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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-methoxyestrone
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Accession:CHEBI:1189 term browser browse the term
Definition:A 17-oxo steroid that is estrone in which the hydrogen at position 2 has been replaced by a methoxy group.
Synonyms:exact_synonym: 3=hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one
 related_synonym: Formula=C19H24O3;   InChI=1S/C19H24O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,20H,3-8H2,1-2H3/t12-,13+,15-,19-/m0/s1;   InChIKey=WHEUWNKSCXYKBU-QPWUGHHJSA-N;   SMILES=[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc1cc(O)c(OC)cc21
 xref: CAS:362-08-3;   KEGG:C05299;   LIPID_MAPS_instance:LMST02010033
 xref_mesh: MESH:C003655
 xref: PMID:14577664;   PMID:21488127


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2-methoxyestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 multiple interactions ISO [HSD17B2 protein results in increased metabolism of and results in decreased activity of 2-methoxyestradiol] which results in increased chemical synthesis of 2-methoxyestrone CTD PMID:16397246 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      application 19730
        pharmaceutical 19564
          drug 19564
            antineoplastic agent 17834
              estrone 128
                2-methoxyestrone 1
                  2-methoxyestrone 3-O-(beta-D-glucuronide) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19774
                        carbon atom 19790
                          organic molecular entity 19790
                            organic molecule 19743
                              organic cyclic compound 19533
                                organic polycyclic compound 17311
                                  steroid 14726
                                    hydroxy steroid 14473
                                      3-hydroxy steroid 12810
                                        phenolic steroid 11309
                                          estrone 128
                                            2-methoxyestrone 1
                                              2-methoxyestrone 3-O-(beta-D-glucuronide) 0
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