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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfamethazine
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Accession:CHEBI:102265 term browser browse the term
Definition:A sulfonamide consisting of pyrimidine with methyl substituents at the 4- and 6-positions and a 4-aminobenzenesulfonamido group at the 2-position.
Synonyms:related_synonym: (p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin;   2-(4-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine;   2-(p-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine;   2-Sulfanilamido-4,6-dimethylpyrimidine;   4,6-Dimethyl-2-sulfanilamidopyrimidine;   4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide;   4-Amino-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide;   4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide;   6-(4'-Aminobenzol-sulfonamido)-2,4-dimethylpyrimidin;   Formula=C12H14N4O2S;   InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16);   InChIKey=ASWVTGNCAZCNNR-UHFFFAOYSA-N;   N(1)-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide;   N(1)-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide;   N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide;   SMILES=Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1;   SMZ;   Sulfadimethyldiazine;   Sulfadimethylpyrimidine;   Sulfametazina;   Sulfametazyny;   Sulfamezathine;   Sulphadimethylpyrimidine;   Sulphamethazine;   sulfadimidina;   sulfadimidine;   sulfadimidinum;   sulfamethazone
 xref: Beilstein:261304;   CAS:57-68-1;   DrugBank:DB01582;   Drug_Central:2502;   Gmelin:1009759;   HMDB:HMDB0015522;   KEGG:C19530;   KEGG:D02436;   LINCS:LSM-5295
 xref_mesh: MESH:D013418
 xref: PMID:11431418;   PMID:14552772;   PMID:15603963;   PMID:17311370;   PMID:17596632;   PMID:20028131;   PMID:22903812;   PMID:23218311;   PMID:23384282;   PMID:23434485;   PMID:23454458;   PMID:23562141;   PMID:23636590;   PMID:23673752;   PMID:23673946;   PMID:23704574;   PMID:6864729;   PMID:7021831;   PMID:7328159;   PMID:8199304;   PMID:9886437;   Patent:EP1861101;   Patent:GB546158;   Patent:GB552887;   Patent:US2407966;   Patent:US3119818;   Patent:WO2005016386;   Reaxys:261304;   VSDB:1829;   Wikipedia:Sulfadimidine



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sulfamethazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity ISO Sulfamethazine results in increased activity of CYP3A4 protein CTD PMID:12065438 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
affects acetylation
increases metabolic processing
ISO NAT2 protein results in increased acetylation of Sulfamethazine
NAT2 polymorphism affects the acetylation of Sulfamethazine
NAT2 protein results in increased metabolism of Sulfamethazine
CTD PMID:12222688 PMID:15627487 PMID:15880531 PMID:21317369 PMID:28516247 More... NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Sulfamethazine results in increased activity of NR1I2 protein CTD PMID:12065438 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19915
    role 19885
      biological role 19883
        antimicrobial agent 18267
          sulfamethazine 3
            sulfabromomethazine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19915
    subatomic particle 19913
      composite particle 19895
        hadron 19895
          baryon 19913
            nucleon 19895
              atomic nucleus 19913
                atom 19895
                  main group element atom 19852
                    main group molecular entity 19834
                      s-block molecular entity 19685
                        hydrogen molecular entity 19647
                          hydrides 19151
                            inorganic hydride 18162
                              pnictogen hydride 18152
                                nitrogen hydride 18065
                                  azane 17894
                                    ammonia 17893
                                      organic amino compound 17893
                                        aromatic amine 15507
                                          anilines 14418
                                            substituted aniline 14078
                                              sulfanilamide 2923
                                                sulfamethazine 3
                                                  sulfabromomethazine 0
paths to the root