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The protein kinase C family (PKC) comprises approximately 2% of the human kinome. PKC signaling occurs downstream of the signaling cascades mediated by a variety of G protein coupled receptors and their associated Gαq family signal transducers. Signaling via the conventional/classical, novel and atypical PKCs plays important roles in cell proliferation, differentiation, polarity and death. In addition, deregulation of the PKC signaling pathway has been implicated in tumorigenesis and neurodegeneration. Click here to begin exploring this complex and vital signaling system. |
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