EC 2.1.1.8 (histamine N-methyltransferase) inhibitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	EC 2.1.1.8 (histamine N-methyltransferase) inhibitor	go back to main search page
Accession:	CHEBI:110725	browse the term
Definition:	An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of histamine N-methyltransferase (EC 2.1.1.8).
Synonyms:	related_synonym:	EC 2.1.1.8 (histamine N-methyltransferase) inhibitors; EC 2.1.1.8 inhibitor; EC 2.1.1.8 inhibitors; S-adenosyl-L-methionine:histamine N-tele-methyltransferase inhibitor; S-adenosyl-L-methionine:histamine N-tele-methyltransferase inhibitors; S-adenosylmethionine-histamine N-methyltransferase inhibitor; S-adenosylmethionine-histamine N-methyltransferase inhibitors; histamine 1-methyltransferase inhibitor; histamine 1-methyltransferase inhibitors; histamine methyltransferase inhibitor; histamine methyltransferase inhibitors; histamine-methylating enzyme inhibitor; histamine-methylating enzyme inhibitors; imidazolemethyltransferase inhibitor; imidazolemethyltransferase inhibitors

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Genes (49)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 4

decreases activity

ISO

Amodiaquine results in decreased activity of ABCB4 protein

NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231

G

acetylcholinesterase

multiple interactions

ISO

Amodiaquine analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Amodiaquine inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]

NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728

G

BCL2-associated X protein

multiple interactions
increases expression

ISO

[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein
Amodiaquine results in increased expression of BAX protein

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

butyrylcholinesterase

multiple interactions

ISO

Amodiaquine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]

NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748

G

B cell leukemia/lymphoma 2

multiple interactions
decreases expression

ISO

[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein
Amodiaquine results in decreased expression of BCL2 protein

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

bone morphogenetic protein 6

increases expression

ISO

Amodiaquine results in increased expression of BMP6 mRNA

NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278

G

caspase 3

increases cleavage

ISO

Amodiaquine results in increased cleavage of CASP3 protein

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

cyclin D1

affects expression

ISO

Amodiaquine affects the expression of CCND1 protein

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

cyclin dependent kinase inhibitor 1A

affects expression

ISO

Amodiaquine affects the expression of CDKN1A mRNA; Amodiaquine affects the expression of CDKN1A protein

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

cytotoxic T-lymphocyte-associated protein 4

multiple interactions

EXP

CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]

NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991

G

cathepsin B

decreases activity

ISO

Amodiaquine results in decreased activity of CTSB protein

NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372

G

cathepsin D

decreases activity

ISO

Amodiaquine results in decreased activity of CTSD protein

NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775

G

cathepsin L

decreases activity

ISO

Amodiaquine results in decreased activity of CTSL protein

NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
decreases response to substance
increases metabolic processing
multiple interactions

ISO

Amodiaquine results in increased activity of CYP1A1 protein
CYP1A1 protein results in decreased susceptibility to Amodiaquine
CYP1A1 protein results in increased metabolism of Amodiaquine
[CYP1A1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

PMID:12451431 PMID:31629065

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
multiple interactions
increases metabolic processing

ISO

Amodiaquine results in decreased activity of CYP1A2 protein
[CYP1A2 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [Gemfibrozil results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine; [Trimethoprim results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine

PMID:11124226 PMID:26599973 PMID:31629065

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases response to substance
multiple interactions
increases metabolic processing

ISO

CYP1B1 protein results in decreased susceptibility to Amodiaquine
[CYP1B1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490

G

cytochrome P450, family 2, subfamily a, polypeptide 5

multiple interactions
increases metabolic processing

ISO

[CYP2A6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973

G

cytochrome P450, family 2, subfamily b, polypeptide 10

increases metabolic processing
multiple interactions

ISO

CYP2B6 protein results in increased metabolism of Amodiaquine
[CYP2B6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049

G

cytochrome P450, family 2, subfamily c, polypeptide 29

increases metabolic processing
multiple interactions
affects metabolic processing
increases response to substance

ISO

CYP2C8 protein results in increased metabolism of Amodiaquine
[5-bromotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [5-chlorotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [5-fluorotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased abundance of and results in increased secretion of desethylamodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of desethylamodiaquine; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein; [Gemfibrozil co-treated with Amodiaquine] results in decreased activity of CYP2C8 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Tryptamines analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; Felodipine inhibits the reaction [CYP2C8 protein results in increased metabolism of Amodiaquine]; Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]
CYP2C8 protein affects the metabolism of Amodiaquine

PMID:12920490 PMID:15155557 PMID:15601807 PMID:15626586 PMID:15771232 More...

NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157

G

cytochrome P450, family 2, subfamily c, polypeptide 38

decreases activity
increases metabolic processing
multiple interactions

ISO

Amodiaquine results in decreased activity of CYP2C19 protein
CYP2C19 protein results in increased metabolism of Amodiaquine
[CYP2C19 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

PMID:11124226 PMID:31629065

NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519

G

cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene

multiple interactions
increases metabolic processing

ISO

[CYP2C18 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733

G

cytochrome P450, family 2, subfamily c, polypeptide 65

decreases activity

ISO

Amodiaquine results in decreased activity of CYP2C9 protein

NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388

G

cytochrome P450, family 2, subfamily d, polypeptide 22

multiple interactions
increases metabolic processing

ISO

[CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine

PMID:28478157 PMID:31629065 PMID:33259822

NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
increases metabolic processing

ISO

[CYP2E1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

cytochrome P450, family 3, subfamily a, polypeptide 13

increases metabolic processing
multiple interactions

ISO

CYP3A5 protein results in increased metabolism of Amodiaquine
[CYP3A5 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881

G

E2F transcription factor 1

affects expression

ISO

Amodiaquine affects the expression of E2F1 mRNA; Amodiaquine affects the expression of E2F1 protein

NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812

G

epiregulin

increases expression

ISO

Amodiaquine results in increased expression of EREG mRNA

NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505

G

glutamic pyruvic transaminase, soluble

multiple interactions

EXP

[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]; PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

interleukin 1 alpha

decreases expression

ISO

Amodiaquine results in decreased expression of IL1A mRNA

NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892

G

lymphocyte-activation gene 3

multiple interactions

EXP

[PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]

NCBI chr 6:124,881,322...124,888,668
Ensembl chr 6:124,881,324...124,888,668

G

lymphocyte antigen 6 family member C1

multiple interactions

EXP

[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]; PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]

NCBI chr15:74,915,867...74,920,690
Ensembl chr15:74,915,867...74,920,679

G

lymphocyte antigen 6 family member G

multiple interactions

EXP

[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]; PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]

NCBI chr15:75,027,110...75,030,977
Ensembl chr15:75,027,089...75,030,975

G

mitogen-activated protein kinase 1

multiple interactions

ISO

[CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions

ISO

[CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitogen-activated protein kinase 8

multiple interactions

ISO

[CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

G

myeloid cell leukemia sequence 1

decreases expression
multiple interactions

ISO

Amodiaquine results in decreased expression of MCL1 protein
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein

NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487

G

met proto-oncogene

increases expression

ISO

Amodiaquine results in increased expression of MET mRNA

NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979

G

myeloperoxidase

affects response to substance

EXP

MPO protein affects the susceptibility to Amodiaquine

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

N-ribosyldihydronicotinamide quinone reductase 2

multiple interactions

ISO

Amodiaquine inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3]

NCBI chr13:34,148,642...34,172,448
Ensembl chr13:34,148,670...34,172,426

G

nuclear receptor subfamily 4, group A, member 2

multiple interactions

ISO

Amodiaquine binds to and results in increased activity of NR4A2 protein

NCBI chr 2:56,996,845...57,014,152
Ensembl chr 2:56,996,842...57,014,015

G

programmed cell death 1

multiple interactions

EXP

[PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]; PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]

NCBI chr 1:93,966,027...93,980,278
Ensembl chr 1:93,966,027...93,980,278

G

phosphotyrosine interaction domain containing 1

increases expression

ISO

Amodiaquine results in increased expression of PID1 mRNA

NCBI chr 1:84,014,014...84,317,550
Ensembl chr 1:84,014,017...84,341,901

G

prostaglandin-endoperoxide synthase 2

decreases expression

ISO

Amodiaquine results in decreased expression of PTGS2 mRNA

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

RB transcriptional corepressor 1

affects phosphorylation

ISO

Amodiaquine affects the phosphorylation of RB1 protein

NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262

G

sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1

decreases activity

ISO

Amodiaquine results in decreased activity of SULT2A1 protein

NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334

G

transforming growth factor, beta 1

multiple interactions

EXP

[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

tumor necrosis factor alpha induced protein 6

decreases expression

ISO

Amodiaquine results in decreased expression of TNFAIP6 mRNA

NCBI chr 2:51,928,125...51,946,693
Ensembl chr 2:51,928,021...51,946,698

G

transformation related protein 53

increases activity
affects expression

ISO

Amodiaquine results in increased activity of TP53 protein
Amodiaquine affects the expression of TP53 protein

PMID:12082016 PMID:24113242

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

UDP glucuronosyltransferase 2 family, polypeptide B34

decreases activity

ISO

Amodiaquine results in decreased activity of UGT2B7 protein

NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22426
role	22410
biological role	22409
biochemical role	21637
enzyme inhibitor	20054
EC 2.* (transferase) inhibitor	15368
EC 2.1.* (C1-transferase) inhibitor	3795
EC 2.1.1.* (methyltransferases) inhibitor	713
EC 2.1.1.8 (histamine N-methyltransferase) inhibitor	49
amodiaquine +	49

paths to the root