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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:salubrinal
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Accession:CHEBI:131923 term browser browse the term
Definition:A member of the class of quinolines that is a mixed aminal resulting from the formal condensation oftrichloroacetaldehyde with the amide nitrogen of trans-cinnamamide and the primary amino group of 1-quinolin-8-ylthiourea. It is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha).
Synonyms:exact_synonym: (2E)-3-phenyl-N-{2,2,2-trichloro-1-[(quinolin-8-ylcarbamothioyl)amino]ethyl}acrylamide
 related_synonym: (E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide;   Formula=C21H17Cl3N4OS;   InChI=1S/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+;   InChIKey=LCOIAYJMPKXARU-VAWYXSNFSA-N;   SMILES=C=1C=2C(C(=CC1)NC(NC(NC(/C=C/C=3C=CC=CC3)=O)C(Cl)(Cl)Cl)=S)=NC=CC2
 xref: CAS:405060-95-9
 xref_mesh: MESH:C496827
 xref: PMID:15705855;   PMID:22610062;   PMID:23178987;   PMID:23473976;   PMID:23603983;   PMID:23816340;   PMID:23824972;   PMID:24418467;   PMID:24728926;   PMID:25030410;   PMID:25157407;   PMID:25230871;   PMID:25435425;   PMID:25582550;   PMID:25619567;   PMID:25816071;   PMID:25882497;   PMID:25977571;   PMID:26021511;   PMID:26193263;   PMID:26328492;   PMID:26505387;   PMID:26743901;   PMID:26889171;   PMID:27123756;   PMID:27131989;   Patent:EP2589593;   Reaxys:13925629;   Wikipedia:Salubrinal


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salubrinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP salubrinal inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; salubrinal inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; salubrinal inhibits the reaction [AGT protein results in increased expression of FN1 protein]; salubrinal inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; salubrinal inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; salubrinal inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; salubrinal inhibits the reaction [AGT protein results in increased secretion of TGFB1 protein] CTD PMID:25398788 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP salubrinal inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein] CTD PMID:25398788 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO salubrinal results in increased expression of ATF3 mRNA CTD PMID:23690448 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression 		ISO
EXP 		[salubrinal co-treated with EPO protein] results in decreased expression of ATF4 protein; salubrinal inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATF4 protein]; salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of ATF4 protein]]; salubrinal promotes the reaction [T-2 Toxin results in increased expression of ATF4 protein]
salubrinal results in increased expression of ATF4 protein
salubrinal inhibits the reaction [decamethrin results in increased expression of ATF4 protein]; salubrinal promotes the reaction [Cisplatin results in increased expression of ATF4 protein]
salubrinal inhibits the reaction [Acrylamide results in increased expression of ATF4 protein]; salubrinal promotes the reaction [Thapsigargin results in increased expression of ATF4 protein]; salubrinal promotes the reaction [Tunicamycin results in increased expression of ATF4 protein] 		CTD PMID:21616140 PMID:21809093 PMID:23690448 PMID:25950987 PMID:28844859 More... NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO salubrinal results in increased expression of ATF6 mRNA CTD PMID:23958496 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP 		Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased expression of BAX protein]]; salubrinal promotes the reaction [Cisplatin results in increased expression of BAX protein]
salubrinal inhibits the reaction [Acrylamide results in increased expression of BAX protein]; salubrinal inhibits the reaction [cadmium acetate results in increased expression of BAX protein] 		CTD PMID:21616140 PMID:30605698 PMID:38604440 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP 		salubrinal inhibits the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]
Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]]; salubrinal promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]
salubrinal inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein] 		CTD PMID:20686688 PMID:21616140 PMID:30605698 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO salubrinal inhibits the reaction [Cadmium Chloride results in increased expression of BECN1 protein]; salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein]; salubrinal promotes the reaction [MAP3K5 protein results in increased expression of BECN1 protein] CTD PMID:20929985 PMID:33127495 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO salubrinal inhibits the reaction [Cadmium Chloride results in increased expression of BNIP3 protein] CTD PMID:33127495 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962 		JBrowse link
G Calr calreticulin multiple interactions ISO [salubrinal results in decreased activity of [PPP1CC protein binds to PPP1R15A protein]] which affects the localization of CALR protein CTD PMID:17187072 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO
EXP 		Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP12 protein]]; salubrinal inhibits the reaction [decamethrin results in increased expression of CASP12 protein]; salubrinal inhibits the reaction [Rotenone results in increased expression of CASP12 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of CASP12 mRNA]; salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP12 protein]
salubrinal inhibits the reaction [arsenite results in increased activity of CASP12 protein]; salubrinal inhibits the reaction [Rotenone results in increased cleavage of CASP12 protein]
salubrinal inhibits the reaction [T-2 Toxin results in increased expression of CASP12 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of CASP12 protein] 		CTD PMID:18226606 PMID:21616140 PMID:25428620 PMID:26446018 PMID:31841155 More... NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP 		salubrinal inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; salubrinal inhibits the reaction [MAP3K5 protein results in increased activity of CASP3 protein]; salubrinal inhibits the reaction [Paraquat results in increased activity of CASP3 protein]
salubrinal inhibits the reaction [decamethrin results in increased activity of CASP3 protein]; salubrinal inhibits the reaction [decamethrin results in increased cleavage of and results in increased activity of CASP3 protein]; salubrinal inhibits the reaction [Rotenone results in increased expression of CASP3 mRNA]; salubrinal promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]
salubrinal inhibits the reaction [Rotenone results in increased expression of CASP3 mRNA]; salubrinal inhibits the reaction [Tetrachlorodibenzodioxin results in increased cleavage of CASP3 protein] 		CTD PMID:19735704 PMID:20929985 PMID:21616140 PMID:21809093 PMID:24932542 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP9 protein]]; salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP9 protein] CTD PMID:21616140 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO salubrinal inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; salubrinal inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA] CTD PMID:23958496 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO salubrinal inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; salubrinal inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA] CTD PMID:23958496 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO salubrinal inhibits the reaction [Cyclosporine results in decreased expression of CDH1 protein] CTD PMID:22155090 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP salubrinal inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA] CTD PMID:23690541 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP salubrinal inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA] CTD PMID:23690541 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO salubrinal inhibits the reaction [decamethrin results in increased expression of CYBB mRNA]; salubrinal inhibits the reaction [decamethrin results in increased expression of CYBB protein] CTD PMID:35741090 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO salubrinal inhibits the reaction [MAP3K5 protein affects the localization of CYCS protein]; salubrinal inhibits the reaction [Paraquat affects the localization of CYCS protein] CTD PMID:20929985 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
decreases expression 		ISO
EXP 		EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]]; salubrinal inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of DDIT3 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of DDIT3 protein]
Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased expression of DDIT3 protein]]; salubrinal inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [decamethrin results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of DDIT3 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Cisplatin results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Cyclosporine results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Tacrolimus results in increased expression of DDIT3 protein]
salubrinal results in increased expression of DDIT3 mRNA
salubrinal results in decreased expression of DDIT3 protein
salubrinal inhibits the reaction [Acrylamide results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; salubrinal promotes the reaction [Tunicamycin results in increased expression of DDIT3 protein] 		CTD PMID:18305250 PMID:19735704 PMID:20686688 PMID:21616140 PMID:21809093 More... NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 multiple interactions ISO salubrinal inhibits the reaction [Paraquat results in increased expression of EDEM1 protein] CTD PMID:19735704 NCBI chr 4:143,350,989...143,385,693
Ensembl chr 4:143,353,624...143,388,060 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions
increases phosphorylation
affects phosphorylation
increases expression 		ISO
EXP 		salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein]; salubrinal inhibits the reaction [EIF2A protein results in decreased susceptibility to nonivamide]
salubrinal results in increased phosphorylation of EIF2A protein
Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased phosphorylation of EIF2A protein]]; salubrinal promotes the reaction [Cisplatin results in increased phosphorylation of EIF2A protein]
salubrinal affects the phosphorylation of EIF2A protein
salubrinal results in increased expression of EIF2A protein modified form 		CTD PMID:17332266 PMID:17418795 PMID:18305250 PMID:18684481 PMID:20071420 More... NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:144,911,153...144,945,201 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases expression
multiple interactions
increases phosphorylation 		ISO
EXP 		salubrinal results in increased expression of EIF2S1 protein modified form
[salubrinal co-treated with EPO protein] results in increased phosphorylation of EIF2S1 protein; [salubrinal results in decreased activity of EIF2S1 protein] which results in decreased susceptibility to decamethrin; EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]]; EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]]; salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased phosphorylation of EIF2S1 protein]]; salubrinal promotes the reaction [Cadmium Chloride results in increased phosphorylation of EIF2S1 protein]; salubrinal promotes the reaction [Paraquat results in increased expression of EIF2S1 protein modified form]; salubrinal results in increased phosphorylation of and results in decreased activity of EIF2S1 protein
salubrinal results in increased phosphorylation of EIF2S1 protein
[salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK1 protein; [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK3 protein; [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK8 protein; [salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK9 protein; salubrinal inhibits the reaction [cadmium acetate results in increased expression of EIF2S1 protein modified form]; salubrinal inhibits the reaction [Rotenone results in decreased phosphorylation of EIF2S1 protein]; salubrinal inhibits the reaction [Thapsigargin results in increased expression of EIF2S1 mRNA]; salubrinal inhibits the reaction [Tunicamycin results in increased expression of EIF2S1 mRNA]; salubrinal promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of EIF2S1 protein]
salubrinal inhibits the reaction [Rotenone results in decreased phosphorylation of EIF2S1 protein]; salubrinal promotes the reaction [T-2 Toxin results in increased phosphorylation of EIF2S1 protein] 		CTD PMID:21147958 PMID:21555338 PMID:21809093 PMID:23690448 PMID:24932542 More... NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649 		JBrowse link
G Epo erythropoietin multiple interactions ISO [salubrinal co-treated with EPO protein] results in decreased expression of ATF4 protein; [salubrinal co-treated with EPO protein] results in increased phosphorylation of EIF2S1 protein CTD PMID:23690448 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP salubrinal inhibits the reaction [AGT protein results in increased expression of FN1 protein] CTD PMID:25398788 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO salubrinal inhibits the reaction [Cadmium Chloride results in increased expression of FOXO3 protein] CTD PMID:33127495 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP salubrinal inhibits the reaction [Rotenone results in decreased activity of GSR protein] CTD PMID:26446018 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO salubrinal promotes the reaction [Cisplatin results in increased expression of HAVCR1 mRNA] CTD PMID:21616140 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions EXP salubrinal inhibits the reaction [Thapsigargin results in decreased expression of HGF mRNA]; salubrinal inhibits the reaction [Thapsigargin results in decreased expression of HGF protein]; salubrinal inhibits the reaction [Tunicamycin results in decreased expression of HGF mRNA]; salubrinal inhibits the reaction [Tunicamycin results in decreased expression of HGF protein] CTD PMID:28844859 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO salubrinal inhibits the reaction [Isoniazid results in increased expression of HMOX1 mRNA] CTD PMID:40015660 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression 		ISO
EXP 		EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]]; salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]; salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 protein]
salubrinal inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]; salubrinal inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; salubrinal promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HSPA5 protein]
salubrinal results in increased expression of HSPA5 protein
salubrinal inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 protein] 		CTD PMID:19735704 PMID:24932542 PMID:25428620 PMID:26446018 PMID:28844859 More... NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO salubrinal inhibits the reaction [decamethrin results in increased expression of IL1B mRNA]; salubrinal inhibits the reaction [decamethrin results in increased expression of IL1B protein] CTD PMID:35741090 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO salubrinal inhibits the reaction [decamethrin results in increased expression of IL6 mRNA]; salubrinal inhibits the reaction [decamethrin results in increased expression of IL6 protein] CTD PMID:35741090 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 affects response to substance
multiple interactions 		ISO salubrinal affects the susceptibility to MAP3K5 protein
salubrinal affects the susceptibility to [Paraquat co-treated with MAP3K5 protein]; salubrinal inhibits the reaction [MAP3K5 protein affects the localization of CYCS protein]; salubrinal inhibits the reaction [MAP3K5 protein results in increased activity of CASP3 protein]; salubrinal inhibits the reaction [Paraquat results in increased phosphorylation of and results in increased activity of MAP3K5 protein]; salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased degradation of SQSTM1 protein]; salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein]; salubrinal promotes the reaction [MAP3K5 protein results in increased degradation of SQSTM1 protein]; salubrinal promotes the reaction [MAP3K5 protein results in increased expression of BECN1 protein] 		CTD PMID:19735704 PMID:20929985 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP 		salubrinal inhibits the reaction [Cyclosporine results in increased phosphorylation of MAPK1 protein]
[salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK1 protein 		CTD PMID:21147958 PMID:22155090 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO salubrinal inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK14 protein] CTD PMID:21809093 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP 		salubrinal inhibits the reaction [Cyclosporine results in increased phosphorylation of MAPK3 protein]
[salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK3 protein 		CTD PMID:21147958 PMID:22155090 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP
ISO 		[salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK8 protein
salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK8 protein]; salubrinal inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] 		CTD PMID:20686688 PMID:21147958 PMID:21809093 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO
EXP 		salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein]
[salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK9 protein 		CTD PMID:20686688 PMID:21147958 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO [salubrinal co-treated with T-2 Toxin] results in increased expression of MMP13 mRNA; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of MMP13 protein] CTD PMID:34673134 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105 		JBrowse link
G Myh3 myosin heavy chain 3 decreases expression ISO salubrinal results in decreased expression of MYH3 protein CTD PMID:29380555 NCBI chr10:52,269,185...52,293,000
Ensembl chr10:52,269,185...52,293,000 		JBrowse link
G Myod1 myogenic differentiation 1 decreases expression ISO salubrinal results in decreased expression of MYOD1 protein CTD PMID:29380555 NCBI chr 1:106,021,161...106,023,871
Ensembl chr 1:106,021,161...106,023,871 		JBrowse link
G Myog myogenin decreases expression ISO salubrinal results in decreased expression of MYOG protein CTD PMID:29380555 NCBI chr13:48,297,476...48,300,065
Ensembl chr13:48,297,235...48,300,065 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO salubrinal inhibits the reaction [decamethrin results in decreased expression of NGF protein] CTD PMID:31841155 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO salubrinal inhibits the reaction [decamethrin results in increased expression of NOS2 protein] CTD PMID:35741090 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
increases expression 		ISO Acetylcysteine inhibits the reaction [salubrinal results in increased expression of [Cisplatin results in increased expression of NOX4 protein]] CTD PMID:21616140 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO salubrinal inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]; salubrinal inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein] CTD PMID:21809093 PMID:22155090 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma multiple interactions ISO [salubrinal results in decreased activity of [PPP1CC protein binds to PPP1R15A protein]] which affects the localization of CALR protein CTD PMID:17187072 NCBI chr12:40,043,822...40,061,301
Ensembl chr12:40,043,822...40,061,341 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions
increases expression 		ISO [salubrinal results in decreased activity of [PPP1CC protein binds to PPP1R15A protein]] which affects the localization of CALR protein
salubrinal results in increased expression of PPP1R15A protein 		CTD PMID:17187072 PMID:23690448 NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions ISO salubrinal promotes the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA] CTD PMID:23892647 NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO salubrinal inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein] CTD PMID:22155090 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO salubrinal inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 protein]; salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased degradation of SQSTM1 protein]; salubrinal promotes the reaction [MAP3K5 protein results in increased degradation of SQSTM1 protein] CTD PMID:20929985 PMID:33127495 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP salubrinal inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; salubrinal inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; salubrinal inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA] CTD PMID:25398788 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP salubrinal inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; salubrinal inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; salubrinal inhibits the reaction [AGT protein results in increased secretion of TGFB1 protein] CTD PMID:25398788 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP salubrinal inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:26446018 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO salubrinal inhibits the reaction [Cyclosporine results in decreased expression of TJP1 protein] CTD PMID:22155090 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO salubrinal inhibits the reaction [decamethrin results in increased expression of TNF mRNA]; salubrinal inhibits the reaction [decamethrin results in increased expression of TNF protein] CTD PMID:35741090 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions ISO salubrinal promotes the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA] CTD PMID:23892647 NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions 		EXP salubrinal results in increased expression of VEGFA mRNA
salubrinal promotes the reaction [Thapsigargin results in increased expression of VEGFA mRNA] 		CTD PMID:28844859 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      chemical role 20396
        oxidising agent 12057
          acetaldehyde 561
            trichloroacetaldehyde 65
              salubrinal 60
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      carboacyl group 18085
                                        univalent carboacyl group 18085
                                          carbamoyl group 17921
                                            carboxamide 17921
                                              alpha,beta-unsaturated carboxylic acid amide 7298
                                                enamide 7298
                                                  cinnamamides 1355
                                                    cinnamamide 60
                                                      trans-cinnamamide 60
                                                        salubrinal 60
paths to the root