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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:calmodulin antagonist
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Accession:CHEBI:130181 term browser browse the term
Definition:An antagonist that interferes with the action of the calcium-binding messenger protein calmodulin.
Synonyms:xref: PMID:26717596



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calmidazolium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO calmidazolium results in increased activity of CASP3 protein CTD PMID:27247146 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 multiple interactions ISO calmidazolium inhibits the reaction [Potassium results in increased expression of CYP11B2 mRNA] CTD PMID:12193581 NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G F2 coagulation factor II, thrombin multiple interactions ISO calmidazolium affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate] CTD PMID:2030746 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO calmidazolium inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19281832 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mt1 metallothionein 1 increases expression EXP calmidazolium results in increased expression of MT1A mRNA CTD PMID:8128501 NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO calmidazolium results in decreased expression of MYC CTD PMID:27247146 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myl9 myosin light chain 9 decreases phosphorylation EXP calmidazolium results in decreased phosphorylation of MYL9 protein CTD PMID:17272349 NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:145,281,937...145,288,333
JBrowse link
G Ngf nerve growth factor multiple interactions EXP calmidazolium inhibits the reaction [NGF protein results in increased uptake of Calcium] CTD PMID:1374475 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nos3 nitric oxide synthase 3 decreases activity EXP calmidazolium results in decreased activity of NOS3 protein CTD PMID:1374468 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions ISO calmidazolium inhibits the reaction [Adenosine Triphosphate binds to and results in increased activity of P2RX7 protein] CTD PMID:31263019 NCBI chr12:39,550,531...39,594,984
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO calmidazolium results in decreased phosphorylation of RB1 protein CTD PMID:12901840 PMID:15708436 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 decreases phosphorylation ISO calmidazolium results in decreased phosphorylation of RBL2 protein CTD PMID:15708436 NCBI chr19:32,049,690...32,096,467
Ensembl chr19:15,876,853...15,923,572
JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions ISO calmidazolium inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 6:31,039,865...31,051,671
Ensembl chr 6:25,320,442...25,331,712
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO calmidazolium inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19281832 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
pentamidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Pentamidine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Asic5 acid sensing ion channel subunit family member 5 decreases activity ISO Pentamidine results in decreased activity of ASIC5 protein CTD PMID:21828194 NCBI chr 2:167,307,984...167,336,812
Ensembl chr 2:167,307,984...167,336,812
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Pentamidine results in increased expression of ASNS mRNA CTD PMID:15342952 NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Atm ATM serine/threonine kinase affects localization
decreases activity
ISO Pentamidine affects the localization of ATM protein modified form
Pentamidine results in decreased activity of ATM protein
CTD PMID:20144237 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Pentamidine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO Pentamidine results in decreased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Pentamidine results in decreased activity of CYP2D6 protein CTD PMID:11124226 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Pentamidine results in decreased activity of CYP3A4 protein CTD PMID:11124226 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Pentamidine results in increased expression of DEPP1 mRNA CTD PMID:15342952 NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:149,910,779...149,914,542
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Pentamidine results in decreased expression of FABP1 mRNA CTD PMID:15342952 NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Pentamidine results in increased expression of FNDC4 mRNA CTD PMID:15342952 NCBI chr 6:30,797,102...30,800,782
Ensembl chr 6:25,077,349...25,080,675
JBrowse link
G H2ax H2A.X variant histone affects localization ISO Pentamidine affects the localization of H2AX protein modified form CTD PMID:20144237 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239
JBrowse link
G Hpn hepsin increases expression ISO Pentamidine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:95,464,468...95,480,169
Ensembl chr 1:86,337,087...86,352,811
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
CTD PMID:15588918 PMID:29594315 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifngr1 interferon gamma receptor 1 increases expression ISO Pentamidine results in increased expression of IFNGR1 mRNA; Pentamidine results in increased expression of IFNGR1 protein CTD PMID:12803856 NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:14,333,187...14,351,785
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression
ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL10 protein
Pentamidine results in decreased expression of IL10 protein
CTD PMID:15588918 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Pentamidine results in decreased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD PMID:15588918 PMID:29594315 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein CTD PMID:15588918 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Pentamidine results in increased expression of INHBE mRNA CTD PMID:15342952 NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:63,176,219...63,179,172
JBrowse link
G Kat5 lysine acetyltransferase 5 multiple interactions
decreases activity
ISO Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein]
Pentamidine results in decreased activity of KAT5 protein
CTD PMID:20144237 NCBI chr 1:212,325,089...212,332,640
Ensembl chr 1:202,895,751...202,903,458
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO Pentamidine affects the localization of and affects the activity of KCNH2 protein; Pentamidine affects the localization of and results in decreased activity of KCNH2 protein; Pentamidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Pentamidine results in decreased activity of KCNH2 protein
CTD PMID:15340016 PMID:15711590 PMID:21158687 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Lss lanosterol synthase decreases expression ISO Pentamidine results in decreased expression of LSS mRNA CTD PMID:15342952 NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases activity ISO Pentamidine results in decreased activity of MRE11 protein CTD PMID:20144237 NCBI chr 8:19,900,211...19,961,906
Ensembl chr 8:11,632,354...11,678,279
JBrowse link
G Nbn nibrin affects localization ISO Pentamidine affects the localization of NBN protein CTD PMID:20144237 NCBI chr 5:34,256,678...34,291,163
Ensembl chr 5:29,459,457...29,494,150
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Pentamidine results in increased expression of NR0B2 mRNA CTD PMID:15342952 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO Pentamidine results in increased activity of NR1H4 protein CTD PMID:22414727 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Pentamidine results in increased expression of NUPR1 mRNA CTD PMID:15342952 NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:181,213,368...181,215,281
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Pentamidine affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G Serpina3n serpin family A member 3N increases expression ISO Pentamidine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:123,323,629...123,332,433
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Pentamidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Pentamidine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein] CTD PMID:20144237 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Pentamidine results in increased expression of WIPI1 mRNA CTD PMID:15342952 NCBI chr10:95,042,451...95,079,679
Ensembl chr10:94,542,946...94,579,846
JBrowse link
trifluoperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases activity ISO Trifluoperazine results in increased activity of ABCB1 protein CTD PMID:2900677 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Ache acetylcholinesterase multiple interactions
increases activity
decreases expression
EXP
ISO
energostim inhibits the reaction [Trifluoperazine results in decreased expression of ACHE protein]
Trifluoperazine results in increased activity of ACHE protein
CTD PMID:15232633 PMID:29614332 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP
ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:19233221 PMID:21544200 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atg5 autophagy related 5 increases expression ISO Trifluoperazine results in increased expression of ATG5 protein CTD PMID:38360085 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atp6v1h ATPase H+ transporting V1 subunit H multiple interactions ISO [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA CTD PMID:28366621 NCBI chr 5:14,379,029...14,484,703
Ensembl chr 5:14,378,257...14,537,962
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Trifluoperazine results in increased expression of BAX protein CTD PMID:21475906 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Trifluoperazine results in decreased expression of BCL2 protein CTD PMID:21475906 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Becn1 beclin 1 increases expression ISO Trifluoperazine results in increased expression of BECN1 protein CTD PMID:38360085 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein] CTD PMID:19233221 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:21544200 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cd44 CD44 molecule multiple interactions ISO Trifluoperazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD44 protein] CTD PMID:9929743 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP
ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:21544200 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases oxidation ISO FMO2 protein results in increased oxidation of Trifluoperazine CTD PMID:26062974 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO Trifluoperazine inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]] CTD PMID:15627515 NCBI chr20:1,469,779...1,499,352
Ensembl chr20:1,464,534...1,493,994
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 multiple interactions ISO Trifluoperazine inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]] CTD PMID:15627515 NCBI chr 5:65,743,073...66,083,695
Ensembl chr 5:60,947,526...61,288,104
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Trifluoperazine results in decreased expression of HIF1A protein CTD PMID:18822394 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Trifluoperazine inhibits the reaction [Hydrogen Peroxide results in decreased expression of IL12B protein] CTD PMID:16249388 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Trifluoperazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity EXP Trifluoperazine results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:40,004,693...40,445,043
Ensembl chr18:37,817,957...38,258,347
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions ISO [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA CTD PMID:28366621 NCBI chr16:83,058,131...83,082,843
Ensembl chr16:76,355,984...76,381,883
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Trifluoperazine inhibits the reaction [Dinoprost results in increased activity of MAPK1 protein] CTD PMID:11914123 PMID:21544200 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO
EXP
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK14 protein] CTD PMID:21544200 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Trifluoperazine inhibits the reaction [Dinoprost results in increased activity of MAPK3 protein] CTD PMID:11914123 PMID:21544200 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO
EXP
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein] CTD PMID:21544200 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO
EXP
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK9 protein] CTD PMID:21544200 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mt1 metallothionein 1 increases expression EXP Trifluoperazine results in increased expression of MT1A mRNA CTD PMID:8128501 NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
EXP
ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]
Trifluoperazine analog results in decreased phosphorylation of MTOR protein; Trifluoperazine results in decreased phosphorylation of MTOR protein
STON2 protein inhibits the reaction [Trifluoperazine analog results in decreased phosphorylation of MTOR protein]
CTD PMID:21544200 PMID:36702439 PMID:38360085 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myl9 myosin light chain 9 multiple interactions EXP Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MYL9 protein]; Trifluoperazine inhibits the reaction [Ionomycin results in increased phosphorylation of MYL9 protein] CTD PMID:19233221 NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:145,281,937...145,288,333
JBrowse link
G Nefl neurofilament light chain multiple interactions EXP Trifluoperazine inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA] CTD PMID:31969611 NCBI chr15:46,477,330...46,481,203
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO Trifluoperazine results in decreased activity of NR3C1 protein CTD PMID:7887964 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP
ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein] CTD PMID:21544200 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]] CTD PMID:28366621 NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase affects localization
multiple interactions
ISO Trifluoperazine affects the localization of PRKN protein
PRKN protein affects the reaction [Trifluoperazine affects the localization of PRKN protein]
CTD PMID:28366621 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Prl prolactin increases expression ISO Trifluoperazine results in increased expression of PRL protein CTD PMID:2136057 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO Trifluoperazine inhibits the reaction [Hydrogen Peroxide results in decreased localization of REL protein] CTD PMID:16249388 NCBI chr14:101,891,238...101,922,324
Ensembl chr14:97,695,161...97,720,892
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP
ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein] CTD PMID:21544200 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions ISO Trifluoperazine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 6:31,039,865...31,051,671
Ensembl chr 6:25,320,442...25,331,712
JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO Trifluoperazine results in decreased expression of SQSTM1 protein CTD PMID:38360085 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Ston2 stonin 2 decreases expression
multiple interactions
ISO Trifluoperazine analog results in decreased expression of STON2 protein
STON2 protein inhibits the reaction [Trifluoperazine analog results in decreased phosphorylation of MTOR protein]
CTD PMID:36702439 NCBI chr 6:116,291,898...116,441,391
Ensembl chr 6:110,567,485...110,676,376
JBrowse link
G Tfeb transcription factor EB multiple interactions ISO [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]] CTD PMID:28366621 NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:13,198,891...13,254,714
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases activity ISO Trifluoperazine results in decreased activity of TNFSF11 CTD PMID:21869564 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation
multiple interactions
increases activity
ISO UGT1A4 protein results in increased glucuronidation of Trifluoperazine
Finasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine]; hecogenin inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine]; licochalcone A inhibits the reaction [Trifluoperazine results in increased activity of UGT1A4 protein]; Trifluoperazine inhibits the reaction [UGT1A4 protein results in increased glucuronidation of afloqualone]
CTD PMID:15135306 PMID:15475412 PMID:25393417 PMID:25448279 PMID:26875642 More... NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases expression
increases phosphorylation
ISO Trifluoperazine results in increased expression of ULK1 mRNA
Trifluoperazine results in increased phosphorylation of ULK1 protein
CTD PMID:38360085 NCBI chr12:51,511,492...51,537,746
Ensembl chr12:45,851,710...45,877,966
JBrowse link

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  CHEBI ontology 19899
    role 19870
      biological role 19868
        pharmacological role 19105
          antagonist 17268
            calmodulin antagonist 85
              calmidazolium + 14
              calmidazolium chloride 0
              pentamidine 34
              trifluoperazine + 43
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