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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cefalotin
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Accession:CHEBI:124991 term browser browse the term
Definition:A semisynthetic, first-generation cephalosporin antibiotic with acetoxymethyl and (2-thienylacetyl)nitrilo moieties at positions 3 and 7, respectively, of the core structure. Administered parenterally during surgery and to treat a wide spectrum of blood infections.
Synonyms:related_synonym: (6R,7R)-3-(acetoxymethyl)-8-oxo-7-(thiophen-2-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   3-Acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid;   7-(2-Thienylacetamido)cephalosporanic acid;   7-(Thiophene-2-acetamido)cephalosporin;   7beta-(thiophen-2-ylacetamido)-3-acetoxymethyl-3,4-didehydrocepham-4-carboxylic acid;   CET;   Cefalothin;   Cephalothin;   Cephalotin;   cefalotina;   cefalotine;   cefalotinum
 alt_id: CHEBI:41547;   CHEBI:50895
 xref: Beilstein:945586;   CAS:153-61-7;   DrugBank:DB00456;   HMDB:HMDB0014599
 xref_mesh: MESH:D002512
 xref: Patent:FR1384197;   Patent:US3218318;   Reaxys:945586;   drugcentral:574;   kegg.compound:C07761;   kegg.drug:D07635;   lincs.smallmolecule:LSM-15184;   pdb-ccd:CLS;   pubmed:10930630;   pubmed:12569987;   pubmed:12833570;   pubmed:1384868;   pubmed:13963283;   pubmed:1701026;   pubmed:2083978;   pubmed:23472927;   pubmed:23680238;   pubmed:29017833;   pubmed:6176550;   wikipedia.en:Cephalothin
 chemrof_formula: C16H16N2O6S2
 chemrof_inchi: InChI=1S/C16H16N2O6S2/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23)/t12-,15-/m1/s1
 chemrof_inchikey: XIURVHNZVLADCM-IUODEOHRSA-N
 chemrof_smiles: [H][C@]12SCC(COC(C)=O)=C(C(=O)O)N1C(=O)[C@@]2([H])NC(=O)Cc1cccs1
 cyclic_relationship: is_conjugate_acid_of CHEBI:50897


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cefalotin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of ABCB11 mRNA CTD PMID:24657338 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of ABCC2 mRNA CTD PMID:24657338 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of ABCC3 mRNA CTD PMID:24657338 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Cephalothin results in increased expression of BAX protein CTD PMID:15012731 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Cephalothin results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:15012731 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in decreased expression of CYP8B1 mRNA CTD PMID:24657338 NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689 		JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of FGF15 mRNA CTD PMID:24657338 NCBI chr 1:209,485,813...209,490,267
Ensembl chr 1:209,485,813...209,490,267 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of NPC1L1 mRNA CTD PMID:24657338 NCBI chr14:85,285,387...85,305,050
Ensembl chr14:85,285,390...85,305,050 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of NR5A2 mRNA CTD PMID:24657338 NCBI chr13:50,865,253...50,985,107
Ensembl chr13:50,867,920...50,984,938 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of SLC10A1 mRNA CTD PMID:24657338 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions EXP Cephalothin binds to and results in decreased activity of SLC25A20 protein; Cephalothin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine] CTD PMID:18452908 NCBI chr 8:118,243,573...118,265,027
Ensembl chr 8:118,243,519...118,265,027 		JBrowse link
G Slc51b SLC51 subunit beta multiple interactions ISO [Cephalothin co-treated with Neomycin] results in decreased expression of SLC51B mRNA CTD PMID:24657338 NCBI chr 8:74,827,047...74,835,109
Ensembl chr 8:74,827,047...74,835,109 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of SLCO1B2 mRNA CTD PMID:24657338 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Cephalothin results in increased expression of TP53 protein CTD PMID:15012731 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Vdr vitamin D receptor multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of VDR mRNA CTD PMID:24657338 NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:130,866,745...130,916,757 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        antimicrobial agent 18216
          cefalotin 15
            cephalothin sodium 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carboxamide 17697
                                    lactam 4145
                                      beta-lactam 851
                                        beta-lactam antibiotic 835
                                          cephem 561
                                            cephalosporin 560
                                              cefalotin 15
                                                cephalothin sodium 0
paths to the root