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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfisoxazole
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Accession:CHEBI:102484 term browser browse the term
Definition:A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms.
Synonyms:exact_synonym: 4-amino-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide
 related_synonym: 3,4-Dimethyl-5-sulfanilamidoisoxazole;   3,4-Dimethyl-5-sulfonamidoisoxazole;   3,4-Dimethyl-5-sulphanilamidoisoxazole;   3,4-Dimethyl-5-sulphonamidoisoxazole;   3,4-Dimethylisoxazole-5-sulfanilamide;   3,4-Dimethylisoxazole-5-sulphanilamide;   4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide;   4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulphonamide;   5-(4-Aminophenylsulfonamido)-3,4-dimethylisoxazole;   5-(p-Aminobenzenesulfonamido)-3,4-dimethylisoxazole;   5-(p-Aminobenzenesulphonamido)-3,4-dimethylisoxazole;   5-Sulfanilamido-3,4-dimethylisoxazole;   5-Sulphanilamido-3,4-dimethyl-isoxazole;   Formula=C11H13N3O3S;   InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3;   InChIKey=NHUHCSRWZMLRLA-UHFFFAOYSA-N;   N'-(3,4)Dimethylisoxazol-5-yl-sulphanilamide;   N(1)-(3,4-dimethyl-5-isoxazolyl)sulfanilamide;   N(1)-(3,4-dimethyl-5-isoxazolyl)sulphanilamide;   SMILES=Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C;   Sulfadimethylisoxazole;   Sulfafurazol;   Sulfaisoxazole;   Sulfasoxazole;   Sulfisonazole;   Sulfisoxasole;   Sulfisoxazol;   Sulfofurazole;   Sulphadimethylisoxazole;   Sulphafurazol;   Sulphafurazole;   Sulphaisoxazole;   Sulphisoxazol;   Sulphofurazole;   sulfafurazole;   sulfafurazolum
 alt_id: CHEBI:9343
 xref: Beilstein:263871;   CAS:127-69-5;   DrugBank:DB00263;   Drug_Central:2529;   Gmelin:864477;   KEGG:C07318;   KEGG:D00450;   LINCS:LSM-3120
 xref_mesh: MESH:D013444
 xref: PMID:1861917;   PMID:4960234;   PMID:7356572;   Patent:US2430094;   Wikipedia:Sulfisoxazole



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sulfisoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO Sulfisoxazole inhibits the reaction [Bilirubin binds to ALB protein] CTD PMID:21280114 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO Sulfisoxazole results in increased expression of CYP3A4 mRNA
Sulfisoxazole results in increased expression of and results in increased activity of CYP3A4 protein
CTD PMID:18505790 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Hmbs hydroxymethylbilane synthase decreases activity EXP Sulfisoxazole decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Sulfisoxazole results in decreased activity of PON1 protein CTD PMID:28665493 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Sulfisoxazole results in increased expression of SRXN1 mRNA CTD PMID:22003191 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        antimicrobial agent 18250
          sulfonamide antibiotic 2928
            sulfisoxazole 5
              sulfisoxazole diolamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            inorganic hydride 18161
                              pnictogen hydride 18151
                                nitrogen hydride 18064
                                  azane 17872
                                    ammonia 17871
                                      organic amino compound 17871
                                        aromatic amine 15483
                                          anilines 14421
                                            substituted aniline 14051
                                              sulfanilamide 2923
                                                sulfisoxazole 5
                                                  sulfisoxazole diolamine 0
paths to the root