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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:roxadustat
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Accession:CHEBI:132774 term browser browse the term
Definition:An N-acylglycine resulting from the formal condensation of the amino group of glycine with the carboxy group of 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylic acid. It is an inhibitor of hypoxia inducible factor prolyl hydroxylase (HIF-PH).
Synonyms:exact_synonym: N-[(4-hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]glycine
 related_synonym: ASP1517;   FG 4592;   FG4592;   Formula=C19H16N2O5;   HIF prolyl-hydroxylase inhibitor;   InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23);   InChIKey=YOZBGTLTNGAVFU-UHFFFAOYSA-N;   SMILES=O(C=1C=CC2=C(C1)C(=NC(=C2O)C(NCC(O)=O)=O)C)C=3C=CC=CC3;   roxadustatum
 xref: CAS:808118-40-3;   KEGG:D10593
 xref_mesh: MESH:C584543
 xref: PMID:26238121;   PMID:26494833;   PMID:26707978;   PMID:26808067;   PMID:26846333;   PMID:26947173;   PMID:27021233;   PMID:27082295;   PMID:27091985;   PMID:27094610;   PMID:27352308;   Reaxys:23352808


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roxadustat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG5 autophagy related 5 multiple interactions ISO roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of ATG5 protein] CTD PMID:27082295 NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791 		JBrowse link
G BNIP3 BCL2 interacting protein 3 multiple interactions ISO roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of BNIP3 protein] CTD PMID:27082295 NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,967,684...131,981,967 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases activity
multiple interactions		 EXP
ISO		 roxadustat results in increased activity of HIF1A protein
[Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [roxadustat results in increased activity of HIF1A protein]
roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of HIF1A protein]		 CTD PMID:27082295 PMID:29741670 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G HK2 hexokinase 2 increases expression EXP roxadustat results in increased expression of HK2 mRNA CTD PMID:33596451 NCBI chr 2:74,834,127...74,893,359
Ensembl chr 2:74,834,127...74,893,359 		JBrowse link
G LDHA lactate dehydrogenase A increases expression EXP roxadustat results in increased expression of LDHA mRNA CTD PMID:33596451 NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions ISO roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of MAP1LC3B protein] CTD PMID:27082295 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779 		JBrowse link
G SLC2A1 solute carrier family 2 member 1 increases expression EXP roxadustat results in increased expression of SLC2A1 mRNA CTD PMID:33596451 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26506
    role 26329
      biological role 26308
        molecular messenger 20318
          neurotransmitter 11907
            glycine 3266
              glycine derivative 3256
                N-acylglycine 32
                  roxadustat 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 26506
    subatomic particle 26482
      composite particle 26482
        hadron 26482
          baryon 26482
            nucleon 26482
              atomic nucleus 26482
                atom 26482
                  main group element atom 26220
                    main group molecular entity 26220
                      s-block molecular entity 25463
                        hydrogen molecular entity 24872
                          hydrides 23081
                            inorganic hydride 20549
                              pnictogen hydride 20491
                                nitrogen hydride 20276
                                  azane 20004
                                    ammonia 20003
                                      organic amino compound 20003
                                        amino acid 17298
                                          alpha-amino acid 14769
                                            serine family amino acid 6387
                                              glycine 3266
                                                glycine derivative 3256
                                                  N-acylglycine 32
                                                    roxadustat 7
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