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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diclofenamide
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Accession:CHEBI:101085 term browser browse the term
Definition:A sulfonamide that is benzene-1,3-disulfonamide in which the hydrogens at positions 4 and 5 are substituted by chlorine. An oral carbonic anhydrase inhibitor, it partially suppresses the secretion (inflow) of aqueous humor in the eye and so reduces intraocular pressure. It is used for the treatment of glaucoma.
Synonyms:related_synonym: 1,3-disulfamoyl-4,5-dichlorobenzene;   1,3-disulfamyl-4,5-dichlorobenzene;   3,4-dichloro-5-sulfamylbenzenesulfonamide;   4,5-DICHLOROBENZENE-1,3-DISULFONAMIDE;   4,5-dichloro-1,3-benzenedisulfonamide;   4,5-dichloro-1,3-disulfamoylbenzene;   4,5-dichloro-benzene-1,3-disulfonic acid diamide;   4,5-dichloro-m-benzenedisulfonamide;   DICHLORPHENAMIDE;   Dichlorophenamide;   Formula=C6H6Cl2N2O4S2;   InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14);   InChIKey=GJQPMPFPNINLKP-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O;   dichlofenamide;   diclofenamida;   diclofenamidum
 alt_id: CHEBI:4505;   CHEBI:47477
 xref: Beilstein:2703329;   CAS:120-97-8;   DrugBank:DB01144;   Drug_Central:864;   KEGG:C07459;   KEGG:D00518;   LINCS:LSM-3602
 xref_mesh: MESH:D004005
 xref: PDBeChem:I7A;   Patent:US2835702;   Wikipedia:Dichlorphenamide


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diclofenamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car2 carbonic anhydrase 2 multiple interactions ISO Dichlorphenamide binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Car3 carbonic anhydrase 3 multiple interactions ISO Dichlorphenamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        pharmaceutical 19532
          drug 19532
            ophthalmology drug 436
              diclofenamide 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                carbocyclic compound 18584
                                  benzenoid aromatic compound 18008
                                    benzenes 17873
                                      chlorobenzenes 15046
                                        dichlorobenzene 11550
                                          diclofenamide 2
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