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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:methohexital
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Accession:CHEBI:102216 term browser browse the term
Definition:A barbiturate, the structure of which is that of barbituric acid substituted at N-1 by a methyl group and at C-5 by allyl and 1-methylpent-2-ynyl groups.
Synonyms:exact_synonym: 1-methyl-5-(1-methylpent-2-yn-1-yl)-5-(prop-2-en-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
 related_synonym: (+-)-5-allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid;   5-Allyl-1-methyl-5-(1-methyl-pent-2-ynyl)-pyrimidine-2,4,6-trione;   5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbituric acid;   5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrione;   Formula=C14H18N2O3;   InChI=1S/C14H18N2O3/c1-5-7-8-10(3)14(9-6-2)11(17)15-13(19)16(4)12(14)18/h6,10H,2,5,9H2,1,3-4H3,(H,15,17,19);   InChIKey=NZXKDOXHBHYTKP-UHFFFAOYSA-N;   Methohexitalum;   Methohexitone;   Metohexital;   SMILES=CCC#CC(C)C1(CC=C)C(=O)NC(=O)N(C)C1=O;   alpha-DL-1-methyl-5-allyl-5-(1'-methylpentyn-2-yl)barbituric acid
 alt_id: CHEBI:6833
 xref: CAS:151-83-7;   DrugBank:DB00474;   Drug_Central:1748;   KEGG:C07844;   KEGG:D04985
 xref_mesh: MESH:D008723
 xref: PMID:13919899;   PMID:20045848;   PMID:22330701;   PMID:22914630;   PMID:22914634;   PMID:23164727;   PMID:23399487;   PMID:23422530;   PMID:23813116;   PMID:3654008;   PMID:6864729;   Reaxys:89964;   Wikipedia:Methohexital
 cyclic_relationship: is_conjugate_acid_of CHEBI:60792


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methohexital term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Methohexital inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of JUN mRNA] CTD PMID:15263067 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Methohexital inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of KRAS protein] CTD PMID:15263067 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Methohexital results in decreased phosphorylation of MAPK1 protein CTD PMID:15263067 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Methohexital results in decreased phosphorylation of MAPK3 protein CTD PMID:15263067 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Methohexital inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein] CTD PMID:15263067 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          drug 19525
            drug allergen 11849
              methohexital 5
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Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteromonocyclic compound 17791
                                    diazines 13215
                                      pyrimidines 13085
                                        pyrimidone 10512
                                          barbiturates 4627
                                            methohexital 5
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