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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:zafirlukast
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Accession:CHEBI:10100 term browser browse the term
Definition:A N-sulfonylcarboxamide that has formula C31H33N3O6S.
Synonyms:related_synonym: 4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide;   Accolate;   cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamate;   cyclopentyl 3-[2-methoxy-4-(2-methylphenylsulfonylcarbamoyl)benzyl]-1-methyl-1H-indol-5-ylcarbamate
 xref: CAS:107753-78-6;   DrugBank:DB00549;   HMDB:HMDB0014689
 xref_mesh: MESH:C062735
 xref: Reaxys:3641829;   drugcentral:2855;   kegg.compound:C07206;   kegg.drug:D00411;   lincs.smallmolecule:LSM-5792;   pubmed:11888331;   pubmed:19331987;   pubmed:22159431;   pubmed:22614107;   pubmed:24258705;   pubmed:25798389;   pubmed:25834030;   wikipedia.en:Zafirlukast
 chemrof_formula: C31H33N3O6S
 chemrof_smiles: COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12
 chemrof_inchi: InChI=1S/C31H33N3O6S/c1-20-8-4-7-11-29(20)41(37,38)33-30(35)22-13-12-21(28(17-22)39-3)16-23-19-34(2)27-15-14-24(18-26(23)27)32-31(36)40-25-9-5-6-10-25/h4,7-8,11-15,17-19,25H,5-6,9-10,16H2,1-3H3,(H,32,36)(H,33,35)
 chemrof_inchikey: YEEZWCHGZNKEEK-UHFFFAOYSA-N



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zafirlukast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO zafirlukast results in decreased activity of ABCB11 protein CTD PMID:23956101 PMID:28437613 PMID:39023798 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO zafirlukast results in decreased activity of ABCB4 protein CTD PMID:28437613 PMID:39023798 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO zafirlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine] CTD PMID:15180633 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO zafirlukast results in decreased activity of ABCC2 protein CTD PMID:39023798 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases activity ISO zafirlukast results in decreased activity of ABCC3 protein CTD PMID:39023798 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases activity ISO zafirlukast results in decreased activity of ABCC4 protein CTD PMID:39023798 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375
JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO zafirlukast results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261
JBrowse link
G Cat catalase increases expression EXP zafirlukast results in increased expression of CAT protein CTD PMID:12962976 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO zafirlukast results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO zafirlukast inhibits the reaction [CYP1A2 protein results in increased metabolism of Theophylline] CTD PMID:9701106 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO zafirlukast results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions
decreases activity
ISO zafirlukast inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]
zafirlukast results in decreased activity of CYP2C19 protein
CTD PMID:15370959 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO zafirlukast results in decreased activity of CYP2C8 protein CTD PMID:15601807
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases metabolic processing
multiple interactions
ISO zafirlukast metabolite results in decreased activity of CYP3A4 protein; zafirlukast results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased metabolism of zafirlukast
zafirlukast inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]
CTD PMID:15370959 PMID:16167835 PMID:39023798 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 multiple interactions
affects binding
ISO [zafirlukast binds to and results in decreased activity of CYSLTR1 protein] which affects the abundance of Calcium; alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [zafirlukast binds to and results in decreased activity of CYSLTR1 protein]; zafirlukast binds to and results in decreased activity of CYSLTR1 protein; zafirlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein]; zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of IL6 protein]; zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of TNF protein]; zafirlukast inhibits the reaction [[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; zafirlukast inhibits the reaction [[Uridine Diphosphate metabolite results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein]; zafirlukast inhibits the reaction [CYSLTR1 protein promotes the reaction [Leukotriene D4 results in increased abundance of Calcium]]; zafirlukast inhibits the reaction [CYSLTR1 protein results in increased susceptibility to Leukotriene D4]; zafirlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; zafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; zafirlukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]
zafirlukast binds to CYSLTR1 protein
zafirlukast binds to and results in decreased activity of CYSLTR1 protein; zafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]
CTD PMID:1554195 PMID:8014876 PMID:8384568 PMID:8389103 PMID:8389105 More... NCBI chr  X:75,734,281...75,762,873
Ensembl chr  X:75,734,270...75,763,050
JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 multiple interactions ISO zafirlukast binds to and results in decreased activity of CYSLTR2 protein; zafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein] CTD PMID:10851239 NCBI chr15:54,599,043...54,638,314
Ensembl chr15:54,598,818...54,713,597
JBrowse link
G Edn1 endothelin 1 multiple interactions
decreases expression
ISO zafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 mRNA]; zafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 protein]
zafirlukast results in decreased expression of EDN1 protein
CTD PMID:11372388 PMID:12781059 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687
JBrowse link
G Ereg epiregulin increases expression ISO zafirlukast results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260
JBrowse link
G Ifng interferon gamma multiple interactions ISO [zafirlukast co-treated with Prednisone co-treated with Budesonide] inhibits the reaction [Antigens results in increased secretion of IFNG protein] CTD PMID:16160912 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO zafirlukast results in decreased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il24 interleukin 24 increases expression ISO zafirlukast results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760
JBrowse link
G Il6 interleukin 6 multiple interactions ISO zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of IL6 protein] CTD PMID:18704935 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO zafirlukast results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 mRNA]; zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein] CTD PMID:31816286 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP9 mRNA]; zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP9 protein] CTD PMID:31816286 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
JBrowse link
G Mpo myeloperoxidase decreases activity
decreases expression
EXP zafirlukast results in decreased activity of MPO protein
zafirlukast results in decreased expression of MPO protein
CTD PMID:11438310 PMID:12962976 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
JBrowse link
G Ocln occludin multiple interactions ISO zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of OCLN mRNA]; zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of OCLN protein] CTD PMID:31816286 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO zafirlukast results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:92,732,471...92,951,168
Ensembl chr 9:92,734,214...92,750,070
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO zafirlukast results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Rnase3 ribonuclease A family member 3 decreases expression ISO zafirlukast results in decreased expression of RNASE3 protein CTD PMID:15612964 NCBI chr15:26,985,399...26,986,269
Ensembl chr15:26,985,271...26,986,400
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases activity ISO zafirlukast results in decreased activity of SLC10A1 protein CTD PMID:39023798 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO zafirlukast inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO zafirlukast inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO zafirlukast inhibits the reaction [SLC47A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO zafirlukast results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases activity ISO zafirlukast results in decreased activity of SLCO1B3 protein CTD PMID:39023798 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO zafirlukast results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TJP1 mRNA]; zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TJP1 protein] CTD PMID:31816286 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of TNF protein] CTD PMID:18704935 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 decreases expression ISO zafirlukast results in decreased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:56,911,252...56,930,796
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO zafirlukast results in decreased activity of UGT1A3 protein CTD PMID:39023798 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link

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  CHEBI ontology 20874
    role 20844
      application 20572
        anti-asthmatic agent 9365
          zafirlukast 41
Path 2
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  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  organic heteropolycyclic compound 18616
                                    organic heterobicyclic compound 17442
                                      benzopyrrole 6369
                                        indoles 5968
                                          zafirlukast 41
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