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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:erlotinib
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Accession:CHEBI:114785 term browser browse the term
Definition:A quinazoline compound having a (3-ethynylphenyl)amino group at the 4-position and two 2-methoxyethoxy groups at the 6- and 7-positions.
Synonyms:exact_synonym: N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
 related_synonym: Formula=C22H23N3O4;   InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);   InChIKey=AAKJLRGGTJKAMG-UHFFFAOYSA-N;   SMILES=COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC;   [6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amine;   [6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine;   erlotinibum
 alt_id: CHEBI:40877
 xref: CAS:183321-74-6;   DrugBank:DB00530;   Drug_Central:1045;   HMDB:HMDB0014671;   KEGG:D07907;   LINCS:LSM-1097;   PDBeChem:AQ4;   PMID:12270171;   PMID:14684309;   PMID:15711537;   PMID:16014882;   PMID:16014883;   PMID:16480284;   PMID:17889528;   PMID:17983745;   PMID:29448920;   PMID:29579331;   PMID:29687154;   PMID:30039303;   PMID:30071517;   PMID:30150014;   PMID:30158288;   Patent:US2010094004;   Reaxys:8798958;   Wikipedia:Erlotinib


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erlotinib hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [ABCG2 gene mutant form results in decreased susceptibility to Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 protein results in increased export of Methotrexate]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 results in increased export of Methotrexate] CTD PMID:18829547 PMID:19232821 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO Erlotinib Hydrochloride results in increased phosphorylation of ACACA protein CTD PMID:23707608 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO [Interleukin 1 Receptor Antagonist Protein co-treated with Erlotinib Hydrochloride] results in decreased expression of ADGRE1 protein CTD PMID:27738319 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO Erlotinib Hydrochloride results in decreased phosphorylation of AKT1 protein
Erlotinib Hydrochloride inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased phosphorylation of AKT1 protein]		 CTD PMID:21195724 PMID:30623574 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in increased expression of APAF1 mRNA CTD PMID:29274334 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Areg amphiregulin affects response to substance ISO AREG protein affects the susceptibility to Erlotinib Hydrochloride CTD PMID:18980991 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Arf1 ARF GTPase 1 decreases response to substance ISO ARF1 mRNA results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:23125191 NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434 		JBrowse link
G Atf4 activating transcription factor 4 increases expression EXP Erlotinib Hydrochloride results in increased expression of ATF4 protein CTD PMID:24768708 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atg5 autophagy related 5 decreases response to substance
increases expression		 ISO ATG5 protein results in decreased susceptibility to Erlotinib Hydrochloride
Erlotinib Hydrochloride results in increased expression of ATG5 protein		 CTD PMID:21655094 PMID:23917044 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg7 autophagy related 7 increases expression ISO Erlotinib Hydrochloride results in increased expression of ATG7 protein CTD PMID:21655094 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of ATM mRNA] CTD PMID:29274334 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atr ATR serine/threonine kinase multiple interactions
increases expression		 ISO Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of ATR mRNA]
Erlotinib Hydrochloride results in increased expression of ATR mRNA		 CTD PMID:29274334 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Axl Axl receptor tyrosine kinase decreases response to substance
multiple interactions		 ISO AXL results in decreased susceptibility to Erlotinib Hydrochloride
[amuvatinib results in decreased activity of AXL protein] which results in increased susceptibility to Erlotinib Hydrochloride; [GSK 1363089 results in decreased activity of AXL protein] which results in increased susceptibility to Erlotinib Hydrochloride		 CTD PMID:22751098 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of BAD mRNA] CTD PMID:29274334 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of BAX mRNA] CTD PMID:29274334 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
increases expression		 ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in increased expression of BBC3 mRNA; Erlotinib Hydrochloride promotes the reaction [Resveratrol results in increased expression of BBC3 protein]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased expression of BBC3 protein] CTD PMID:25895606 PMID:29274334 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 ISO Erlotinib Hydrochloride results in increased expression of BCL2 mRNA; Erlotinib Hydrochloride results in increased expression of BCL2 protein
[Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of BCL2 mRNA; [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]		 CTD PMID:23894143 PMID:29274334 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions
increases expression		 ISO Harmine promotes the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L11 protein] CTD PMID:30171258 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl2l2 Bcl2-like 2 increases expression
multiple interactions		 ISO Erlotinib Hydrochloride results in increased expression of BCL2L2 mRNA; Erlotinib Hydrochloride results in increased expression of BCL2L2 protein
[Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]		 CTD PMID:23894143 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Becn1 beclin 1 decreases response to substance ISO BECN1 protein results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:23917044 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression		 ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of BIRC5 mRNA; Erlotinib Hydrochloride inhibits the reaction [Betulinic Acid results in decreased expression of BIRC5 protein]; Erlotinib Hydrochloride promotes the reaction [Resveratrol results in decreased expression of BIRC5 protein]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in decreased expression of BIRC5 protein] CTD PMID:25895606 PMID:29274334 PMID:30136359 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein] CTD PMID:25981168 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases activity ISO Erlotinib Hydrochloride results in decreased activity of BRAF protein mutant form CTD PMID:29407956 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO [Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased phosphorylation of BRCA1 protein CTD PMID:23548265 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity		 ISO Erlotinib Hydrochloride results in increased cleavage of CASP3 protein
Erlotinib Hydrochloride promotes the reaction [resveratrol results in increased activity of CASP3 protein]; resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased activity of CASP3 protein]
[TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased cleavage of CASP3 protein		 CTD PMID:23125191 PMID:25895606 PMID:30171258 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased expression of CCL2 mRNA; [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of CCL2 mRNA CTD PMID:27738319 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of CCNB1 mRNA CTD PMID:29274334 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [sodium arsenite results in increased expression of CCND1 protein] CTD PMID:19168569 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd69 Cd69 molecule decreases expression ISO Erlotinib Hydrochloride results in decreased expression of CD69 protein CTD PMID:21195724 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression		 ISO
EXP		 Erlotinib Hydrochloride promotes the reaction [Deoxycholic Acid results in decreased glycosylation of and results in increased degradation of CDH1 protein]; Erlotinib Hydrochloride results in decreased glycosylation of and results in increased degradation of CDH1 protein
Erlotinib Hydrochloride results in decreased expression of CDH1 protein
DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in decreased expression of CDH1 protein]
Erlotinib Hydrochloride results in decreased expression of CDH1 mRNA; Erlotinib Hydrochloride results in decreased expression of CDH1 protein		 CTD PMID:22223758 PMID:24768708 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases phosphorylation ISO Erlotinib Hydrochloride results in decreased phosphorylation of CDK4 protein CTD PMID:21195724 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
decreases expression		 ISO Betulinic Acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of CDK6 protein] CTD PMID:30136359 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO Erlotinib Hydrochloride results in increased expression of CDKN1A mRNA
Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A mRNA]		 CTD PMID:29274334 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chfr checkpoint with forkhead and ring finger domains multiple interactions ISO CHFR protein affects the susceptibility to [Cisplatin co-treated with Erlotinib Hydrochloride] CTD PMID:20705357 NCBI chr12:46,504,497...46,538,104
Ensembl chr12:46,504,497...46,538,014 		JBrowse link
G Chrdl2 chordin-like 2 multiple interactions ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CHRDL2 protein CTD PMID:24979617 NCBI chr 1:154,343,201...154,370,651
Ensembl chr 1:154,343,201...154,370,640 		JBrowse link
G Csf3 colony stimulating factor 3 increases secretion ISO Erlotinib Hydrochloride results in increased secretion of CSF3 protein CTD PMID:27738319 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
affects phosphorylation		 ISO [Betulinic Acid co-treated with Erlotinib Hydrochloride] results in decreased expression of CTNNB1 protein
Erlotinib Hydrochloride results in decreased expression of CTNNB1 protein
Erlotinib Hydrochloride affects the phosphorylation of CTNNB1 protein		 CTD PMID:30136359 PMID:34463000 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CXCL11 protein CTD PMID:24979617 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Erlotinib Hydrochloride results in decreased activity of CYP19A1 protein CTD PMID:26141389 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Erlotinib Hydrochloride results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Erlotinib Hydrochloride results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Erlotinib Hydrochloride results in increased expression of CYP2B6 mRNA CTD PMID:30364229 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases expression		 ISO Erlotinib Hydrochloride results in decreased activity of CYP3A4 protein
Erlotinib Hydrochloride results in increased expression of CYP3A4 mRNA		 CTD PMID:18839173 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp51 cytochrome P450, family 51 increases response to substance ISO CYP51A1 mRNA results in increased susceptibility to Erlotinib Hydrochloride CTD PMID:23125191 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 ISO
EXP		 Erlotinib Hydrochloride results in increased expression of DDIT3 protein
DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in decreased expression of CDH1 protein]; DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in increased expression of IL6 mRNA]; DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in increased secretion of IL6 protein]		 CTD PMID:24768708 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dennd6b DENN domain containing 6B decreases expression ISO Erlotinib Hydrochloride results in decreased expression of DENND6B mRNA CTD PMID:27720938 NCBI chr 7:120,261,679...120,273,667
Ensembl chr 7:120,261,679...120,273,494 		JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of DUSP1 mRNA CTD PMID:27738319 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Egf epidermal growth factor multiple interactions ISO
EXP		 Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Cisplatin]]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in decreased susceptibility to Crizotinib]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased activity of ELK1 protein]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]; Erlotinib Hydrochloride promotes the reaction [EGF protein binds to EGFR protein]
Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:21613822 PMID:21787763 PMID:22553343 PMID:25625231 PMID:27427493 More... NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor affects response to substance
decreases response to substance
multiple interactions
decreases activity
decreases phosphorylation
decreases expression		 ISO EGFR protein affects the susceptibility to Erlotinib Hydrochloride; EGFR protein mutant form affects the susceptibility to Erlotinib Hydrochloride
EGFR protein mutant form results in decreased susceptibility to Erlotinib Hydrochloride
[Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased expression of RAD50 protein; [Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased expression of RAD51 protein; [Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased phosphorylation of BRCA1 protein; EGFR gene mutant form results in increased susceptibility to [Gemcitabine co-treated with Cisplatin co-treated with Erlotinib Hydrochloride]; Erlotinib Hydrochloride inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of EGFR protein]; Erlotinib Hydrochloride inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased phosphorylation of EGFR protein]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 mRNA]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 protein]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 mRNA]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 protein]; Erlotinib Hydrochloride inhibits the reaction [Particulate Matter analog results in increased phosphorylation of EGFR protein]; Erlotinib Hydrochloride inhibits the reaction [sodium arsenite results in increased phosphorylation of EGFR protein]; Erlotinib Hydrochloride promotes the reaction [Deoxycholic Acid results in decreased glycosylation of and results in decreased expression of EGFR protein]; Erlotinib Hydrochloride promotes the reaction [EGF protein binds to EGFR protein]; Erlotinib Hydrochloride results in decreased activity of and results in decreased phosphorylation of EGFR protein; Erlotinib Hydrochloride results in decreased glycosylation of and results in decreased expression of EGFR protein
Erlotinib Hydrochloride results in decreased phosphorylation of EGFR protein
Erlotinib Hydrochloride results in decreased expression of EGFR protein modified form		 CTD PMID:12907618 PMID:16407879 PMID:16891461 PMID:19168569 PMID:21080748 More... NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases expression EXP Erlotinib Hydrochloride results in increased expression of EIF2S1 protein modified form CTD PMID:24768708 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased activity of ELK1 protein]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 PMID:30364229 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases response to substance ISO ERBB3 mRNA results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:23125191 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Erlotinib Hydrochloride affects the expression of and affects the phosphorylation of ESR1 protein CTD PMID:34463000 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Foxg1 forkhead box G1 multiple interactions
decreases expression		 ISO Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 mRNA]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 protein]
Erlotinib Hydrochloride results in decreased expression of FOXG1 protein		 CTD PMID:26455392 NCBI chr 6:66,674,797...66,677,611
Ensembl chr 6:66,666,587...66,678,607 		JBrowse link
G Foxo3 forkhead box O3 decreases phosphorylation ISO Erlotinib Hydrochloride results in decreased phosphorylation of FOXO3 protein CTD PMID:23099361 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of GDF15 protein CTD PMID:24979617 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gmpr guanosine monophosphate reductase decreases expression ISO Erlotinib Hydrochloride results in decreased expression of GMPR mRNA CTD PMID:27720938 NCBI chr17:19,151,820...19,189,626
Ensembl chr17:19,151,815...19,189,621 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO Erlotinib Hydrochloride results in decreased expression of GSK3B protein modified form CTD PMID:30136359 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression		 ISO Erlotinib Hydrochloride promotes the reaction [Resveratrol results in increased expression of H2AX protein modified form]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased expression of H2AX protein modified form] CTD PMID:25895606 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [HBEGF protein results in decreased susceptibility to crizotinib] CTD PMID:22553343 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 decreases expression ISO Erlotinib Hydrochloride results in decreased expression of IFITM3 mRNA CTD PMID:27720938 NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203 		JBrowse link
G Ifng interferon gamma decreases secretion ISO Erlotinib Hydrochloride results in decreased secretion of IFNG protein CTD PMID:21195724 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il17f interleukin 17F increases expression ISO
EXP		 Erlotinib Hydrochloride results in increased expression of IL17F mRNA CTD PMID:24768708 NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of IL1A mRNA CTD PMID:27738319 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion		 ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of IL1B mRNA
Erlotinib Hydrochloride results in increased secretion of IL1B protein		 CTD PMID:27738319 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased expression of IL1R1 mRNA CTD PMID:27738319 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il1r2 interleukin 1 receptor type 2 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which affects the expression of IL1R2 mRNA CTD PMID:27738319 NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725 		JBrowse link
G Il1rap interleukin 1 receptor accessory protein multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of IL1RAP mRNA CTD PMID:27738319 NCBI chr11:74,062,999...74,199,530
Ensembl chr11:74,070,304...74,199,530 		JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which affects the expression of IL1RN mRNA; [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased expression of IL1RN mRNA; [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased secretion of IL1RN protein CTD PMID:27738319 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il2 interleukin 2 decreases secretion ISO Erlotinib Hydrochloride results in decreased secretion of IL2 protein CTD PMID:21195724 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il25 interleukin 25 increases expression ISO
EXP		 Erlotinib Hydrochloride results in increased expression of IL25 mRNA CTD PMID:24768708 NCBI chr15:28,408,766...28,412,157
Ensembl chr15:28,408,842...28,411,893 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression ISO Erlotinib Hydrochloride results in decreased expression of IL2RA protein CTD PMID:21195724 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
increases secretion		 ISO
EXP		 Erlotinib Hydrochloride results in increased expression of IL6 mRNA
DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in increased expression of IL6 mRNA]; DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in increased secretion of IL6 protein]
Erlotinib Hydrochloride inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased expression of IL6 mRNA]; Erlotinib Hydrochloride inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased secretion of IL6 protein]; Interleukin 1 Receptor Antagonist Protein inhibits the reaction [Erlotinib Hydrochloride results in increased secretion of IL6 protein]		 CTD PMID:24768708 PMID:27738319 PMID:30623574 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased expression of IRAK1 mRNA CTD PMID:27738319 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression EXP Erlotinib Hydrochloride results in decreased expression of ITGB1 mRNA CTD PMID:24768708 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO Erlotinib Hydrochloride results in decreased phosphorylation of JAK2 protein CTD PMID:23894143 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects activity
decreases activity		 ISO Erlotinib Hydrochloride affects the activity of KCNH2 protein
Erlotinib Hydrochloride results in decreased activity of KCNH2 protein		 CTD PMID:23707608 PMID:35680041 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kitlg KIT ligand multiple interactions ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of KITLG protein CTD PMID:24979617 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Kras KRAS proto-oncogene, GTPase increases response to substance ISO KRAS protein results in increased susceptibility to Erlotinib Hydrochloride CTD PMID:20705357 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Ldha lactate dehydrogenase A increases secretion ISO Erlotinib Hydrochloride results in increased secretion of LDHA protein CTD PMID:37660997 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Erlotinib Hydrochloride promotes the reaction [Betulinic Acid results in increased expression of MAP1LC3B protein modified form] CTD PMID:30136359 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions		 ISO
EXP		 Erlotinib Hydrochloride results in decreased phosphorylation of MAPK1 protein
Erlotinib Hydrochloride inhibits the reaction [Alprenolol results in increased phosphorylation of MAPK1 protein]; Erlotinib Hydrochloride inhibits the reaction [carvedilol results in increased phosphorylation of MAPK1 protein]
Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]
Erlotinib Hydrochloride inhibits the reaction [Particulate Matter analog results in increased phosphorylation of MAPK1 protein]		 CTD PMID:18787115 PMID:18980991 PMID:21195724 PMID:27427493 PMID:28101945 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions		 ISO
EXP		 Erlotinib Hydrochloride results in decreased phosphorylation of MAPK3 protein
Erlotinib Hydrochloride inhibits the reaction [Alprenolol results in increased phosphorylation of MAPK3 protein]; Erlotinib Hydrochloride inhibits the reaction [carvedilol results in increased phosphorylation of MAPK3 protein]
Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]
Erlotinib Hydrochloride inhibits the reaction [Particulate Matter analog results in increased phosphorylation of MAPK3 protein]		 CTD PMID:18787115 PMID:18980991 PMID:21195724 PMID:27427493 PMID:28101945 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions		 ISO Erlotinib Hydrochloride results in decreased expression of MCL1 protein
resveratrol promotes the reaction [Erlotinib Hydrochloride results in decreased expression of MCL1 protein]		 CTD PMID:25895606 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions
decreases phosphorylation		 ISO [Erlotinib Hydrochloride co-treated with Dasatinib] results in decreased phosphorylation of MET protein
Erlotinib Hydrochloride results in decreased phosphorylation of MET protein		 CTD PMID:21106725 PMID:23894143 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Micb MHC class I polypeptide-related sequence B increases expression ISO Erlotinib Hydrochloride results in increased expression of MICB protein CTD PMID:21951556 NCBI chr 1:78,495,779...78,513,030
Ensembl chr 1:78,495,779...78,512,827 		JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA] CTD PMID:19661247 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of MMP2 mRNA CTD PMID:29274334 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of MMP9 mRNA CTD PMID:29274334 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases response to substance
multiple interactions		 ISO MSMO1 protein results in decreased susceptibility to Erlotinib Hydrochloride
MSMO1 protein inhibits the reaction [Erlotinib Hydrochloride results in decreased expression of RPS6 protein modified form]		 CTD PMID:23125191 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions		 ISO Erlotinib Hydrochloride results in decreased phosphorylation of MTOR protein
resveratrol promotes the reaction [Erlotinib Hydrochloride results in decreased phosphorylation of MTOR protein]		 CTD PMID:21655094 PMID:25895606 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA] CTD PMID:18006877 PMID:19661247 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor affects expression ISO Erlotinib Hydrochloride affects the expression of MYC protein CTD PMID:34463000 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which affects the expression of MYD88 mRNA CTD PMID:27738319 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which affects the expression of NFKBIA mRNA CTD PMID:27738319 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nol10 nucleolar protein 10 decreases expression ISO Erlotinib Hydrochloride results in decreased expression of NOL10 mRNA CTD PMID:27720938 NCBI chr 6:40,144,217...40,225,353
Ensembl chr 6:40,144,235...40,225,353 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
increases expression
decreases response to substance		 ISO Erlotinib Hydrochloride results in increased expression of and results in increased stability of NOX4 mRNA
Erlotinib Hydrochloride results in increased expression of NOX4 protein
NOX4 protein results in decreased susceptibility to Erlotinib Hydrochloride		 CTD PMID:23917044 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Erlotinib Hydrochloride binds to and results in increased activity of NR1I2 protein CTD PMID:18839173 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization ISO Erlotinib Hydrochloride affects the localization of NR1I3 protein mutant form CTD PMID:30364229 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like decreases response to substance ISO NSDHL protein results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:23125191 NCBI chr  X:150,775,034...150,807,161
Ensembl chr  X:150,775,080...150,807,142 		JBrowse link
G Osm oncostatin M multiple interactions ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of OSM protein CTD PMID:24979617 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
increases expression
multiple interactions		 ISO Erlotinib Hydrochloride results in increased cleavage of PARP1 protein
Erlotinib Hydrochloride results in increased expression of PARP1 protein modified form
[TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased cleavage of PARP1 protein; Harmine promotes the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased expression of PARP1 protein modified form]; TWIST1 protein inhibits the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein]		 CTD PMID:23125191 PMID:25895606 PMID:30171258 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [carvacrol results in increased phosphorylation of PIK3CA protein] CTD PMID:32535744 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pml PML nuclear body scaffold increases expression
increases localization
decreases response to substance		 ISO Erlotinib Hydrochloride results in increased expression of PML protein
Erlotinib Hydrochloride results in increased localization of PML protein
PML protein results in decreased susceptibility to Erlotinib Hydrochloride		 CTD PMID:23440206 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of PTGS2 mRNA CTD PMID:27738319 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptpn9 protein tyrosine phosphatase, non-receptor type 9 decreases expression
decreases response to substance		 ISO Erlotinib Hydrochloride results in decreased expression of PTPN9 protein
PTPN9 mutant form results in decreased susceptibility to Erlotinib Hydrochloride		 CTD PMID:23894143 NCBI chr 8:57,391,290...57,472,352
Ensembl chr 8:57,391,259...57,470,952 		JBrowse link
G Rad50 RAD50 double strand break repair protein multiple interactions ISO [Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased expression of RAD50 protein CTD PMID:23548265 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO [Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased expression of RAD51 protein CTD PMID:23548265 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation ISO Erlotinib Hydrochloride results in decreased phosphorylation of RAF1 protein CTD PMID:21195724 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation
decreases expression
multiple interactions		 ISO Erlotinib Hydrochloride results in decreased phosphorylation of RB1 protein
Erlotinib Hydrochloride results in decreased expression of RB1 protein modified form
Betulinic Acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of RB1 protein modified form]; Erlotinib Hydrochloride promotes the reaction [Betulinic Acid results in decreased expression of RB1 protein modified form]		 CTD PMID:21195724 PMID:30136359 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [carvacrol results in increased phosphorylation of RELA protein]; Erlotinib Hydrochloride inhibits the reaction [Particulate Matter analog results in increased acetylation of RELA protein] CTD PMID:28101945 PMID:32535744 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation
multiple interactions
decreases expression		 ISO Erlotinib Hydrochloride results in decreased phosphorylation of RPS6 protein
MSMO1 protein inhibits the reaction [Erlotinib Hydrochloride results in decreased expression of RPS6 protein modified form]		 CTD PMID:23125191 PMID:23440206 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions		 ISO Erlotinib Hydrochloride results in decreased phosphorylation of RPS6KB1 protein
resveratrol promotes the reaction [Erlotinib Hydrochloride results in decreased phosphorylation of RPS6KB1 protein]		 CTD PMID:21655094 PMID:25895606 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression ISO Erlotinib Hydrochloride results in decreased expression of SELENBP1 mRNA CTD PMID:27720938 NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594 		JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 decreases expression ISO Erlotinib Hydrochloride results in decreased expression of SIAH2 mRNA CTD PMID:27720938 NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of SNAI1 mRNA CTD PMID:29274334 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of SNAI2 mRNA CTD PMID:29274334 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression EXP Erlotinib Hydrochloride results in increased expression of SOCS3 mRNA CTD PMID:24768708 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions
decreases expression		 ISO Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 mRNA]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 protein]
Erlotinib Hydrochloride results in decreased expression of SOX9 protein		 CTD PMID:26455392 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Erlotinib Hydrochloride results in increased expression of SQSTM1 protein CTD PMID:30136359 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation ISO Erlotinib Hydrochloride results in decreased phosphorylation of SRC protein CTD PMID:23894143 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
multiple interactions
decreases response to substance
increases response to substance
decreases expression		 ISO Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein
[Betulinic Acid co-treated with Erlotinib Hydrochloride] results in decreased expression of STAT3 protein modified form; [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]
STAT3 mRNA results in decreased susceptibility to Erlotinib Hydrochloride
STAT3 mutant form results in increased susceptibility to Erlotinib Hydrochloride
Erlotinib Hydrochloride results in decreased expression of STAT3 protein modified form		 CTD PMID:23125191 PMID:23894143 PMID:30136359 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tent5c terminal nucleotidyltransferase 5C decreases expression ISO Erlotinib Hydrochloride results in decreased expression of TENT5C mRNA CTD PMID:27720938 NCBI chr 2:187,853,026...187,875,260
Ensembl chr 2:187,853,024...187,894,744 		JBrowse link
G Tfap2a transcription factor AP-2 alpha multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]; Tetradecanoylphorbol Acetate inhibits the reaction [Erlotinib Hydrochloride inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]] CTD PMID:21499124 PMID:21951556 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [TGFA protein results in decreased susceptibility to crizotinib] CTD PMID:22553343 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Cisplatin]]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]] CTD PMID:21613822 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 decreases response to substance ISO TMED2 mRNA results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:23125191 NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903 		JBrowse link
G Tnfsf8 TNF superfamily member 8 multiple interactions ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of TNFSF8 protein CTD PMID:24979617 NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421 		JBrowse link
G Tollip toll interacting protein multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of TOLLIP mRNA CTD PMID:27738319 NCBI chr 1:196,961,585...196,984,252
Ensembl chr 1:196,950,771...196,983,625 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of TP53 mRNA]; Erlotinib Hydrochloride promotes the reaction [Resveratrol results in increased expression of TP53 protein]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased expression of TP53 protein] CTD PMID:25895606 PMID:29274334 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of TRAF6 mRNA CTD PMID:27738319 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 increases expression
decreases response to substance
multiple interactions		 ISO Erlotinib Hydrochloride results in increased expression of TWIST1 protein
TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride
[TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased cleavage of CASP3 protein
[TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased cleavage of PARP1 protein; TWIST1 protein inhibits the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein]		 CTD PMID:30171258 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Tyms thymidylate synthetase decreases expression
multiple interactions		 ISO Erlotinib Hydrochloride results in decreased expression of TYMS protein
Betulinic Acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of TYMS protein]; Erlotinib Hydrochloride promotes the reaction [Betulinic Acid results in decreased expression of TYMS protein]		 CTD PMID:30136359 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Ulbp1 UL16 binding protein 1 increases expression
multiple interactions		 ISO Erlotinib Hydrochloride results in increased expression of ULBP1 mRNA; Erlotinib Hydrochloride results in increased expression of ULBP1 protein
Erlotinib Hydrochloride inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]; Tetradecanoylphorbol Acetate inhibits the reaction [Erlotinib Hydrochloride inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]]; Tetradecanoylphorbol Acetate inhibits the reaction [Erlotinib Hydrochloride results in increased expression of ULBP1 mRNA]		 CTD PMID:21499124 PMID:21951556 NCBI chr 1:1,694,255...1,716,160 JBrowse link
G Xbp1 X-box binding protein 1 increases expression EXP Erlotinib Hydrochloride results in increased expression of XBP1 protein modified form CTD PMID:24768708 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        pharmaceutical 19532
          drug 19532
            antineoplastic agent 17823
              erlotinib 135
                erlotinib hydrochloride 135
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            inorganic hydride 18161
                              pnictogen hydride 18151
                                nitrogen hydride 18064
                                  azane 17872
                                    ammonia 17871
                                      organic amino compound 17871
                                        secondary amino compound 6954
                                          erlotinib 135
                                            erlotinib hydrochloride 135
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