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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mono(2-ethyl-5-hydroxyhexyl) phthalate
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Accession:CHEBI:132607 term browser browse the term
Definition:A phthalic acid monoester obtained by formal condensation of one of the carboxy groups of phthalic acid with the primary hydroxy group of 2-ethylhexane-1,5-diol
Synonyms:exact_synonym: 2-{[(2-ethyl-5-hydroxyhexyl)oxy]carbonyl}benzoic acid
 related_synonym: 1,2-Benzenedicarboxylic acid, mono(2-ethyl-5-hydroxyhexyl) ester;   Formula=C16H22O5;   InChI=1S/C16H22O5/c1-3-12(9-8-11(2)17)10-21-16(20)14-7-5-4-6-13(14)15(18)19/h4-7,11-12,17H,3,8-10H2,1-2H3,(H,18,19);   InChIKey=RYPQSGURZSTFSX-UHFFFAOYSA-N;   Mono(2-ethyl-5-hydroxyhexyl) 1,2-benzenedicarboxylate;   SMILES=C1(=CC=CC=C1C(=O)OCC(CC)CCC(C)O)C(=O)O;   phthalic acid mono(2-ethyl-5-hydroxyhexyl) ester
 xref: CAS:40321-99-1
 xref_mesh: MESH:C479069
 xref: PMID:26545148;   PMID:26608625;   PMID:26766535;   PMID:26987946;   PMID:27208644;   PMID:27372718;   Reaxys:9208635


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mono(2-ethyl-5-hydroxyhexyl) phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam33 ADAM metallopeptidase domain 33 multiple interactions ISO [[Endocrine Disruptors results in increased abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate] which results in increased methylation of ADAM33 intron] which results in increased expression of ADAM33 mRNA CTD PMID:30226539 NCBI chr 3:118,262,395...118,283,456
Ensembl chr 3:118,271,029...118,283,461 		JBrowse link
G Ccdc163 coiled-coil domain containing 163 multiple interactions ISO [mono(2-ethyl-5-hydroxyhexyl) phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono(2-ethyl-5-oxohexyl)phthalate co-treated with 2-ethyl-5-carboxypentyl phthalate co-treated with mono-isobutyl phthalate co-treated with mono-benzyl phthalate co-treated with monoethyl phthalate co-treated with monobutyl phthalate] affects the expression of CCDC163 mRNA CTD PMID:37160244 NCBI chr 5:130,172,014...130,178,934
Ensembl chr 5:130,172,774...130,178,929 		JBrowse link
G Crp C-reactive protein decreases expression ISO mono(2-ethyl-5-hydroxyhexyl) phthalate results in decreased expression of CRP protein CTD PMID:21349512 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO
EXP		 [CYP2C19 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate
[CYP2C6 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate		 CTD PMID:22186153 PMID:23545481 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP
ISO		 [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate
[CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate		 CTD PMID:23545481 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dcakd dephospho-CoA kinase domain containing multiple interactions ISO [mono(2-ethyl-5-hydroxyhexyl) phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono(2-ethyl-5-oxohexyl)phthalate co-treated with 2-ethyl-5-carboxypentyl phthalate co-treated with mono-isobutyl phthalate co-treated with mono-benzyl phthalate co-treated with monoethyl phthalate co-treated with monobutyl phthalate] affects the expression of DCAKD mRNA CTD PMID:37160244 NCBI chr10:87,957,738...87,989,002
Ensembl chr10:87,957,740...87,980,054 		JBrowse link
G Flg filaggrin multiple interactions ISO [FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate CTD PMID:24380925 NCBI chr 2:178,884,793...178,912,986 JBrowse link
G Jak3 Janus kinase 3 multiple interactions ISO [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate] which results in increased expression of JAK3 mRNA CTD PMID:37093692 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Mirlet7c1 microRNA let-7c-1 multiple interactions ISO [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate] which affects the expression of MIRLET7C CTD PMID:30481674 NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265 		JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO mono(2-ethyl-5-hydroxyhexyl) phthalate results in increased expression of MMP1 protein CTD PMID:36113809 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression ISO mono(2-ethyl-5-hydroxyhexyl) phthalate results in increased expression of MMP2 protein CTD PMID:36113809 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Nefl neurofilament light chain multiple interactions ISO [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate] which results in increased expression of NEFL protein CTD PMID:37097562 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Pax8 paired box 8 multiple interactions ISO [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate] which results in increased expression of PAX8 mRNA CTD PMID:34708313 NCBI chr 3:7,185,721...7,242,363
Ensembl chr 3:7,185,723...7,242,363 		JBrowse link
G Pfas phosphoribosylformylglycinamidine synthase multiple interactions ISO [mono(2-ethyl-5-hydroxyhexyl) phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono(2-ethyl-5-oxohexyl)phthalate co-treated with 2-ethyl-5-carboxypentyl phthalate co-treated with mono-isobutyl phthalate co-treated with mono-benzyl phthalate co-treated with monoethyl phthalate co-treated with monobutyl phthalate] affects the expression of PFAS mRNA CTD PMID:37160244 NCBI chr10:53,690,301...53,711,811
Ensembl chr10:53,691,626...53,708,420 		JBrowse link
G Shbg sex hormone binding globulin decreases secretion ISO mono(2-ethyl-5-hydroxyhexyl) phthalate results in decreased secretion of SHBG protein CTD PMID:24945889 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions ISO [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate] which results in increased expression of STAT5B mRNA CTD PMID:37093692 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Tug1 taurine up-regulated 1 affects expression ISO mono(2-ethyl-5-hydroxyhexyl) phthalate affects the expression of TUG1 mRNA CTD PMID:29385630 NCBI chr14:78,519,894...78,526,927
Ensembl chr14:78,522,506...78,526,927 		JBrowse link
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Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      biological role 19864
        biochemical role 19596
          metabolite 19558
            xenobiotic metabolite 16153
              human xenobiotic metabolite 15786
                mono(2-ethyl-5-hydroxyhexyl) phthalate 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            heteroorganic entity 19556
                              organochalcogen compound 19315
                                organooxygen compound 19205
                                  carbon oxoacid 18694
                                    carboxylic acid 18691
                                      aromatic carboxylic acid 12705
                                        benzoic acids 12658
                                          benzenedicarboxylic acid 8670
                                            phthalic acid 8451
                                              phthalate ester 8433
                                                phthalic acid monoester 2538
                                                  mono(2-ethyl-5-hydroxyhexyl) phthalate 17
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