CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Xamoterol
Accession: CHEBI:10055
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Definition: A morpholine that has formula C16H25N3O5.
Synonyms: related_synonym: Formula=C16H25N3O5; InChI=1S/C16H25N3O5/c20-13-1-3-15(4-2-13)24-12-14(21)11-17-5-6-18-16(22)19-7-9-23-10-8-19/h1-4,14,17,20-21H,5-12H2,(H,18,22); InChIKey=DXPOSRCHIDYWHW-UHFFFAOYSA-N; SMILES=OC(CNCCNC(=O)N1CCOCC1)COc1ccc(O)cc1; xamoterol fumarate; xamoterol hemifumarate
xref: CAS:81801-12-9; Drug_Central:2848; KEGG:C11775; KEGG:D06328
xref_mesh: MESH:D017307
G
Adrb1
adrenoceptor beta 1
multiple interactions
EXP ISO
Xamoterol binds to and results in decreased activity of ADRB1 protein Xamoterol binds to and results in increased activity of ADRB1 protein
CTD
PMID:2888869 PMID:11562432
NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:255,771,597...255,807,259
G
Atf1
activating transcription factor 1
increases phosphorylation
ISO
Xamoterol results in increased phosphorylation of ATF1 protein
CTD
PMID:16671086
NCBI chr 7:133,240,774...133,283,488
Ensembl chr 7:131,362,450...131,404,670
G
Creb1
cAMP responsive element binding protein 1
increases phosphorylation
ISO
Xamoterol results in increased phosphorylation of CREB1 protein
CTD
PMID:16671086
NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816
G
Hmox1
heme oxygenase 1
increases expression multiple interactions
EXP
Xamoterol results in increased expression of HMOX1 mRNA; Xamoterol results in increased expression of HMOX1 protein Metoprolol inhibits the reaction [Xamoterol results in increased expression of HMOX1 protein]
CTD
PMID:15179140
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
G
Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
Xamoterol results in increased phosphorylation of MAPK1 protein
CTD
PMID:16671086
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
Xamoterol results in increased phosphorylation of MAPK3 protein
CTD
PMID:16671086
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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