4-pyranones - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	4-pyranones	go back to main search page
Accession:	CHEBI:131906	browse the term
Definition:	A pyranone based on the structure of 4H-pyran-4-one and its substituted derivatives.
Synonyms:	related_synonym:	pyran-4-ones

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Rat (422) Mouse (420) Human (431) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (422)

kojic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 13

decreases expression

kojic acid results in decreased expression of ABCA13 mRNA

NCBI chr14:83,873,397...84,376,138
Ensembl chr14:83,873,940...84,375,075

G

ATP binding cassette subfamily C member 2

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in increased expression of ABCC2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 6

multiple interactions

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCC6 mRNA
[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of ABCC6 mRNA

PMID:17917374 PMID:18544905

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

G

ATP binding cassette subfamily C member 9

multiple interactions

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCC9 mRNA

NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356

G

ATP binding cassette subfamily D member 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCD1 mRNA

NCBI chr X:151,428,334...151,450,115
Ensembl chr X:151,428,578...151,450,115

G

ATP binding cassette subfamily F member 2

multiple interactions

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCF2 mRNA

NCBI chr 4:10,594,802...10,607,620
Ensembl chr 4:10,594,907...10,607,606

G

abhydrolase domain containing 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of ABHD1 mRNA

NCBI chr 6:25,422,526...25,427,514
Ensembl chr 6:25,422,526...25,427,514

G

alkaline ceramidase 3

increases expression

kojic acid results in increased expression of ACER3 mRNA

NCBI chr 1:152,504,180...152,606,596
Ensembl chr 1:152,504,186...152,606,591

G

aminocarboxymuconate semialdehyde decarboxylase

decreases expression

kojic acid results in decreased expression of ACMSD mRNA

NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209

G

activin A receptor like type 1

decreases expression

kojic acid results in decreased expression of ACVRL1 mRNA

NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591

G

adrenoceptor beta 3

decreases expression

kojic acid results in decreased expression of ADRB3 mRNA

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

increases expression

kojic acid results in increased expression of AGAP3 mRNA

NCBI chr 4:10,674,746...10,724,848
Ensembl chr 4:10,674,064...10,725,244

G

AGBL carboxypeptidase 4

decreases expression

kojic acid results in decreased expression of AGBL4 mRNA

NCBI chr 5:125,254,963...126,534,367
Ensembl chr 5:125,254,956...126,534,367

G

AHNAK nucleoprotein

decreases expression

kojic acid results in decreased expression of AHNAK mRNA

NCBI chr 1:205,882,225...205,970,934
Ensembl chr 1:205,882,273...205,970,926

G

AKT serine/threonine kinase 1

decreases expression

kojic acid results in decreased expression of AKT1 mRNA

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

alkaline phosphatase, intestinal

decreases expression

kojic acid results in decreased expression of ALPI mRNA

NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877

G

amelotin

decreases expression

kojic acid results in decreased expression of AMTN mRNA

NCBI chr14:19,648,624...19,661,181
Ensembl chr14:19,648,625...19,661,181

G

annexin A1

decreases expression

kojic acid results in decreased expression of ANXA1 mRNA

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A5

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ANXA5 mRNA

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

adaptor related protein complex 1 subunit sigma 1

decreases expression

kojic acid results in decreased expression of AP1S1 mRNA

NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713

G

apolipoprotein B mRNA editing enzyme catalytic subunit 1

decreases expression

kojic acid results in decreased expression of APOBEC1 mRNA

NCBI chr 4:155,800,030...155,828,515
Ensembl chr 4:155,800,887...155,827,390

G

amyloid beta precursor protein

increases expression

kojic acid results in increased expression of APP mRNA

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

aprataxin

decreases expression

kojic acid results in decreased expression of APTX mRNA

NCBI chr 5:55,798,896...55,822,963
Ensembl chr 5:55,800,248...55,822,855

G

aquaporin 1

increases expression

kojic acid results in increased expression of AQP1 mRNA

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

ARF interacting protein 2

decreases expression

kojic acid results in decreased expression of ARFIP2 mRNA

NCBI chr 1:159,974,255...159,980,398
Ensembl chr 1:159,974,201...159,980,336

G

Rho guanine nucleotide exchange factor 16

decreases expression

kojic acid results in decreased expression of ARHGEF16 mRNA

NCBI chr 5:164,843,656...164,866,212
Ensembl chr 5:164,844,161...164,866,212

G

ARF like GTPase 6 interacting protein 5

increases expression

kojic acid results in increased expression of ARL6IP5 mRNA

NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608

G

asparagine synthetase domain containing 1

decreases expression

kojic acid results in decreased expression of ASNSD1 mRNA

NCBI chr 9:48,126,808...48,139,073
Ensembl chr 9:48,126,808...48,139,073

G

activating transcription factor 6 beta

decreases expression

kojic acid results in decreased expression of ATF6B mRNA

NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894

G

ATM serine/threonine kinase

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

beta-1,4-N-acetyl-galactosaminyl transferase 4

decreases expression

kojic acid results in decreased expression of B4GALNT4 mRNA

NCBI chr 1:196,171,394...196,182,294
Ensembl chr 1:196,171,394...196,182,294

G

BAG cochaperone 5

decreases expression

kojic acid results in decreased expression of BAG5 mRNA

NCBI chr 6:130,768,467...130,772,122
Ensembl chr 6:130,768,141...130,772,970

G

BCL2-related protein A1

increases expression

kojic acid results in increased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

Bcl2-like 2

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of BCL2L2 mRNA

NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624

G

baculoviral IAP repeat-containing 2

decreases expression

kojic acid results in decreased expression of BIRC2 mRNA

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

bone morphogenetic protein 5

decreases expression

kojic acid results in decreased expression of BMP5 mRNA

NCBI chr 8:76,517,164...76,639,925
Ensembl chr 8:76,517,164...76,639,925

G

BR serine/threonine kinase 1

decreases expression

kojic acid results in decreased expression of BRSK1 mRNA

NCBI chr 1:69,134,166...69,159,947
Ensembl chr 1:69,134,565...69,160,365

G

bone marrow stromal cell antigen 2

decreases expression

kojic acid results in decreased expression of BST2 mRNA

NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979

G

similar to human chromosome 1 open reading frame 54

increases expression

kojic acid results in increased expression of C1ORF54 mRNA

NCBI chr 2:183,424,989...183,434,713
Ensembl chr 2:183,424,984...183,435,089

G

similar to human chromosome 1 open reading frame 87

decreases expression

kojic acid results in decreased expression of C1ORF87 mRNA

NCBI chr 5:111,342,381...111,411,576
Ensembl chr 5:111,342,387...111,411,590

G

calcium binding protein 39-like

increases expression

kojic acid results in increased expression of CAB39L mRNA

NCBI chr15:33,606,588...33,710,518
Ensembl chr15:33,606,694...33,743,545

G

calreticulin

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CALR mRNA

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

carbonic anhydrase 13

increases expression

kojic acid results in increased expression of CAR13 mRNA

NCBI chr 2:86,928,401...86,959,525
Ensembl chr 2:86,928,383...86,959,525

G

carbonic anhydrase 14

increases expression

kojic acid results in increased expression of CA14 mRNA

NCBI chr 2:183,442,263...183,449,231
Ensembl chr 2:183,441,667...183,449,693

G

caspase 4

multiple interactions

[kojic acid co-treated with Diethylnitrosamine] results in increased expression of CASP4 mRNA; Ascorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of CASP4 mRNA]

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 8

multiple interactions

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

catalase

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CAT mRNA

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cell division cycle and apoptosis regulator 1

increases expression

kojic acid results in increased expression of CCAR1 mRNA

NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526

G

coiled-coil domain containing 50

increases expression

kojic acid results in increased expression of CCDC50 mRNA

NCBI chr11:73,332,798...73,395,333
Ensembl chr11:73,334,248...73,395,150

G

C-C motif chemokine ligand 21

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CCL21A mRNA

NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686

G

C-C motif chemokine ligand 3

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CCL3 mRNA

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

cyclin B1

increases expression

kojic acid results in increased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin C

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CCNC mRNA

NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584

G

cyclin D1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of CCND1 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CCND1 mRNA

PMID:17917374 PMID:18544905

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin G1

multiple interactions

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in increased expression of CCNG1 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CCNG1 mRNA

PMID:17917374 PMID:18544905

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

cell cycle progression 1

decreases expression

kojic acid results in decreased expression of CCPG1 mRNA

NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430

G

C-C motif chemokine receptor 4

decreases expression

kojic acid results in decreased expression of CCR4 mRNA

NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056

G

CD22 molecule

decreases expression

kojic acid results in decreased expression of CD22 mRNA

NCBI chr 1:86,116,376...86,132,782
Ensembl chr 1:86,117,459...86,132,322

G

CD274 molecule

increases expression

kojic acid results in increased expression of CD274 mRNA

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

G

CD3 gamma subunit of T-cell receptor complex

decreases expression

kojic acid results in decreased expression of CD3G mRNA

NCBI chr 8:45,280,797...45,287,271
Ensembl chr 8:45,281,204...45,287,147

G

CDAN1 interacting nuclease 1

increases expression

kojic acid results in increased expression of CDIN1 mRNA

NCBI chr 3:102,441,553...102,646,935
Ensembl chr 3:102,441,704...102,646,682

G

cyclin-dependent kinase 10

decreases expression

kojic acid results in decreased expression of CDK10 mRNA

NCBI chr19:51,260,012...51,273,009
Ensembl chr19:51,261,356...51,269,078

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CDKN1A mRNA
[Diethylnitrosamine co-treated with kojic acid] results in increased expression of CDKN1A mRNA

PMID:17917374 PMID:18544905

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA; [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

CEA cell adhesion molecule 1

decreases expression

kojic acid results in decreased expression of CEACAM1 mRNA

NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992

G

CCAAT/enhancer binding protein delta

increases expression

kojic acid results in increased expression of CEBPD mRNA

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

G

centromere protein Q

decreases expression

kojic acid results in decreased expression of CENPQ mRNA

NCBI chr 9:19,957,122...19,972,807
Ensembl chr 9:19,957,048...19,972,789

G

centrosomal protein 192

increases expression

kojic acid results in increased expression of CEP192 mRNA

NCBI chr18:61,373,937...61,458,405
Ensembl chr18:61,332,158...61,458,379

G

centrosomal protein 72

increases expression

kojic acid results in increased expression of CEP72 mRNA

NCBI chr 1:29,225,312...29,255,294
Ensembl chr 1:29,225,361...29,255,271

G

carboxylesterase 1D

multiple interactions

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of CES1 mRNA

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

checkpoint kinase 2

multiple interactions

[kojic acid co-treated with Diethylnitrosamine] results in increased expression of CHEK2 mRNA; Ascorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of CHEK2 mRNA]

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

carbohydrate sulfotransferase 4

multiple interactions

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of CHST4 mRNA

NCBI chr19:37,993,471...38,002,123
Ensembl chr19:37,991,417...38,003,608

G

CBY1 interacting BAR domain containing 1

increases expression

kojic acid results in increased expression of CIBAR1 mRNA

NCBI chr 5:25,613,993...25,632,440
Ensembl chr 5:25,614,033...25,632,489

G

claudin 3

decreases expression

kojic acid results in decreased expression of CLDN3 mRNA

NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001

G

claudin domain containing 2

decreases expression

kojic acid results in decreased expression of CLDND2 mRNA

NCBI chr 1:93,848,533...93,851,693
Ensembl chr 1:93,848,533...93,851,217

G

C-type lectin domain family 4, member B2

decreases expression

kojic acid results in decreased expression of CLEC4C mRNA

NCBI chr 4:156,462,742...156,486,240
Ensembl chr 4:156,462,742...156,486,240

G

CXADR-like membrane protein

decreases expression

kojic acid results in decreased expression of CLMP mRNA

NCBI chr 8:41,060,527...41,168,841
Ensembl chr 8:41,060,799...41,168,838

G

clusterin

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

cornichon family member 1

increases expression

kojic acid results in increased expression of CNIH1 mRNA

NCBI chr15:20,037,885...20,049,857
Ensembl chr15:20,037,885...20,049,761

G

connector enhancer of kinase suppressor of Ras 2

decreases expression

kojic acid results in decreased expression of CNKSR2 mRNA

NCBI chr X:36,908,135...37,148,337
Ensembl chr X:36,907,850...37,150,555

G

collagen type XVII alpha 1 chain

decreases expression

kojic acid results in decreased expression of COL17A1 mRNA

NCBI chr 1:246,530,589...246,577,559
Ensembl chr 1:246,531,367...246,577,632

G

collagen type XXIV alpha 1 chain

decreases expression

kojic acid results in decreased expression of COL24A1 mRNA

NCBI chr 2:234,212,256...234,469,445
Ensembl chr 2:234,212,324...234,469,441

G

collagen like tail subunit of asymmetric acetylcholinesterase

increases expression

kojic acid results in increased expression of COLQ mRNA

NCBI chr16:6,731,850...6,824,973
Ensembl chr16:6,731,858...6,787,107

G

catechol-O-methyltransferase

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of COMT mRNA

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

COP9 signalosome subunit 2

decreases expression

kojic acid results in decreased expression of COPS2 mRNA

NCBI chr 3:113,084,174...113,110,090
Ensembl chr 3:113,084,176...113,109,947

G

coenzyme Q10A

increases expression

kojic acid results in increased expression of COQ10A mRNA

NCBI chr 7:792,089...798,392
Ensembl chr 7:792,089...800,161

G

coenzyme Q8A

increases expression

kojic acid results in increased expression of COQ8A mRNA

NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431

G

carboxypeptidase B1

decreases expression

kojic acid results in decreased expression of CPB1 mRNA

NCBI chr 2:102,755,241...102,785,628
Ensembl chr 2:102,755,241...102,785,628

G

carboxypeptidase E

increases expression

kojic acid results in increased expression of CPE mRNA

NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233

G

copine 5

increases expression

kojic acid results in increased expression of CPNE5 mRNA

NCBI chr20:7,206,742...7,289,309
Ensembl chr20:7,206,742...7,288,883

G

cAMP responsive element binding protein 1

decreases phosphorylation

kojic acid results in decreased phosphorylation of CREB1 protein

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

chromosome segregation 1 like

decreases expression

kojic acid results in decreased expression of CSE1L mRNA

NCBI chr 3:155,641,104...155,678,866
Ensembl chr 3:155,641,166...155,678,865

G

catenin alpha-like 1

decreases expression

kojic acid results in decreased expression of CTNNAL1 mRNA

NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431

G

cathepsin Z

increases expression

kojic acid results in increased expression of CTSZ mRNA

NCBI chr 3:163,224,875...163,235,645
Ensembl chr 3:163,224,875...163,235,645

G

cytochrome b5 reductase 3

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYB5R3 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYB5R3 mRNA

NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298

G

cytochrome P450, family 26, subfamily b, polypeptide 1

increases expression

kojic acid results in increased expression of CYP26B1 mRNA

NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628

G

cytochrome P450, family 2, subfamily b, polypeptide 15

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2B15 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP2B15 mRNA

NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CYP2B10 mRNA

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2C mRNA

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily c, polypeptide 13

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2C13 mRNA

NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191

G

cytochrome P450, family 2, subfamily c, polypeptide 7

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2C7 mRNA

NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2D22 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP2D22 mRNA

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 2, subfamily f, polypeptide 4

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2F2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP2F2 mRNA

NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896

G

cytochrome P450, family 4, subfamily a, polypeptide 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP4A22 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP4A22 mRNA

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

G

cytochrome P450, family 4, subfamily b, polypeptide 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of CYP4B1 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP4B1 mRNA

PMID:17917374 PMID:18544905

NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348

G

cytochrome P450, family 4, subfamily f, polypeptide 4

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP4F2 mRNA

NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CYP7A1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 8 subfamily B member 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP8B1 mRNA

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

cytohesin 3

increases expression

kojic acid results in increased expression of CYTH3 mRNA

NCBI chr12:10,840,137...10,933,792
Ensembl chr12:10,840,157...10,933,812

G

cytohesin 1 interacting protein

increases expression

kojic acid results in increased expression of CYTIP mRNA

NCBI chr 3:42,698,058...42,774,955
Ensembl chr 3:42,698,768...42,725,993

G

diacylglycerol lipase, alpha

increases expression

kojic acid results in increased expression of DAGLA mRNA

NCBI chr 1:206,890,635...206,947,332
Ensembl chr 1:206,890,638...206,947,232

G

DAZ associated protein 2

increases expression

kojic acid results in increased expression of DAZAP2 mRNA

NCBI chr 7:131,714,749...131,720,266
Ensembl chr 7:131,714,745...131,720,265

G

DDB1 and CUL4 associated factor 13

decreases expression

kojic acid results in decreased expression of DCAF13 mRNA

NCBI chr 7:70,160,983...70,196,142
Ensembl chr 7:70,160,941...70,196,142

G

dopachrome tautomerase

decreases expression

kojic acid results in decreased expression of DCT protein

NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836

G

DNA-damage inducible transcript 3

multiple interactions

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DEK proto-oncogene

decreases expression

kojic acid results in decreased expression of DEK mRNA

NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808

G

DLG associated protein 4

increases expression

kojic acid results in increased expression of DLGAP4 mRNA

NCBI chr 3:145,124,189...145,271,791
Ensembl chr 3:145,175,479...145,270,490

G

distal-less homeobox 1

decreases expression

kojic acid results in decreased expression of DLX1 mRNA

NCBI chr 3:56,356,190...56,360,780
Ensembl chr 3:56,356,190...56,360,780

G

Dmx-like 1

decreases expression

kojic acid results in decreased expression of DMXL1 mRNA

NCBI chr18:42,993,292...43,163,457
Ensembl chr18:42,993,340...43,163,456

G

DnaJ heat shock protein family (Hsp40) member A1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of DNAJA1 mRNA

NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967

G

DnaJ heat shock protein family (Hsp40) member A2

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of DNAJA2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of DNAJA2 mRNA

NCBI chr19:21,497,792...21,516,904
Ensembl chr19:21,497,729...21,516,901

G

deoxynucleotidyltransferase, terminal, interacting protein 2

decreases expression

kojic acid results in decreased expression of DNTTIP2 mRNA

NCBI chr 2:210,374,321...210,386,366
Ensembl chr 2:210,374,289...210,385,581

G

dedicator of cytokinesis 4

increases expression

kojic acid results in increased expression of DOCK4 mRNA

NCBI chr 6:57,512,929...57,902,597
Ensembl chr 6:57,512,908...57,901,855

G

docking protein 4

decreases expression

kojic acid results in decreased expression of DOK4 mRNA

NCBI chr19:10,146,520...10,157,187
Ensembl chr19:10,146,474...10,158,203

G

dihydropyrimidine dehydrogenase

multiple interactions

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of DPYD mRNA

NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982

G

dentin sialophosphoprotein

decreases expression

kojic acid results in decreased expression of DSPP mRNA

NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672

G

destrin, actin depolymerizing factor

increases expression

kojic acid results in increased expression of DSTN mRNA

NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379

G

dynein light chain Tctex-type 3

decreases expression

kojic acid results in decreased expression of DYNLT3 mRNA

NCBI chr X:13,327,933...13,337,139
Ensembl chr X:13,327,892...13,337,139

G

E2F transcription factor 3

increases expression

kojic acid results in increased expression of E2F3 mRNA

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

G

E2F transcription factor 8

increases expression

kojic acid results in increased expression of E2F8 mRNA

NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098

G

ephrin A3

decreases expression

kojic acid results in decreased expression of EFNA3 mRNA

NCBI chr 2:174,729,192...174,738,111
Ensembl chr 2:174,729,764...174,738,736

G

early growth response 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 4E

decreases expression

kojic acid results in decreased expression of EIF4E mRNA

NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683

G

eukaryotic translation initiation factor 5A2

increases expression

kojic acid results in increased expression of EIF5A2 mRNA

NCBI chr 2:111,728,587...111,746,087
Ensembl chr 2:111,729,323...111,746,087

G

elastase, neutrophil expressed

decreases expression

kojic acid results in decreased expression of ELANE mRNA

NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100

G

E1A binding protein p300

increases expression

kojic acid results in increased expression of EP300 mRNA

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

EPH receptor A10

decreases expression

kojic acid results in decreased expression of EPHA10 mRNA

NCBI chr 5:137,139,588...137,175,637
Ensembl chr 5:137,140,735...137,174,157

G

Eph receptor A4

increases expression

kojic acid results in increased expression of EPHA4 mRNA

NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139

G

epoxide hydrolase 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of EPHX1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of EPHX1 mRNA

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

epoxide hydrolase 2

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of EPHX2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of EPHX2 mRNA

NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615

G

ERCC excision repair 2, TFIIH core complex helicase subunit

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ERCC2 mRNA

NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102

G

ERCC excision repair 3, TFIIH core complex helicase subunit

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of ERCC3 mRNA

NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329

G

ERCC excision repair 4, endonuclease catalytic subunit

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ERCC4 mRNA

NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369
Ensembl chr10:2,419,038...2,448,369

G

ERCC excision repair 5, endonuclease

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ERCC5 mRNA

NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472

G

endothelial cell adhesion molecule

increases expression

kojic acid results in increased expression of ESAM mRNA

NCBI chr 8:37,238,228...37,249,217
Ensembl chr 8:37,238,287...37,249,215

G

epithelial splicing regulatory protein 1

increases expression

kojic acid results in increased expression of ESRP1 mRNA

NCBI chr 5:24,427,611...24,482,157
Ensembl chr 5:24,428,717...24,482,062

G

exonuclease 3'-5' domain containing 1

decreases expression

kojic acid results in decreased expression of EXD1 mRNA

NCBI chr 3:106,507,839...106,535,922
Ensembl chr 3:106,508,076...106,535,922

G

exocyst complex component 2

increases expression

kojic acid results in increased expression of EXOC2 mRNA

NCBI chr17:33,506,289...33,698,246
Ensembl chr17:33,506,338...33,693,289

G

coagulation factor X

increases expression

kojic acid results in increased expression of F10 mRNA

NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141

G

family with sequence similarity 241 member A

increases expression

kojic acid results in increased expression of FAM241A mRNA

NCBI chr 2:216,344,563...216,375,193
Ensembl chr 2:216,343,822...216,375,242

G

fibrillin 2

increases expression

kojic acid results in increased expression of FBN2 mRNA

NCBI chr18:51,499,670...51,703,976
Ensembl chr18:51,499,737...51,703,976

G

F-box protein 16

increases expression

kojic acid results in increased expression of FBXO16 mRNA

NCBI chr15:39,492,268...39,541,493
Ensembl chr15:39,492,377...39,541,480

G

FERRY endosomal RAB5 effector complex subunit 3

decreases expression

kojic acid results in decreased expression of FERRY3 mRNA

NCBI chr 4:159,772,693...159,809,322
Ensembl chr 4:159,772,786...159,806,382

G

fibroblast growth factor 12

increases expression

kojic acid results in increased expression of FGF12 mRNA

NCBI chr11:71,997,151...72,564,757
Ensembl chr11:71,997,099...72,562,607

G

fibroblast growth factor 5

decreases expression

kojic acid results in decreased expression of FGF5 mRNA

NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997

G

fibroblast growth factor receptor 3

decreases expression

kojic acid results in decreased expression of FGFR3 mRNA

NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341

G

fibrinogen C domain containing 1

decreases expression

kojic acid results in decreased expression of FIBCD1 mRNA

NCBI chr 3:15,092,682...15,126,371
Ensembl chr 3:15,092,681...15,126,399

G

FKBP prolyl isomerase 10

increases expression

kojic acid results in increased expression of FKBP10 mRNA

NCBI chr10:85,345,434...85,357,998
Ensembl chr10:85,346,126...85,427,330

G

flavin containing dimethylaniline monoxygenase 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of FMO1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of FMO1 mRNA

NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647

G

fucose-1-phosphate guanylyltransferase

decreases expression

kojic acid results in decreased expression of FPGT mRNA

NCBI chr 2:244,099,031...244,119,967
Ensembl chr 2:244,099,076...244,119,899

G

FERM and PDZ domain containing 4

decreases expression

kojic acid results in decreased expression of FRMPD4 mRNA

NCBI chr X:25,853,849...26,814,642
Ensembl chr X:25,853,934...26,814,637

G

40S small subunit processome assembly factor 1

decreases expression

kojic acid results in decreased expression of FSAF1 mRNA

NCBI chr19:52,807,932...52,822,259
Ensembl chr19:52,807,934...52,822,267

G

ferritin heavy chain 1

increases expression

kojic acid results in increased expression of FTH1 mRNA; kojic acid results in increased expression of FTH1 protein

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

frizzled class receptor 8

increases expression

kojic acid results in increased expression of FZD8 mRNA

NCBI chr17:57,312,924...57,320,551
Ensembl chr17:57,314,450...57,320,650

G

growth arrest and DNA-damage-inducible, beta

multiple interactions

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

polypeptide N-acetylgalactosaminyltransferase 1

decreases expression

kojic acid results in decreased expression of GALNT1 mRNA

NCBI chr18:15,489,015...15,568,849
Ensembl chr18:15,489,020...15,568,245

G

Gfo/Idh/MocA-like oxidoreductase domain containing 1

decreases expression

kojic acid results in decreased expression of GFOD1 mRNA

NCBI chr17:21,400,142...21,504,972
Ensembl chr17:21,399,479...21,499,938

G

GLE1 RNA export mediator

decreases expression

kojic acid results in decreased expression of GLE1 mRNA

NCBI chr 3:13,209,312...13,237,018
Ensembl chr 3:13,209,322...13,237,379

G

guanosine monophosphate reductase

decreases expression

kojic acid results in decreased expression of GMPR mRNA

NCBI chr17:19,151,820...19,189,626
Ensembl chr17:19,151,815...19,189,621

G

G protein subunit beta 1

increases expression

kojic acid results in increased expression of GNB1 mRNA

NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124

G

G protein-coupled receptor 146

decreases expression

kojic acid results in decreased expression of GPR146 mRNA

NCBI chr12:15,251,936...15,267,217
Ensembl chr12:15,251,813...15,267,206

G

G protein-coupled receptor 26

decreases expression

kojic acid results in decreased expression of GPR26 mRNA

NCBI chr 1:186,766,001...186,805,435
Ensembl chr 1:186,767,062...186,784,568

G

G protein-coupled receptor 32

increases expression

kojic acid results in increased expression of GPR32 mRNA

NCBI chr 1:94,756,863...94,757,895

G

G protein-coupled receptor 61

decreases expression

kojic acid results in decreased expression of GPR61 mRNA

NCBI chr 2:195,781,931...195,789,798
Ensembl chr 2:195,782,752...195,789,621

G

glutathione peroxidase 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GPX1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

gasdermin A

decreases expression

kojic acid results in decreased expression of GSDMA mRNA

NCBI chr10:83,614,336...83,639,543
Ensembl chr10:83,627,051...83,639,543

G

glutathione-disulfide reductase

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 2

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTA2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTA2 mRNA

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase alpha 3

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTA3 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTA3 mRNA

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase alpha 4

multiple interactions

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTA4 mRNA

NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182

G

glutathione S-transferase mu 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTM1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM1 mRNA

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTM2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase, mu 5

multiple interactions

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM3 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTM3 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM3 mRNA

PMID:17917374 PMID:18544905

NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553

G

guanylate cyclase 1 soluble subunit alpha 2

decreases expression

kojic acid results in decreased expression of GUCY1A2 mRNA

NCBI chr 8:500,212...900,201
Ensembl chr 8:500,212...889,203

G

H1.1 linker histone, cluster member

increases expression

kojic acid results in increased expression of H1-1 mRNA

NCBI chr17:41,366,268...41,367,011
Ensembl chr17:41,366,268...41,367,011

G

heart and neural crest derivatives expressed 1

increases expression

kojic acid results in increased expression of HAND1 mRNA

NCBI chr10:42,006,646...42,009,213
Ensembl chr10:42,006,651...42,009,213

G

harbinger transposase derived 1

decreases expression

kojic acid results in decreased expression of HARBI1 mRNA

NCBI chr 3:77,681,431...77,689,749
Ensembl chr 3:77,681,431...77,689,724

G

3-hydroxyisobutyryl-CoA hydrolase

decreases expression

kojic acid results in decreased expression of HIBCH mRNA

NCBI chr 9:48,590,097...48,669,896
Ensembl chr 9:48,590,099...48,669,824

G

histidine triad nucleotide binding protein 3

increases expression

kojic acid results in increased expression of HINT3 mRNA

NCBI chr 1:27,035,936...27,045,799
Ensembl chr 1:27,035,905...27,047,721

G

huntingtin interacting protein 1

increases expression

kojic acid results in increased expression of HIP1 mRNA

NCBI chr12:21,133,364...21,267,796
Ensembl chr12:21,133,406...21,267,725

G

histone cluster 1 H2A family like 1

increases expression

kojic acid results in increased expression of H2AC6 mRNA

NCBI chr17:42,707,954...42,708,420

G

HLF transcription factor, PAR bZIP family member

decreases expression

kojic acid results in decreased expression of HLF mRNA

NCBI chr10:75,154,244...75,211,884
Ensembl chr10:75,154,507...75,211,935

G

hyaluronan-mediated motility receptor

decreases expression

kojic acid results in decreased expression of HMMR mRNA

NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060

G

heme oxygenase 2

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HMOX2 mRNA

NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148

G

heterogeneous nuclear ribonucleoprotein H2

increases expression

kojic acid results in increased expression of HNRNPH2 mRNA

NCBI chr X:97,780,890...97,786,846
Ensembl chr X:97,780,785...97,787,041

G

HPS3, biogenesis of lysosomal organelles complex 2 subunit 1

decreases expression

kojic acid results in decreased expression of HPS3 mRNA

NCBI chr 2:102,484,574...102,527,580
Ensembl chr 2:102,484,574...102,526,047

G

heat shock protein 90 alpha family class A member 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein 90 alpha family class B member 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSP90AB1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPA1A mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 5

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family B (small) member 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family D (Hsp60) member 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family E (Hsp10) member 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPE1 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of HSPE1 mRNA

PMID:17917374 PMID:18544905

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

hypoxia up-regulated 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HYOU1 mRNA

NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186

G

insulin-like growth factor 2 receptor

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of IGF2R mRNA

NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501

G

interleukin 1 alpha

multiple interactions

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor-like 1

increases expression

kojic acid results in increased expression of IL1RL1 mRNA

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 22 receptor subunit alpha 1

increases expression

kojic acid results in increased expression of IL22RA1 mRNA

NCBI chr 5:147,961,496...147,986,296
Ensembl chr 5:147,961,349...147,986,296

G

interleukin 6

decreases expression

kojic acid results in decreased expression of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 cytokine family signal transducer

decreases expression

kojic acid results in decreased expression of IL6ST mRNA

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

G

inner centromere protein

increases expression

kojic acid results in increased expression of INCENP mRNA

NCBI chr 1:206,520,655...206,550,575
Ensembl chr 1:206,523,380...206,553,265

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

kojic acid results in increased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

lysyl-tRNA synthetase 1

decreases expression

kojic acid results in decreased expression of KARS1 mRNA

NCBI chr19:39,957,846...39,976,837
Ensembl chr19:39,957,846...39,977,632

G

potassium voltage-gated channel subfamily A regulatory beta subunit 3

decreases expression

kojic acid results in decreased expression of KCNAB3 mRNA

NCBI chr10:54,047,830...54,056,401
Ensembl chr10:54,047,825...54,054,174

G

potassium channel tetramerization domain containing 17

decreases expression

kojic acid results in decreased expression of KCTD17 mRNA

NCBI chr 7:109,979,060...110,009,091
Ensembl chr 7:109,979,060...110,008,927

G

lysine demethylase 4D

increases expression

kojic acid results in increased expression of KDM4D mRNA

NCBI chr 8:11,279,756...11,304,920
Ensembl chr 8:11,268,859...11,305,290

G

KLF transcription factor 5

increases expression

kojic acid results in increased expression of KLF5 mRNA

NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445

G

kelch-like family member 13

increases expression

kojic acid results in increased expression of KLHL13 mRNA

NCBI chr X:113,942,309...114,107,299
Ensembl chr X:113,942,309...114,107,321

G

kallikrein B1

decreases expression

kojic acid results in decreased expression of KLKB1 mRNA

NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053

G

keratin 7

increases expression

kojic acid results in increased expression of KRT7 mRNA

NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052

G

kinectin 1

decreases expression

kojic acid results in decreased expression of KTN1 mRNA

NCBI chr15:20,913,665...21,002,588
Ensembl chr15:20,914,642...21,002,578

G

La ribonucleoprotein 7, transcriptional regulator

decreases expression

kojic acid results in decreased expression of LARP7 mRNA

NCBI chr 2:215,997,641...216,012,833
Ensembl chr 2:215,997,649...216,012,865

G

leukocyte immunoglobulin like receptor B3

decreases expression

kojic acid results in decreased expression of LILRB5 mRNA

NCBI chr 1:69,928,948...69,939,461
Ensembl chr 1:69,928,945...69,939,048

G

LDL receptor related protein 6

decreases expression

kojic acid results in decreased expression of LRP6 mRNA

NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497

G

leucine rich repeat containing 4

decreases expression

kojic acid results in decreased expression of LRRC4 mRNA

NCBI chr 4:57,433,518...57,437,114
Ensembl chr 4:57,433,428...57,437,911

G

leucine rich repeat containing 9

increases expression

kojic acid results in increased expression of LRRC9 mRNA

NCBI chr 6:91,017,739...91,095,847
Ensembl chr 6:91,017,736...91,100,237

G

macrophage erythroblast attacher, E3 ubiquitin ligase

increases expression

kojic acid results in increased expression of MAEA mRNA

NCBI chr14:77,357,261...77,390,683
Ensembl chr14:77,357,264...77,390,671

G

MAF bZIP transcription factor K

decreases expression

kojic acid results in decreased expression of MAFK mRNA

NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048
Ensembl chr12:14,833,984...14,837,048

G

MAGE family member C2

increases expression

kojic acid results in increased expression of MAGEC2 mRNA

NCBI chr X:140,610,610...140,615,484
Ensembl chr X:140,606,825...140,615,471

G

monoamine oxidase A

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MAOA mRNA

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

monoamine oxidase B

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MAOB mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of MAOB mRNA

NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003

G

MAP7 domain containing 2

decreases expression

kojic acid results in decreased expression of MAP7D2 mRNA

NCBI chr X:35,372,453...35,488,073
Ensembl chr X:35,372,700...35,488,091

G

mitogen activated protein kinase 1

decreases phosphorylation

kojic acid results in decreased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

decreases phosphorylation

kojic acid results in decreased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

decreases expression

kojic acid results in decreased expression of MAPK8 mRNA

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

muscleblind-like splicing regulator 1

decreases expression

kojic acid results in decreased expression of MBNL1 mRNA

NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368

G

melanocortin 1 receptor

decreases expression
increases expression

kojic acid results in decreased expression of MC1R protein
kojic acid results in increased expression of MC1R protein

PMID:23738040 PMID:27586645

NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192

G

MyoD family inhibitor

decreases expression

kojic acid results in decreased expression of MDFI mRNA

NCBI chr 9:13,156,806...13,175,218
Ensembl chr 9:13,156,866...13,175,217

G

MDM2 proto-oncogene

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

malic enzyme 3

decreases expression

kojic acid results in decreased expression of ME3 mRNA

NCBI chr 1:143,534,024...143,735,551
Ensembl chr 1:143,534,139...143,733,132

G

mediator complex subunit 14

increases expression

kojic acid results in increased expression of MED14 mRNA

NCBI chr X:10,036,749...10,127,910
Ensembl chr X:10,036,805...10,126,240

G

mex-3 RNA binding family member B

increases expression

kojic acid results in increased expression of MEX3B mRNA

NCBI chr 1:136,855,130...136,859,365
Ensembl chr 1:136,855,130...136,859,354

G

microfibril associated protein 4

decreases expression

kojic acid results in decreased expression of MFAP4 mRNA

NCBI chr10:46,167,158...46,170,176
Ensembl chr10:46,167,217...46,170,155

G

O-6-methylguanine-DNA methyltransferase

multiple interactions

[kojic acid co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA; Ascorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA]

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

microsomal glutathione S-transferase 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MGST1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of MGST1 mRNA

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

midnolin

decreases expression

kojic acid results in decreased expression of MIDN mRNA

NCBI chr 7:9,548,100...9,559,605
Ensembl chr 7:9,549,650...9,559,752

G

macrophage migration inhibitory factor

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MIF mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of MIF mRNA

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504

G

meiotic nuclear divisions 1

increases expression

kojic acid results in increased expression of GAJ mRNA

NCBI chr 2:169,433,523...169,496,081
Ensembl chr 2:169,433,540...169,496,096

G

mitochondrial ribosomal protein L30

decreases expression

kojic acid results in decreased expression of MRPL30 mRNA

NCBI chr 9:40,125,352...40,136,189
Ensembl chr 9:40,125,430...40,137,257

G

mitochondrially encoded cytochrome c oxidase I

increases expression

kojic acid results in increased expression of COX1 mRNA; kojic acid results in increased expression of COX1 protein

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

Mtr4 exosome RNA helicase

decreases expression

kojic acid results in decreased expression of MTREX mRNA

NCBI chr 2:44,500,326...44,560,624
Ensembl chr 2:44,461,444...44,560,627

G

major vault protein

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MVP mRNA

NCBI chr 1:181,594,734...181,622,336
Ensembl chr 1:181,594,734...181,622,380

G

N(alpha)-acetyltransferase 25, NatB auxiliary subunit

increases expression

kojic acid results in increased expression of NAA25 mRNA

NCBI chr12:35,098,256...35,150,498
Ensembl chr12:35,098,075...35,150,467

G

neurocalcin delta

decreases expression

kojic acid results in decreased expression of NCALD mRNA

NCBI chr 7:68,532,671...68,964,740
Ensembl chr 7:68,534,421...68,964,496

G

NADH:ubiquinone oxidoreductase subunit A1

increases expression

kojic acid results in increased expression of NDUFA1 mRNA

NCBI chr X:116,424,223...116,427,875
Ensembl chr X:116,424,223...116,428,633

G

nectin cell adhesion molecule 4

increases expression

kojic acid results in increased expression of NECTIN4 mRNA

NCBI chr13:83,802,589...83,821,711
Ensembl chr13:83,803,184...83,821,709

G

nuclear factor, interleukin 3 regulated

increases expression

kojic acid results in increased expression of NFIL3 mRNA

NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858

G

NFKB inhibitor alpha

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of NFKBIA mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of NFKBIA mRNA

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NFKB inhibitor epsilon

increases expression

kojic acid results in increased expression of NFKBIE mRNA

NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437

G

NK6 homeobox 1

decreases expression

kojic acid results in decreased expression of NKX6-1 mRNA

NCBI chr14:7,969,756...7,976,689
Ensembl chr14:7,969,756...7,976,681

G

neuroligin 2

decreases expression

kojic acid results in decreased expression of NLGN2 mRNA

NCBI chr10:54,544,461...54,557,854
Ensembl chr10:54,544,588...54,558,434

G

NOC3-like DNA replication regulator

decreases expression

kojic acid results in decreased expression of NOC3L mRNA

NCBI chr 1:236,556,037...236,585,372
Ensembl chr 1:236,556,789...236,585,318

G

nucleolar protein 11

decreases expression

kojic acid results in decreased expression of NOL11 mRNA

NCBI chr10:92,119,000...92,141,688
Ensembl chr10:92,121,833...92,141,677

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of NR1I2 mRNA

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of NR1I3 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of NR1I3 mRNA

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

outer dynein arm docking complex subunit 2

increases expression

kojic acid results in increased expression of ODAD2 mRNA

NCBI chr17:55,216,877...55,409,872
Ensembl chr17:55,218,991...55,409,399

G

olfactomedin-like 1

decreases expression

kojic acid results in decreased expression of OLFML1 mRNA

NCBI chr 1:161,478,129...161,502,541
Ensembl chr 1:161,478,242...161,502,537

G

olfactory receptor family 51 subfamily B member 4

decreases expression

kojic acid results in decreased expression of OR51B4 mRNA

NCBI chr 1:158,317,228...158,318,151
Ensembl chr 1:158,317,228...158,318,151

G

oxysterol binding protein 2

decreases expression

kojic acid results in decreased expression of OSBP2 mRNA

NCBI chr14:78,585,088...78,746,785
Ensembl chr14:78,585,089...78,746,786

G

osteoclastogenesis associated transmembrane protein 1

decreases expression

kojic acid results in decreased expression of OSTM1 mRNA

NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023

G

orthodenticle homeobox 1

increases expression

kojic acid results in increased expression of OTX1 mRNA

NCBI chr14:96,082,146...96,089,161
Ensembl chr14:96,082,151...96,089,086

G

PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1

increases expression

kojic acid results in increased expression of PABIR1 mRNA

NCBI chr 1:222,114,988...222,116,294
Ensembl chr 1:222,112,591...222,116,396

G

Paxip1-associated glutamate-rich protein 1

increases expression

kojic acid results in increased expression of PAGR1 mRNA

NCBI chr 1:181,622,698...181,625,024

G

phenylalanine hydroxylase

decreases expression

kojic acid results in decreased expression of PAH mRNA

NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130

G

poly (ADP-ribose) glycohydrolase

increases expression

kojic acid results in increased expression of PARG mRNA

NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273

G

PDZ binding kinase

decreases expression

kojic acid results in decreased expression of PBK mRNA

NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014

G

proliferating cell nuclear antigen

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of PCNA protein
[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in increased expression of PCNA protein

PMID:17917374 PMID:18544905

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

pecanex 3

decreases expression

kojic acid results in decreased expression of PCNX3 mRNA

NCBI chr 1:202,951,322...202,974,167
Ensembl chr 1:202,951,322...202,976,561

G

proprotein convertase subtilisin/kexin type 4

decreases expression

kojic acid results in decreased expression of PCSK4 mRNA

NCBI chr 7:9,381,366...9,389,589
Ensembl chr 7:9,381,361...9,389,585

G

phosducin like

increases expression

kojic acid results in increased expression of PDCL mRNA

NCBI chr 3:21,110,165...21,119,763
Ensembl chr 3:21,110,167...21,119,715
Ensembl chr 3:21,110,167...21,119,715

G

pyruvate dehydrogenase E1 subunit alpha 1

increases expression

kojic acid results in increased expression of PDHA1 mRNA

NCBI chr X:34,700,481...34,714,309
Ensembl chr X:34,700,409...34,714,311

G

protein disulfide isomerase family A, member 3

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PDIA3 mRNA

NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236

G

PDZ and LIM domain 2

increases expression

kojic acid results in increased expression of PDLIM2 mRNA

NCBI chr15:45,235,421...45,250,187
Ensembl chr15:45,237,477...45,249,242

G

PPARGC1 and ESRR induced regulator, muscle 1

decreases expression

kojic acid results in decreased expression of PERM1 mRNA

NCBI chr 5:166,800,030...166,805,323
Ensembl chr 5:166,800,030...166,805,323

G

peroxisomal biogenesis factor 5-like

decreases expression

kojic acid results in decreased expression of PEX5L mRNA

NCBI chr 2:115,694,868...115,908,365
Ensembl chr 2:115,700,972...115,913,628

G

phosphoglucomutase 2

increases expression

kojic acid results in increased expression of PGM2 mRNA

NCBI chr14:44,166,314...44,199,828
Ensembl chr14:44,164,425...44,199,967

G

phosphatidylinositol glycan anchor biosynthesis, class Q

decreases expression

kojic acid results in decreased expression of PIGQ mRNA

NCBI chr10:14,942,571...14,958,584
Ensembl chr10:14,942,577...14,958,584

G

phosphatidylinositol transfer protein, beta

increases expression

kojic acid results in increased expression of PITPNB mRNA

NCBI chr12:45,249,308...45,298,388
Ensembl chr12:45,249,333...45,298,314

G

PLAG1 like zinc finger 1

increases expression

kojic acid results in increased expression of PLAGL1 mRNA

NCBI chr 1:7,477,295...7,517,229
Ensembl chr 1:7,477,177...7,517,228

G

protein O-glucosyltransferase 2

increases expression

kojic acid results in increased expression of POGLUT2 mRNA

NCBI chr 9:46,256,388...46,268,714
Ensembl chr 9:46,256,390...46,268,532

G

paraoxonase 3

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PON3 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of PON3 mRNA

NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855

G

cytochrome p450 oxidoreductase

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of POR mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of POR mRNA

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

POU class 2 homeobox 3

decreases expression

kojic acid results in decreased expression of POU2F3 mRNA

NCBI chr 8:43,495,408...43,577,795
Ensembl chr 8:43,495,527...43,577,795

G

protein phosphatase 4, regulatory subunit 1

increases expression

kojic acid results in increased expression of PPP4R1 mRNA

NCBI chr 9:105,391,271...105,450,626
Ensembl chr 9:105,391,412...105,450,633

G

peroxiredoxin 1

multiple interactions

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PRDX1 mRNA

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

peroxiredoxin 2

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PRDX2 mRNA

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

proteoglycan 2, pro eosinophil major basic protein

decreases expression

kojic acid results in decreased expression of PRG2 mRNA

NCBI chr 3:70,062,535...70,066,102
Ensembl chr 3:70,062,535...70,066,101

G

prickle planar cell polarity protein 3

decreases expression

kojic acid results in decreased expression of PRICKLE3 mRNA

NCBI chr X:14,837,647...14,849,305
Ensembl chr X:14,837,650...14,848,218

G

DNA primase subunit 1

decreases expression

kojic acid results in decreased expression of PRIM1 mRNA

NCBI chr 7:446,342...462,526
Ensembl chr 7:431,805...462,526

G

protein arginine methyltransferase 2

decreases expression

kojic acid results in decreased expression of PRMT2 mRNA

NCBI chr20:12,394,748...12,420,643
Ensembl chr20:12,394,798...12,420,643

G

pre-mRNA processing factor 40 homolog A

decreases expression

kojic acid results in decreased expression of PRPF40A mRNA

NCBI chr 3:37,625,585...37,689,859
Ensembl chr 3:37,627,690...37,690,886

G

phosphoribosyl pyrophosphate synthetase 2

increases expression

kojic acid results in increased expression of PRPS2 mRNA

NCBI chr X:26,975,915...27,013,184
Ensembl chr X:26,976,061...27,013,181

G

proline rich 18

decreases expression

kojic acid results in decreased expression of PRR18 mRNA

NCBI chr 1:52,400,215...52,403,998
Ensembl chr 1:52,400,215...52,404,309

G

proline-rich coiled-coil 2C

increases expression

kojic acid results in increased expression of PRRC2C mRNA

NCBI chr13:75,003,995...75,073,701
Ensembl chr13:75,004,010...75,073,643

G

paired related homeobox 1

decreases expression

kojic acid results in decreased expression of PRRX1 mRNA

NCBI chr13:75,600,777...75,671,896
Ensembl chr13:75,601,706...75,670,866

G

proteasome 26S subunit, ATPase 6

decreases expression

kojic acid results in decreased expression of PSMC6 mRNA

NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055

G

proteasome 26S subunit, non-ATPase 3

decreases expression

kojic acid results in decreased expression of PSMD3 mRNA

NCBI chr10:83,643,473...83,655,620
Ensembl chr10:83,643,647...83,655,618

G

pseudouridine synthase 7 like

decreases expression

kojic acid results in decreased expression of PUS7L mRNA

NCBI chr 7:125,659,507...125,706,582
Ensembl chr 7:125,659,507...125,682,333

G

RAB3 GTPase activating protein catalytic subunit 1

increases expression

kojic acid results in increased expression of RAB3GAP1 mRNA

NCBI chr13:39,355,698...39,429,154
Ensembl chr13:39,352,247...39,429,169

G

RAB6B, member RAS oncogene family

decreases expression

kojic acid results in decreased expression of RAB6B mRNA

NCBI chr 8:103,695,328...103,764,023
Ensembl chr 8:103,695,631...103,805,732

G

RAD1 checkpoint DNA exonuclease

increases expression

kojic acid results in increased expression of RAD1 mRNA

NCBI chr 2:59,461,597...59,469,707
Ensembl chr 2:59,461,607...59,469,689

G

RAD23 homolog A, nucleotide excision repair protein

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of RAD23A mRNA

NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695

G

RAD50 double strand break repair protein

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of RAD50 mRNA

NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396

G

retinoic acid receptor, alpha

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of RARA mRNA

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

retinoic acid receptor, beta

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of RARB mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of RARB mRNA

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

G

ras related dexamethasone induced 1

increases expression

kojic acid results in increased expression of RASD1 mRNA

NCBI chr10:44,766,451...44,775,773
Ensembl chr10:44,766,455...44,768,186

G

RasGEF domain family, member 1B

decreases expression

kojic acid results in decreased expression of RASGEF1B mRNA

NCBI chr14:9,859,512...10,380,044
Ensembl chr14:9,860,247...10,379,741

G

Ras association domain family member 3

increases expression

kojic acid results in increased expression of RASSF3 mRNA

NCBI chr 7:56,935,888...57,000,554
Ensembl chr 7:56,935,973...57,000,553

G

RB1-inducible coiled-coil 1

decreases expression

kojic acid results in decreased expression of RB1CC1 mRNA

NCBI chr 5:13,161,648...13,225,560
Ensembl chr 5:13,161,648...13,225,560

G

RNA binding motif protein 38

decreases expression

kojic acid results in decreased expression of RBM38 mRNA

NCBI chr 3:161,801,577...161,814,381
Ensembl chr 3:161,801,577...161,814,381

G

RecQ like helicase

decreases expression

kojic acid results in decreased expression of RECQL mRNA

NCBI chr 4:175,308,337...175,332,965
Ensembl chr 4:175,304,117...175,332,945

G

regulating synaptic membrane exocytosis 2

decreases expression

kojic acid results in decreased expression of RIMS2 mRNA

NCBI chr 7:70,248,104...70,759,134
Ensembl chr 7:70,243,872...70,757,491

G

round spermatid basic protein 1

decreases expression

kojic acid results in decreased expression of RSBN1 mRNA

NCBI chr 2:191,416,631...191,470,711
Ensembl chr 2:191,416,631...191,470,711

G

serum amyloid A4

decreases expression

kojic acid results in decreased expression of SAA4 mRNA

NCBI chr 1:97,247,580...97,251,882

G

scavenger receptor class B, member 1

increases expression

kojic acid results in increased expression of SCARB1 mRNA

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

sodium voltage-gated channel alpha subunit 10

decreases expression

kojic acid results in decreased expression of SCN10A mRNA

NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614

G

sterol carrier protein 2

decreases expression

kojic acid results in decreased expression of SCP2 mRNA

NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287

G

syndecan 4

decreases expression

kojic acid results in decreased expression of SDC4 mRNA

NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580

G

SEC24 homolog B, COPII coat complex component

increases expression

kojic acid results in increased expression of SEC24B mRNA

NCBI chr 2:218,562,670...218,632,753
Ensembl chr 2:218,562,676...218,632,699

G

SEC62 homolog, preprotein translocation factor

decreases expression

kojic acid results in decreased expression of SEC62 mRNA

NCBI chr 2:112,570,810...112,598,198
Ensembl chr 2:112,570,819...112,601,814

G

secreted and transmembrane 1B

decreases expression

kojic acid results in decreased expression of SECTM1 mRNA

NCBI chr10:106,324,070...106,333,779
Ensembl chr10:106,325,203...106,333,769

G

septin 7

decreases expression

kojic acid results in decreased expression of SEPTIN7 mRNA

NCBI chr 8:23,719,448...23,783,247
Ensembl chr 8:23,716,030...23,783,243

G

serpin family A member 5

decreases expression

kojic acid results in decreased expression of SERPINA5 mRNA

NCBI chr 6:123,009,224...123,028,412
Ensembl chr 6:123,023,306...123,028,407

G

SHC binding and spindle associated 1

increases expression

kojic acid results in increased expression of SHCBP1 mRNA

NCBI chr16:84,672,277...84,703,843
Ensembl chr16:84,672,321...84,703,844

G

SIN3 transcription regulator family member B

decreases expression

kojic acid results in decreased expression of SIN3B mRNA

NCBI chr16:17,123,277...17,159,978
Ensembl chr16:17,123,434...17,159,978

G

solute carrier family 17, member 2

decreases expression

kojic acid results in decreased expression of SLC17A2 mRNA

NCBI chr17:41,318,312...41,339,012
Ensembl chr17:41,319,701...41,336,325

G

solute carrier family 25 member 2

decreases expression

kojic acid results in decreased expression of SLC25A2 mRNA

NCBI chr18:29,452,943...29,456,324
Ensembl chr18:29,453,582...29,460,383

G

solute carrier family 38, member 4

decreases expression

kojic acid results in decreased expression of SLC38A4 mRNA

NCBI chr 7:128,142,866...128,203,000
Ensembl chr 7:128,144,807...128,202,995

G

structural maintenance of chromosomes 6

decreases expression

kojic acid results in decreased expression of SMC6 mRNA

NCBI chr 6:33,978,730...34,033,201
Ensembl chr 6:33,978,716...34,031,746

G

small integral membrane protein 8

decreases expression

kojic acid results in decreased expression of SMIM8 mRNA

NCBI chr 5:49,336,617...49,345,625
Ensembl chr 5:49,336,617...49,345,441

G

sorting nexin 10

decreases expression

kojic acid results in decreased expression of SNX10 mRNA

NCBI chr 4:80,612,648...80,677,005
Ensembl chr 4:80,612,669...80,676,996

G

sterol O-acyltransferase 2

increases expression

kojic acid results in increased expression of SOAT2 mRNA

NCBI chr 7:133,281,818...133,294,915
Ensembl chr 7:133,281,818...133,294,915

G

superoxide dismutase 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

spermatogenesis associated 25

decreases expression

kojic acid results in decreased expression of SPATA25 mRNA

NCBI chr 3:153,562,479...153,566,508
Ensembl chr 3:153,562,528...153,564,480

G

secreted phosphoprotein 1

increases expression

kojic acid results in increased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

serine palmitoyltransferase, long chain base subunit 1

increases expression

kojic acid results in increased expression of SPTLC1 mRNA

NCBI chr17:11,877,249...11,916,295
Ensembl chr17:11,877,249...11,916,295

G

serine and arginine rich splicing factor 2

increases expression

kojic acid results in increased expression of SRSF2 mRNA

NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338

G

SSX family member 1

increases expression

kojic acid results in increased expression of SSX1 mRNA

NCBI chr X:13,931,433...13,939,732
Ensembl chr X:13,931,470...13,939,720

G

ST13, Hsp70 interacting protein

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of ST13 mRNA

NCBI chr 7:112,891,007...112,925,727
Ensembl chr 7:112,844,375...112,925,945

G

ST18 C2H2C-type zinc finger transcription factor

decreases expression

kojic acid results in decreased expression of ST18 mRNA

NCBI chr 5:12,582,493...12,914,221
Ensembl chr 5:12,584,110...12,671,790

G

StAR-related lipid transfer domain containing 8

decreases expression

kojic acid results in decreased expression of STARD8 mRNA

NCBI chr X:64,079,079...64,196,052
Ensembl chr X:64,124,574...64,196,052

G

syntaxin 6

increases expression

kojic acid results in increased expression of STX6 mRNA

NCBI chr13:67,332,329...67,378,580
Ensembl chr13:67,332,314...67,378,576

G

sulfotransferase family 1A member 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1A1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of SULT1A1 mRNA

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 1B member 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1B1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of SULT1B1 mRNA

NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483

G

sulfotransferase family 1C member 2A

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1C2 mRNA

NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734

G

sulfotransferase family 1C member 3

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1C1 mRNA

NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030

G

sulfotransferase family 1E member 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1E1 mRNA
[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of SULT1E1 mRNA

PMID:17917374 PMID:18544905

NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275

G

sulfotransferase family 4A, member 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT4A1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of SULT4A1 mRNA

NCBI chr 7:115,216,066...115,240,156
Ensembl chr 7:115,216,066...115,240,085

G

SUZ12 polycomb repressive complex 2 subunit

decreases expression

kojic acid results in decreased expression of SUZ12 mRNA

NCBI chr10:64,967,035...65,012,916
Ensembl chr10:64,966,967...65,012,738

G

switching B-cell complex subunit SWAP70

increases expression

kojic acid results in increased expression of SWAP70 mRNA

NCBI chr 1:164,267,588...164,328,796
Ensembl chr 1:164,267,609...164,328,794

G

SYF2 pre-mRNA-splicing factor

decreases expression

kojic acid results in decreased expression of SYF2 mRNA

NCBI chr 5:147,156,492...147,164,416
Ensembl chr 5:147,156,480...147,164,414

G

symplekin scaffold protein

decreases expression

kojic acid results in decreased expression of SYMPK mRNA

NCBI chr 1:78,672,372...78,700,684
Ensembl chr 1:78,672,378...78,700,684

G

synaptotagmin binding, cytoplasmic RNA interacting protein

increases expression

kojic acid results in increased expression of SYNCRIP mRNA

NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515

G

TATA-box binding protein associated factor 15

decreases expression

kojic acid results in decreased expression of TAF15 mRNA

NCBI chr10:68,272,921...68,304,951
Ensembl chr10:68,272,969...68,304,949

G

TAL bHLH transcription factor 1, erythroid differentiation factor

decreases expression

kojic acid results in decreased expression of TAL1 mRNA

NCBI chr 5:128,586,776...128,600,976
Ensembl chr 5:128,587,701...128,600,976

G

thromboxane A synthase 1

multiple interactions

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of TBXAS1 mRNA

NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096

G

transcription factor 21

decreases expression

kojic acid results in decreased expression of TCF21 mRNA

NCBI chr 1:22,701,353...22,704,212
Ensembl chr 1:22,701,353...22,704,202

G

terminal nucleotidyltransferase 4B

decreases expression

kojic acid results in decreased expression of TENT4B mRNA

NCBI chr19:18,807,616...18,868,969
Ensembl chr19:18,807,525...18,869,537

G

transforming growth factor, beta 1

multiple interactions

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

thyroid hormone receptor beta

decreases expression

kojic acid results in decreased expression of THRB mRNA

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

decreases expression

kojic acid results in decreased expression of TIE mRNA

NCBI chr 5:132,000,013...132,019,658
Ensembl chr 5:132,000,015...132,019,592

G

TIR domain containing adaptor protein

decreases expression

kojic acid results in decreased expression of TIRAP mRNA

NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432

G

transmembrane and coiled-coil domains 5A

increases expression

kojic acid results in increased expression of TMCO5 mRNA

NCBI chr 3:103,732,936...103,746,242
Ensembl chr 3:103,732,945...103,746,249

G

transmembrane protein 217

increases expression

kojic acid results in increased expression of TMEM217 mRNA

NCBI chr20:7,584,177...7,619,023
Ensembl chr20:7,592,627...7,619,111
Ensembl chr20:7,592,627...7,619,111

G

transmembrane protein 59-like

decreases expression

kojic acid results in decreased expression of TMEM59L mRNA

NCBI chr16:18,941,370...18,945,381
Ensembl chr16:18,941,567...18,945,381

G

thioredoxin-related transmembrane protein 1

decreases expression

kojic acid results in decreased expression of TMX1 mRNA

NCBI chr 6:88,960,691...88,971,744
Ensembl chr 6:88,960,695...88,971,301

G

tumor necrosis factor

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of TNF mRNA

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 8 like 1

decreases expression

kojic acid results in decreased expression of TNFAIP8L1 mRNA

NCBI chr 9:988,587...999,342
Ensembl chr 9:988,594...1,002,254

G

TNF superfamily member 10

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

torsin family 4, member A

decreases expression

kojic acid results in decreased expression of TOR4A mRNA

NCBI chr 3:8,004,292...8,007,979
Ensembl chr 3:8,002,023...8,008,042

G

tumor protein p53

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of TP53 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of TRP53 mRNA

PMID:17917374 PMID:18544905

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p53 binding protein, 2

increases expression

kojic acid results in increased expression of TP53BP2 mRNA

NCBI chr13:94,088,769...94,145,436
Ensembl chr13:94,088,709...94,145,432

G

two pore segment channel 1

increases expression

kojic acid results in increased expression of TPCN1 mRNA

NCBI chr12:35,972,813...36,029,632
Ensembl chr12:35,972,846...36,029,626

G

tyrosylprotein sulfotransferase 2

multiple interactions

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of TPST2 mRNA

NCBI chr12:44,321,875...44,363,892
Ensembl chr12:44,321,875...44,362,329

G

TNFRSF1A-associated via death domain

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of TRADD mRNA; [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of TRADD mRNA

NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638

G

translocation associated membrane protein 1

decreases expression

kojic acid results in decreased expression of TRAM1 mRNA

NCBI chr 5:5,642,579...5,667,666
Ensembl chr 5:5,642,546...5,686,971

G

translocation associated membrane protein 2

decreases expression

kojic acid results in decreased expression of TRAM2 mRNA

NCBI chr 9:23,419,204...23,498,745
Ensembl chr 9:23,424,232...23,498,689

G

triggering receptor expressed on myeloid cells 1

decreases expression

kojic acid results in decreased expression of TREM1 mRNA

NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203

G

tRNA methyltransferase 10C, mitochondrial RNase P subunit

decreases expression

kojic acid results in decreased expression of TRMT10C mRNA

NCBI chr11:44,584,388...44,589,466
Ensembl chr11:44,584,113...44,589,568

G

tetraspanin 8

increases expression

kojic acid results in increased expression of TSPAN8 mRNA

NCBI chr 7:51,444,946...51,479,360
Ensembl chr 7:51,445,074...51,479,356

G

tetratricopeptide repeat domain 9

increases expression

kojic acid results in increased expression of TTC9 mRNA

NCBI chr 6:101,333,274...101,368,110
Ensembl chr 6:101,333,141...101,368,110

G

Ttk protein kinase

decreases expression

kojic acid results in decreased expression of TTK mRNA

NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651

G

TUB like protein 3

decreases expression

kojic acid results in decreased expression of TULP3 mRNA

NCBI chr 4:161,590,478...161,632,244
Ensembl chr 4:161,590,479...161,632,149

G

twinfilin actin-binding protein 1

decreases expression

kojic acid results in decreased expression of TWF1 mRNA

NCBI chr 7:125,715,938...125,727,834
Ensembl chr 7:125,716,015...125,727,894

G

tyrosinase

decreases activity
increases expression

kojic acid results in decreased activity of TYR protein
kojic acid results in increased expression of TYR mRNA; kojic acid results in increased expression of TYR protein

PMID:23738040 PMID:27586645

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

G

tyrosinase-related protein 1

decreases expression

kojic acid results in decreased expression of TYRP1 protein

NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516

G

ubiquitin-conjugating enzyme E2D 2B

decreases expression

kojic acid results in decreased expression of UBE2D4 mRNA

NCBI chr14:1,915,999...1,917,473
Ensembl chr14:1,916,845...1,917,416

G

ubiquitin-conjugating enzyme E2E 1

decreases expression

kojic acid results in decreased expression of UBE2E1 mRNA

NCBI chr15:7,439,751...7,493,410
Ensembl chr15:7,439,759...7,493,400

G

ubiquitin-conjugating enzyme E2M

decreases expression

kojic acid results in decreased expression of UBE2M mRNA

NCBI chr 1:73,662,576...73,666,113
Ensembl chr 1:73,662,576...73,666,026

G

ubiquitin protein ligase E3 component n-recognin 7

increases expression

kojic acid results in increased expression of UBR7 mRNA

NCBI chr 6:121,898,613...121,918,480
Ensembl chr 6:121,898,623...121,918,477

G

ubiquitin recognition factor in ER associated degradation 1

increases expression

kojic acid results in increased expression of UFD1 mRNA

NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087

G

UDP glucuronosyltransferase 1 family, polypeptide A2

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of UGT1A2 mRNA

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of UGT1A6 mRNA

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

unc-5 netrin receptor C

decreases expression

kojic acid results in decreased expression of UNC5C mRNA

NCBI chr 2:230,180,353...230,535,219
Ensembl chr 2:230,180,951...230,535,217

G

uracil-DNA glycosylase

multiple interactions

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of UNG mRNA

NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206

G

ubiquitin specific peptidase 1

decreases expression

kojic acid results in decreased expression of USP1 mRNA

NCBI chr 5:113,587,564...113,598,934
Ensembl chr 5:113,587,564...113,598,932

G

ubiquitin specific peptidase 44

decreases expression

kojic acid results in decreased expression of USP44 mRNA

NCBI chr 7:28,364,169...28,412,039
Ensembl chr 7:28,364,033...28,410,053

G

UTP11, small subunit processome component

increases expression

kojic acid results in increased expression of UTP11 mRNA

NCBI chr 5:136,931,279...136,946,164
Ensembl chr 5:136,931,008...136,946,191

G

Wnt family member 10A

decreases expression

kojic acid results in decreased expression of WNT10A mRNA

NCBI chr 9:76,349,931...76,362,400
Ensembl chr 9:76,349,931...76,362,400

G

YEATS domain containing 2

increases expression

kojic acid results in increased expression of YEATS2 mRNA

NCBI chr11:80,743,134...80,829,253
Ensembl chr11:80,743,134...80,829,208

G

zinc finger CCCH-type containing 15

decreases expression

kojic acid results in decreased expression of ZC3H15 mRNA

NCBI chr 3:68,744,591...68,764,335
Ensembl chr 3:68,744,604...68,764,333

G

zinc finger DHHC-type palmitoyltransferase 20

decreases expression

kojic acid results in decreased expression of ZDHHC20 mRNA

NCBI chr15:31,980,057...32,039,006
Ensembl chr15:31,983,155...32,038,989

G

zinc finger AN1-type containing 1

decreases expression

kojic acid results in decreased expression of ZFAND1 mRNA

NCBI chr 2:91,444,497...91,457,540
Ensembl chr 2:91,444,508...91,453,246

G

zinc finger protein 146

decreases expression

kojic acid results in decreased expression of ZNF146 mRNA

NCBI chr 1:85,409,570...85,421,835
Ensembl chr 1:85,409,373...85,436,275

G

zinc finger protein 414

decreases expression

kojic acid results in decreased expression of ZNF414 mRNA

NCBI chr 7:14,420,232...14,422,939
Ensembl chr 7:14,420,165...14,438,166

G

zinc finger protein 438

increases expression

kojic acid results in increased expression of ZNF438 mRNA

NCBI chr17:52,426,221...52,547,472
Ensembl chr17:52,426,221...52,547,472

G

zinc finger protein 483

decreases expression

kojic acid results in decreased expression of ZNF483 mRNA

NCBI chr 5:73,763,201...73,780,511
Ensembl chr 5:73,763,179...73,776,223

G

zinc finger with KRAB and SCAN domains 8

decreases expression

kojic acid results in decreased expression of ZKSCAN8 mRNA

NCBI chr17:43,039,383...43,057,391
Ensembl chr17:43,039,383...43,057,391

G

zinc finger, MYND-type containing 15

decreases expression

kojic acid results in decreased expression of ZMYND15 mRNA

NCBI chr10:55,171,198...55,177,812
Ensembl chr10:55,171,198...55,177,812

G

zona pellucida glycoprotein 2

decreases expression

kojic acid results in decreased expression of ZP2 mRNA

NCBI chr 1:174,513,507...174,525,288
Ensembl chr 1:174,513,511...174,525,288

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19874
chemical entity	19872
group	19825
inorganic group	19404
oxo group	18908
organic oxo compound	18908
carbonyl compound	18908
ketone	17258
cyclic ketone	15908
4-pyranones	422
(S)-methyl 4-(6-benzyl-4-oxo-4H-pyran-3-carboxamido)-2-methyl-4-oxobutanoate	0
2-(2-methyl-4-oxo-3-pyranyl)acetaldehyde	0
2-(4-oxo-2-propyl-3-pyranyl)acetaldehyde	0
2-[(3-fluorophenyl)-(2-pyridinylamino)methyl]-3-hydroxy-6-(hydroxymethyl)-4-pyranone	0
3-bromopyran-4-one	0
3-hydroxy-2-methyl-4-pyrone +	0
4H-pyran-4-one	0
Endothion	0
KU-55933	0
KU-58050	0
KU-60019	0
aureothin	0
candelalide A	0
candelalide B	0
candelalide C	0
carbonarone A	0
demethyldeoxyspectinabilin	0
deoxyaureothin +	0
deoxyspectinabilin +	0
kojic acid	422
nalanthalide	0
obolactone	0
pestalamide A	0
spectinabilin	0
Path 2
Term	Annotations
CHEBI ontology	19874
subatomic particle	19872
composite particle	19872
hadron	19872
baryon	19872
nucleon	19872
atomic nucleus	19872
atom	19872
main group element atom	19811
p-block element atom	19811
carbon group element atom	19751
carbon atom	19748
organic molecular entity	19748
organic molecule	19700
organic cyclic compound	19490
organic heterocyclic compound	18868
organic heteromonocyclic compound	17791
pyrans	1163
pyranone	1129
4-pyranones	422
(S)-methyl 4-(6-benzyl-4-oxo-4H-pyran-3-carboxamido)-2-methyl-4-oxobutanoate	0
2-(2-methyl-4-oxo-3-pyranyl)acetaldehyde	0
2-(4-oxo-2-propyl-3-pyranyl)acetaldehyde	0
2-[(3-fluorophenyl)-(2-pyridinylamino)methyl]-3-hydroxy-6-(hydroxymethyl)-4-pyranone	0
3-bromopyran-4-one	0
3-hydroxy-2-methyl-4-pyrone +	0
4H-pyran-4-one	0
Endothion	0
KU-55933	0
KU-58050	0
KU-60019	0
aureothin	0
candelalide A	0
candelalide B	0
candelalide C	0
carbonarone A	0
demethyldeoxyspectinabilin	0
deoxyaureothin +	0
deoxyspectinabilin +	0
kojic acid	422
nalanthalide	0
obolactone	0
pestalamide A	0
spectinabilin	0

paths to the root