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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor
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Accession:CHEBI:132365 term browser browse the term
Definition:An EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor that interferes with the action of procollagen-proline dioxygenase (EC 1.14.11.2).
Synonyms:related_synonym: EC 1.14.11.2 inhibitor;   EC 1.14.11.2 inhibitors;   collagen proline hydroxylase inhibitor;   collagen proline hydroxylase inhibitors;   peptidyl proline hydroxylase inhibitor;   peptidyl proline hydroxylase inhibitors;   procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitor;   procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitors;   procollagen-proline 4-dioxygenase inhibitor;   procollagen-proline 4-dioxygenase inhibitors;   procollagen-proline dioxygenase (EC 1.14.11.2) inhibitors;   procollagen-proline dioxygenase inhibitor;   procollagen-proline dioxygenase inhibitors;   procollagen-proline,2-oxoglutarate-4-dioxygenase inhibitor;   procollagen-proline,2-oxoglutarate-4-dioxygenase inhibitors;   proline hydroxylase inhibitor;   proline hydroxylase inhibitors;   proline protocollagen hydroxylase inhibitor;   proline protocollagen hydroxylase inhibitors;   proline, 2-oxoglutarate dioxygenase inhibitor;   proline, 2-oxoglutarate dioxygenase inhibitors;   proline,2-oxoglutarate 4-dioxygenase inhibitor;   proline,2-oxoglutarate 4-dioxygenase inhibitors;   prolyl 4-hydroxylase inhibitor;   prolyl 4-hydroxylase inhibitors;   prolyl hydroxylase inhibitor;   prolyl hydroxylase inhibitors;   prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating inhibitor;   prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating inhibitors;   prolylprotocollagen dioxygenase inhibitor;   prolylprotocollagen dioxygenase inhibitors;   prolylprotocollagen hydroxylase inhibitor;   prolylprotocollagen hydroxylase inhibitors;   protocollagen hydroxylase inhibitor;   protocollagen hydroxylase inhibitors;   protocollagen proline 4-hydroxylase inhibitor;   protocollagen proline 4-hydroxylase inhibitors;   protocollagen proline dioxygenase inhibitor;   protocollagen proline dioxygenase inhibitors;   protocollagen prolyl hydroxylase inhibitor;   protocollagen prolyl hydroxylase inhibitors
 xref: Wikipedia:Procollagen-proline_dioxygenase


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3,4-dihydroxybenzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO
EXP		 protocatechuic acid inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein]
protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased activity of ACHE protein]		 CTD PMID:32392679 PMID:33497687 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 multiple interactions ISO protocatechuic acid inhibits the reaction [Galactose results in increased expression of AKR1B1 mRNA] CTD PMID:22687555 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Gallic Acid inhibits the reaction [protocatechuic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]]; protocatechuic acid inhibits the reaction [APP protein modified form binds to APP protein modified form] CTD PMID:22129351 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Ass1 argininosuccinate synthase 1 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of ASS1 mRNA] CTD PMID:37105472 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP		 protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of BAX mRNA]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of BAX protein]
protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of BAX mRNA]; protocatechuic acid inhibits the reaction [Isoproterenol results in increased expression of BAX protein]		 CTD PMID:32392679 PMID:33497687 PMID:36593721 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO		 protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 mRNA]; protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; protocatechuic acid inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]
protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of BCL2 mRNA]; protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]		 CTD PMID:18082360 PMID:32392679 PMID:33497687 PMID:36593721 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO
EXP		 protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of BDNF protein]
protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased expression of BDNF protein]		 CTD PMID:32392679 PMID:33497687 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 mRNA]; protocatechuic acid inhibits the reaction [furan results in increased activity of CASP3 protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in increased activity of CASP3 protein]; protocatechuic acid inhibits the reaction [Rotenone results in increased activity of CASP3 protein]
protocatechuic acid inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]		 CTD PMID:18082360 PMID:32392679 PMID:32758512 PMID:33497687 PMID:36593721 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP protocatechuic acid inhibits the reaction [furan results in increased activity of CASP9 protein] CTD PMID:32758512 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase increases activity
multiple interactions		 EXP
ISO		 protocatechuic acid results in increased activity of CAT protein
protocatechuic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of CAT protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of CAT mRNA]
protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased expression of CAT mRNA]; protocatechuic acid inhibits the reaction [furan results in decreased activity of CAT protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]		 CTD PMID:29842870 PMID:32392679 PMID:32758512 PMID:33497687 PMID:36593721 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:31306686 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP protocatechuic acid results in increased expression of CDKN1A protein CTD PMID:16227210 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Comt catechol-O-methyltransferase increases methylation ISO
EXP		 COMT protein results in increased methylation of protocatechuic acid CTD PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cs citrate synthase increases activity ISO protocatechuic acid results in increased activity of CS protein CTD PMID:31306686 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of CYP11A1 mRNA]; protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of CYP11A1 protein] CTD PMID:37105472 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of CYP17A1 mRNA] CTD PMID:37105472 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of CYP19A1 mRNA] CTD PMID:37105472 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP protocatechuic acid inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein] CTD PMID:15302093 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP protocatechuic acid inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein] CTD PMID:15302093 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity		 EXP [protocatechuic acid co-treated with Methylcholanthrene] results in decreased activity of CYP2E1 protein; protocatechuic acid inhibits the reaction [bisphenol A results in increased expression of CYP2E1 mRNA]
protocatechuic acid results in decreased activity of CYP2E1 protein		 CTD PMID:15302093 PMID:37105472 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of CYP7B1 mRNA] CTD PMID:37105472 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698 		JBrowse link
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in increased expression of DKK2 mRNA] CTD PMID:37105472 NCBI chr 2:220,568,338...220,660,225
Ensembl chr 2:220,568,338...220,660,225 		JBrowse link
G Efna2 ephrin A2 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in increased expression of EFNA2 mRNA] CTD PMID:37105472 NCBI chr 7:9,515,635...9,528,071
Ensembl chr 7:9,516,429...9,527,061 		JBrowse link
G Eno1 enolase 1 increases expression ISO protocatechuic acid results in increased expression of ENO1 mRNA CTD PMID:16227210 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336 		JBrowse link
G Epo erythropoietin increases expression
multiple interactions		 EXP protocatechuic acid results in increased expression of EPO protein
protocatechuic acid inhibits the reaction [methylmercuric chloride results in decreased expression of EPO protein]; protocatechuic acid inhibits the reaction [Methylmercury Compounds results in decreased expression of EPO protein]		 CTD PMID:31850806 PMID:32461003 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A binds to ESR1 protein] CTD PMID:37105472 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A binds to ESR2 protein] CTD PMID:37105472 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression
multiple interactions		 EXP protocatechuic acid results in increased expression of FSHB protein
protocatechuic acid inhibits the reaction [furan results in decreased expression of FSHB protein]		 CTD PMID:29842870 PMID:32758512 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity
multiple interactions		 EXP protocatechuic acid results in increased activity of G6PD protein
protocatechuic acid inhibits the reaction [furan results in decreased activity of G6PD protein]		 CTD PMID:29842870 PMID:32758512 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO protocatechuic acid inhibits the reaction [Galactose results in decreased expression of and results in decreased activity of GLO1 protein] CTD PMID:22687555 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions		 ISO
EXP		 protocatechuic acid results in increased expression of GPX1 mRNA
protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of GPX1 mRNA]
protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased expression of GPX1 mRNA]		 CTD PMID:32392679 PMID:33497687 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases activity
increases expression		 ISO
EXP		 protocatechuic acid inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of GSR mRNA]
protocatechuic acid results in increased activity of GSR protein
protocatechuic acid results in increased expression of GSR mRNA
protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased expression of GSR mRNA]; protocatechuic acid inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]		 CTD PMID:32392679 PMID:33497687 PMID:36593721 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases stability
multiple interactions
increases expression		 EXP protocatechuic acid results in increased stability of HIF1A protein
protocatechuic acid inhibits the reaction [methylmercuric chloride results in decreased expression of HIF1A protein]; protocatechuic acid inhibits the reaction [Methylmercury Compounds results in decreased expression of HIF1A protein]
protocatechuic acid results in increased expression of HIF1A protein		 CTD PMID:16227210 PMID:31850806 PMID:32461003 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 EXP protocatechuic acid inhibits the reaction [Isoproterenol results in decreased expression of HMOX1 mRNA]
protocatechuic acid results in increased expression of HMOX1 mRNA		 CTD PMID:36593721 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of HSD17B11 mRNA] CTD PMID:37105472 NCBI chr14:5,693,304...5,743,157
Ensembl chr14:5,711,964...5,743,161 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of HSD17B3 mRNA] CTD PMID:37105472 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 mRNA] CTD PMID:37105472 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of HSD3B2 mRNA] CTD PMID:37105472 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IKBKB protein] CTD PMID:36807594 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP protocatechuic acid inhibits the reaction [furan results in decreased expression of IL10 protein] CTD PMID:32758512 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 protocatechuic acid inhibits the reaction [Galactose results in increased secretion of IL1B protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of IL1B mRNA]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]
protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of IL1B protein]; protocatechuic acid inhibits the reaction [furan results in increased expression of IL1B protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]		 CTD PMID:22687555 PMID:32392679 PMID:32758512 PMID:33497687 PMID:36593721 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO protocatechuic acid inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:22687555 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ldhc lactate dehydrogenase C increases activity EXP protocatechuic acid results in increased activity of LDHC protein CTD PMID:29842870 NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression
multiple interactions		 EXP protocatechuic acid results in increased expression of LHB protein
protocatechuic acid inhibits the reaction [furan results in decreased expression of LHB protein]		 CTD PMID:29842870 PMID:32758512 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK1 protein] CTD PMID:36807594 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 protein] CTD PMID:36807594 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mpo myeloperoxidase increases activity
decreases activity
multiple interactions		 ISO
EXP		 protocatechuic acid results in increased activity of MPO protein
protocatechuic acid results in decreased activity of MPO protein
protocatechuic acid inhibits the reaction [furan results in increased activity of MPO protein]		 CTD PMID:24060682 PMID:29842870 PMID:32758512 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 EXP
ISO		 [protocatechuic acid co-treated with Cadmium Chloride] results in increased expression of NFE2L2 mRNA; protocatechuic acid inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA]
protocatechuic acid results in increased expression of NFE2L2 mRNA
protocatechuic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 mRNA]		 CTD PMID:32392679 PMID:36593721 PMID:36807594 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO protocatechuic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of NFKBIB protein] CTD PMID:20026373 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 protocatechuic acid inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of NOS2 mRNA]; protocatechuic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 mRNA]		 CTD PMID:20026373 PMID:31306686 PMID:32392679 PMID:33497687 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases activity		 EXP
ISO		 [protocatechuic acid co-treated with Methylcholanthrene] results in increased activity of NQO1 protein
protocatechuic acid results in increased activity of NQO1 protein
protocatechuic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of NQO1 mRNA]		 CTD PMID:15302093 PMID:36807594 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Oxtr oxytocin receptor multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in increased expression of OXTR mRNA] CTD PMID:37105472 NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674 		JBrowse link
G Pitx1 paired-like homeodomain 1 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in increased expression of PITX1 mRNA] CTD PMID:37105472 NCBI chr17:8,794,134...8,800,292
Ensembl chr17:8,794,134...8,800,291 		JBrowse link
G Prl prolactin multiple interactions EXP protocatechuic acid inhibits the reaction [furan results in decreased expression of PRL protein] CTD PMID:32758512 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO protocatechuic acid inhibits the reaction [Galactose results in increased expression of PTGS2 mRNA]; protocatechuic acid inhibits the reaction [Galactose results in increased expression of PTGS2 protein]; protocatechuic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of PTGS2 protein]; protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; protocatechuic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of and results in increased expression of PTGS2 protein] CTD PMID:20026373 PMID:22687555 PMID:31306686 PMID:36807594 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 protocatechuic acid inhibits the reaction [Galactose results in increased expression of and results in increased activity of RELA protein]; protocatechuic acid inhibits the reaction [Galactose results in increased expression of RELA mRNA]; protocatechuic acid inhibits the reaction [Galactose results in increased expression of RELA protein]; protocatechuic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]
protocatechuic acid inhibits the reaction [Isoproterenol results in increased expression of RELA protein]		 CTD PMID:20026373 PMID:22687555 PMID:36593721 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of SCARB1 mRNA] CTD PMID:37105472 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Sele selectin E multiple interactions ISO protocatechuic acid inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:30611791 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression
multiple interactions		 EXP protocatechuic acid results in increased expression of SLC2A1 protein
protocatechuic acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC2A1 protein]; protocatechuic acid inhibits the reaction [Methylmercury Compounds results in decreased expression of SLC2A1 protein]		 CTD PMID:31850806 PMID:32461003 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression		 ISO
EXP		 protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of SOD2 mRNA]
protocatechuic acid results in increased expression of SOD2 mRNA
protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased expression of SOD2 mRNA]		 CTD PMID:32392679 PMID:33497687 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of STAR mRNA]; protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of STAR protein] CTD PMID:37105472 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stmn2 stathmin 2 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in increased expression of STMN2 mRNA] CTD PMID:37105472 NCBI chr 2:93,204,690...93,252,011
Ensembl chr 2:93,204,692...93,252,011 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP protocatechuic acid inhibits the reaction [Isoproterenol results in increased expression of TGFB1 protein] CTD PMID:36593721 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:36807594 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 protocatechuic acid inhibits the reaction [Galactose results in increased secretion of TNF protein]; protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of TNF mRNA]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of TNF protein]
protocatechuic acid inhibits the reaction [TNF protein results in increased expression of SELE protein]
protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of TNF mRNA]; protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; protocatechuic acid inhibits the reaction [furan results in increased expression of TNF protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in increased expression of TNF protein]		 CTD PMID:22687555 PMID:30611791 PMID:31306686 PMID:32392679 PMID:32758512 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in increased expression of UGT2A3 mRNA] CTD PMID:37105472 NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729 		JBrowse link
G Ulbp1 UL16 binding protein 1 multiple interactions EXP protocatechuic acid inhibits the reaction [bisphenol A results in increased expression of ULBP1 mRNA] CTD PMID:37105472 NCBI chr 1:1,694,255...1,716,160 JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions		 EXP protocatechuic acid results in increased expression of VEGFA protein
protocatechuic acid inhibits the reaction [methylmercuric chloride results in decreased expression of VEGFA protein]; protocatechuic acid inhibits the reaction [Methylmercury Compounds results in decreased expression of VEGFA protein]		 CTD PMID:16227210 PMID:31850806 PMID:32461003 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
ethyl 3,4-dihydroxybenzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fabp4 fatty acid binding protein 4 multiple interactions ISO ethyl protocatechuate inhibits the reaction [rosiglitazone results in increased expression of FABP4 mRNA] CTD PMID:24338020 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Gata3 GATA binding protein 3 multiple interactions ISO ethyl protocatechuate inhibits the reaction [rosiglitazone results in increased ubiquitination of and results in increased degradation of GATA3 protein] CTD PMID:24338020 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Klf2 KLF transcription factor 2 multiple interactions ISO ethyl protocatechuate inhibits the reaction [rosiglitazone results in increased ubiquitination of and results in increased degradation of KLF2 protein] CTD PMID:24338020 NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO ethyl protocatechuate inhibits the reaction [rosiglitazone results in increased expression of PPARG mRNA] CTD PMID:24338020 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO ethyl protocatechuate inhibits the reaction [Ascorbic Acid results in increased expression of SP7 mRNA]; ethyl protocatechuate inhibits the reaction [Ascorbic Acid results in increased expression of SP7 protein] CTD PMID:21467157 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847 		JBrowse link
G Tafazzin tafazzin, phospholipid-lysophospholipid transacylase multiple interactions ISO ethyl protocatechuate inhibits the reaction [Rosiglitazone results in increased ubiquitination of and results in increased degradation of TAFAZZIN protein] CTD PMID:24338020 NCBI chr  X:152,065,539...152,076,178
Ensembl chr  X:152,065,609...152,074,001 		JBrowse link
roxadustat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 multiple interactions EXP roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of ATG5 protein] CTD PMID:27082295 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions EXP roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of BNIP3 protein] CTD PMID:27082295 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity		 ISO
EXP		 [Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [roxadustat results in increased activity of HIF1A protein]
roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of HIF1A protein]		 CTD PMID:27082295 PMID:29741670 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hk2 hexokinase 2 increases expression ISO roxadustat results in increased expression of HK2 mRNA CTD PMID:33596451 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Ldha lactate dehydrogenase A increases expression ISO roxadustat results in increased expression of LDHA mRNA CTD PMID:33596451 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of MAP1LC3B protein] CTD PMID:27082295 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO roxadustat results in increased expression of SLC2A1 mRNA CTD PMID:33596451 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        biochemical role 19552
          enzyme inhibitor 18753
            EC 1.* (oxidoreductase) inhibitor 17539
              EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 15966
                EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor 94
                  EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor 79
                    3,4-dihydroxybenzoic acid + 74
                    ethyl 3,4-dihydroxybenzoate 6
                    roxadustat 7
paths to the root