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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Xamoterol
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Accession:CHEBI:10055 term browser browse the term
Definition:A morpholine that has formula C16H25N3O5.
Synonyms:related_synonym: Formula=C16H25N3O5;   InChI=1S/C16H25N3O5/c20-13-1-3-15(4-2-13)24-12-14(21)11-17-5-6-18-16(22)19-7-9-23-10-8-19/h1-4,14,17,20-21H,5-12H2,(H,18,22);   InChIKey=DXPOSRCHIDYWHW-UHFFFAOYSA-N;   SMILES=OC(CNCCNC(=O)N1CCOCC1)COc1ccc(O)cc1;   xamoterol fumarate;   xamoterol hemifumarate
 xref: CAS:81801-12-9;   Drug_Central:2848;   KEGG:C11775;   KEGG:D06328
 xref_mesh: MESH:D017307



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Xamoterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions EXP
ISO
Xamoterol binds to and results in decreased activity of ADRB1 protein
Xamoterol binds to and results in increased activity of ADRB1 protein
CTD PMID:2888869 PMID:11562432 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Atf1 activating transcription factor 1 increases phosphorylation ISO Xamoterol results in increased phosphorylation of ATF1 protein CTD PMID:16671086 NCBI chr 7:133,240,774...133,283,488
Ensembl chr 7:131,362,450...131,404,670
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation ISO Xamoterol results in increased phosphorylation of CREB1 protein CTD PMID:16671086 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP Xamoterol results in increased expression of HMOX1 mRNA; Xamoterol results in increased expression of HMOX1 protein
Metoprolol inhibits the reaction [Xamoterol results in increased expression of HMOX1 protein]
CTD PMID:15179140 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Xamoterol results in increased phosphorylation of MAPK1 protein CTD PMID:16671086 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Xamoterol results in increased phosphorylation of MAPK3 protein CTD PMID:16671086 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      atom 19897
        nonmetal atom 19820
          nitrogen atom 19000
            nitrogen molecular entity 19000
              organonitrogen compound 18854
                organonitrogen heterocyclic compound 18178
                  oxazinane 911
                    morpholines 911
                      Xamoterol 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19725
                              organic cyclic compound 19517
                                organic heterocyclic compound 18894
                                  organic heteromonocyclic compound 17817
                                    oxazinane 911
                                      morpholines 911
                                        Xamoterol 6
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