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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor
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Accession:CHEBI:102248 term browser browse the term
Definition:An EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor that interferes with the action of hypoxia-inducible factor-proline dioxygenase (EC 1.14.11.29).
Synonyms:related_synonym: EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitors;   EC 1.14.11.29 inhibitor;   EC 1.14.11.29 inhibitors;   HIF hydroxylase inhibitor;   HIF hydroxylase inhibitors;   hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitor;   hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitors;   prolyl 4-hydroxylase inhibitor;   prolyl 4-hydroxylase inhibitors


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roxadustat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 multiple interactions EXP roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of ATG5 protein] CTD PMID:27082295 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions EXP roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of BNIP3 protein] CTD PMID:27082295 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity		 ISO
EXP		 [Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [roxadustat results in increased activity of HIF1A protein]
roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of HIF1A protein]		 CTD PMID:27082295 PMID:29741670 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hk2 hexokinase 2 increases expression ISO roxadustat results in increased expression of HK2 mRNA CTD PMID:33596451 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Ldha lactate dehydrogenase A increases expression ISO roxadustat results in increased expression of LDHA mRNA CTD PMID:33596451 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of MAP1LC3B protein] CTD PMID:27082295 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO roxadustat results in increased expression of SLC2A1 mRNA CTD PMID:33596451 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        biochemical role 19552
          enzyme inhibitor 18753
            EC 1.* (oxidoreductase) inhibitor 17539
              EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 15966
                EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor 94
                  EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor 7
                    daprodustat 0
                    dimethyloxalylglycine 0
                    roxadustat 7
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