EC 2.1.1.8 (histamine N-methyltransferase) inhibitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	EC 2.1.1.8 (histamine N-methyltransferase) inhibitor	go back to main search page
Accession:	CHEBI:110725	browse the term
Definition:	An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of histamine N-methyltransferase (EC 2.1.1.8).
Synonyms:	related_synonym:	EC 2.1.1.8 (histamine N-methyltransferase) inhibitors; EC 2.1.1.8 inhibitor; EC 2.1.1.8 inhibitors; S-adenosyl-L-methionine:histamine N-tele-methyltransferase inhibitor; S-adenosyl-L-methionine:histamine N-tele-methyltransferase inhibitors; S-adenosylmethionine-histamine N-methyltransferase inhibitor; S-adenosylmethionine-histamine N-methyltransferase inhibitors; histamine 1-methyltransferase inhibitor; histamine 1-methyltransferase inhibitors; histamine methyltransferase inhibitor; histamine methyltransferase inhibitors; histamine-methylating enzyme inhibitor; histamine-methylating enzyme inhibitors; imidazolemethyltransferase inhibitor; imidazolemethyltransferase inhibitors

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Genes (50)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

EXP

Amodiaquine results in decreased activity of ABCB4 protein

NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435

G

acetylcholinesterase (Yt blood group)

multiple interactions

EXP

Amodiaquine analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Amodiaquine inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]

NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

EXP

[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein
Amodiaquine results in increased expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

butyrylcholinesterase

multiple interactions

EXP

Amodiaquine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]

NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462

G

BCL2 apoptosis regulator

decreases expression
multiple interactions

EXP

Amodiaquine results in decreased expression of BCL2 protein
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

bone morphogenetic protein 6

increases expression

EXP

Amodiaquine results in increased expression of BMP6 mRNA

NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728

G

caspase 3

increases cleavage

EXP

Amodiaquine results in increased cleavage of CASP3 protein

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

cyclin D1

affects expression

EXP

Amodiaquine affects the expression of CCND1 protein

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

cyclin dependent kinase inhibitor 1A

affects expression

EXP

Amodiaquine affects the expression of CDKN1A mRNA; Amodiaquine affects the expression of CDKN1A protein

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397

G

cytotoxic T-lymphocyte associated protein 4

multiple interactions

ISO

CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]

NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,853,888...203,873,965

G

cathepsin B

decreases activity

EXP

Amodiaquine results in decreased activity of CTSB protein

NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533

G

cathepsin D

decreases activity

EXP

Amodiaquine results in decreased activity of CTSD protein

NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573

G

cathepsin L

decreases activity

EXP

Amodiaquine results in decreased activity of CTSL protein

NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,724,051...87,731,469

G

cytochrome P450 family 1 subfamily A member 1

increases activity
increases metabolic processing
multiple interactions
decreases response to substance

EXP

Amodiaquine results in increased activity of CYP1A1 protein
CYP1A1 protein results in increased metabolism of Amodiaquine
[CYP1A1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CYP1A1 protein results in decreased susceptibility to Amodiaquine

PMID:12451431 PMID:31629065

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily A member 2

decreases activity
increases metabolic processing
multiple interactions

EXP

Amodiaquine results in decreased activity of CYP1A2 protein
CYP1A2 protein results in increased metabolism of Amodiaquine
[CYP1A2 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [Gemfibrozil results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine; [Trimethoprim results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine

PMID:11124226 PMID:26599973 PMID:31629065

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 1 subfamily B member 1

decreases response to substance
multiple interactions
increases metabolic processing

EXP

CYP1B1 protein results in decreased susceptibility to Amodiaquine
[CYP1B1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

cytochrome P450 family 2 subfamily A member 13

multiple interactions
increases metabolic processing

EXP

[CYP2A13 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr19:41,088,451...41,096,195
Ensembl chr19:41,088,451...41,096,195

G

cytochrome P450 family 2 subfamily A member 6

increases metabolic processing
multiple interactions

EXP

CYP2A6 protein results in increased metabolism of Amodiaquine
[CYP2A6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447

G

cytochrome P450 family 2 subfamily B member 6

increases metabolic processing
multiple interactions

EXP

CYP2B6 protein results in increased metabolism of Amodiaquine
[CYP2B6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398

G

cytochrome P450 family 2 subfamily C member 18

multiple interactions
increases metabolic processing

EXP

[CYP2C18 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190

G

cytochrome P450 family 2 subfamily C member 19

decreases activity
multiple interactions
increases metabolic processing

EXP

Amodiaquine results in decreased activity of CYP2C19 protein
[CYP2C19 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

PMID:11124226 PMID:31629065

NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547

G

cytochrome P450 family 2 subfamily C member 8

multiple interactions
affects metabolic processing
increases metabolic processing
increases response to substance

EXP

[5-bromotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [5-chlorotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [5-fluorotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased abundance of and results in increased secretion of desethylamodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of desethylamodiaquine; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein; [Gemfibrozil co-treated with Amodiaquine] results in decreased activity of CYP2C8 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Tryptamines analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; Felodipine inhibits the reaction [CYP2C8 protein results in increased metabolism of Amodiaquine]; Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]
CYP2C8 protein affects the metabolism of Amodiaquine

PMID:12920490 PMID:15155557 PMID:15601807 PMID:15626586 PMID:15771232 More...

NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497

G

cytochrome P450 family 2 subfamily C member 9

decreases activity

EXP

Amodiaquine results in decreased activity of CYP2C9 protein

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)

multiple interactions
increases metabolic processing

EXP

[CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine

PMID:28478157 PMID:31629065 PMID:33259822

NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865

G

cytochrome P450 family 2 subfamily E member 1

multiple interactions
increases metabolic processing

EXP

[CYP2E1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220

G

cytochrome P450 family 3 subfamily A member 4

increases metabolic processing
decreases activity
increases response to substance
multiple interactions

EXP

CYP3A4 protein results in increased metabolism of Amodiaquine
Amodiaquine results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased susceptibility to Amodiaquine
[CYP3A4 protein results in increased metabolism of Amodiaquine] which results in increased abundance of and results in increased secretion of desethylamodiaquine; [CYP3A4 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]

PMID:28478157 PMID:31629065 PMID:39023798

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

cytochrome P450 family 3 subfamily A member 5

multiple interactions
increases metabolic processing

EXP

[CYP3A5 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996

G

cytochrome P450 family 3 subfamily A member 7

increases metabolic processing
multiple interactions

EXP

CYP3A7 protein results in increased metabolism of Amodiaquine
[CYP3A7 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196

G

E2F transcription factor 1

affects expression

EXP

Amodiaquine affects the expression of E2F1 mRNA; Amodiaquine affects the expression of E2F1 protein

NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385

G

epiregulin

increases expression

EXP

Amodiaquine results in increased expression of EREG mRNA

NCBI chr 4:74,365,145...74,388,749
Ensembl chr 4:74,365,145...74,388,749

G

glutamic--pyruvic transaminase

multiple interactions

ISO

[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]; PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

interleukin 1 alpha

decreases expression

EXP

Amodiaquine results in decreased expression of IL1A mRNA

NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493

G

lymphocyte activating 3

multiple interactions

ISO

[PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]

NCBI chr12:6,772,520...6,778,455
Ensembl chr12:6,772,512...6,778,455

G

mitogen-activated protein kinase 1

multiple interactions

EXP

[CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions

EXP

[CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

multiple interactions

EXP

[CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression
multiple interactions

EXP

Amodiaquine results in decreased expression of MCL1 protein
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein

NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

EXP

Amodiaquine results in increased expression of MET mRNA

NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377

G

myeloperoxidase

affects response to substance

ISO

MPO protein affects the susceptibility to Amodiaquine

NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

multiple interactions

EXP

Amodiaquine inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3]

NCBI chr 6:2,999,894...3,019,755
Ensembl chr 6:2,987,987...3,019,755

G

nuclear receptor subfamily 4 group A member 2

multiple interactions

EXP

Amodiaquine binds to and results in increased activity of NR4A2 protein

NCBI chr 2:156,324,437...156,332,721
Ensembl chr 2:156,324,437...156,342,348

G

programmed cell death 1

multiple interactions

ISO

[PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]; PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]

NCBI chr 2:241,849,884...241,858,894
Ensembl chr 2:241,849,884...241,858,894

G

phosphotyrosine interaction domain containing 1

increases expression

EXP

Amodiaquine results in increased expression of PID1 mRNA

NCBI chr 2:229,023,973...229,271,287
Ensembl chr 2:228,850,526...229,271,287

G

prostaglandin-endoperoxide synthase 2

decreases expression

EXP

Amodiaquine results in decreased expression of PTGS2 mRNA

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

RB transcriptional corepressor 1

affects phosphorylation

EXP

Amodiaquine affects the phosphorylation of RB1 protein

NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436

G

sulfotransferase family 2A member 1

decreases activity

EXP

Amodiaquine results in decreased activity of SULT2A1 protein

NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315

G

transforming growth factor beta 1

multiple interactions

ISO

[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

TNF alpha induced protein 6

decreases expression

EXP

Amodiaquine results in decreased expression of TNFAIP6 mRNA

NCBI chr 2:151,357,592...151,381,340
Ensembl chr 2:151,357,592...151,380,046

G

tumor protein p53

increases activity
affects expression

EXP

Amodiaquine results in increased activity of TP53 protein
Amodiaquine affects the expression of TP53 protein

PMID:12082016 PMID:24113242

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546

G

UDP glucuronosyltransferase family 2 member B7

decreases activity

EXP

Amodiaquine results in decreased activity of UGT2B7 protein

NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26827
role	26655
biological role	26634
biochemical role	25889
enzyme inhibitor	22977
EC 2.* (transferase) inhibitor	16136
EC 2.1.* (C1-transferase) inhibitor	3747
EC 2.1.1.* (methyltransferases) inhibitor	725
EC 2.1.1.8 (histamine N-methyltransferase) inhibitor	50
amodiaquine +	50

paths to the root