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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor
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Accession:CHEBI:102248 term browser browse the term
Definition:An EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor that interferes with the action of hypoxia-inducible factor-proline dioxygenase (EC 1.14.11.29).
Synonyms:related_synonym: EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitors;   EC 1.14.11.29 inhibitor;   EC 1.14.11.29 inhibitors;   HIF hydroxylase inhibitor;   HIF hydroxylase inhibitors;   hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitor;   hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitors;   prolyl 4-hydroxylase inhibitor;   prolyl 4-hydroxylase inhibitors



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roxadustat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG5 autophagy related 5 multiple interactions ISO roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of ATG5 protein] CTD PMID:27082295 NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791
JBrowse link
G BNIP3 BCL2 interacting protein 3 multiple interactions ISO roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of BNIP3 protein] CTD PMID:27082295 NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,967,684...131,981,967
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases activity
multiple interactions
EXP
ISO
roxadustat results in increased activity of HIF1A protein
[Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [roxadustat results in increased activity of HIF1A protein]
roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of HIF1A protein]
CTD PMID:27082295 PMID:29741670 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HK2 hexokinase 2 increases expression EXP roxadustat results in increased expression of HK2 mRNA CTD PMID:33596451 NCBI chr 2:74,834,127...74,893,359
Ensembl chr 2:74,834,127...74,893,359
JBrowse link
G LDHA lactate dehydrogenase A increases expression EXP roxadustat results in increased expression of LDHA mRNA CTD PMID:33596451 NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425
JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions ISO roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of MAP1LC3B protein] CTD PMID:27082295 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779
JBrowse link
G SLC2A1 solute carrier family 2 member 1 increases expression EXP roxadustat results in increased expression of SLC2A1 mRNA CTD PMID:33596451 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 26505
    role 26328
      biological role 26307
        biochemical role 25519
          enzyme inhibitor 22389
            EC 1.* (oxidoreductase) inhibitor 19441
              EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 16663
                EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor 94
                  EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor 7
                    daprodustat 0
                    dimethyloxalylglycine 0
                    roxadustat 7
paths to the root