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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzocaine
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Accession:CHEBI:116735 term browser browse the term
Definition:A benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina.
Synonyms:exact_synonym: ethyl 4-aminobenzoate
 related_synonym: 4-aminobenzoic acid ethyl ester;   Amben ethyl ester;   Benzocaina;   Benzocainum;   Ethyl aminobenzoate;   Ethyl p-aminobenzoate;   Ethyl p-aminophenylcarboxylate;   Formula=C9H11NO2;   InChI=1S/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3;   InChIKey=BLFLLBZGZJTVJG-UHFFFAOYSA-N;   SMILES=CCOC(=O)c1ccc(N)cc1;   p-(Ethoxycarbonyl)aniline;   p-Carbethoxyaniline;   p-Ethoxycarboxylic aniline
 alt_id: CHEBI:3030
 xref: Beilstein:638434;   CAS:94-09-7;   DrugBank:DB01086;   Drug_Central:323;   HMDB:HMDB0004992;   KEGG:C07527;   KEGG:D00552;   LINCS:LSM-5830
 xref_mesh: MESH:D001566
 xref: PMID:10866370;   PMID:1155304;   PMID:12574744;   PMID:12873507;   PMID:16640711;   PMID:18971079;   PMID:21616561;   PMID:22015737;   PMID:22105694;   PMID:22551703;   PMID:22556388;   PMID:23301559;   PMID:23565580;   PMID:23696166;   PMID:25097477;   PMID:2579237;   PMID:29079364;   Reaxys:638434;   Wikipedia:Benzocaine


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benzocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Benzocaine results in increased expression of CCL4 protein CTD PMID:18353026 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Benzocaine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein CTD PMID:15588918 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Benzocaine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL10 protein CTD PMID:15588918 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il18 interleukin 18 increases activity ISO Benzocaine results in increased activity of IL18 protein CTD PMID:15840424 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha increases activity ISO Benzocaine results in increased activity of IL1A protein CTD PMID:15840424 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Benzocaine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein CTD PMID:15588918 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        aetiopathogenetic role 19250
          sensitiser 9852
            benzocaine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        aromatic amine 15504
                                          anilines 14403
                                            substituted aniline 14042
                                              benzocaine 6
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