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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fotemustine
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Accession:CHEBI:131848 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-fotemustine. It is an alkylating agent used in the treatment of malignant melanoma.
Synonyms:related_synonym: (+-)-diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate;   Formula=C9H19ClN3O5P;   Muphoran;   Mustoforan;   S 10036;   Servier-10036;   diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate;   fotemustina;   fotemustinum;   rac-fotemustine
 alt_id: MESH:C054368
 xref: CAS:92118-27-9;   KEGG:D07255
 xref_mesh: MESH:C054368
 xref: PMID:15020614;   PMID:23560594;   PMID:24023343;   PMID:24800248;   PMID:25538176;   PMID:25702193;   PMID:2627116;   PMID:26458240;   PMID:26542177;   PMID:26750128;   PMID:26951379;   PMID:27057436;   Patent:FR2536075;   Patent:US4567169;   Reaxys:8626774;   Wikipedia:Fotemustine


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fotemustine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO fotemustine results in increased expression of CDKN1A mRNA CTD PMID:25125662 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO fotemustine results in increased expression of FAS mRNA CTD PMID:25125662 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression 		ISO FOS mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]
fotemustine results in increased expression of FOS mRNA; fotemustine results in increased expression of FOS protein 		CTD PMID:23578789 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO fotemustine results in increased expression of GADD45A mRNA CTD PMID:25125662 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO fotemustine results in increased expression of H2AX protein modified form CTD PMID:25125662 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO fotemustine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression 		ISO fotemustine promotes the reaction [JUN protein binds to TREX1 promoter]; JUN mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]
fotemustine results in increased expression of JUN mRNA; fotemustine results in increased expression of JUN protein 		CTD PMID:23578789 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases response to substance ISO MGMT protein results in decreased susceptibility to fotemustine CTD PMID:12970393 PMID:16039682 PMID:20556481 NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482 		JBrowse link
G Polh DNA polymerase eta multiple interactions
increases expression
decreases response to substance 		ISO Dactinomycin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; fotemustine promotes the reaction [TP53 protein binds to POLH promoter]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH protein]
fotemustine results in increased expression of POLH mRNA; fotemustine results in increased expression of POLH protein
POLH protein results in decreased susceptibility to fotemustine 		CTD PMID:25125662 NCBI chr 9:22,275,929...22,310,576
Ensembl chr 9:22,275,946...22,310,577 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression 		ISO fotemustine promotes the reaction [TP53 protein binds to POLH promoter]
fotemustine results in increased expression of TP53 protein; fotemustine results in increased expression of TP53 protein modified form 		CTD PMID:25125662 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Trex1 three prime repair exonuclease 1 multiple interactions
increases expression
affects response to substance 		ISO FOS mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]; fotemustine promotes the reaction [JUN protein binds to TREX1 promoter]; JUN mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]
fotemustine results in increased expression of TREX1 mRNA; fotemustine results in increased expression of TREX1 protein
TREX1 affects the susceptibility to fotemustine 		CTD PMID:23578789 NCBI chr 8:118,585,082...118,586,382
Ensembl chr 8:118,585,081...118,586,083 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      chemical substance 14605
        mixture 13923
          racemate 12316
            fotemustine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      carboacyl group 18085
                                        univalent carboacyl group 18085
                                          carbamoyl group 17921
                                            carboxamide 17921
                                              monocarboxylic acid amide 15953
                                                urea 6336
                                                  ureas 6334
                                                    N-nitrosoureas 2222
                                                      diethyl (1-\{[(2-chloroethyl)(nitroso)carbamoyl]amino\}ethyl)phosphonate 11
                                                        (R)-fotemustine 11
                                                          fotemustine 11
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