| Gene | Phenotype | Suceptible Strain | Date | Complementation | Human Trait | Reference |
|---|---|---|---|---|---|---|
| Cd36 | Insulin resistance, hyperlipidaemia | SHR | 1999,2001 | Yes | Dyslipidaemia, insulin resistance, hypertension | |
| Mertk | Retinal dystrophy | RCS | 2000, 2001 | |||
| Atrn | Hypomyelination, mahogany coat color | ZI | 2001 | Kuramoto etal. PNAS 2001 98:559-64 | ||
| Ncf1 | Pristane induced arthritis | DA | 2002 | Olofsson etal. Nat. Genet. 2003 33:25-32 | ||
| Cblb | Type 1 diabetes | KDP | 2002 | Yokoi etal. Nat. Genet. 2002 31:391-4 | ||
| Gimap5 (Ian4) | Type 1 diabetes | BB | 2002 | |||
| PKHD1 | Polycystic kidney disease | sd Pck-/- | 2002 | Polycystic kidney disease | Ward etal. Nat. Genet. 2002 30:259-69 | |
| Rab38 | Platelet storage pool disease, Renal Failure | FH, LE, FHH | 2004,2005 | |||
| C2ta (Mhc2ta) | MHC expression | DA | 2005 | Rheumatoid arthritis, multiple sclerosis, myocardial infarction | Swanberg etal. Nat. Genet. 2005 37:486-94 | |
| Fcgr3 | Crescentic glomerulonephritis | WKY | 2006 | SLE, systemic autoimmunity | Rangel-Filho etal. J. Am. Soc. Nephrol. 2005 16:852-6 | |
| Fbxo10, Frmpd1 | Breast cancer | WF | 2007 | Breast cancer | Oiso etal. Mamm. Genome 2004 15:307 | |
| Srebf1 | Hepatic steatosis | SHR | 2008 | Pravenec et al. Hypertension 2008 51:148-53 |
Genes for Rat QTL
This page lists the genes for rat disease phenotypes that have been identified by positional cloning since 1999. The table below was compiled from the published literature. Every effort is made to keep this complete as new genes are identified, however, checking PubMed would also be worthwhile.
