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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:zonisamide
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Accession:CHEBI:10127 term browser browse the term
Definition:A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.
Synonyms:exact_synonym: 1-(1,2-benzisoxazol-3-yl)methanesulfonamide
 related_synonym: 1,2-Benzisoxazole-3-methanesulfonamide;   3-(Sulfamoylmethyl)-1,2-benzisoxazole;   Benzo[d]isoxazol-3-yl-methanesulfonamide;   Formula=C8H8N2O3S;   InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12);   InChIKey=UBQNRHZMVUUOMG-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)Cc1noc2ccccc12;   zonisamida;   zonisamidum
 alt_id: CHEBI:139857
 xref: Beilstein:1077076;   CAS:68291-97-4;   DrugBank:DB00909;   Drug_Central:2872;   KEGG:C07504;   KEGG:D00538;   LINCS:LSM-3062
 xref_mesh: MESH:C022189
 xref: Patent:JP7877057;   Patent:US4172896;   Wikipedia:Zonisamide



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zonisamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car1 carbonic anhydrase 1 multiple interactions ISO zonisamide binds to and results in decreased activity of CA1 protein CTD PMID:17826101 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO zonisamide binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Car3 carbonic anhydrase 3 multiple interactions ISO zonisamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP DRD1 protein promotes the reaction [zonisamide affects the secretion of Dopamine]; DRD1 protein promotes the reaction [zonisamide affects the secretion of gamma-Aminobutyric Acid] CTD PMID:19482038 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP zonisamide inhibits the reaction [Tacrine results in increased expression of FOS protein] CTD PMID:18693129 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO zonisamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein] CTD PMID:19199078 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Ifng interferon gamma decreases expression ISO zonisamide results in decreased expression of IFNG protein CTD PMID:10982153 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Maob monoamine oxidase B multiple interactions
decreases activity
ISO zonisamide inhibits the reaction [[MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased chemical synthesis of 1-Methyl-4-phenylpyridinium]; zonisamide inhibits the reaction [Selegiline binds to MAOB protein]
zonisamide results in decreased activity of MAOB protein
CTD PMID:19948168 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP zonisamide results in increased expression of NOS2 mRNA CTD PMID:12429386 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Slc1a1 solute carrier family 1 member 1 increases expression EXP zonisamide results in increased expression of SLC1A1 protein CTD PMID:12941455 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions
ISO Zonisamide results in increased expression of TH mRNA; Zonisamide results in increased expression of TH protein
[zonisamide co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] affects the activity of TH protein; zonisamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]
zonisamide results in increased expression of TH protein
CTD PMID:19199078 PMID:19948168 PMID:20196486 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link

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  CHEBI ontology 19915
    role 19885
      chemical role 19492
        antioxidant 16172
          zonisamide 11
Path 2
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  CHEBI ontology 19915
    subatomic particle 19913
      composite particle 19895
        hadron 19895
          baryon 19913
            nucleon 19895
              atomic nucleus 19913
                atom 19895
                  main group element atom 19852
                    p-block element atom 19834
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic molecule 19722
                              organic cyclic compound 19529
                                organic heterocyclic compound 18893
                                  organic heteropolycyclic compound 18315
                                    organic heterobicyclic compound 17239
                                      benzoxazole 136
                                        benzisoxazole 78
                                          1,2-benzoxazoles 78
                                            zonisamide 11
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