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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:roxadustat
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Accession:CHEBI:132774 term browser browse the term
Definition:An N-acylglycine resulting from the formal condensation of the amino group of glycine with the carboxy group of 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylic acid. It is an inhibitor of hypoxia inducible factor prolyl hydroxylase (HIF-PH).
Synonyms:exact_synonym: N-[(4-hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]glycine
 related_synonym: ASP1517;   FG 4592;   FG4592;   Formula=C19H16N2O5;   HIF prolyl-hydroxylase inhibitor;   InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23);   InChIKey=YOZBGTLTNGAVFU-UHFFFAOYSA-N;   SMILES=O(C=1C=CC2=C(C1)C(=NC(=C2O)C(NCC(O)=O)=O)C)C=3C=CC=CC3;   roxadustatum
 xref: CAS:808118-40-3;   KEGG:D10593
 xref_mesh: MESH:C584543
 xref: PMID:26238121;   PMID:26494833;   PMID:26707978;   PMID:26808067;   PMID:26846333;   PMID:26947173;   PMID:27021233;   PMID:27082295;   PMID:27091985;   PMID:27094610;   PMID:27352308;   Reaxys:23352808



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roxadustat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 multiple interactions EXP roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of ATG5 protein] CTD PMID:27082295 NCBI chr20:49,380,835...49,471,826 JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions EXP roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of BNIP3 protein] CTD PMID:27082295 NCBI chr 1:203,137,778...203,154,962 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity
ISO
EXP
[Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [roxadustat results in increased activity of HIF1A protein]
roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of HIF1A protein]
CTD PMID:27082295 PMID:29741670 NCBI chr 6:98,357,788...98,405,068 JBrowse link
G Hk2 hexokinase 2 increases expression ISO roxadustat results in increased expression of HK2 mRNA CTD PMID:33596451 NCBI chr 4:116,792,258...116,841,275 JBrowse link
G Ldha lactate dehydrogenase A increases expression ISO roxadustat results in increased expression of LDHA mRNA CTD PMID:33596451 NCBI chr 1:97,371,823...97,381,247 JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of MAP1LC3B protein] CTD PMID:27082295 NCBI chr19:66,571,631...66,582,270 JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO roxadustat results in increased expression of SLC2A1 mRNA CTD PMID:33596451 NCBI chr 5:138,002,522...138,030,742 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      biological role 19867
        molecular messenger 18692
          neurotransmitter 11690
            glycine 3330
              glycine derivative 3320
                N-acylglycine 30
                  roxadustat 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19670
                        hydrogen molecular entity 19652
                          hydrides 19164
                            inorganic hydride 18180
                              pnictogen hydride 18170
                                nitrogen hydride 18083
                                  azane 17892
                                    ammonia 17891
                                      organic amino compound 17891
                                        amino acid 16077
                                          alpha-amino acid 13948
                                            serine family amino acid 5762
                                              glycine 3330
                                                glycine derivative 3320
                                                  N-acylglycine 30
                                                    roxadustat 7
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