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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sodium propionate
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Accession:CHEBI:132106 term browser browse the term
Definition:An organic sodium salt comprising equal numbers of sodium and propionate ions.
Synonyms:related_synonym: E281;   Natriumpropionat;   Propanoic acid, sodium salt;   Propionic acid sodium salt;   Sodium propionate anhydrous;   sodium propanoate
 xref: CAS:137-40-6
 xref_mesh: MESH:C514135
 xref: Reaxys:3566934;   kegg.drug:D08440;   pubmed:26141376;   pubmed:27173555;   wikipedia.en:Sodium_propionate
 chemrof_formula: C3H5O2.Na
 chemrof_smiles: CCC(=O)[O-].[Na+]
 chemrof_inchi: InChI=1S/C3H6O2.Na/c1-2-3(4)5;/h2H2,1H3,(H,4,5);/q;+1/p-1
 chemrof_inchikey: JXKPEJDQGNYQSM-UHFFFAOYSA-M


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sodium propionate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in increased expression of BAX mRNA] CTD PMID:35639301 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in increased expression of and results in increased cleavage of CASP3 mRNA] CTD PMID:35639301 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in increased expression of CASP8 mRNA] CTD PMID:35639301 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Cldn1 claudin 1 multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in decreased expression of CLDN1 protein] CTD PMID:35639301 NCBI chr11:87,926,376...87,941,533
Ensembl chr11:87,926,337...87,941,529 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO sodium propionate promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:31621310 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO sodium propionate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; sodium propionate promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] CTD PMID:31621310 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in increased expression of HDAC2 mRNA]; sodium propionate inhibits the reaction [Ethanol results in increased expression of HDAC2 protein] CTD PMID:35639301 NCBI chr20:42,101,815...42,126,486
Ensembl chr20:42,102,861...42,126,311 		JBrowse link
G Hdac6 histone deacetylase 6 multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in increased expression of HDAC6 mRNA] CTD PMID:35639301 NCBI chr  X:17,222,538...17,244,373
Ensembl chr  X:17,222,856...17,244,370 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of IFNG mRNA] CTD PMID:37269894 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of IKBKB mRNA]; [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of IKBKB protein] CTD PMID:37269894 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of IL6 mRNA] CTD PMID:37269894 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mt1a metallothionein 1A multiple interactions
increases expression 		EXP [sodium propionate co-treated with Cadmium] results in increased expression of MT1A mRNA; [sodium propionate co-treated with Dexamethasone] results in increased expression of MT1A mRNA
sodium propionate results in increased expression of MT1A mRNA 		CTD PMID:1597404 NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr  X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of MYD88 mRNA] CTD PMID:37269894 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in decreased expression of NFKBIA protein] CTD PMID:37269894 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in increased expression of NOS2 mRNA] CTD PMID:35639301 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in increased expression of NOX1 mRNA]; sodium propionate inhibits the reaction [TNF protein affects the acetylation of NOX1 promoter] CTD PMID:35639301 NCBI chr  X:101,572,338...101,625,571
Ensembl chr  X:101,572,340...101,595,520 		JBrowse link
G Ocln occludin multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in decreased expression of OCLN protein] CTD PMID:35639301 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of and results in increased phosphorylation of RELA protein]; [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of RELA mRNA] CTD PMID:37269894 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TGFB1 mRNA] CTD PMID:37269894 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO sodium propionate inhibits the reaction [Ethanol results in decreased expression of TJP1 protein] CTD PMID:35639301 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TLR2 mRNA]; [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TLR2 protein] CTD PMID:37269894 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TLR4 mRNA]; [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TLR4 protein] CTD PMID:37269894 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TNF mRNA]; sodium propionate inhibits the reaction [TNF protein affects the acetylation of NOX1 promoter] CTD PMID:35639301 PMID:37269894 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO sodium propionate promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA] CTD PMID:31621310 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      application 20572
        food additive 15060
          food preservative 2700
            sodium propionate 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic ion 11556
                              organic anion 6893
                                carboxylic acid anion 2553
                                  monocarboxylic acid anion 1673
                                    fatty acid anion 25
                                      short-chain fatty acid anion 24
                                        fatty acid anion 3:0 24
                                          propionate 24
                                            sodium propionate 24
paths to the root