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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:reumycin
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Accession:CHEBI:121196 term browser browse the term
Definition:A pyrimidotriazine that is 6-methyl-5,6,7,8-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 6.
Synonyms:exact_synonym: 6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione
 related_synonym: 1-demethyltoxoflavin;   6-methyl-8H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione;   6-methyl-pyrimido-[5,4-e]-as-triazine-5,7(6H,8H)-dione;   Formula=C6H5N5O2;   InChI=1S/C6H5N5O2/c1-11-5(12)3-4(9-6(11)13)10-8-2-7-3/h2H,1H3,(H,9,10,13);   InChIKey=ZLLAXLPOOMLVRF-UHFFFAOYSA-N;   SMILES=CN1C(=O)C2=C(NC1=O)N=NC=N2;   reumicine;   reumitsin;   rheumycin;   rheumygin
 xref: CAS:5016-18-2;   LINCS:LSM-32639;   MetaCyc:CPD-21062;   PMID:1656661;   PMID:3566230;   PMID:4026251;   PMID:4062279;   PMID:4322358;   PMID:4792066;   PMID:5907865;   PMID:6486750;   Reaxys:614208


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toxoflavin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [toxoflavin results in decreased activity of ERN1 protein]; [dihydrolipoic acid co-treated with toxoflavin] results in decreased activity of ERN1 protein; [Dithiothreitol co-treated with toxoflavin] results in decreased activity of ERN1 protein; [toxoflavin co-treated with Dithiothreitol] results in increased oxidation of ERN1 protein; Dithiothreitol promotes the reaction [toxoflavin results in decreased activity of ERN1 protein]; toxoflavin binds to and results in decreased activity of ERN1 protein; toxoflavin inhibits the reaction [Tunicamycin results in decreased sulfation of ERN1 protein]; toxoflavin inhibits the reaction [Tunicamycin results in increased phosphorylation of ERN1 protein] CTD PMID:35840659 NCBI chr10:91,826,663...91,920,976 JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions ISO toxoflavin analog inhibits the reaction [[Dexamethasone co-treated with TNFSF11 protein] results in increased expression of P4HB protein] CTD PMID:39393751 NCBI chr10:105,836,972...105,848,583 JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO toxoflavin analog inhibits the reaction [[Dexamethasone co-treated with TNFSF11 protein] results in increased expression of P4HB protein] CTD PMID:39393751 NCBI chr15:60,083,008...60,114,479 JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [toxoflavin inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]]; Acetylcysteine inhibits the reaction [toxoflavin inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]]; toxoflavin inhibits the reaction [Deoxyglucose results in increased splicing of XBP1 mRNA]; toxoflavin inhibits the reaction [Disulfiram results in increased splicing of XBP1 mRNA]; toxoflavin inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA] CTD PMID:35840659 NCBI chr14:84,604,623...84,609,707 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      biological role 19867
        antimicrobial agent 18275
          reumycin 4
            toxoflavin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic molecule 19724
                              organic cyclic compound 19516
                                organic heterocyclic compound 18896
                                  organic heteropolycyclic compound 18323
                                    organic heterobicyclic compound 17262
                                      pyrimidotriazine 4
                                        1,6-didemethyltoxoflavin 4
                                          reumycin 4
                                            toxoflavin 4
paths to the root