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Rat Genetic Models

Gene Symbol	Gene	No. of Models	Background Strain	Strain Symbol	Aliases	Method	Availability	Origination
Aldh2	aldehyde dehydrogenase 2 family member	1	SS/JrHsdMcwi	SS-Aldh2^em2Mcwi		ZFN	Cryopreserved Sperm (as of 2017-01-26)	PhysGen Knockouts
Dmd	dystrophin	2
			Crl:SD	SD-Dmd^em1Ang	Dmd^mdx line 61 ; SD-Dmd^mdx ; Dmd^mdx	TALEN	Unknown
			WIST/Iar	W-Dmd^em1Kykn	Dystrophin mutated rat (Out of Frame-1) ; NBRP Rat No: 0779	CRISPR/Cas9	Cryopreserved Sperm (as of 2016-12-08)	National BioResource Project for the Rat in Japan
Nek8	NIMA-related kinase 8	1	LEW/SsNArc	LEW-Nek8^lpk/Arc			Unknown
Avpr2	arginine vasopressin receptor 2	2
			SS/JrHsdMcwi	SS-Avpr2^em4Mcwi		CRISPR/Cas9	Cryopreserved Embryo (as of 2018-10-03)	MCW Gene Editing Rat Resource Center
			SS/JrHsdMcwi	SS-Avpr2^em5Mcwi		CRISPR/Cas9	Cryopreserved Sperm (as of 2018-10-03)	MCW Gene Editing Rat Resource Center
Trpc6	transient receptor potential cation channel, subfamily C, member 6	3
			SS/JrHsdMcwi	SS-Trpc6^em1Mcwi		CRISPR/Cas9	Live Animals (as of 2017-01-26)	MCW Gene Editing Rat Resource Center
			SS/JrHsdMcwi	SS-Trpc6^em4Mcwi	SS-Trpc6^{em1(P112Q)Mcwi}	CRISPR/Cas9	Live Animals (as of 2017-01-26)	MCW Gene Editing Rat Resource Center
			SS/JrHsdMcwi	SS-Trpc6^em3Mcwi		CRISPR/Cas9	Cryorecovery (as of 2017-07-18)	MCW Gene Editing Rat Resource Center
Trpc3	transient receptor potential cation channel, subfamily C, member 3	2
			SS/JrHsdMcwi	SS-Trpc3^em1Mcwi		CRISPR/Cas9	Cryopreserved Sperm (as of 2018-10-10)	MCW Gene Editing Rat Resource Center
			SS/JrHsdMcwi	SS-Trpc3^em2Mcwi		CRISPR/Cas9	Cryopreserved Sperm; Cryorecovery (as of 2018-10-10)	MCW Gene Editing Rat Resource Center
Cyp27b1	cytochrome P450, family 27, subfamily b, polypeptide 1	1	Jcl:WI	W-Cyp27b1^em1Thka	Cyp27b1-KO	CRISPR/Cas9	Unknown
Cyp1a1	cytochrome P450, family 1, subfamily a, polypeptide 1	2
			SS/JrHsdMcwi	SS-Cyp1a1^em2Mcwi		ZFN	Cryopreserved Sperm (as of 2017-01-26)	PhysGen Knockouts
			SS/JrHsdMcwi	SS-Cyp1a1^em1Mcwi		ZFN	Cryopreserved Sperm (as of 2017-01-26)	PhysGen Knockouts
Dcc	DCC netrin 1 receptor	1	F344/NCrl	F344-Dcc^{Tn(sb-T2/Bart3)2.205Mcwi}	RRRC:0384	Sleeping Beauty	Cryopreserved Sperm (as of 2017-01-26)	PhysGen
Cftr	CF transmembrane conductance regulator	4
			Crl:SD	SD-Cftr^em1Ang	F508del	CRISPR/Cas9	Unknown
			Crl:SD	SD-Cftr^em2Ang	CFTR KO rats	CRISPR/Cas9	Unknown	INSERM 1151 INEM Universit? de Paris Paris France.
			NTac:SD	SD-Cftr^em1Sage-/-		ZFN	Unknown (as of 2019-03-04)	Horizon Discovery
			NTac:SD	SD-Cftr^em1Sage+/-	CFTR Knockout Rat ; SD- Cftr tm1sage	ZFN	Cryopreserved Embryo; Cryopreserved Sperm (as of 2019-03-04)	Horizon Discovery
Trpv2	transient receptor potential cation channel, subfamily V, member 2	1	WKY/NCrl	WKY-Trpv2^em1Mcwi		CRISPR/Cas9	Live Animals (as of 2017-01-26)	MCW Gene Editing Rat Resource Center
Apoe	apolipoprotein E	2
				SD-Apoe^em1Sage	SD- ApoE tm1sage ; TGRA3710	ZFN	Live Animals (as of 2017-05-01)	Horizon Discovery
			SS/JrHsdMcwi	SS-Apoe^em9Mcwi		ZFN	Cryopreserved Sperm (as of 2017-01-26)	PhysGen Knockouts
Bsn	bassoon (presynaptic cytomatrix protein)	1		SD-Bsn^em1Ionsz			Unknown	Institute of Neuroscience, Chinese Academy of Sciences
Spetex-2H	Spetex-2H protein	1	F344/NCrl	F344-Spetex-2H^{Tn(sb-T2/Bart3)2.136Mcwi}		Sleeping Beauty	Unknown	PGA
Crb1	crumbs cell polarity complex component 1	1	BN/Rj	BN-Crb1^m1		Other	Unknown
Prkdc	protein kinase, DNA-activated, catalytic subunit	3
				TM-Prkdc^em4KyoIl2rg^em5Kyo	TM-DSCID ; NBRP Rat No: 0648	ZFN	Cryopreserved Sperm (as of 2017-07-12)	National BioResource Project for the Rat in Japan
			F344/Stm	F344-Prkdc^em2KyoIl2rg^em6Kyo	DSCID ; NBRP Rat No: 0647	ZFN	Cryopreserved Sperm (as of 2017-06-08)	National BioResource Project for the Rat in Japan
				F344-Prkdc^em1Kyo	SCID ; NBRP Rat No: 0646	ZFN	Cryopreserved Sperm (as of 2017-06-08)	National BioResource Project for the Rat in Japan
Agbl4	AGBL carboxypeptidase 4	1	F344/NCrl	F344-Agbl4^{Tn(sb-T2/Bart3)2.337Mcwi}	RRRC:0473	Sleeping Beauty	Cryopreserved Sperm (as of 2017-01-26)	PhysGen
Entpd6	ectonucleoside triphosphate diphosphohydrolase 6	1	F344/NCrl	F344-Entpd6^{Tn(sb-T2/Bart3)2.174Mcwi}		Sleeping Beauty	Unknown	PGA
Mmp2	matrix metallopeptidase 2	1	SS/JrHsdMcwi	SS-Mmp2^em2Mcwi		ZFN	Unknown (as of 2017-07-18)	PhysGen Knockouts
Adra1a	adrenoceptor alpha 1A	1	FHH/EurMcwi	FHH-Adra1a^m1Mcwi	RRRC:00408	ENU	Cryopreserved Sperm (as of 2017-01-26)	PhysGen
Scn2a	sodium voltage-gated channel alpha subunit 2	2
			Crl:LE	LE-Scn2a^em1Mcwi		CRISPR/Cas9	Unknown	MCW Gene Editing Rat Resource Center
			Crl:LE	LE-Scn2a^em2Mcwi		CRISPR/Cas9	Unknown	MCW Gene Editing Rat Resource Center
Itga9	integrin subunit alpha 9	1	SS/JrHsdMcwi	SS-Itga9^em1Mcwi		ZFN	Cryopreserved Sperm (as of 2017-01-26)	PhysGen Knockouts
Bcas3	BCAS3, microtubule associated cell migration factor	1	SS/JrHsdMcwi	SS-Bcas3^em4Mcwi		ZFN	Cryopreserved Sperm (as of 2017-01-26)	PhysGen Knockouts

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