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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(8xi)-cinchonan-9-ol
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Accession:CHEBI:115155 term browser browse the term
Definition:Cinchonan or (8S)-cinchonan in which one of the hydrogens at position 9 is substituted by hydroxy.
Synonyms:related_synonym: Formula=C19H22N2O;   InChI=1S/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2/t13-,14-,18?,19?/m0/s1;   InChIKey=KMPWYEUPVWOPIM-IHWOHKJGSA-N;   Quinolin-4-yl-((1S,4S,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol;   SMILES=OC(C1C[C@@H]2CC[N@]1C[C@@H]2C=C)c1ccnc2ccccc12;   quinolin-4-yl(3-vinylquinuclidin-7-yl)methanol
 xref: Beilstein:4699614


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cinchonidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO cinchonidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO cinchonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
cinchonine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases expression		 ISO cinchonine analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to docetaxel]; cinchonine analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; cinchonine inhibits the reaction [ABCB1 protein results in decreased susceptibility to docetaxel]; cinchonine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]
cinchonine analog results in decreased expression of ABCB1 protein; cinchonine results in decreased expression of ABCB1 protein		 CTD PMID:20196146 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO cinchonine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO cinchonine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO cinchonine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    chemical entity 19865
      molecular entity 19865
        polyatomic entity 19817
          molecule 19707
            cyclic compound 19500
              aromatic compound 19346
                organic aromatic compound 19346
                  quinolines 2660
                    (8xi)-cinchonan-9-ol 4
                      cinchonidine 2
                      cinchonine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            organic molecule 19692
                              organic cyclic compound 19482
                                organic heterocyclic compound 18872
                                  organonitrogen heterocyclic compound 18150
                                    quinolines 2660
                                      (8xi)-cinchonan 66
                                        (8xi)-cinchonan-9-ol 4
                                          cinchonidine 2
                                          cinchonine 4
paths to the root