RGD recently released three new interactive pathway diagrams related to angiotensin system signaling: the renin-angiotensin system signaling pathway diagram, a general angiotensin II signaling pathway diagram and a diagram for specific angiotensin II signaling via receptor type 1.
The renin-angiotensin system has wide-ranging, and sometimes opposing, endocrine, paracrine and autocrine functions in the cardiovascular and renal systems and beyond. Downstream outcomes of this system's various signaling pathways include effects on vasoconstriction, vasodilation, cell proliferation and cognition.
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| The renin-angiotensin system signaling pathway exerts pleiotropic effects via the generation of several active peptides which signal through distinct receptors. Click here to explore this vital and complex network of related pathways. |
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Angiotensin II, probably the most potent of the biologically active peptides the renin-angiotensin system generates, elicits distinct responses through signaling via receptor types 1 and 2, Agtr1 and Agtr2, respectively. Click here to explore these two complementary and counterbalancing sides of angiotensin II signaling. |
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Angiotensin II signaling via receptor type 1 is the better understood route of angiotensin II signaling. The Agtr1 mediated pathway is involved in vasoconstriction, proliferation, hormone release and fluid homeostasis. Click here to explore how this important and well-characterized pathway elicits effects through a variety of other downstream signaling pathways. |
