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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor
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Accession:CHEBI:102248 term browser browse the term
Definition:An EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor that interferes with the action of hypoxia-inducible factor-proline dioxygenase (EC 1.14.11.29).
Synonyms:related_synonym: EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitors;   EC 1.14.11.29 inhibitor;   EC 1.14.11.29 inhibitors;   HIF hydroxylase inhibitor;   HIF hydroxylase inhibitors;   hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitor;   hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitors;   prolyl 4-hydroxylase inhibitor;   prolyl 4-hydroxylase inhibitors



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roxadustat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 multiple interactions ISO roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of ATG5 protein] CTD PMID:27082295 NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 multiple interactions ISO roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of BNIP3 protein] CTD PMID:27082295 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions
increases activity
ISO roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of HIF1A protein]
[Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [roxadustat results in increased activity of HIF1A protein]
CTD PMID:27082295 PMID:29741670 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
JBrowse link
G Hk2 hexokinase 2 increases expression ISO roxadustat results in increased expression of HK2 mRNA CTD PMID:33596451 NCBI chr 6:82,702,004...82,751,437
Ensembl chr 6:82,702,006...82,751,435
JBrowse link
G Ldha lactate dehydrogenase A increases expression ISO roxadustat results in increased expression of LDHA mRNA CTD PMID:33596451 NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of MAP1LC3B protein] CTD PMID:27082295 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499
JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 increases expression ISO roxadustat results in increased expression of SLC2A1 mRNA CTD PMID:33596451 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 22327
    role 22313
      biological role 22312
        biochemical role 21543
          enzyme inhibitor 19934
            EC 1.* (oxidoreductase) inhibitor 18035
              EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 16440
                EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor 93
                  EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor 7
                    daprodustat 0
                    dimethyloxalylglycine 0
                    roxadustat 7
paths to the root