CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: sulfamethazine
Accession: CHEBI:102265
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Definition: A sulfonamide consisting of pyrimidine with methyl substituents at the 4- and 6-positions and a 4-aminobenzenesulfonamido group at the 2-position.
Synonyms: related_synonym: (p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin; 2-(4-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine; 2-(p-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine; 2-Sulfanilamido-4,6-dimethylpyrimidine; 4,6-Dimethyl-2-sulfanilamidopyrimidine; 4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide; 4-Amino-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide; 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide; 6-(4'-Aminobenzol-sulfonamido)-2,4-dimethylpyrimidin; Formula=C12H14N4O2S; InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16); InChIKey=ASWVTGNCAZCNNR-UHFFFAOYSA-N; N(1)-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide; N(1)-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide; N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide; SMILES=Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1; SMZ; Sulfadimethyldiazine; Sulfadimethylpyrimidine; Sulfametazina; Sulfametazyny; Sulfamezathine; Sulphadimethylpyrimidine; Sulphamethazine; sulfadimidina; sulfadimidine; sulfadimidinum; sulfamethazone
xref: Beilstein:261304; CAS:57-68-1; DrugBank:DB01582; Drug_Central:2502; Gmelin:1009759; HMDB:HMDB0015522; KEGG:C19530; KEGG:D02436; LINCS:LSM-5295
xref_mesh: MESH:D013418
xref: PMID:11431418; PMID:14552772; PMID:15603963; PMID:17311370; PMID:17596632; PMID:20028131; PMID:22903812; PMID:23218311; PMID:23384282; PMID:23434485; PMID:23454458; PMID:23562141; PMID:23636590; PMID:23673752; PMID:23673946; PMID:23704574; PMID:6864729; PMID:7021831; PMID:7328159; PMID:8199304; PMID:9886437; Patent:EP1861101; Patent:GB546158; Patent:GB552887; Patent:US2407966; Patent:US3119818; Patent:WO2005016386; Reaxys:261304; VSDB:1829; Wikipedia:Sulfadimidine
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases activity
ISO
Sulfamethazine results in increased activity of CYP3A4 protein
CTD
PMID:12065438
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Nat2
N-acetyltransferase 2
increases acetylation affects acetylation increases metabolic processing
ISO
NAT2 protein results in increased acetylation of Sulfamethazine NAT2 polymorphism affects the acetylation of Sulfamethazine NAT2 protein results in increased metabolism of Sulfamethazine
CTD
PMID:12222688 PMID:15627487 PMID:15880531 PMID:21317369 PMID:28516247 PMID:30358977 More...
NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
Sulfamethazine results in increased activity of NR1I2 protein
CTD
PMID:12065438
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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