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Mammalian de novo pyrimidine biosynthesis is accomplished by six enzymatic activities, encoded by only three genes - two encode multifunctional proteins. CTP and UTP generated by the pathway are directly incorporated into RNA, and CTP is important in one of the pathways of phospholipid biosynthesis. Uracil nucleotides are essential in the formation of nucleotide sugars such as UDP-glucose, used for glycosylation reactions, and UDP-N-acetylglucosamine, used in protein glycosylation. UDP and UTP also serve as signaling molecules operating through metabotropic receptors. Click here to view this pathway central to nucleic acid metabolism. |
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