CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: calmodulin antagonist
Accession: CHEBI:130181
browse the term
Definition: An antagonist that interferes with the action of the calcium-binding messenger protein calmodulin.
Synonyms: xref: PMID:26717596
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Casp3
caspase 3
increases activity
ISO
calmidazolium results in increased activity of CASP3 protein
CTD
PMID:27247146
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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Cyp11b3
cytochrome P450, family 11, subfamily b, polypeptide 3
multiple interactions
ISO
calmidazolium inhibits the reaction [Potassium results in increased expression of CYP11B2 mRNA]
CTD
PMID:12193581
NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:106,808,559...106,814,048
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F2
coagulation factor II, thrombin
multiple interactions
ISO
calmidazolium affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]
CTD
PMID:2030746
NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:77,596,198...77,609,486
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Il1b
interleukin 1 beta
multiple interactions
ISO
calmidazolium inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]
CTD
PMID:19281832
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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Mt1
metallothionein 1
increases expression
EXP
calmidazolium results in increased expression of MT1A mRNA
CTD
PMID:8128501
NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression
ISO
calmidazolium results in decreased expression of MYC
CTD
PMID:27247146
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
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Myl9
myosin light chain 9
decreases phosphorylation
EXP
calmidazolium results in decreased phosphorylation of MYL9 protein
CTD
PMID:17272349
NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:145,281,937...145,288,333
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Ngf
nerve growth factor
multiple interactions
EXP
calmidazolium inhibits the reaction [NGF protein results in increased uptake of Calcium]
CTD
PMID:1374475
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452
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Nos3
nitric oxide synthase 3
decreases activity
EXP
calmidazolium results in decreased activity of NOS3 protein
CTD
PMID:1374468
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
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P2rx7
purinergic receptor P2X 7
multiple interactions
ISO
calmidazolium inhibits the reaction [Adenosine Triphosphate binds to and results in increased activity of P2RX7 protein]
CTD
PMID:31263019
NCBI chr12:39,550,531...39,594,984
Ensembl chr12:33,879,745...33,934,619
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Rb1
RB transcriptional corepressor 1
decreases phosphorylation
ISO
calmidazolium results in decreased phosphorylation of RB1 protein
CTD
PMID:12901840 PMID:15708436
NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
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Rbl2
RB transcriptional corepressor like 2
decreases phosphorylation
ISO
calmidazolium results in decreased phosphorylation of RBL2 protein
CTD
PMID:15708436
NCBI chr19:32,049,690...32,096,467
Ensembl chr19:15,876,853...15,923,572
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Slc5a6
solute carrier family 5 member 6
multiple interactions
ISO
calmidazolium inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]
CTD
PMID:15561972
NCBI chr 6:31,039,865...31,051,671
Ensembl chr 6:25,320,442...25,331,712
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Vcam1
vascular cell adhesion molecule 1
multiple interactions
ISO
calmidazolium inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]
CTD
PMID:19281832
NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958
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Ar
androgen receptor
multiple interactions
ISO
Pentamidine binds to and results in decreased activity of AR protein
CTD
PMID:25752796
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925
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Asic5
acid sensing ion channel subunit family member 5
decreases activity
ISO
Pentamidine results in decreased activity of ASIC5 protein
CTD
PMID:21828194
NCBI chr 2:167,307,984...167,336,812
Ensembl chr 2:167,307,984...167,336,812
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Asns
asparagine synthetase (glutamine-hydrolyzing)
increases expression
ISO
Pentamidine results in increased expression of ASNS mRNA
CTD
PMID:15342952
NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:35,785,237...35,803,423
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Atm
ATM serine/threonine kinase
affects localization decreases activity
ISO
Pentamidine affects the localization of ATM protein modified form Pentamidine results in decreased activity of ATM protein
CTD
PMID:20144237
NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Pentamidine results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases activity
ISO
Pentamidine results in decreased activity of CYP2C19 protein
CTD
PMID:11124226
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity
ISO
Pentamidine results in decreased activity of CYP2D6 protein
CTD
PMID:11124226
NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity
ISO
Pentamidine results in decreased activity of CYP3A4 protein
CTD
PMID:11124226
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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Depp1
DEPP autophagy regulator 1
increases expression
ISO
Pentamidine results in increased expression of DEPP1 mRNA
CTD
PMID:15342952
NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:149,910,779...149,914,542
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Fabp1
fatty acid binding protein 1
decreases expression
ISO
Pentamidine results in decreased expression of FABP1 mRNA
CTD
PMID:15342952
NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:103,191,006...103,194,788
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Fndc4
fibronectin type III domain containing 4
increases expression
ISO
Pentamidine results in increased expression of FNDC4 mRNA
CTD
PMID:15342952
NCBI chr 6:30,797,102...30,800,782
Ensembl chr 6:25,077,349...25,080,675
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H2ax
H2A.X variant histone
affects localization
ISO
Pentamidine affects the localization of H2AX protein modified form
CTD
PMID:20144237
NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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Hpn
hepsin
increases expression
ISO
Pentamidine results in increased expression of HPN mRNA
CTD
PMID:15342952
NCBI chr 1:95,464,468...95,480,169
Ensembl chr 1:86,337,087...86,352,811
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Ifng
interferon gamma
multiple interactions
ISO
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
CTD
PMID:15588918 PMID:29594315
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
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Ifngr1
interferon gamma receptor 1
increases expression
ISO
Pentamidine results in increased expression of IFNGR1 mRNA; Pentamidine results in increased expression of IFNGR1 protein
CTD
PMID:12803856
NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:14,333,187...14,351,785
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Il10
interleukin 10
multiple interactions decreases expression
ISO
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL10 protein Pentamidine results in decreased expression of IL10 protein
CTD
PMID:15588918
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
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Il1b
interleukin 1 beta
decreases expression
ISO
Pentamidine results in decreased expression of IL1B mRNA
CTD
PMID:29594315
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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Il2
interleukin 2
multiple interactions
ISO
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD
PMID:15588918 PMID:29594315
NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566
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Il4
interleukin 4
multiple interactions
ISO
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein
CTD
PMID:15588918
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
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Inhbe
inhibin subunit beta E
increases expression
ISO
Pentamidine results in increased expression of INHBE mRNA
CTD
PMID:15342952
NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:63,176,219...63,179,172
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Kat5
lysine acetyltransferase 5
multiple interactions decreases activity
ISO
Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein] Pentamidine results in decreased activity of KAT5 protein
CTD
PMID:20144237
NCBI chr 1:212,325,089...212,332,640
Ensembl chr 1:202,895,751...202,903,458
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Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions decreases activity
ISO
Pentamidine affects the localization of and affects the activity of KCNH2 protein; Pentamidine affects the localization of and results in decreased activity of KCNH2 protein; Pentamidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Pentamidine results in decreased activity of KCNH2 protein
CTD
PMID:15340016 PMID:15711590 PMID:21158687
NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
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Lss
lanosterol synthase
decreases expression
ISO
Pentamidine results in decreased expression of LSS mRNA
CTD
PMID:15342952
NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,092,774...12,118,762
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Mre11
MRE11 homolog, double strand break repair nuclease
decreases activity
ISO
Pentamidine results in decreased activity of MRE11 protein
CTD
PMID:20144237
NCBI chr 8:19,900,211...19,961,906
Ensembl chr 8:11,632,354...11,678,279
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Nbn
nibrin
affects localization
ISO
Pentamidine affects the localization of NBN protein
CTD
PMID:20144237
NCBI chr 5:34,256,678...34,291,163
Ensembl chr 5:29,459,457...29,494,150
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Pentamidine results in increased expression of NR0B2 mRNA
CTD
PMID:15342952
NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:145,779,294...145,782,609
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
increases activity
ISO
Pentamidine results in increased activity of NR1H4 protein
CTD
PMID:22414727
NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:23,846,122...23,942,047
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Nupr1
nuclear protein 1, transcriptional regulator
increases expression
ISO
Pentamidine results in increased expression of NUPR1 mRNA
CTD
PMID:15342952
NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:181,213,368...181,215,281
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RT1-Bb
RT1 class II, locus Bb
affects expression
ISO
Pentamidine affects the expression of HLA-DQB1 mRNA
CTD
PMID:25811541
NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,596,559...4,607,597
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Serpina3n
serpin family A member 3N
increases expression
ISO
Pentamidine results in increased expression of SERPINA3 mRNA
CTD
PMID:15342952
NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:123,323,629...123,332,433
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Pentamidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
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Slc2a3
solute carrier family 2 member 3
decreases expression
ISO
Pentamidine results in decreased expression of SLC2A3 mRNA
CTD
PMID:15342952
NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:155,960,946...156,025,472
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Tp53
tumor protein p53
multiple interactions
ISO
Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein]
CTD
PMID:20144237
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
Pentamidine results in increased expression of WIPI1 mRNA
CTD
PMID:15342952
NCBI chr10:95,042,451...95,079,679
Ensembl chr10:94,542,946...94,579,846
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Abcb1a
ATP binding cassette subfamily B member 1A
increases activity
ISO
Trifluoperazine results in increased activity of ABCB1 protein
CTD
PMID:2900677
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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Ache
acetylcholinesterase
multiple interactions increases activity decreases expression
EXP ISO
energostim inhibits the reaction [Trifluoperazine results in decreased expression of ACHE protein] Trifluoperazine results in increased activity of ACHE protein
CTD
PMID:15232633 PMID:29614332
NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651
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Akt1
AKT serine/threonine kinase 1
multiple interactions
EXP ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD
PMID:19233221 PMID:21544200
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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Atg5
autophagy related 5
increases expression
ISO
Trifluoperazine results in increased expression of ATG5 protein
CTD
PMID:38360085
NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209
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Atp6v1h
ATPase H+ transporting V1 subunit H
multiple interactions
ISO
[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA
CTD
PMID:28366621
NCBI chr 5:14,379,029...14,484,703
Ensembl chr 5:14,378,257...14,537,962
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Trifluoperazine results in increased expression of BAX protein
CTD
PMID:21475906
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Trifluoperazine results in decreased expression of BCL2 protein
CTD
PMID:21475906
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Becn1
beclin 1
increases expression
ISO
Trifluoperazine results in increased expression of BECN1 protein
CTD
PMID:38360085
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742
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Camk2a
calcium/calmodulin-dependent protein kinase II alpha
multiple interactions
EXP
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein]
CTD
PMID:19233221
NCBI chr18:56,648,779...56,711,505
Ensembl chr18:54,378,784...54,438,994
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Casp3
caspase 3
multiple interactions
EXP ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of CASP3 protein]
CTD
PMID:21544200
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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Cd44
CD44 molecule
multiple interactions
ISO
Trifluoperazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD44 protein]
CTD
PMID:9929743
NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620
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Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
multiple interactions
EXP ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein]
CTD
PMID:21544200
NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984
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Fmo2
flavin containing dimethylaniline monoxygenase 2
increases oxidation
ISO
FMO2 protein results in increased oxidation of Trifluoperazine
CTD
PMID:26062974
NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
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Gabbr1
gamma-aminobutyric acid type B receptor subunit 1
multiple interactions
ISO
Trifluoperazine inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]
CTD
PMID:15627515
NCBI chr20:1,469,779...1,499,352
Ensembl chr20:1,464,534...1,493,994
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Gabbr2
gamma-aminobutyric acid type B receptor subunit 2
multiple interactions
ISO
Trifluoperazine inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]
CTD
PMID:15627515
NCBI chr 5:65,743,073...66,083,695
Ensembl chr 5:60,947,526...61,288,104
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Hif1a
hypoxia inducible factor 1 subunit alpha
decreases expression
ISO
Trifluoperazine results in decreased expression of HIF1A protein
CTD
PMID:18822394
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
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Il12b
interleukin 12B
multiple interactions
ISO
Trifluoperazine inhibits the reaction [Hydrogen Peroxide results in decreased expression of IL12B protein]
CTD
PMID:16249388
NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
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Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions
ISO
Trifluoperazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
CTD
PMID:21158687
NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
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Kcnn2
potassium calcium-activated channel subfamily N member 2
decreases activity
EXP
Trifluoperazine results in decreased activity of KCNN2 protein
CTD
PMID:10915830
NCBI chr18:40,004,693...40,445,043
Ensembl chr18:37,817,957...38,258,347
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Lamp1
lysosomal-associated membrane protein 1
multiple interactions
ISO
[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA
CTD
PMID:28366621
NCBI chr16:83,058,131...83,082,843
Ensembl chr16:76,355,984...76,381,883
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Mapk1
mitogen activated protein kinase 1
multiple interactions
EXP ISO
Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Trifluoperazine inhibits the reaction [Dinoprost results in increased activity of MAPK1 protein]
CTD
PMID:11914123 PMID:21544200
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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Mapk14
mitogen activated protein kinase 14
multiple interactions
ISO EXP
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK14 protein]
CTD
PMID:21544200
NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589
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Mapk3
mitogen activated protein kinase 3
multiple interactions
EXP ISO
Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Trifluoperazine inhibits the reaction [Dinoprost results in increased activity of MAPK3 protein]
CTD
PMID:11914123 PMID:21544200
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO EXP
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]
CTD
PMID:21544200
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
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Mapk9
mitogen-activated protein kinase 9
multiple interactions
ISO EXP
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK9 protein]
CTD
PMID:21544200
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178
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Mt1
metallothionein 1
increases expression
EXP
Trifluoperazine results in increased expression of MT1A mRNA
CTD
PMID:8128501
NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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Mtor
mechanistic target of rapamycin kinase
multiple interactions decreases phosphorylation
EXP ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein] Trifluoperazine analog results in decreased phosphorylation of MTOR protein; Trifluoperazine results in decreased phosphorylation of MTOR protein STON2 protein inhibits the reaction [Trifluoperazine analog results in decreased phosphorylation of MTOR protein]
CTD
PMID:21544200 PMID:36702439 PMID:38360085
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
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Myl9
myosin light chain 9
multiple interactions
EXP
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MYL9 protein]; Trifluoperazine inhibits the reaction [Ionomycin results in increased phosphorylation of MYL9 protein]
CTD
PMID:19233221
NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:145,281,937...145,288,333
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Nefl
neurofilament light chain
multiple interactions
EXP
Trifluoperazine inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA]
CTD
PMID:31969611
NCBI chr15:46,477,330...46,481,203
Ensembl chr15:42,301,916...42,305,793
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
decreases activity
ISO
Trifluoperazine results in decreased activity of NR3C1 protein
CTD
PMID:7887964
NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
EXP ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]
CTD
PMID:21544200
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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Pink1
PTEN induced kinase 1
multiple interactions
ISO
[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]]
CTD
PMID:28366621
NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:150,530,523...150,542,635
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Prkn
parkin RBR E3 ubiquitin protein ligase
affects localization multiple interactions
ISO
Trifluoperazine affects the localization of PRKN protein PRKN protein affects the reaction [Trifluoperazine affects the localization of PRKN protein]
CTD
PMID:28366621
NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555
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Prl
prolactin
increases expression
ISO
Trifluoperazine results in increased expression of PRL protein
CTD
PMID:2136057
NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062
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Rel
REL proto-oncogene, NF-kB subunit
multiple interactions
ISO
Trifluoperazine inhibits the reaction [Hydrogen Peroxide results in decreased localization of REL protein]
CTD
PMID:16249388
NCBI chr14:101,891,238...101,922,324
Ensembl chr14:97,695,161...97,720,892
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Rps6kb1
ribosomal protein S6 kinase B1
multiple interactions
EXP ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]
CTD
PMID:21544200
NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
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Slc5a6
solute carrier family 5 member 6
multiple interactions
ISO
Trifluoperazine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]
CTD
PMID:15561972
NCBI chr 6:31,039,865...31,051,671
Ensembl chr 6:25,320,442...25,331,712
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Sqstm1
sequestosome 1
decreases expression
ISO
Trifluoperazine results in decreased expression of SQSTM1 protein
CTD
PMID:38360085
NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673
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Ston2
stonin 2
decreases expression multiple interactions
ISO
Trifluoperazine analog results in decreased expression of STON2 protein STON2 protein inhibits the reaction [Trifluoperazine analog results in decreased phosphorylation of MTOR protein]
CTD
PMID:36702439
NCBI chr 6:116,291,898...116,441,391
Ensembl chr 6:110,567,485...110,676,376
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Tfeb
transcription factor EB
multiple interactions
ISO
[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]]
CTD
PMID:28366621
NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:13,198,891...13,254,714
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Tnfsf11
TNF superfamily member 11
decreases activity
ISO
Trifluoperazine results in decreased activity of TNFSF11
CTD
PMID:21869564
NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445
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Ugt1a5
UDP glucuronosyltransferase family 1 member A5
increases glucuronidation multiple interactions increases activity
ISO
UGT1A4 protein results in increased glucuronidation of Trifluoperazine Finasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine]; hecogenin inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine]; licochalcone A inhibits the reaction [Trifluoperazine results in increased activity of UGT1A4 protein]; Trifluoperazine inhibits the reaction [UGT1A4 protein results in increased glucuronidation of afloqualone]
CTD
PMID:15135306 PMID:15475412 PMID:25393417 PMID:25448279 PMID:26875642 PMID:33290829 More...
NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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Ulk1
unc-51 like autophagy activating kinase 1
increases expression increases phosphorylation
ISO
Trifluoperazine results in increased expression of ULK1 mRNA Trifluoperazine results in increased phosphorylation of ULK1 protein
CTD
PMID:38360085
NCBI chr12:51,511,492...51,537,746
Ensembl chr12:45,851,710...45,877,966
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