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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:disodium cromoglycate
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Accession:CHEBI:128458 term browser browse the term
Definition:An organic sodium salt that is the disodium salt of cromoglycic acid.
Synonyms:related_synonym: DSCG;   Dinatrium salz von 1,3-bis-(2-carboxychromon-5-yloxy)-2-hydroxypropan;   Disodium 5,5'-((2-hydroxytrimethylene)bis(oxy))bis(4-oxo-4H-1-benzopyran-2-carboxylate);   FPL-670;   Natrium cromoglicat;   Sodium cromoglicate;   Sodium cromoglycate;   Sodium cromolyn;   Sodium salt of 5-[3-(2-carboxy-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4H-2-chromenecarboxylic acid;   disodium 5,5'-[(2-hydroxypropane-1,3-diyl)bis(oxy)]bis(4-oxo-4H-chromene-2-carboxylate);   disodium 5-[3-(2-carboxylato-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4H-2-chromenecarboxylate;   disodium 5-{3-[(2-carboxylato-4-oxo-4H-chromen-5-yl)oxy]-2-hydroxypropoxy}-4-oxo-4H-chromene-2-carboxylate
 alt_id: CHEBI:106480;   CHEBI:3922;   CHEBI:3923
 xref: Beilstein:3647577;   CAS:15826-37-6
 xref_mesh: MESH:D004205
 xref: kegg.drug:D00526;   pubmed:12001789;   pubmed:19107959;   pubmed:26176755;   pubmed:26656593;   pubmed:26871132;   pubmed:26964003;   pubmed:3128591
 chemrof_formula: C23H14O11.2Na
 chemrof_inchi: InChI=1S/C23H16O11.2Na/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30;;/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30);;/q;2*+1/p-2
 chemrof_smiles: O=C([O-])c1cc(=O)c2c(OCC(O)COc3cccc4oc(C(=O)[O-])cc(=O)c34)cccc2o1.[Na+].[Na+]
 chemrof_inchikey: VLARUOGDXDTHEH-UHFFFAOYSA-L


show annotations for term's descendants           Sort by:
disodium cromoglycate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions EXP [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of ABCC4 protein; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of MRP4 protein] CTD PMID:35114312 PMID:36464070 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression
multiple interactions 		ISO
EXP 		Cromolyn Sodium results in increased expression of ABCG2 protein
Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of ABCG2 protein] 		CTD PMID:36464070 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein] CTD PMID:35114312 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Cromolyn Sodium results in increased expression of ADIPOQ protein CTD PMID:23784744 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Adora3 adenosine A3 receptor decreases activity EXP Cromolyn Sodium results in decreased activity of ADORA3 protein CTD PMID:15641640 NCBI chr 2:196,077,042...196,080,686
Ensembl chr 2:196,077,042...196,080,686 		JBrowse link
G Agt angiotensinogen multiple interactions EXP Cromolyn Sodium inhibits the reaction [[Probenecid co-treated with adefovir] results in increased expression of AGT protein]; Cromolyn Sodium inhibits the reaction [Purines analog results in increased secretion of AGT protein] CTD PMID:35114312 PMID:36464070 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of AKT1 protein] CTD PMID:28732690 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of BCL2 protein] CTD PMID:28732690 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Cromolyn Sodium inhibits the reaction [Paclitaxel results in increased expression of CALCA protein] CTD PMID:15033348 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529 		JBrowse link
G Cst3 cystatin C multiple interactions EXP Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of CST3 protein] CTD PMID:35114312 NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:156,790,079...156,793,937 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of CTNNB1 protein] CTD PMID:28732690 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO [pristane co-treated with Cromolyn Sodium] results in increased expression of CTSD protein CTD PMID:8812242 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO Cromolyn Sodium results in decreased expression of DNMT1 mRNA; Cromolyn Sodium results in decreased expression of DNMT1 protein CTD PMID:35961540 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119 		JBrowse link
G Gpr35 G protein-coupled receptor 35 affects localization
multiple interactions 		ISO
EXP 		Cromolyn Sodium affects the localization of GPR35 protein
Cromolyn Sodium binds to and results in increased activity of GPR35 protein
2-hydroxy-4-(4-(5-(2-methyl-3-phenylprop-2-enylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoylamino)benzoic acid inhibits the reaction [Cromolyn Sodium affects the localization of GPR35 protein]; 2-hydroxy-4-(4-(5-(2-methyl-3-phenylprop-2-enylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoylamino)benzoic acid inhibits the reaction [Cromolyn Sodium binds to and results in increased activity of GPR35 protein]; Cromolyn Sodium binds to and results in increased activity of GPR35 protein; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Cromolyn Sodium affects the localization of GPR35 protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Cromolyn Sodium binds to and results in increased activity of GPR35 protein] 		CTD PMID:20919992 PMID:22967846 NCBI chr 9:100,974,580...100,995,330
Ensembl chr 9:100,962,538...100,986,985 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of GPX1 protein] CTD PMID:36464070 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of GSK3B protein] CTD PMID:28732690 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Ins1 insulin 1 increases expression ISO Cromolyn Sodium results in increased expression of INS1 protein CTD PMID:23784744 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Cromolyn Sodium results in decreased phosphorylation of MAPK1 protein CTD PMID:35961540 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation 		EXP
ISO 		[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of MAPK3 protein]
Cromolyn Sodium results in decreased phosphorylation of MAPK3 protein 		CTD PMID:28732690 PMID:35961540 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit decreases expression ISO Cromolyn Sodium results in decreased expression of METTL3 mRNA; Cromolyn Sodium results in decreased expression of METTL3 protein CTD PMID:35961540 NCBI chr15:27,476,659...27,491,134
Ensembl chr15:27,476,660...27,487,487 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression 		EXP Cromolyn Sodium inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]
Cromolyn Sodium results in increased expression of MMP2 mRNA 		CTD PMID:14577597 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP Cromolyn Sodium inhibits the reaction [POMC results in increased secretion of Corticosterone] CTD PMID:1659878 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of RELA protein] CTD PMID:28732690 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Ren renin multiple interactions EXP Cromolyn Sodium inhibits the reaction [Purines analog results in increased secretion of REN protein] CTD PMID:36464070 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Retn resistin decreases expression ISO Cromolyn Sodium results in decreased expression of RETN protein CTD PMID:23784744 NCBI chr12:6,508,653...6,511,115
Ensembl chr12:6,508,801...6,511,116 		JBrowse link
G S100b S100 calcium binding protein B multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of S100P protein] CTD PMID:28732690 NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions EXP Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A12 protein] CTD PMID:36464070 NCBI chr 1:213,274,266...213,282,793
Ensembl chr 1:213,274,275...213,281,380 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions EXP [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of SLC22A6 protein; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A6 protein] CTD PMID:35114312 PMID:36464070 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] results in increased expression of SLC22A8 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein]; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A8 protein] CTD PMID:35114312 PMID:36464070 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SOD1 protein] CTD PMID:36464070 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Cromolyn Sodium inhibits the reaction [Paclitaxel results in increased expression of TAC1 protein] CTD PMID:15033348 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases secretion 		ISO
EXP 		[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with masitinib co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein; [masitinib co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein
Cromolyn Sodium results in increased secretion of TGFB1 protein
Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein] 		CTD PMID:35007524 PMID:35114312 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Cromolyn Sodium inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride] CTD PMID:22414385 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      application 20572
        anti-asthmatic agent 9365
          anti-asthmatic drug 8710
            disodium cromoglycate 33
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  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic ion 11556
                              organic anion 6893
                                carboxylic acid anion 2553
                                  dicarboxylic acid anion 255
                                    dicarboxylic acid dianion 255
                                      cromoglycate(2-) 34
                                        disodium cromoglycate 33
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