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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:wedelolactone
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Accession:CHEBI:10037 term browser browse the term
Definition:A member of the class of coumestans that is coumestan with hydroxy substituents as positions 1, 8 and 9 and a methoxy substituent at position 3.
Synonyms:exact_synonym: 1,8,9-trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one
 related_synonym: 1,8,9-trihydroxy-3-methoxycoumestan;   Formula=C16H10O7;   InChI=1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3;   InChIKey=XQDCKJKKMFWXGB-UHFFFAOYSA-N;   SMILES=COc1cc(O)c2c(c1)oc(=O)c1c3cc(O)c(O)cc3oc21
 xref: CAS:524-12-9;   KEGG:C10541;   KNApSAcK:C00002585;   LIPID_MAPS_instance:LMPK12090046
 xref_mesh: MESH:C051122
 xref: PMID:21315506;   PMID:21463376;   PMID:22198514;   PMID:22204306;   PMID:23076676;   PMID:23141142;   Reaxys:332398;   Wikipedia:Wedelolactone



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wedelolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO 2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [wedelolactone inhibits the reaction [Oxygen results in increased expression of BAX protein]]; wedelolactone inhibits the reaction [Oxygen results in increased expression of BAX protein] CTD PMID:39110510 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO 2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [wedelolactone inhibits the reaction [Oxygen results in decreased expression of BCL2 protein]]; wedelolactone inhibits the reaction [Oxygen results in decreased expression of BCL2 protein] CTD PMID:39110510 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
wedelolactone inhibits the reaction [Methamphetamine results in increased cleavage of and results in increased activity of CASP3 protein]; wedelolactone inhibits the reaction [Quinolinic Acid results in increased activity of CASP3 protein]
2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [wedelolactone inhibits the reaction [Oxygen results in increased cleavage of CASP3 protein]]; wedelolactone inhibits the reaction [Oxygen results in increased cleavage of CASP3 protein]
CTD PMID:25631491 PMID:29981346 PMID:39110510 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 decreases expression EXP wedelolactone results in decreased expression of CASP4 protein alternative form CTD PMID:25631491 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [wedelolactone results in increased cleavage of PARP1 protein] CTD PMID:22733624 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP wedelolactone inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein] CTD PMID:22207076 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP wedelolactone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; wedelolactone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]; wedelolactone inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]; wedelolactone inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]; wedelolactone inhibits the reaction [Smoke results in increased expression of EDNRB protein]; wedelolactone inhibits the reaction [TNF protein results in increased expression of EDNRB mRNA]; wedelolactone inhibits the reaction [TNF protein results in increased expression of EDNRB protein] CTD PMID:18718921 PMID:20561571 PMID:22207076 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO 2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [wedelolactone inhibits the reaction [Oxygen results in increased expression of FTH1 protein]]; wedelolactone inhibits the reaction [Oxygen results in decreased expression of FTH1 protein] CTD PMID:39110510 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO 2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [wedelolactone inhibits the reaction [Oxygen results in increased expression of GPX4 protein]]; wedelolactone inhibits the reaction [Oxygen results in decreased expression of GPX4 protein] CTD PMID:39110510 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO wedelolactone inhibits the reaction [Oxygen results in decreased expression of HMOX1 protein] CTD PMID:39110510 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions
decreases activity
ISO [wedelolactone results in decreased activity of IKBKB protein] which results in decreased phosphorylation of NFKBIA protein CTD PMID:25450232 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il18 interleukin 18 multiple interactions ISO 2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [wedelolactone inhibits the reaction [Oxygen results in increased secretion of IL18 protein]]; wedelolactone inhibits the reaction [Oxygen results in increased secretion of IL18 protein] CTD PMID:39110510 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
wedelolactone inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein]
2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [wedelolactone inhibits the reaction [Oxygen results in increased secretion of IL1B protein]]; wedelolactone inhibits the reaction [Oxygen results in increased secretion of IL1B protein]
CTD PMID:29981346 PMID:39110510 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
wedelolactone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]
wedelolactone inhibits the reaction [Quinolinic Acid results in increased expression of IL6 protein]
CTD PMID:27793764 PMID:29981346 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO wedelolactone inhibits the reaction [[Cisplatin co-treated with TNF protein] results in increased phosphorylation of JUN protein] CTD PMID:23103562 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO wedelolactone inhibits the reaction [Oxygen results in decreased expression of NFE2L2 protein] CTD PMID:39110510 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP
ISO
wedelolactone inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
[wedelolactone results in decreased activity of IKBKB protein] which results in decreased phosphorylation of NFKBIA protein
CTD PMID:22207076 PMID:25450232 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
EXP
ISO
wedelolactone inhibits the reaction [Methamphetamine results in increased cleavage of PARP1 protein]
Acetylcysteine inhibits the reaction [wedelolactone results in increased cleavage of PARP1 protein]; Buthionine Sulfoximine promotes the reaction [wedelolactone results in increased cleavage of PARP1 protein]; CAT protein inhibits the reaction [wedelolactone results in increased cleavage of PARP1 protein]; S-ethyl glutathione inhibits the reaction [wedelolactone results in increased cleavage of PARP1 protein]
CTD PMID:22733624 PMID:25631491 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO wedelolactone inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:27793764 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
wedelolactone inhibits the reaction [TNF protein results in increased expression of RELA protein]
wedelolactone affects the localization of and results in decreased activity of RELA protein; wedelolactone inhibits the reaction [Palmitic Acid affects the localization of and results in increased activity of RELA protein]
CTD PMID:22207076 PMID:26422990 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sele selectin E multiple interactions ISO wedelolactone inhibits the reaction [Palmitic Acid results in increased expression of SELE mRNA] CTD PMID:26422990 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
decreases activity
ISO [wedelolactone results in decreased activity of SLC22A6 protein] which results in increased susceptibility to and results in increased activity of aristolochic acid I CTD PMID:32159797 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
decreases activity
ISO [wedelolactone results in decreased activity of SLC22A8 protein] which results in increased susceptibility to and results in increased activity of aristolochic acid I CTD PMID:32159797 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions ISO 2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [wedelolactone inhibits the reaction [Oxygen results in increased expression of SLC7A11 protein]]; wedelolactone inhibits the reaction [Oxygen results in decreased expression of SLC7A11 protein] CTD PMID:39110510 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO 2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [wedelolactone inhibits the reaction [Oxygen results in decreased expression of TFRC protein]]; wedelolactone inhibits the reaction [Oxygen results in increased expression of TFRC protein] CTD PMID:39110510 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
wedelolactone inhibits the reaction [TNF protein results in increased expression of EDNRB mRNA]; wedelolactone inhibits the reaction [TNF protein results in increased expression of EDNRB protein]; wedelolactone inhibits the reaction [TNF protein results in increased expression of RELA protein]; wedelolactone inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]; wedelolactone inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [wedelolactone inhibits the reaction [Oxygen results in increased secretion of TNF protein]]; wedelolactone inhibits the reaction [[Cisplatin co-treated with TNF protein] results in increased phosphorylation of JUN protein]; wedelolactone inhibits the reaction [Oxygen results in increased secretion of TNF protein]
wedelolactone inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; wedelolactone inhibits the reaction [TNF protein results in increased abundance of Thromboxane B2]; wedelolactone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; wedelolactone inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
CTD PMID:22207076 PMID:23103562 PMID:27793764 PMID:39110510 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO wedelolactone inhibits the reaction [Palmitic Acid results in increased expression of VCAM1 mRNA] CTD PMID:26422990 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

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  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          metabolite 19544
            wedelolactone 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  ester 17458
                                    carboxylic ester 16743
                                      lactone 13299
                                        delta-lactone 4208
                                          coumestan 1782
                                            wedelolactone 18
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