ensembl chr 7:8,622,614...8,631,048

G

C-reactive protein

decreases expression

obeticholic acid results in decreased expression of CRP mRNA

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

C-X-C motif chemokine ligand 2

multiple interactions

obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of CXCL2 mRNA]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

multiple interactions

obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of CXCL1 mRNA]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases expression

obeticholic acid results in decreased expression of CYP19A1 mRNA

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases expression

obeticholic acid results in decreased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
decreases expression
decreases activity

obeticholic acid inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of Acetaminophen]; obeticholic acid inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
obeticholic acid results in decreased expression of CYP1A2 mRNA
obeticholic acid results in decreased activity of CYP1A2 protein
[Dietary Fats co-treated with obeticholic acid] results in decreased expression of CYP1A2 mRNA; [Dietary Fats co-treated with obeticholic acid] results in decreased expression of CYP1A2 protein

PMID:27939613 PMID:35267068

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases expression

obeticholic acid results in decreased expression of CYP27A1 mRNA

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases expression

obeticholic acid results in decreased expression of CYP2C8 mRNA

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases expression

obeticholic acid results in increased expression of CYP2D6 mRNA

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression

obeticholic acid results in decreased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 2, subfamily r, polypeptide 1

increases expression

obeticholic acid results in increased expression of CYP2R1 mRNA

NCBI chr 1:168,749,302...168,798,079
Ensembl chr 1:168,751,038...168,797,759

G

cytochrome P450, family 2, subfamily s, polypeptide 1

decreases expression

obeticholic acid results in decreased expression of CYP2S1 mRNA

NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303

G

cytochrome P450, family 2, subfamily u, polypeptide 1

increases expression

obeticholic acid results in increased expression of CYP2U1 mRNA

NCBI chr 2:219,849,403...219,866,959
Ensembl chr 2:219,849,407...219,866,882

G

cytochrome P450, family 39, subfamily a, polypeptide 1

decreases expression

obeticholic acid results in decreased expression of CYP39A1 mRNA

NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775

G

cytochrome P450, family 3, subfamily a, polypeptide 18

decreases expression

obeticholic acid results in decreased expression of CYP3A43 mRNA

NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
decreases activity
decreases expression

obeticholic acid inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; obeticholic acid inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone]
obeticholic acid results in decreased activity of CYP3A4 protein
obeticholic acid results in decreased expression of CYP3A4 mRNA
obeticholic acid results in decreased expression of CYP3A2 mRNA

PMID:27939613 PMID:35267068

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

decreases expression

obeticholic acid results in decreased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

decreases expression

obeticholic acid results in decreased expression of CYP3A5 mRNA

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 4, subfamily f, polypeptide 1

decreases expression

obeticholic acid results in decreased expression of CYP4F12 mRNA

NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046

G

cytochrome P450, family 4, subfamily f, polypeptide 18

decreases expression

obeticholic acid results in decreased expression of CYP4F3 mRNA

NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940

G

cytochrome P450, family 4, subfamily f, polypeptide 39

decreases expression

obeticholic acid results in decreased expression of CYP4F22 mRNA

NCBI chr 7:11,426,806...11,505,553
Ensembl chr 7:11,433,371...11,536,181

G

cytochrome P450, family 4, subfamily f, polypeptide 40

decreases expression

obeticholic acid results in decreased expression of CYP4F11 mRNA

NCBI chr 7:11,691,648...11,707,437
Ensembl chr 7:11,692,086...11,706,229

G

cytochrome P450, family 51

decreases expression

obeticholic acid results in decreased expression of CYP51A1 mRNA

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410

G

cytochrome P450 family 7 subfamily A member 1

decreases expression
multiple interactions

obeticholic acid results in decreased expression of CYP7A1 mRNA
obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP7A1 protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 protein]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]
obeticholic acid decreases expression of CYP7a1 mRNA in liver in porcine serum induced model of cirrhosis in rat
Obeticholic acid inhibits the reaction [ethanol increases expression of Cyp7a1 protein in liver]
obeticholic acid inhibits the reaction [Isoniazid results in increased expression of CYP7A1 mRNA]

CTD
RGD

PMID:15644430 PMID:15911693 PMID:27939613 PMID:29660435 PMID:32673658 More...

RGD:15045602, RGD:15036816

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 8 subfamily B member 1

decreases expression
increases expression
multiple interactions

obeticholic acid results in decreased expression of CYP8B1 mRNA
obeticholic acid results in increased expression of CYP8B1 mRNA
obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 mRNA]

PMID:15644430 PMID:27939613 PMID:29660435

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

DNA-damage inducible transcript 3

multiple interactions

obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of DDIT3 protein]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

diacylglycerol O-acyltransferase 2

decreases expression

obeticholic acid results in decreased expression of DGAT2 mRNA

NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428

G

7-dehydrocholesterol reductase

increases expression

obeticholic acid results in increased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

DnaJ heat shock protein family (Hsp40) member B11

increases expression

obeticholic acid results in increased expression of DNAJB11 mRNA

NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407

G

dihydropyrimidine dehydrogenase

decreases expression

obeticholic acid results in decreased expression of DPYD mRNA

NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982

G

dual specificity phosphatase 6

increases expression

obeticholic acid results in increased expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

ECSIT signaling integrator

decreases expression

obeticholic acid results in decreased expression of ECSIT mRNA

NCBI chr 8:20,605,583...20,618,453
Ensembl chr 8:20,605,583...20,618,390

G

ELOVL fatty acid elongase 1

increases expression

obeticholic acid results in increased expression of ELOVL1 mRNA

NCBI chr 5:131,961,478...131,965,961
Ensembl chr 5:131,961,322...131,965,958

G

ELOVL fatty acid elongase 2

increases expression

obeticholic acid results in increased expression of ELOVL2 mRNA

NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,544,568...23,584,848

G

ELOVL fatty acid elongase 6

decreases expression

obeticholic acid results in decreased expression of ELOVL6 mRNA

NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186

G

ELOVL fatty acid elongase 7

increases expression

obeticholic acid results in increased expression of ELOVL7 mRNA

NCBI chr 2:39,789,229...39,858,579
Ensembl chr 2:39,789,250...39,856,845

G

ectodermal-neural cortex 1

increases expression

obeticholic acid results in increased expression of ENC1 mRNA

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

G

enolase 1

decreases expression

obeticholic acid results in decreased expression of ENO1 mRNA

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

enolase 3

increases expression

obeticholic acid results in increased expression of ENO3 mRNA

NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921

G

fatty acid binding protein 6

multiple interactions
increases expression

NR1H4 gene mutant form inhibits the reaction [obeticholic acid results in increased expression of FABP6 mRNA]

NCBI chr10:28,063,603...28,068,276
Ensembl chr10:28,063,603...28,068,282

G

Fas associated via death domain

increases expression

obeticholic acid results in increased expression of FADD mRNA

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

Fas cell surface death receptor

multiple interactions

Obeticholic acid inhibits the reaction [ethanol increases expression of Fas mRNA and protein in liver]

RGD

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

multiple interactions
decreases expression

obeticholic acid inhibits the reaction [Palmitic Acid results in increased expression of FASN mRNA]
obeticholic acid results in decreased expression of FASN mRNA
obeticholic acid inhibits the reaction [Ethanol results in increased expression of FASN protein]

PMID:26655953 PMID:27939613 PMID:27939985

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fructose-bisphosphatase 1

decreases expression

obeticholic acid results in decreased expression of FBP1 mRNA

NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071

G

farnesyl diphosphate synthase

decreases expression

obeticholic acid results in decreased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

fetuin B

increases expression

obeticholic acid results in increased expression of FETUB mRNA

NCBI chr11:78,082,158...78,093,022
Ensembl chr11:78,082,156...78,095,135

G

fibroblast growth factor 19

increases expression
multiple interactions
increases secretion

obeticholic acid results in increased expression of FGF15 mRNA
NR1H4 gene mutant form inhibits the reaction [obeticholic acid results in increased expression of FGF15 mRNA]
obeticholic acid results in increased expression of FGF19 mRNA
obeticholic acid results in increased secretion of FGF19 protein
Obeticholic acid inhibits the reaction [ethanol decreases expression of FGF19 protein in liver and intestine]

CTD
RGD

PMID:22918042 PMID:27939613 PMID:27939985

NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287

G

fibroblast growth factor receptor 4

decreases expression

obeticholic acid results in decreased expression of FGFR4 mRNA

NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242

G

fibronectin 1

decreases expression

obeticholic acid decreases expression of fibronectin mRNA in liver in porcine serum induced model of cirrhosis in rat

RGD

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

obeticholic acid results in decreased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box M1

multiple interactions
increases expression

NR1H4 affects the reaction [obeticholic acid results in increased expression of FOXM1 mRNA]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 protein]

PMID:22135065 PMID:29660435

NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684

G

forkhead box P3

increases expression

obeticholic acid results in increased expression of FOXP3 mRNA

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression

obeticholic acid results in decreased expression of GAPDH mRNA

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

glutamate cysteine ligase, modifier subunit

increases expression

obeticholic acid results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

growth factor, augmenter of liver regeneration

multiple interactions

[Dietary Fats co-treated with obeticholic acid] results in decreased expression of GFER mRNA; [Dietary Fats co-treated with obeticholic acid] results in decreased expression of GFER protein

NCBI chr10:13,718,489...13,721,782
Ensembl chr10:13,718,489...13,720,869

G

glycerol kinase

decreases expression

obeticholic acid results in decreased expression of GK mRNA

NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631

G

glycerol-3-phosphate acyltransferase, mitochondrial

decreases expression

obeticholic acid results in decreased expression of GPAM mRNA

NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639

G

glycerol-3-phosphate dehydrogenase 1

decreases expression

obeticholic acid results in decreased expression of GPD1 mRNA

NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529

G

glutamic--pyruvic transaminase

multiple interactions

obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of GPT protein]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; obeticholic acid promotes the reaction [Dietary Fats results in increased expression of GPT protein]

PMID:35267068 PMID:36328986 PMID:36581201 PMID:36787806

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

increases expression

obeticholic acid results in increased expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

decreases expression

obeticholic acid results in decreased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutathione peroxidase 3

increases expression

obeticholic acid results in increased expression of GPX3 mRNA

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

gasdermin D

multiple interactions

obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of GSDMD protein]

NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055

G

glutathione-disulfide reductase

increases expression

obeticholic acid results in increased expression of GSR mRNA

PMID:26655953 PMID:27939613

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase pi 1

decreases expression

obeticholic acid results in decreased expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

increases expression

obeticholic acid results in increased expression of GSTT1 mRNA

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

glycogen synthase 2

increases expression

obeticholic acid results in increased expression of GYS2 mRNA

NCBI chr 4:175,365,054...175,406,228
Ensembl chr 4:175,365,054...175,406,228

G

histone cluster 2 H2B family member E

decreases expression

obeticholic acid results in decreased expression of H2BC11 mRNA

NCBI chr 2:183,780,583...183,783,030

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases expression

obeticholic acid results in decreased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

decreases expression

obeticholic acid results in decreased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

hepatocyte nuclear factor 4, alpha

decreases expression
multiple interactions

obeticholic acid results in decreased expression of HNF4A mRNA
[Dietary Fats co-treated with obeticholic acid] results in decreased expression of HNF4A mRNA; [Dietary Fats co-treated with obeticholic acid] results in decreased expression of HNF4A protein

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

HRas proto-oncogene, GTPase

decreases expression

obeticholic acid results in decreased expression of HRAS mRNA

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

hydroxysteroid (17-beta) dehydrogenase 7

decreases expression

obeticholic acid results in decreased expression of HSD17B7 mRNA

NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

decreases expression

obeticholic acid results in decreased expression of HSD3B7 mRNA

NCBI chr 1:182,412,216...182,415,447
Ensembl chr 1:182,412,151...182,415,442

G

heat shock protein family A (Hsp70) member 5

multiple interactions

obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of HSPA5 protein]; obeticholic acid inhibits the reaction [Palmitic Acid results in increased expression of HSPA5 protein]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heparan sulfate proteoglycan 2

decreases expression

obeticholic acid results in decreased expression of HSPG2 mRNA

NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594

G

inhibitor of DNA binding 2

decreases expression

obeticholic acid results in decreased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

obeticholic acid results in decreased expression of IDI1 mRNA

NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357

G

insulin-like growth factor binding protein, acid labile subunit

decreases expression

obeticholic acid results in decreased expression of IGFALS mRNA

NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677

G

interleukin 10

multiple interactions

obeticholic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL10 protein]; obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 18

multiple interactions

obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of IL18 mRNA]

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions

obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]; obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of IL1B mRNA]

PMID:27865854 PMID:29660435 PMID:35688268 PMID:38103844

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

multiple interactions

obeticholic acid promotes the reaction [Carbon Tetrachloride results in increased expression of IL4 mRNA]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions

obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA]; obeticholic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of IL6 mRNA]

PMID:29660435 PMID:30745416 PMID:35688268 PMID:36720452 PMID:38103844

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 receptor

decreases expression

obeticholic acid results in decreased expression of IL6R mRNA

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

interleukin 6 cytokine family signal transducer

decreases expression

obeticholic acid results in decreased expression of IL6ST mRNA

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

G

inhibin subunit beta B

increases expression

obeticholic acid results in increased expression of INHBB mRNA

NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832

G

interleukin-1 receptor-associated kinase 1

decreases expression

obeticholic acid results in decreased expression of IRAK1 mRNA

NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521

G

interleukin-1 receptor-associated kinase 2

decreases expression

obeticholic acid results in decreased expression of IRAK2 mRNA

NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

obeticholic acid results in increased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

decreases expression

obeticholic acid results in decreased expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

JunD proto-oncogene, AP-1 transcription factor subunit

multiple interactions

NR0B2 protein affects the reaction [obeticholic acid inhibits the reaction [JUND protein binds to TIMP1 promoter]]

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

G

keratin 18

multiple interactions

[Dietary Fats co-treated with obeticholic acid] results in decreased expression of KRT18 mRNA

NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
Ensembl chr10:133,157,475...133,161,166

G

lamin B receptor

decreases expression

obeticholic acid results in decreased expression of LBR mRNA

NCBI chr13:93,539,386...93,564,026
Ensembl chr13:93,538,920...93,564,017

G

lecithin cholesterol acyltransferase

decreases expression

obeticholic acid results in decreased expression of LCAT mRNA

NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231

G

low density lipoprotein receptor

decreases expression

obeticholic acid results in decreased expression of LDLR mRNA

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

leukocyte receptor cluster member 8

increases expression

obeticholic acid results in increased expression of LENG8 mRNA

NCBI chr 1:70,040,785...70,052,662
Ensembl chr 1:70,040,785...70,052,488

G

leucine-rich repeat LGI family, member 4

increases expression

obeticholic acid results in increased expression of LGI4 mRNA

NCBI chr 1:86,294,539...86,305,909
Ensembl chr 1:86,295,074...86,304,874

G

Lck interacting transmembrane adaptor 1

decreases expression

obeticholic acid results in decreased expression of LIME1 mRNA

NCBI chr 3:168,490,535...168,496,627
Ensembl chr 3:168,490,074...168,493,127

G

lipase C, hepatic type

decreases expression

obeticholic acid results in decreased expression of LIPC mRNA

NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464

G

lipin 1

decreases expression

obeticholic acid results in decreased expression of LPIN1 mRNA

NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097

G

lipin 2

decreases expression

obeticholic acid results in decreased expression of LPIN2 mRNA

NCBI chr 9:111,083,378...111,158,193
Ensembl chr 9:111,083,745...111,158,193

G

lanosterol synthase

decreases expression

obeticholic acid results in decreased expression of LSS mRNA

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

MAF bZIP transcription factor

increases expression

obeticholic acid results in increased expression of MAF mRNA

NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365

G

MAF bZIP transcription factor F

increases expression

obeticholic acid results in increased expression of MAFF mRNA

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

obeticholic acid inhibits the reaction [Dietary Fats results in decreased expression of MAP1LC3B protein]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mitogen activated protein kinase kinase 3

decreases expression

obeticholic acid results in decreased expression of MAP2K3 mRNA

NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492

G

mitogen-activated protein kinase kinase 6

decreases expression

obeticholic acid results in decreased expression of MAP2K6 mRNA

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

G

mitogen activated protein kinase kinase 7

decreases expression

obeticholic acid results in decreased expression of MAP2K7 mRNA

NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222

G

mitogen-activated protein kinase kinase kinase 14

decreases expression

obeticholic acid results in decreased expression of MAP3K14 mRNA

NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523

G

mitogen-activated protein kinase kinase kinase 5

decreases expression

obeticholic acid results in decreased expression of MAP3K5 mRNA

NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800

G

mitogen-activated protein kinase kinase kinase 8

increases expression

obeticholic acid results in increased expression of MAP3K8 mRNA

NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216

G

mitogen activated protein kinase 1

multiple interactions

obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen-activated protein kinase 11

decreases expression

obeticholic acid results in decreased expression of MAPK11 mRNA

NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395

G

mitogen-activated protein kinase 12

decreases expression

obeticholic acid results in decreased expression of MAPK12 mRNA

NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664

G

mitogen activated protein kinase 3

multiple interactions

obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

malate dehydrogenase 1

increases expression

obeticholic acid results in increased expression of MDH1 mRNA

NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925

G

meteorin-like, glial cell differentiation regulator

decreases expression

obeticholic acid results in decreased expression of METRNL mRNA

NCBI chr10:106,963,880...106,977,875
Ensembl chr10:106,963,880...106,977,869

G

MFSD2 lysolipid transporter A, lysophospholipid

increases expression

obeticholic acid results in increased expression of MFSD2A mRNA

NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690

G

mixed lineage kinase domain like pseudokinase

decreases expression

obeticholic acid results in decreased expression of MLKL mRNA

NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502

G

MLLT11, transcription factor 7 cofactor

increases expression

obeticholic acid results in increased expression of MLLT11 mRNA

NCBI chr 2:182,795,790...182,804,960
Ensembl chr 2:182,795,790...182,797,199

G

matrix metallopeptidase 2

increases activity

obeticholic acid results in increased activity of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

myeloperoxidase

multiple interactions

obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

myocardin related transcription factor B

decreases expression

obeticholic acid results in decreased expression of MRTFB mRNA

NCBI chr10:1,116,315...1,278,106
Ensembl chr10:1,116,310...1,277,897

G

methylsterol monooxygenase 1

decreases expression

obeticholic acid results in decreased expression of MSMO1 mRNA

NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016

G

mevalonate diphosphate decarboxylase

decreases expression

obeticholic acid results in decreased expression of MVD mRNA

NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971

G

mevalonate kinase

decreases expression

obeticholic acid results in decreased expression of MVK mRNA

NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

obeticholic acid results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

MYD88, innate immune signal transduction adaptor

multiple interactions

obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of MYD88 protein]

PMID:35688268 PMID:36720452

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

NFE2 like bZIP transcription factor 2

increases expression
multiple interactions

obeticholic acid results in increased expression of NFE2L2 mRNA
[Dietary Fats co-treated with obeticholic acid] results in decreased expression of NFE2L2 protein

PMID:27939613 PMID:35267068

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

increases expression
multiple interactions

obeticholic acid results in increased expression of NFKB1 mRNA
Obeticholic acid inhibits the reaction [ethanol increases expression of NF-kB protein in liver]

CTD
RGD

PMID:27939613 PMID:27939985

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nuclear factor kappa B subunit 2

decreases expression

obeticholic acid results in decreased expression of NFKB2 mRNA

NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213

G

NFKB inhibitor alpha

multiple interactions

Obeticholic acid inhibits the reaction [ethanol decreases expression of Nfkbia protein in liver]

RGD

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NLR family, pyrin domain containing 3

multiple interactions

Obeticholic acid inhibits the reaction [ethanol increases expression of Nrlp3 protein in liver]

RGD

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

neuropeptide W

decreases expression

obeticholic acid results in decreased expression of NPW mRNA

NCBI chr10:13,680,275...13,681,618
Ensembl chr10:13,680,321...13,681,586

G

nuclear receptor subfamily 0, group B, member 2

multiple interactions
increases expression

obeticholic acid promotes the reaction [PRMT2 protein binds to NR0B2 promoter]
obeticholic acid results in increased expression of NR0B2 mRNA
obeticholic acid results in increased expression of NR0B2 mRNA; obeticholic acid results in increased expression of NR0B2 protein
NR0B2 protein affects the reaction [obeticholic acid inhibits the reaction [JUND protein binds to TIMP1 promoter]]; NR0B2 protein affects the reaction [obeticholic acid results in decreased expression of and results in decreased secretion of TIMP1 protein]; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of NR0B2 mRNA]; obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR0B2 mRNA]
Obeticholic acid inhibits the reaction [ethanol decreases expression of Nr0b2 protein in liver and intestine]
obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR0B2 protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of NR0B2 protein]; obeticholic acid inhibits the reaction [Dietary Fats results in decreased expression of NR0B2 mRNA]

CTD
RGD

PMID:15644430 PMID:15860571 PMID:15911693 PMID:15980055 PMID:26655953 More...

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group H, member 4

increases activity
multiple interactions
increases response to substance
increases expression

obeticholic acid results in increased activity of NR1H4 protein
obeticholic acid binds to and results in increased activity of NR1H4 protein; obeticholic acid promotes the reaction [NR1H4 protein binds to PRMT1 protein]
[obeticholic acid co-treated with 1-Naphthylisothiocyanate] results in increased expression of NR1H4 protein; NR1H4 affects the reaction [obeticholic acid results in increased expression of FOXM1 mRNA]; NR1H4 gene mutant form inhibits the reaction [obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA]]; NR1H4 gene mutant form inhibits the reaction [obeticholic acid results in increased expression of FABP6 mRNA]; NR1H4 gene mutant form inhibits the reaction [obeticholic acid results in increased expression of FGF15 mRNA]; NR1H4 promotes the reaction [obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]]; obeticholic acid binds to and results in increased activity of NR1H4 protein; obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of NR1H4 protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of NR1H4 mRNA]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of NR1H4 protein]
NR1H4 protein results in increased susceptibility to obeticholic acid
obeticholic acid binds to and results in increased activity of NR1H4 protein; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of NR1H4 mRNA]; obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR1H4 mRNA]
obeticholic acid results in increased expression of NR1H4 mRNA
obeticholic acid results in increased expression of NR1H4 protein
obeticholic acid increases expression of Nr1H4 mRNA in rat hepatic stellate cells; obeticholic acid increases expression of Nr1h4 mRNA in bile duct ligation and porcine serum induced models of cirrhosis in rat
Obeticholic acid inhibits the reaction [ethanol decreases expression of Nr1h4 mRNA and protein in liver and liver cell nuclei and intestine]

CTD
RGD

PMID:15860571 PMID:15911693 PMID:15980055 PMID:17567710 PMID:21242261 More...

RGD:1625201, RGD:15036816

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

nuclear receptor subfamily 5, group A, member 2

decreases expression

obeticholic acid results in decreased expression of NR5A2 mRNA

NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326

G

occludin

multiple interactions

obeticholic acid inhibits the reaction [Methamphetamine results in decreased expression of OCLN protein]; obeticholic acid promotes the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in increased expression of OCLN protein]

PMID:35439472 PMID:36720452

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

prolyl 4-hydroxylase subunit beta

increases expression

obeticholic acid results in increased expression of P4HB mRNA

NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500

G

pyruvate carboxylase

decreases expression

obeticholic acid results in decreased expression of PC mRNA

NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380

G

phosphoenolpyruvate carboxykinase 1

decreases expression

obeticholic acid results in decreased expression of PCK1 mRNA

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

increases expression

obeticholic acid results in increased expression of PFKFB1 mRNA

NCBI chr X:19,508,522...19,562,165
Ensembl chr X:19,508,546...19,562,182

G

phosphoglucomutase 1

decreases expression

obeticholic acid results in decreased expression of PGM1 mRNA

NCBI chr 5:114,595,298...114,654,728
Ensembl chr 5:114,595,293...114,654,728

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta

decreases expression

obeticholic acid results in decreased expression of PIK3CD mRNA

NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930

G

phosphoinositide-3-kinase regulatory subunit 1

decreases expression

obeticholic acid results in decreased expression of PIK3R1 mRNA

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

phospholipid transfer protein

decreases expression

obeticholic acid results in decreased expression of PLTP mRNA

NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647

G

peroxisome proliferator activated receptor alpha

multiple interactions
increases expression

Palmitic Acid inhibits the reaction [obeticholic acid results in increased expression of PPARA mRNA]
obeticholic acid results in increased expression of PPARA mRNA; obeticholic acid results in increased expression of PPARA protein
obeticholic acid inhibits the reaction [Ethanol results in decreased expression of PPARA protein]
Obeticholic acid inhibits the reaction [ethanol decreases expression of Ppara mRNA and protein in liver]

CTD
RGD

PMID:15980055 PMID:26655953 PMID:27939985 PMID:27939985

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

increases expression

obeticholic acid results in increased expression of PPARG mRNA; obeticholic acid results in increased expression of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase 1, regulatory subunit 3C

decreases expression

obeticholic acid results in decreased expression of PPP1R3C mRNA

NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961

G

protein phosphatase 2 catalytic subunit beta

increases expression

obeticholic acid results in increased expression of PPP2CB mRNA

NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576

G

protein phosphatase 2 scaffold subunit A beta

increases expression

obeticholic acid results in increased expression of PPP2R1B mRNA

NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485

G

peroxiredoxin 1

decreases expression

obeticholic acid results in decreased expression of PRDX1 mRNA

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

peroxiredoxin 6

decreases expression

obeticholic acid results in decreased expression of PRDX6 mRNA

NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355

G

protein kinase C, alpha

increases expression

obeticholic acid results in increased expression of PRKCA mRNA

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, epsilon

increases expression

obeticholic acid results in increased expression of PRKCE mRNA

NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719

G

protein arginine methyltransferase 1

multiple interactions
increases activity

obeticholic acid promotes the reaction [NR1H4 protein binds to PRMT1 protein]; obeticholic acid promotes the reaction [PRMT1 protein binds to ABCB11 promoter]
obeticholic acid results in increased activity of PRMT1 protein

NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345

G

protein arginine methyltransferase 2

multiple interactions

obeticholic acid promotes the reaction [PRMT2 protein binds to NR0B2 promoter]

NCBI chr20:12,394,748...12,420,643
Ensembl chr20:12,394,798...12,420,643

G

polypyrimidine tract binding protein 2

decreases expression

obeticholic acid results in decreased expression of PTBP2 mRNA

NCBI chr 2:207,812,659...207,874,019
Ensembl chr 2:207,812,920...207,873,506

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of and results in increased phosphorylation of RELA protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of RELA protein]

PMID:29660435 PMID:35688268 PMID:36720452

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ROS proto-oncogene 1 , receptor tyrosine kinase

increases expression

obeticholic acid results in increased expression of ROS1 mRNA

NCBI chr20:31,432,636...31,583,998
Ensembl chr20:31,432,637...31,583,865

G

ribosomal protein S6 kinase A2

increases expression

obeticholic acid results in increased expression of RPS6KA2 mRNA

NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739

G

ribosomal protein S6 kinase A4

decreases expression

obeticholic acid results in decreased expression of RPS6KA4 mRNA

NCBI chr 1:204,021,805...204,032,781
Ensembl chr 1:204,021,806...204,032,761

G

ribosomal protein S6 kinase A5

decreases expression

obeticholic acid results in decreased expression of RPS6KA5 mRNA

NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224

G

RAS related 2

increases expression

obeticholic acid results in increased expression of RRAS2 mRNA

NCBI chr 1:168,233,693...168,303,111
Ensembl chr 1:168,233,693...168,303,111

G

receptor (chemosensory) transporter protein 3

increases expression

obeticholic acid results in increased expression of RTP3 mRNA

NCBI chr 8:110,970,154...110,975,000
Ensembl chr 8:110,970,160...110,974,699

G

retinoid X receptor alpha

decreases expression

obeticholic acid results in decreased expression of RXRA mRNA

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

G

S100 calcium binding protein A3

decreases expression

obeticholic acid results in decreased expression of S100A3 mRNA

NCBI chr 2:176,034,283...176,089,702
Ensembl chr 2:176,049,520...176,089,702

G

sterol-C5-desaturase

decreases expression

obeticholic acid results in decreased expression of SC5D mRNA

NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273

G

scavenger receptor class B, member 1

increases expression

obeticholic acid results in increased expression of SCARB1 mRNA

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

syndecan 1

increases expression

obeticholic acid results in increased expression of SDC1 mRNA

NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264

G

succinate dehydrogenase complex flavoprotein subunit A

multiple interactions

obeticholic acid inhibits the reaction [Dietary Fats results in decreased expression of SDHA protein]

NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535

G

selectin P

multiple interactions

NR1H4 gene mutant form inhibits the reaction [obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA]]; obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA]

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

serpin family A member 1

decreases expression

obeticholic acid results in decreased expression of SERPINA1 mRNA

NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339

G

serpin family E member 1

decreases expression

obeticholic acid results in decreased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

stratifin

decreases expression

obeticholic acid results in decreased expression of SFN mRNA

NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314

G

single Ig and TIR domain containing

decreases expression

obeticholic acid results in decreased expression of SIGIRR mRNA

NCBI chr 1:196,195,363...196,208,692
Ensembl chr 1:196,199,462...196,202,269

G

solute carrier family 10 member 1

decreases expression
multiple interactions

obeticholic acid results in decreased expression of SLC10A1 mRNA
[1-Naphthylisothiocyanate co-treated with obeticholic acid] results in decreased expression of SLC10A1 protein; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of SLC10A1 mRNA]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 protein]
Obeticholic acid inhibits the reaction [ethanol decreases expression of Slc10a1 protein in liver]
obeticholic acid promotes the reaction [Isoniazid results in decreased expression of SLC10A1 mRNA]

CTD
RGD

PMID:15644430 PMID:15911693 PMID:29660435 PMID:32673658 PMID:36328986 More...

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 13 member 5

decreases expression

obeticholic acid results in decreased expression of SLC13A5 mRNA

NCBI chr10:56,866,249...56,891,189
Ensembl chr10:56,866,249...56,890,945

G

solute carrier family 25 member 1

decreases expression

obeticholic acid results in decreased expression of SLC25A1 mRNA

NCBI chr11:83,055,764...83,058,781
Ensembl chr11:83,055,748...83,058,781

G

solute carrier family 25 member 10

decreases expression

obeticholic acid results in decreased expression of SLC25A10 mRNA

NCBI chr10:105,765,598...105,775,159
Ensembl chr10:105,765,372...105,773,556

G

solute carrier family 25 member 12

decreases expression

obeticholic acid results in decreased expression of SLC25A12 mRNA

NCBI chr 3:56,097,166...56,191,841
Ensembl chr 3:56,097,269...56,192,100

G

solute carrier family 27 member 5

decreases expression

obeticholic acid results in decreased expression of SLC27A5 mRNA

NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172

G

solute carrier family 51 member A

increases expression

obeticholic acid results in increased expression of SLC51A mRNA; obeticholic acid results in increased expression of SLC51A protein

PMID:26655953 PMID:27939613

NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485

G

SLC51 subunit beta

increases expression
multiple interactions

obeticholic acid results in increased expression of SLC51B mRNA
obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of SLC51B mRNA]

PMID:26655953 PMID:27255380 PMID:27939613

NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145

G

solute carrier organic anion transporter family member 1B2

multiple interactions
increases expression

obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of SLCO1B2 mRNA]
obeticholic acid results in increased expression of SLCO1B2 mRNA
obeticholic acid results in increased expression of SLCO1B3 mRNA

PMID:27255380 PMID:27939613

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

suppressor of cytokine signaling 2

decreases expression

obeticholic acid results in decreased expression of SOCS2 mRNA

NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548

G

superoxide dismutase 2

decreases expression

obeticholic acid results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sequestosome 1

multiple interactions

obeticholic acid inhibits the reaction [Dietary Fats results in decreased expression of SQSTM1 protein]

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sterol regulatory element binding transcription factor 1

multiple interactions
decreases expression

obeticholic acid inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]
obeticholic acid results in decreased expression of SREBF1 mRNA
Obeticholic acid inhibits the reaction [ethanol increases expression of Srebf1 mRNA and protein in liver]

CTD
RGD

PMID:27939613 PMID:27939985 PMID:27939985

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

sterol regulatory element binding transcription factor 2

multiple interactions
decreases expression

obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA]
obeticholic acid results in decreased expression of SREBF2 mRNA

PMID:26655953 PMID:27939613

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

sulfotransferase family 2A member 1

multiple interactions

obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of SULT2A1 mRNA]

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

G

SUZ RNA binding domain containing 1

increases expression

obeticholic acid results in increased expression of SZRD1 mRNA

NCBI chr 5:153,418,748...153,443,286
Ensembl chr 5:153,418,748...153,443,252

G

TGF-beta activated kinase 1/MAP3K7 binding protein 1

decreases expression

obeticholic acid results in decreased expression of TAB1 mRNA

NCBI chr 7:111,675,829...111,707,058
Ensembl chr 7:111,686,371...111,707,058

G

TAP binding protein

decreases expression

obeticholic acid results in decreased expression of TAPBP mRNA

NCBI chr20:4,956,937...4,966,191
Ensembl chr20:4,956,937...4,966,181

G

transcription elongation factor A2

increases expression

obeticholic acid results in increased expression of TCEA2 mRNA

NCBI chr 3:168,796,244...168,804,125
Ensembl chr 3:168,796,331...168,804,116

G

trans-2,3-enoyl-CoA reductase

decreases expression

obeticholic acid results in decreased expression of TECR mRNA

NCBI chr19:24,526,700...24,568,168
Ensembl chr19:24,541,615...24,568,168

G

tubulin epsilon and delta complex 1

decreases expression

obeticholic acid results in decreased expression of TEDC1 mRNA

NCBI chr 6:132,234,764...132,245,164
Ensembl chr 6:132,236,925...132,244,928

G

transforming growth factor, beta 1

multiple interactions
decreases expression

obeticholic acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
obeticholic acid results in decreased expression of TGFB1 mRNA
obeticholic acid inhibits the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in increased expression of TGFB1 protein]

PMID:15980055 PMID:27939613 PMID:35439472

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

decreases expression

obeticholic acid results in decreased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

transforming growth factor, beta 3

increases expression

obeticholic acid results in increased expression of TGFB3 mRNA

NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564

G

transforming growth factor, beta receptor 1

decreases expression

obeticholic acid results in decreased expression of TGFBR1 mRNA

NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777

G

TIMP metallopeptidase inhibitor 1

multiple interactions
decreases expression

NR0B2 protein affects the reaction [obeticholic acid inhibits the reaction [JUND protein binds to TIMP1 promoter]]; NR0B2 protein affects the reaction [obeticholic acid results in decreased expression of and results in decreased secretion of TIMP1 protein]; obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]; obeticholic acid results in decreased expression of and results in decreased secretion of TIMP1 protein
obeticholic acid results in decreased expression of TIMP1 mRNA

PMID:15860571 PMID:27939613

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 2

multiple interactions

obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

tight junction protein 1

multiple interactions

obeticholic acid promotes the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in increased expression of TJP1 protein]

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

thymidine kinase 1

decreases expression

obeticholic acid results in decreased expression of TK1 mRNA

NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920

G

toll-like receptor 4

multiple interactions

obeticholic acid inhibits the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in increased expression of TLR4 protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of TLR4 protein]

PMID:35439472 PMID:35688268 PMID:36720452

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions
decreases secretion

NR1H4 gene mutant form inhibits the reaction [obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA]]; obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF mRNA]; obeticholic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]; obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA]
obeticholic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
obeticholic acid results in decreased secretion of TNF protein
Obeticholic acid inhibits the reaction [ethanol increases expression of Tnf protein in liver]

CTD
RGD

PMID:21242261 PMID:22135065 PMID:27865854 PMID:29660435 PMID:30745416 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1B

increases expression

obeticholic acid results in increased expression of TNFRSF1B mRNA

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

Tnf receptor-associated factor 2

decreases expression

obeticholic acid results in decreased expression of TRAF2 mRNA

NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538

G

thioredoxin 1

decreases expression

obeticholic acid results in decreased expression of TXN mRNA

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin reductase 2

decreases expression

obeticholic acid results in decreased expression of TXNRD2 mRNA

NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156

G

tyrosine kinase 2

decreases expression

obeticholic acid results in decreased expression of TYK2 mRNA

NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044

G

thymidine phosphorylase

decreases expression

obeticholic acid results in decreased expression of TYMP mRNA

NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874

G

ubiquitin-conjugating enzyme E2E 3

increases expression

obeticholic acid results in increased expression of UBE2E3 mRNA

NCBI chr 3:63,786,976...63,851,400
Ensembl chr 3:63,786,650...63,843,237

G

UBX domain protein 10

increases expression

obeticholic acid results in increased expression of UBXN10 mRNA

NCBI chr 5:150,953,772...150,959,608
Ensembl chr 5:150,950,731...150,959,744

G

uridine-cytidine kinase 1-like 1

decreases expression

obeticholic acid results in decreased expression of UCKL1 mRNA

NCBI chr 3:168,674,849...168,687,513
Ensembl chr 3:168,674,849...168,698,091

G

UDP-glucose pyrophosphorylase 2

increases expression

obeticholic acid results in increased expression of UGP2 mRNA

NCBI chr14:95,456,330...95,497,483
Ensembl chr14:95,456,330...95,496,830

G

UDP glucuronosyltransferase family 1 member A1

increases expression
increases glucuronidation

obeticholic acid results in increased expression of UGT1A1 mRNA
UGT1A1 protein results in increased glucuronidation of obeticholic acid

PMID:27939613 PMID:31299240

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation
multiple interactions

UGT1A3 protein results in increased glucuronidation of obeticholic acid
[Lapatinib results in decreased activity of UGT1A3 protein] which results in decreased glucuronidation of obeticholic acid

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A5

decreases expression
increases glucuronidation

obeticholic acid results in decreased expression of UGT1A4 mRNA
UGT1A4 protein results in increased glucuronidation of obeticholic acid

PMID:27939613 PMID:31299240

NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

decreases expression

obeticholic acid results in decreased expression of UGT1A6 mRNA

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

decreases expression

obeticholic acid results in decreased expression of UGT1A9 mRNA

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

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UDP glucuronosyltransferase family 2 member B7

decreases expression

obeticholic acid results in decreased expression of UGT2B7 mRNA

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

G

beta-ureidopropionase 1

decreases expression

obeticholic acid results in decreased expression of UPB1 mRNA

NCBI chr20:13,217,252...13,243,590
Ensembl chr20:13,217,258...13,243,590

G

uridine phosphorylase 1

increases expression

obeticholic acid results in increased expression of UPP1 mRNA

NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462

G

uridine phosphorylase 2

increases expression

obeticholic acid results in increased expression of UPP2 mRNA

NCBI chr 3:43,273,048...43,317,417
Ensembl chr 3:43,273,048...43,317,417

G

urocanate hydratase 1

increases expression

obeticholic acid results in increased expression of UROC1 mRNA

NCBI chr 4:122,844,933...122,876,584
Ensembl chr 4:122,844,926...122,876,591

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xanthine dehydrogenase

increases expression

obeticholic acid results in increased expression of XDH mRNA

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19867
role	19837
biological role	19835
pharmacological role	19069
agonist	18596
farnesoid X receptor agonist	291
bufol +	0
obeticholic acid	291

paths to the root