Strain Report

Basic details

Annotations:

Reproduction

The average generation is 49 days and the average litter size is 2.7 pups.	629526
Cowley et al. maintained their stock on a 0.4% NaCl rat chow as a 0.1%NaCl diet impairs fertility in SS though it has not been tested in BN.	629526

Lifespan and Spontaneous Disease

These are a suitable model for resistance to myocardial ischemia.

1342469

Physiology and Biochemistry

Cowley et al. reported the following arterial blood pressure measurements for this strain: Systolic arterial pressure (SAP) averaged 127 +/- 3 mmHg, and diastolic arterial pressure (DAP) averaged 94 +/- 2 mmHg. Mean arterial blood pressure determined during the inactive light cycle of male rats (n = 42) maintained for nearly 4 wk on 8% NaCl rat chow averaged 109 +/- 2 mmHg and ranged from 89 to 145 mmHg. Active MAP of rats on day 2 of recording averaged 114 +/- 4 mmHg, Inactive MAP on the same day averaged 109 +/- 3 mmHg. The reduction of MAP that occurs during the 36 h following sodium depletion averaged 14 +/- 2 mmHg.

629526

Drugs and Chemicals

The aortic rings of animals on low-salt diet and high salt-diet were less sensitive to phenylephrine as compared to the parental SS and less sensitive to acetylcholine when on high salt-diet.

1598768

Ontology (?)

Disease

Mammary Neoplasms, Experimental	Resistance	IED	.	2301186	induced by DMBA	RGD
Myocardial Ischemia	.	TAS	.	1342469	.	RGD

Phenotype

crystalluria	Induced	IED	.	2313354	hydroxyproline induced	RGD
decreased renin activity	.	IED	.	727992	.	RGD
mammary adenocarcinoma	Resistance	IED	.	2301186	induced by DMBA	RGD

Strain SSLP data (?)

BN/NHsdMcwi: 44 SSLP markers have been typed in this strain

Strain QTL data

Associated References (?)

Database Information (?)