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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-(6-acetamidohexyl)acetamide
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Accession:CHEBI:125472 term browser browse the term
Definition:An acetamide that has formula C10H20N2O2.
Synonyms:exact_synonym: hexamethylene bisacetamide
 related_synonym: Formula=C10H20N2O2;   InChI=1S/C10H20N2O2/c1-9(13)11-7-5-3-4-6-8-12-10(2)14/h3-8H2,1-2H3,(H,11,13)(H,12,14);   InChIKey=BNQSTAOJRULKNX-UHFFFAOYSA-N;   SMILES=CC(=O)NCCCCCCNC(=O)C
 alt_id: MESH:C014026
 xref: HMDB:HMDB0041901;   LINCS:LSM-36966
 xref_mesh: MESH:C014026


show annotations for term's descendants           Sort by:
N-(6-acetamidohexyl)acetamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator affects expression ISO hexamethylene bisacetamide affects the expression of BAX CTD PMID:15543656 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO hexamethylene bisacetamide affects the expression of BCL2 CTD PMID:15543656 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO [Tretinoin co-treated with arsenic trioxide co-treated with hexamethylene bisacetamide] results in increased expression of BCL2A1 mRNA; [Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of BCL2A1 mRNA CTD PMID:12130515 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890 		JBrowse link
G Bcl2l1 Bcl2-like 1 affects expression ISO hexamethylene bisacetamide affects the expression of BCL2L1 CTD PMID:15543656 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Brd2 bromodomain containing 2 multiple interactions ISO hexamethylene bisacetamide inhibits the reaction [BRD2 protein binds to SRM promoter] CTD PMID:26941288 NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,951...4,737,290 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of CCNE1 mRNA CTD PMID:17349212 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:99,918,674...99,927,822 		JBrowse link
G Cd2 Cd2 molecule decreases expression ISO hexamethylene bisacetamide results in decreased expression of CD2 mRNA CTD PMID:26941288 NCBI chr 2:191,399,510...191,412,659
Ensembl chr 2:191,399,510...191,413,665 		JBrowse link
G Cd44 CD44 molecule decreases expression ISO hexamethylene bisacetamide results in decreased expression of CD44 mRNA CTD PMID:17349212 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424 		JBrowse link
G Cd52 CD52 molecule decreases expression ISO hexamethylene bisacetamide results in decreased expression of CD52 mRNA CTD PMID:26941288 NCBI chr 5:146,319,789...146,321,348
Ensembl chr 5:151,603,524...151,605,086 		JBrowse link
G Cd69 Cd69 molecule decreases expression ISO hexamethylene bisacetamide results in decreased expression of CD69 mRNA CTD PMID:26941288 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:164,411,485...164,419,509 		JBrowse link
G Cd74 CD74 molecule decreases expression ISO hexamethylene bisacetamide results in decreased expression of CD74 mRNA CTD PMID:26941288 NCBI chr18:56,527,071...56,536,406
Ensembl chr18:56,527,132...56,536,410 		JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO hexamethylene bisacetamide results in decreased expression of CDC6 mRNA CTD PMID:26941288 NCBI chr10:84,360,361...84,374,239
Ensembl chr10:84,360,381...84,374,241 		JBrowse link
G Cdc7 cell division cycle 7 decreases expression ISO hexamethylene bisacetamide results in decreased expression of CDC7 mRNA CTD PMID:26941288 NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,949,539...2,969,656 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO hexamethylene bisacetamide results in decreased expression of CDK2 mRNA CTD PMID:26941288 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions 		ISO hexamethylene bisacetamide results in increased expression of CDKN1A mRNA; hexamethylene bisacetamide results in increased expression of CDKN1A protein
[Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of CDKN1A mRNA 		CTD PMID:10597302 PMID:12130515 PMID:17349212 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO hexamethylene bisacetamide results in increased expression of CDKN1B mRNA CTD PMID:17349212 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of CDT1 mRNA CTD PMID:26941288 NCBI chr19:67,529,249...67,534,195
Ensembl chr19:67,529,201...67,534,194 		JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon multiple interactions ISO [Tretinoin co-treated with arsenic trioxide co-treated with hexamethylene bisacetamide] results in increased expression of CEBPE mRNA; [Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of CEBPE mRNA CTD PMID:12130515 NCBI chr15:32,139,716...32,141,476
Ensembl chr15:32,139,716...32,141,476 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 multiple interactions ISO [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein]; [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [thiamet G results in increased O-linked glycosylation of CHD4 protein]; [Hemin co-treated with hexamethylene bisacetamide] results in decreased O-linked glycosylation of CHD4 protein CTD PMID:27231347 NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:159,584,654...159,617,866 		JBrowse link
G Csf1r colony stimulating factor 1 receptor increases expression ISO hexamethylene bisacetamide results in increased expression of CSF1R mRNA CTD PMID:8445950 NCBI chr18:56,834,152...56,860,804
Ensembl chr18:56,817,049...56,860,806 		JBrowse link
G Dbf4 DBF4-CDC7 kinase regulatory subunit decreases expression ISO hexamethylene bisacetamide results in decreased expression of DBF4 mRNA CTD PMID:26941288 NCBI chr 4:25,676,570...25,701,152
Ensembl chr 4:26,631,514...26,656,562 		JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression ISO hexamethylene bisacetamide results in decreased expression of DUSP6 protein mutant form CTD PMID:17569113 NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833 		JBrowse link
G Eif6 eukaryotic translation initiation factor 6 increases expression ISO hexamethylene bisacetamide results in increased expression of EIF6 protein CTD PMID:17569113 NCBI chr 3:144,325,038...144,331,396
Ensembl chr 3:164,785,163...164,791,525 		JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 increases expression ISO hexamethylene bisacetamide results in increased expression of HBA-A1 mRNA CTD PMID:26941288 NCBI chr10:15,841,724...15,842,580
Ensembl chr10:15,841,763...15,842,603 		JBrowse link
G Hexim1 HEXIM P-TEFb complex subunit 1 increases expression ISO hexamethylene bisacetamide results in increased expression of HEXIM1 mRNA; hexamethylene bisacetamide results in increased expression of HEXIM1 protein CTD PMID:16222702 NCBI chr10:88,062,808...88,064,920
Ensembl chr10:88,560,519...88,580,000 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO hexamethylene bisacetamide inhibits the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA] CTD PMID:12042074 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hoxa9 homeobox A9 increases expression ISO hexamethylene bisacetamide results in increased expression of HOXA9 protein CTD PMID:16973558 NCBI chr 4:81,323,235...81,329,344
Ensembl chr 4:82,653,825...82,662,093 		JBrowse link
G Hpx hemopexin multiple interactions ISO hexamethylene bisacetamide inhibits the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA]; hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT1 mRNA]; hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT2 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA] CTD PMID:12042074 NCBI chr 1:169,344,647...169,352,155
Ensembl chr 1:169,344,583...169,352,156 		JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 multiple interactions ISO [Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of IFIT3 mRNA CTD PMID:12130515 NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:241,526,880...241,532,521 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 decreases expression ISO hexamethylene bisacetamide results in decreased expression of IGFBP2 mRNA CTD PMID:26941288 NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171 		JBrowse link
G Itgam integrin subunit alpha M increases expression ISO hexamethylene bisacetamide results in increased expression of ITGAM protein CTD PMID:10597302 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation
increases expression 		ISO hexamethylene bisacetamide results in increased phosphorylation of JUN protein
hexamethylene bisacetamide results in increased expression of JUN protein 		CTD PMID:10597302 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM10 mRNA CTD PMID:26941288 NCBI chr17:73,263,788...73,288,346
Ensembl chr17:78,175,398...78,197,636 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM2 mRNA CTD PMID:26941288 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:122,903,682...122,918,094 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM3 mRNA CTD PMID:26941288 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:30,715,602...30,733,746 		JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM4 mRNA CTD PMID:26941288 NCBI chr11:85,258,443...85,272,144
Ensembl chr11:98,762,634...98,776,536 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM5 mRNA CTD PMID:26941288 NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,488,813...13,517,758 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM6 mRNA CTD PMID:26941288 NCBI chr13:42,379,161...42,404,352
Ensembl chr13:42,379,162...42,465,467 		JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM7 mRNA CTD PMID:26941288 NCBI chr12:17,042,207...17,049,470
Ensembl chr12:22,155,921...22,163,771 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Tretinoin co-treated with arsenic trioxide co-treated with hexamethylene bisacetamide] results in decreased expression of MPO mRNA CTD PMID:12130515 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mt1a metallothionein 1A multiple interactions ISO hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT1 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA] CTD PMID:12042074 NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr  X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200 		JBrowse link
G Mt2 metallothionein 2 multiple interactions ISO hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT2 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA] CTD PMID:12042074 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,837,927...10,838,709 		JBrowse link
G Myb MYB proto-oncogene, transcription factor decreases expression ISO hexamethylene bisacetamide results in decreased expression of MYB protein CTD PMID:10597302 NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:17,759,309...17,792,547 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO hexamethylene bisacetamide results in decreased expression of MYC protein CTD PMID:10597302 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Npm1 nucleophosmin 1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of NPM1 protein CTD PMID:17569113 NCBI chr10:18,245,739...18,255,913
Ensembl chr10:18,245,740...18,256,024
Ensembl chr  X:18,245,740...18,256,024 		JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase multiple interactions ISO [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein] CTD PMID:27231347 NCBI chr  X:70,811,317...70,856,123
Ensembl chr  X:70,811,319...70,856,123 		JBrowse link
G Pml PML nuclear body scaffold multiple interactions ISO [Tretinoin co-treated with hexamethylene bisacetamide] results in increased cleavage of PML protein mutant form CTD PMID:12130515 NCBI chr 8:67,523,164...67,557,801
Ensembl chr 8:67,523,164...67,576,083 		JBrowse link
G Pola2 DNA polymerase alpha 2, accessory subunit decreases expression ISO hexamethylene bisacetamide results in decreased expression of POLA2 mRNA CTD PMID:26941288 NCBI chr 1:203,227,183...203,251,350
Ensembl chr 1:212,656,501...212,680,542 		JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit decreases expression ISO hexamethylene bisacetamide results in decreased expression of POLE mRNA CTD PMID:26941288 NCBI chr12:46,345,420...46,393,984
Ensembl chr12:52,005,155...52,053,662 		JBrowse link
G Prim1 DNA primase subunit 1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of PRIM1 mRNA CTD PMID:26941288 NCBI chr 7:446,342...462,526 JBrowse link
G Prim2 DNA primase subunit 2 decreases expression ISO hexamethylene bisacetamide results in decreased expression of PRIM2 mRNA CTD PMID:26941288 NCBI chr 9:35,692,376...35,904,521
Ensembl chr 9:43,188,350...43,398,990 		JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO [Tretinoin co-treated with hexamethylene bisacetamide] results in increased cleavage of RARA protein mutant form CTD PMID:12130515 NCBI chr10:84,379,780...84,424,371
Ensembl chr10:84,389,622...84,425,160 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO hexamethylene bisacetamide results in decreased phosphorylation of RB1 protein CTD PMID:10597302 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857 		JBrowse link
G Rpa1 replication protein A1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of RPA1 mRNA CTD PMID:26941288 NCBI chr10:60,148,869...60,199,970
Ensembl chr10:60,647,185...60,698,279 		JBrowse link
G Rpa2 replication protein A2 decreases expression ISO hexamethylene bisacetamide results in decreased expression of RPA2 mRNA CTD PMID:26941288 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:150,260,723...150,271,546 		JBrowse link
G Rpa3 replication protein A3 decreases expression ISO hexamethylene bisacetamide results in decreased expression of RPA3 mRNA CTD PMID:26941288 NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:37,270,966...37,274,183 		JBrowse link
G RT1-Ba RT1 class II, locus Ba decreases expression ISO hexamethylene bisacetamide results in decreased expression of H2-AA mRNA CTD PMID:26941288 NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,576,843...4,581,653 		JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression ISO hexamethylene bisacetamide results in decreased expression of H2-AB1 mRNA CTD PMID:26941288 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of H2-EB1 mRNA CTD PMID:26941288 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,550,596...4,560,165 		JBrowse link
G Sin3b SIN3 transcription regulator family member B increases expression ISO hexamethylene bisacetamide results in increased expression of SIN3B protein CTD PMID:17569113 NCBI chr16:17,123,277...17,159,978
Ensembl chr16:17,157,352...17,270,664 		JBrowse link
G Sla src-like adaptor decreases expression ISO hexamethylene bisacetamide results in decreased expression of SLA mRNA CTD PMID:26941288 NCBI chr 7:100,423,467...100,473,840
Ensembl chr 7:100,424,169...100,473,684 		JBrowse link
G Slamf9 SLAM family member 9 decreases expression ISO hexamethylene bisacetamide results in decreased expression of SLAMF9 mRNA CTD PMID:26941288 NCBI chr13:84,941,896...84,944,749
Ensembl chr13:87,474,290...87,477,107 		JBrowse link
G Srm spermidine synthase multiple interactions
decreases expression 		ISO hexamethylene bisacetamide inhibits the reaction [BRD2 protein binds to SRM promoter]
hexamethylene bisacetamide results in decreased expression of SRM mRNA 		CTD PMID:26941288 NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:164,308,991...164,332,705 		JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 increases expression ISO hexamethylene bisacetamide results in increased expression of SRSF1 protein CTD PMID:17569113 NCBI chr10:72,838,926...72,859,066
Ensembl chr10:73,336,422...73,342,548 		JBrowse link
G Tubb4b tubulin, beta 4B class IVb increases expression ISO hexamethylene bisacetamide results in increased expression of TUBB4B protein CTD PMID:17569113 NCBI chr 3:8,037,838...8,040,294
Ensembl chr 3:28,435,148...28,439,719 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          nitrogen atom 19595
            nitrogen molecular entity 19595
              organonitrogen compound 19403
                carboxamide 17921
                  acetamides 14869
                    N-(6-acetamidohexyl)acetamide 65
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      carboacyl group 18085
                                        univalent carboacyl group 18085
                                          carbamoyl group 17921
                                            carboxamide 17921
                                              acetamides 14869
                                                N-(6-acetamidohexyl)acetamide 65
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