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Maintaining a homeostatic balance between the stimulation of inflammation in response to infection and other stresses and the down-regulation of those responses to prevent damage to the organism is an exquisitely choreographed dance. To allow researchers to follow some of the steps of that "dance", RGD has assembled the Balancing Inflammatory Responses Pathway Suite Network which brings together suites of diagrams for both the pro- and anti-inflammatory responses. This "suite of pathway suites" covers the pro-inflammatory NFkappaB and related pathways suite, including information on the NFkappaB signaling pathway as well as two of its upstream "feeder" pathways, tumor necrosis factor signaling and interleukin-1 signaling. On the anti-inflammatory side, the hypothalamus-pituitary-adrenal (HPA) axis includes the corticotropin-releasing hormone signaling pathway, signaling through protein kinase A. This triggers the melanocortin system, leading to the biosynthesis of cortisol and downstream signaling through its receptor. In addition, the cholesterol biosynthetic and SREBP signaling pathways are shown as related pathways which can influence the HPA axis. Click here to begin exploring this complex network of vital pathways. |
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