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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:thiopental
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Accession:CHEBI:102166 term browser browse the term
Definition:A barbiturate, the structure of which is that of 2-thiobarbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Synonyms:related_synonym: 2-Thio-5-ethyl-5-sec-pentylbarbituric acid;   5-Ethyl-5-(1-methyl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione;   5-ethyl-5-(pentan-2-yl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione;   Penthiobarbital;   Pentothiobarbital;   Thiopentobarbital;   Thiopentobarbitone;   Thiopentobarbituric acid;   Thiopentone
 alt_id: CHEBI:9560
 xref: Beilstein:209361;   CAS:76-75-5;   DrugBank:DB00599
 xref_mesh: MESH:D013874
 xref: Reaxys:209361;   drugcentral:2633;   kegg.compound:C07521;   pubmed:10666006;   pubmed:10841799;   pubmed:15857133;   pubmed:16166909;   pubmed:16897573;   pubmed:18484074;   pubmed:20488867;   pubmed:2215478;   pubmed:23305916;   pubmed:23422796;   pubmed:23490495;   pubmed:23542731;   pubmed:23644730;   pubmed:23879844;   pubmed:3654008;   pubmed:6864729;   pubmed:9171876;   pubmed:9699097
 chemrof_formula: C11H18N2O2S
 chemrof_smiles: CCCC(C)C1(CC)C(=O)NC(=S)NC1=O
 chemrof_inchikey: IUJDSEJGGMCXSG-UHFFFAOYSA-N
 chemrof_inchi: InChI=1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)
 cyclic_relationship: has_functional_parent CHEBI:33202;   is_conjugate_acid_of CHEBI:61485


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thiopental term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases expression ISO Thiopental results in increased expression of AGT protein CTD PMID:6349867 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Thiopental CTD PMID:15644869 NCBI chr 7:113,716,266...113,827,670
Ensembl chr 7:113,716,266...113,827,670 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions 		ISO Thiopental results in increased activity of CASP3 protein
Thiopental inhibits the reaction [Staurosporine results in increased activity of CASP3 protein] 		CTD PMID:16129983 PMID:18218830 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions ISO Thiopental binds to and results in decreased activity of CHRM3 protein; Thiopental inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein] CTD PMID:12456425 NCBI chr17:64,696,549...65,158,622
Ensembl chr17:64,696,066...65,173,304 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Thiopental affects the reaction [TNF protein results in increased activity of CHUK protein] CTD PMID:12883408 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 affects response to substance ISO GRIA2 protein affects the susceptibility to Thiopental CTD PMID:10551584 NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:168,247,496...168,367,616 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases phosphorylation
increases activity 		ISO Thiopental results in increased phosphorylation of HSF1 protein
Thiopental results in increased activity of HSF1 protein 		CTD PMID:18218830 NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression ISO Thiopental results in increased expression of HSP90AA1 mRNA CTD PMID:18218830 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO Thiopental results in increased expression of HSPB1 mRNA CTD PMID:18218830 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Thiopental promotes the reaction [IL1B protein results in increased abundance of Nitrites]; Thiopental promotes the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Thiopental promotes the reaction [IL1B protein results in increased expression of NOS2 protein] CTD PMID:9436821 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases secretion ISO Thiopental results in decreased secretion of IL2RA protein CTD PMID:16119599 NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thiopental inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of JUN mRNA] CTD PMID:15263067 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases degradation
multiple interactions 		ISO Thiopental results in decreased degradation of NFKBIA protein
TNF protein affects the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Thiopental] affects the phosphorylation of NFKBIA protein] 		CTD PMID:12883408 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP Bicuculline inhibits the reaction [Thiopental inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein]]; Thiopental inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein] CTD PMID:11991087 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Thiopental promotes the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Thiopental promotes the reaction [IL1B protein results in increased expression of NOS2 protein] CTD PMID:9436821 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Npy neuropeptide Y multiple interactions EXP Thiopental inhibits the reaction [Kainic Acid results in increased expression of NPY mRNA] CTD PMID:9427505 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310 		JBrowse link
G Penk proenkephalin multiple interactions EXP Thiopental inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA] CTD PMID:9427505 NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:21,981,382...21,986,705 		JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions
increases phosphorylation 		EXP bisindolylmaleimide I inhibits the reaction [Thiopental results in increased phosphorylation of PTK2 protein]; bisindolylmaleimide IX inhibits the reaction [Thiopental results in increased phosphorylation of PTK2 protein]; chelerythrine inhibits the reaction [Thiopental results in increased phosphorylation of PTK2 protein]; Thiopental affects the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased phosphorylation of PTK2 protein] CTD PMID:15194624 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091 		JBrowse link
G Sftpc surfactant protein C increases expression EXP Thiopental results in increased expression of SFTPC mRNA CTD PMID:10969314 NCBI chr15:52,006,274...52,009,324
Ensembl chr15:52,006,283...52,009,475 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Thiopental affects the reaction [TNF protein results in increased activity of CHUK protein]; TNF protein affects the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Thiopental] affects the phosphorylation of NFKBIA protein] CTD PMID:12883408 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        xenobiotic 19528
          thiopental 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  organic heteromonocyclic compound 18004
                                    diazines 13662
                                      pyrimidines 13531
                                        pyrimidone 5091
                                          barbiturates 4651
                                            thiopental 20
paths to the root