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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sodium disulfite
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Accession:CHEBI:114786 term browser browse the term
Definition:An inorganic sodium salt composed of sodium and disulfite ions in a 2:1 ratio.
Synonyms:exact_synonym: disodium oxido(oxo)-kappa(4)-sulfanesulfonate
 related_synonym: Disodium disulfite;   Disodium disulphite;   Disodium metabisulfite;   Disodium pyrosulfite;   Disulfurous acid, disodium salt;   E223;   Formula=Na2O5S2;   InChI=1S/2Na.H2O5S2/c;;1-6(2)7(3,4)5/h;;(H,1,2)(H,3,4,5)/q2*+1;/p-2;   InChIKey=HRZFUMHJMZEROT-UHFFFAOYSA-L;   Na2S2O5;   Pyrosulfurous acid, disodium salt;   SMILES=S(S([O-])=O)([O-])(=O)=O.[Na+].[Na+];   Sodium metabisulphite;   Sodium pyrosulfite;   sodium metabisulfite;   sodium pyrosulphite
 xref: CAS:7681-57-4;   KEGG:D02054
 xref_mesh: MESH:C005200
 xref: PMID:26515667;   PMID:26700884;   PMID:26799451;   PMID:26928470;   PMID:27037703;   Reaxys:18846778;   Wikipedia:Sodium_metabisulfite


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sodium disulfite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP binding cassette subfamily C member 9 increases expression EXP sodium metabisulfite results in increased expression of ABCC9 mRNA; sodium metabisulfite results in increased expression of ABCC9 protein CTD PMID:25463229 PMID:26015265 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO sodium metabisulfite results in increased expression of BAX mRNA CTD PMID:33957602 PMID:35067933 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO sodium metabisulfite results in decreased expression of BCL2 mRNA CTD PMID:33957602 PMID:35067933 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C decreases expression EXP sodium metabisulfite results in decreased expression of CACNA1C mRNA; sodium metabisulfite results in decreased expression of CACNA1C protein CTD PMID:25463229 PMID:26015265 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D decreases expression EXP sodium metabisulfite results in decreased expression of CACNA1D mRNA; sodium metabisulfite results in decreased expression of CACNA1D protein CTD PMID:25463229 PMID:26015265 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 EXP
ISO		 GHRL protein inhibits the reaction [sodium metabisulfite results in increased activity of CASP3 protein]
sodium metabisulfite results in increased expression of and results in increased cleavage of and results in increased activity of CASP3 protein		 CTD PMID:25486021 PMID:33957602 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases expression
multiple interactions
increases activity		 ISO
EXP		 sodium metabisulfite results in increased expression of CASP8 mRNA
GHRL protein inhibits the reaction [sodium metabisulfite results in increased activity of CASP8 protein]		 CTD PMID:25486021 PMID:33957602 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases expression
multiple interactions
increases activity		 ISO
EXP		 sodium metabisulfite results in increased expression of CASP9 mRNA
GHRL protein inhibits the reaction [sodium metabisulfite results in increased activity of CASP9 protein]		 CTD PMID:25486021 PMID:33957602 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP sodium metabisulfite results in increased expression of DDIT3 protein CTD PMID:25486021 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions EXP GHRL protein inhibits the reaction [sodium metabisulfite results in increased activity of CASP3 protein]; GHRL protein inhibits the reaction [sodium metabisulfite results in increased activity of CASP8 protein]; GHRL protein inhibits the reaction [sodium metabisulfite results in increased activity of CASP9 protein]; GHRL protein inhibits the reaction [sodium metabisulfite results in increased activity of XDH protein] CTD PMID:25486021 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP sodium metabisulfite results in increased expression of HSPA5 protein CTD PMID:25486021 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 increases expression EXP sodium metabisulfite results in increased expression of KCNJ11 mRNA; sodium metabisulfite results in increased expression of KCNJ11 protein CTD PMID:25463229 PMID:26015265 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 increases expression EXP sodium metabisulfite results in increased expression of KCNJ8 mRNA; sodium metabisulfite results in increased expression of KCNJ8 protein CTD PMID:25463229 NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603 		JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 increases expression EXP sodium metabisulfite results in increased expression of KCNMA1 mRNA; sodium metabisulfite results in increased expression of KCNMA1 protein CTD PMID:25463229 NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198 		JBrowse link
G Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 increases expression EXP sodium metabisulfite results in increased expression of KCNMB1 mRNA; sodium metabisulfite results in increased expression of KCNMB1 protein CTD PMID:25463229 NCBI chr10:18,557,510...18,614,824
Ensembl chr10:18,557,904...18,565,798 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO sodium metabisulfite results in decreased expression of NFKB1 mRNA CTD PMID:35067933 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation EXP sodium metabisulfite results in increased phosphorylation of RELA protein CTD PMID:25486021 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 increases expression EXP sodium metabisulfite results in increased expression of SCN1A protein CTD PMID:29188487 NCBI chr 3:50,952,790...51,071,804
Ensembl chr 3:50,952,791...51,071,699 		JBrowse link
G Tp53 tumor protein p53 decreases expression ISO sodium metabisulfite results in decreased expression of TP53 mRNA CTD PMID:35067933 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases activity		 EXP GHRL protein inhibits the reaction [sodium metabisulfite results in increased activity of XDH protein] CTD PMID:25486021 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      chemical role 19473
        antioxidant 16145
          food antioxidant 1113
            sodium disulfite 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      chalcogen 19563
                        oxygen atom 19535
                          oxygen molecular entity 19535
                            oxide 12868
                              oxoanion 10448
                                chalcogen oxoanion 659
                                  sulfur oxoanion 657
                                    disulfite 20
                                      sodium disulfite 20
paths to the root