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Rat Genetic Models

Gene Symbol	Gene	No. of Models	Background Strain	Strain Symbol	Aliases	Method	Availability	Origination
Apoe	apolipoprotein E	3	SS/JrHsdMcwi
				SD-Apoe^em1Ejt	apoE -/-	TALEN	Unknown	Purdue Center for Cancer Research, 201 South University Street, Purdue University, West Lafayette, Indiana, 47907, United States
			SS/JrHsdMcwi	SS-Apoe^em9Mcwi		ZFN	Cryopreserved Sperm (as of 2017-01-26)	PhysGen Knockouts
				SD-Apoe^em1Sage	SD- ApoE tm1sage ; TGRA3710	ZFN	Live Animals (as of 2017-05-01)	Horizon Discovery
Mybphl	myosin binding protein H-like	2	FHH/EurMcwi
			FHH/EurMcwi	FHH-Mybphl^em1Mcwi		CRISPR/Cas9	Cryopreserved Sperm (as of 2021-11-03)	MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu
			FHH/EurMcwi	FHH-Mybphl^em2Mcwi		CRISPR/Cas9	Cryopreserved Sperm (as of 2021-11-03)	MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu
Nr4a1	nuclear receptor subfamily 4, group A, member 1	1	FHH/EurMcwi	FHH-Nr4a1^m1Mcwi	Nr4a1-deficient rat ; Nr4a1-/-	ENU	Cryopreserved Sperm (as of 2017-01-26)	PhysGen
Sh2b3	SH2B adaptor protein 3	5	SS/JrHsdMcwi
			SS/JrHsdMcwi	SS-Sh2b3^em2Mcwi		ZFN	Cryopreserved Sperm (as of 2021-11-03)	PhysGen Knockouts
			SS/JrHsdMcwi	SS-Sh2b3^em2Mcwi-/-	SS-Sh2b3em2Mcwi/1Mcwi ; SS-Sh2b3^em2Mcwi/1Mcwi ; SS-Sh2b3em2Mcwi-/Sh2b3em2Mcwi-	ZFN	Cryopreserved Sperm (as of 2021-11-03)	PhysGen Knockouts
			SS/JrHsdMcwi	SS-Sh2b3^em1Mcwi		ZFN	Cryopreserved Sperm (as of 2021-11-03)	PhysGen Knockouts
			SS/JrHsdMcwi	SS-Sh2b3^em1Mcwi-/-	SS-Sh2b3em1Mcwi/1Mcwi ; SS-Sh2b3^em1Mcwi/1Mcwi ; SS-Sh2b3em1Mcwi-/Sh2b3em1Mcwi-	ZFN	Cryopreserved Sperm (as of 2021-11-03)	PhysGen Knockouts
			SS/JrHsdMcwi	SS-Sh2b3^em1Mcwi-/+	SS-Sh2b3em1Mcwi/2Mcwi ; SS-Sh2b3^em1Mcwi/2Mcwi ; SS-Sh2b3em1Mcwi-/Sh2b3em1Mcwi+	ZFN	Cryopreserved Sperm (as of 2021-11-03)	PhysGen Knockouts
Helz2	helicase with zinc finger 2	2	FHH-Chr 3^BN/Mcwi
			FHH-Chr 3^BN/Mcwi	FHH-Chr 3^BN-Helz2^em4Mcwi		CRISPR/Cas9	Cryopreserved Sperm (as of 2018-10-22)	MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu
			FHH-Chr 3^BN/Mcwi	FHH-Chr 3^BN-Helz2^em3Mcwi		CRISPR/Cas9	Live Animals; Cryopreserved Sperm (as of 2018-10-22)	MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu
Dnmt1	DNA methyltransferase 1	1		SD-Dnmt1^{tm1(Myh6-cre)Cqin}	Dnmt1-KO	Other	Unknown	Beijing Engineering Research Center for Experimental Animal Models of Human Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College (ZLF18003), Beijing, China
Dsg4	desmoglein 4	1	Crl:OFA(SD)	OFA(SD)-Dsg4^hr/Crl	IC hairless rat ; IC rat ; IC homozygous ; Iffa Credo hairless rat		Unknown	Iffa Credo (L'Arbresle Cedex, France; www.criver.com/ ico/iffa_reachus.html).
Mgat4c	MGAT4 family, member C	1	F344/NCrl	F344-Mgat4c^{Tn(sb-T2/Bart3)2.244Mcwi}		Sleeping Beauty	Cryopreserved Sperm (as of 2017-01-26)	PhysGen
Rbm20	RNA binding motif protein 20	7	SS/JrHsdMcwi
				(SDxF344)F1-Rbm20^m1Mlgw			Cryopreserved Sperm (as of 2017-01-25)	University of Wisconsin, Madison
				(SDxF344)F1xBN-Rbm20^m1Mlgw+/+	(SDxF344)F1xBN-Rbm20m1Mlgw+/+;(SDxF344)F1xBN-Rbm20m1+/Rbm20m1+		Cryopreserved Sperm	University of Wisconsin, Madison
				(SDxF344)F1xBN-Rbm20^m1Mlgw			Cryopreserved Sperm (as of 2017-01-25)	University of Wisconsin, Madison
				(SDxF344)F1-Rbm20^m1Mlgw+/+	(SDxF344)F1-Rbm20m1Mlgw+/+;(SDxF344)F1-Rbm20m1+/Rbm20m1+		Cryopreserved Sperm	University of Wisconsin, Madison
			SS/JrHsdMcwi	SS-Rbm20^em5Mcwi		ZFN	Cryopreserved Sperm (as of 2017-01-26)	MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu
			SS/JrHsdMcwi	SS-Rbm20^em10Mcwi		ZFN	Cryopreserved Sperm (as of 2017-01-26)	MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu
			SS/JrHsdMcwi	SS-Rbm20^em8Mcwi		ZFN	Cryopreserved Sperm (as of 2017-01-26)	MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu
Abcg2	ATP binding cassette subfamily G member 2	2	Crl:SD
			Crl:SD	SD-Abcb1a^em1Sage Abcg2^em1Sage	TGRS7490 ; SD-Abcb1a- Abcg2tm1sage ; Mdr1a-Bcrp Knockout Rat	ZFN	Live Animals (as of 2017-05-17)	Horizon Discovery
			Crl:SD	SD-Abcg2^em1Sage	TGRS4200 ; SD- Abcg2 tm1sage ; Bcrp Knockout Rat	ZFN	Live Animals (as of 2017-05-16)	Horizon Discovery
Mrs2	magnesium transporter MRS2	1		DMY/Kyo	NBRP Rat No: 0003 ; MDC-01-69		Live Animals; Cryopreserved Embryo; Cryopreserved Sperm	National BioResource Project for the Rat in Japan
Aqp4	aquaporin 4	1		SD-Aqp4^em1Hrt		TALEN	Unknown	Department of Anatomy and Histology, School of Basic Medical Sciences, Peking University, Beijing, China
Ngly1	N-glycanase 1	1	Crl:CD(SD)	SD-Ngly1^em1Ta-/-	NBRP Rat No: 0755 ; SD- Ngly1^em1-/-	CRISPR/Cas9	Cryopreserved Sperm (as of 2021-07-22)	National BioResource Project for the Rat in Japan
Lrrc7	leucine rich repeat containing 7	1	F344/NCrl	F344-Lrrc7^{Tn(sb-T2/Bart3)2.253Mcwi}		Sleeping Beauty	Cryopreserved Sperm (as of 2017-01-26)	PhysGen
Met	MET proto-oncogene, receptor tyrosine kinase	1		SD-Met^em1Sage	TGRS8750 ; SD-Met^tm1Sage	ZFN	Cryopreserved Embryo (as of 2016-12-07)	Horizon Discovery
Spp1	secreted phosphoprotein 1	4	SHRSP/A3NCrl, SS/JrHsdMcwi
			SHRSP/A3NCrl	SHRSP-Spp1^em1Mcwi		CRISPR/Cas9	Cryopreserved Sperm (as of 2017-01-26)	MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu
			SS/JrHsdMcwi	SS-Spp1^em3Mcwi	Strain00438	CRISPR/Cas9	Cryopreserved Sperm (as of 2021-11-03)	MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu
			SS/JrHsdMcwi	SS-Spp1^em4Mcwi		CRISPR/Cas9	Cryopreserved Sperm (as of 2021-11-03)	MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu
			SHRSP/A3NCrl	SHRSP-Spp1^em2Mcwi		CRISPR/Cas9	Cryopreserved Sperm (as of 2018-10-01)	MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu
Trpa1	transient receptor potential cation channel, subfamily A, member 1	2	Crl:WI
				SD-Trpa1^em1Gne		CRISPR/Cas9	Unknown	Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080 USA
			Crl:WI	W-Trpa1^em1Kcrd	NBRP Rat No: 0903 ; TRPA1 KO rat	ZFN	Cryopreserved Embryo (as of 2020-09-17)	National BioResource Project for the Rat in Japan
Gad1	glutamate decarboxylase 1	1		LE-Gad1^em15Yyan	NBRP Rat No: 0906	CRISPR/Cas9	Cryopreserved Sperm (as of 2021-07-22)	National BioResource Project for the Rat in Japan
Brca1	BRCA1, DNA repair associated	2	CrljJcl:SD
				SD-Brca1^m1Uwm			Cryopreserved Embryo; Cryopreserved Sperm (as of 2016-12-01)	University of Wisconsin-Madison, Madison, Wisconsin, Rat Resource and Research Center
			CrljJcl:SD	SD-Brca1^em1Kyo		CRISPR/Cas9	Unknown	Kyoto University Institute of Laboratory Animals Graduate School of Medicine Yoshida Konoe-cho, Skyo-ku, Kyoto 606-8501 JAPAN
Mkx	mohawk homeobox	1		WI-Mkx^em1Asah		CRISPR/Cas9	Unknown
Npy	neuropeptide Y	3	iNP/Iusm
			iNP/Iusm	iNP-Npy^em6Sage/Iusm	NP/Iusm-Npyem6Sage ; NP/Iusm-Npy^em6Sage	ZFN	Unknown	Department of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
			iNP/Iusm	iNP-Npy^em6Sage-/-/Iusm	Npy-/- ; NP/Iusm-Npyem6Sage-/- ; NP/Iusm-Npy^em6Sage-/-	ZFN	Unknown	Department of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
			iNP/Iusm	iNP-Npy^em6Sage+/-/Iusm	Npy+/- ; NP/Iusm-Npyem6Sage+/- ; NP-Npy^em6Sage+/-/Iusm ; NP/Iusm-Npy^em6Sage+/-	ZFN	Unknown	Department of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN 46202, USA

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