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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:beta-amyrin
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Accession:CHEBI:10352 term browser browse the term
Definition:A pentacyclic triterpenoid that is oleanane substituted at the 3beta-position by a hydroxy group and containing a double bond between positions 12 and 13. It is one of the most commonly occurring triterpenoids in higher plants.
Synonyms:exact_synonym: olean-12-en-3beta-ol
 related_synonym: (3beta)-olean-12-en-3-ol;   3beta-hydroxyolean-12-ene;   Formula=C30H50O;   InChI=1S/C30H50O/c1-25(2)15-16-27(5)17-18-29(7)20(21(27)19-25)9-10-23-28(6)13-12-24(31)26(3,4)22(28)11-14-30(23,29)8/h9,21-24,31H,10-19H2,1-8H3/t21-,22-,23+,24-,27+,28-,29+,30+/m0/s1;   InChIKey=JFSHUTJDVKUMTJ-QHPUVITPSA-N;   SMILES=[H][C@@]12CC(C)(C)CC[C@]1(C)CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]12C;   amyrin;   beta-Amyrenol
 xref: CAS:559-70-6;   KEGG:C08616;   KNApSAcK:C00003738;   LIPID_MAPS_instance:LMPR0106150015
 xref_mesh: MESH:C036380
 xref: MetaCyc:CPD-6948;   PMID:16478469;   PMID:17803686;   PMID:21046981;   PMID:24079177;   PMID:24960408;   PMID:25026352;   PMID:25115087;   PMID:5639923;   PMID:6875511;   Reaxys:2063468



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beta-amyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in decreased expression of ARG1 mRNA] CTD PMID:29501766 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Casp3 caspase 3 multiple interactions EXP beta-amyrin inhibits the reaction [Dimethylnitrosamine results in increased cleavage of CASP3 protein]; beta-amyrin inhibits the reaction [Dimethylnitrosamine results in increased expression of CASP3 mRNA] CTD PMID:27009110 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP beta-amyrin inhibits the reaction [Glycerol results in increased expression of GJA1 mRNA] CTD PMID:32081053 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Ifng interferon gamma multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in decreased expression of ARG1 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B protein]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein] CTD PMID:29501766 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B protein] CTD PMID:29501766 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein] CTD PMID:29501766 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nes nestin decreases expression
multiple interactions
EXP beta-amyrin results in decreased expression of NES mRNA
beta-amyrin inhibits the reaction [Glycerol results in increased expression of NES mRNA]
CTD PMID:32081053 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] CTD PMID:29501766 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA] CTD PMID:29501766 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions ISO [alpha-amyrin co-treated with beta-amyrin] inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein] CTD PMID:18210232 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP beta-amyrin inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 protein] CTD PMID:27009110 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]
beta-amyrin inhibits the reaction [Dimethylnitrosamine results in increased expression of TNF protein]
CTD PMID:27009110 PMID:29501766 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vim vimentin multiple interactions
decreases expression
EXP beta-amyrin inhibits the reaction [Glycerol results in increased expression of VIM mRNA]
beta-amyrin results in decreased expression of VIM mRNA
CTD PMID:32081053 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          metabolite 19544
            eukaryotic metabolite 19368
              plant metabolite 17985
                beta-amyrin 10
                  11-oxo-beta-amyrin 0
                  11alpha-hydroxy-beta-amyrin 0
                  16alpha-hydroxy-beta-amyrin 0
                  24-hydroxy-beta-amyrin 0
                  30-hydroxy-11-oxo-beta-amyrin 0
                  erythrodiol + 0
                  glycyrrhetaldehyde 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            organic hydride 18691
                              organic fundamental parent 18691
                                hydrocarbon 18442
                                  terpene 14066
                                    triterpene 1229
                                      triterpenoid 1225
                                        pentacyclic triterpenoid 486
                                          beta-amyrin 10
                                            11-oxo-beta-amyrin 0
                                            11alpha-hydroxy-beta-amyrin 0
                                            16alpha-hydroxy-beta-amyrin 0
                                            24-hydroxy-beta-amyrin 0
                                            30-hydroxy-11-oxo-beta-amyrin 0
                                            erythrodiol + 0
                                            glycyrrhetaldehyde 0
paths to the root