Strain Report

Physgen Data:

Basic details

Annotations:

Reproduction

Low fertility

1004, 634612

Lifespan and Spontaneous Disease

Rats display genetic resistant to hepatocellular carcinoma

619598

Endocardial disease 7% at an average age of 31 months (Boorman et al 1973). Tumours of epithelium 28% in males, 2% in females. Ureter tumours 20% in females, 6% in males. Estimated median life-span more than 24 months in males and more than 25 months in females (Boorman and Hollander 1974). Median lifespan 29 months in males (n=74) and 31 months in females (n=236). Most common neoplastic lesions in males were urinary bladder carcinoma 35%, pancreas islet adenoma 15%,pituitary adenoma 14%, lymphoreticular sarcoma 14%, adrenal cortex adeneoma 12%, medullarythyroid carcinoma 9%, adrenal pheochromocytoma 8%. Four other types of tumours were observed. In females: pituitary adenoma 26%, ureter carcinoma 22%, adrenal cortical adenoma19%, cervix sarcoma 15%, mammary gland fibroadenoma 11%, islet adenoma 11%. Twelve other tumour types were observed (Burek and Hollander 1975a). The chance of death from metastases increased with age in females, but reaches a peak at 25-30 months in males (Burek and Hollander 1975b). The cervical and vaginal tumours have been studied in more detail by Burek et al (1975a), and further details of an aging colony are given by Hollander (1976) and Burek and Hollander (1977). Vaginal and cervical tumours, mostly sarcomas but also seven squamous-cell carcinomas and four leiomyomas, were seen in 20% of animals that died naturally (Burek et al 1976). High incidence (31%) of hydronephrosis reported in 2-month-old BN/Bi (Cohen et al 1970), but little seen by Gray et al (1982) before 30 months,after which the disease progressed slowly. A high incidence was observed at all ages by Spangleret al (1994).

1004, 634612

Immunology

Resistant to induction of experimental allergic encephalomyelitis (1/7) (Gasser et al 1975,McFarlin et al 1975a,b). However, resistance can be modulated by endogenous corticosteroids (Peers et al, 1995). Resistant to induction of autologous immune compex glomerulonephritis (Strenglein et al 1975). Like strain MAXX, but in contrast to 17 other strains BN is susceptible tothe development of mercury-induced autoimmunity to renal basement membranes with the development of membraneous glomerulonephritis (Henry et al 1988). Susceptible to theautoimmune effects of mercury showing a decrease of peripheral RT6.2(+) T lymphocytes compared with strain LEW (Kosuda et al 1994), but no release of hydrogen peroxide in peritoneal polymorphonuclear leukocytes and macrophages in contrast with LEW (Contrino et al,1992). Susceptible to the development of autoimmunity to skin-injected HgCl2 , in contrast toLEW (Warfvinge and Larsson, 1994). Develop a T-helper 2 cell-mediated autoimmune syndrome following treatment with mercuric chloride, gold or D-penicillamine which may be associated with the response of mast cells (Oliveira et al, 1995) Moderately sensitive to the development of experimental glomerulonephritis following injection of nephritogenic antigen from bovine renal basement membrane (Naito et al, 1991) Develops severe experimental allergic encephalomyelitis when immunised with rat spinal cord and carbonyl iron adjuvent (Levine and Sowinski 1975). Linington et al (1986) induced experimental allergic neuritis using T-cells and bovine P2 (a peripheral nerve myelin protein). Resistant to the induction of Haymann nephritis (Badalamenti et al 1987). High IgE response to Japanese Cedarpollen antigen (1/7): may be a useful model for studying physiological and pathological changes in the nose after pollen challenge (Imaoka et al, 1993). Resident macrophages (ramified microglea)of the central nervous system are constitutively major histocompatibility complex class-II positive, in contrast with LEW (Sedgwick et al, 1993). Following lethal irradiation and re-constitution with syngeneic bone marrow and given cyclosporin A for several weeks LEW rats will develop cyclosporin-induced autoimmunity after withdrawal of the cyclosporin. The condition resembles graft-versus host disease in terms of acute dermatitis and chronic scleroderma. However, BN rats do not develop this disease (Wodzig et al, 1993). Resistant to the induction of experimental autoimmune uveoretinitis and endotoxin-induced uveitis which appears to be associated with the production of tumour necrosis factor (TNF) by retinal Muller glia and retinal pigmented epithelium. Strain LEW is susceptible (Dekozak et al, 1994). Susceptible to the induction of proteinuria following treatment with the monoclonal antibody 5-6-1, like LEW and outbred Wistar, but unlike resistant outbred Sprague-Dawley rats which were also resistant to glomerular damage (Gollner et al, 1995).Low antibody response to phytohaemagglutinin, concanavalin A and streptococcal group A carbohydrate (Koch 1976, Stankus and Leslie 1976, Williams et al 1973). Good (1/5) antibody response to a synthetic 20 amino acid peptide derived from the alpha helical region of the RT1-D-u beta chain (Murphy et al, 1994).

1004, 634612

Infection

Resistant to the induction of encephalitis by coronavirus, with a much shorter delay in lymphocyte proliferation following infection than in the susceptible LEW strain (Imrich et al, 1994). Low plasma ceruloplasmin levels (Stolc 1984) .

1004, 634612

Drugs and Chemicals

Dimethylbenzanthracene induced a transplantable myeloid leukaemia (Colly and Hagenbeek1977). Intermediate susceptibility to pentobarbital sodium (3/7) with LD50 of 90mg/kg (Sheareret al 1973).

1004, 634612

Behavior

Can not be triggered into paradoxical sleep by dark pulse stimulation (ie. turning off the lights), incontrast with LEW (Leung et al, 1992). Higher precentage of paradoxical sleep than LEW (Rosenberg et al 1987). Low preference for ethanol and low capability to develop acute tolerance to ethanol hypnosis (York et al, 1994). Behavioural performance declined less rapidly with aging than in strain F344 (Spangler et al, 1994). Somewhat vicious. Poor performance in an active avoidance learning task (4/4), but good reference memory (VanLuijtelaar et al 1988)

1004, 634612

Ontology (?)

Phenotype

abnormal mononuclear leukocyte differentiation	.	TAS	.	1004	.	RGD
decreased susceptibility to viral infection	.	TAS	.	1004	.	RGD
hydronephrosis	.	TAS	.	1004	.	RGD
pituitary adenoma	.	TAS	.	1004	.	RGD
proteinuria	.	TAS	.	1004	.	RGD

Strain SSLP data (?)

BN/NHsdMcwi: 44 SSLP markers have been typed in this strain

BN/SsNHsd: 4085 SSLP markers have been typed in this strain

Strain QTL data

Associated References (?)

BN/Crl

1:	Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
2:	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.
3:	Guryev V, etal., Genome Res. 2004 Jul;14(7):1438-43.
4:	St. Lezin E, etal., Hypertension 1997 Oct;30(4):854-9
5:	Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.
6:	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
7:	Dumas ME, etal., Nat Genet. 2007 Apr 15;.

BN/CrlCrlj

1:	Tsuji A, etal., Genomics 2001 Jun 15;74(3):365-9.
2:	Yamashita S, etal., Genetics 2005 Aug 3;.
3:	Personal Communication with Dr. Takashi Kuramoto and Dr. Tomoji Mashimo

BN/Crli

1:	De Miglio MR, etal., Cancer Res 2002 Aug 1;62(15):4459-63.
2:	De Miglio MR, etal., Int J Cancer 2003 May 20;105(1):70-5.

BN/Cub

1:	Institute for Animal Experimentation University of Tokushima School of Medicine
2:	Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
3:	Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
4:	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

BN/Elh

1:	Chen A, etal., Mamm Genome 1997 Sep;8(9):701-3.
2:	Harris EL, etal., Clin Exp Pharmacol Physiol 1998 Mar-Apr;25(3-4):204-7.
3:	Harris EL, etal., J Hypertens 1995 Apr;13(4):397-404.
4:	Bilusic M, etal., Croat Med J. 2008 Oct;49(5):586-99.
5:	Harris EL, etal., Physiol Genomics 2001 Aug 28;6(3):183-9.

BN/Gro

1:	Institute for Animal Experimentation University of Tokushima School of Medicine
2:	Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
3:	Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
4:	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

BN/Gut

1:	Institute for Animal Experimentation University of Tokushima School of Medicine
2:	Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
3:	Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
4:	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

BN/Han

1:	Bender K, etal., Immunogenetics 1984;19(3):257-66.
2:	Institute for Animal Experimentation University of Tokushima School of Medicine
3:	Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
4:	Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
5:	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

BN/HanKini

1:	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.

BN/HsdMcwiCrl

1:	Personal communication with Charles River Laboratories

BN/HsdMcwiCwr

1:	Personal communication between Dr. Carol Moreno and the RGD curators.

BN/Ka

1:	Kaschina E, etal., Physiol Genomics 2004 Sep 16;19(1):41-9. Epub 2004 Jul 06.
2:	Sainz IM, etal., Arthritis Rheum. 2005 Aug;52(8):2549-52.
3:	Rhaleb NE, etal., Hypertension 2001 Jan;37(1):121-128.

BN/KtsSlc

1:	Personal Communication with Dr. Takashi Kuramoto and Dr. Tomoji Mashimo

BN/KunKtsSlc

1:	Personal Communication with Dr. Takashi Kuramoto and Dr. Tomoji Mashimo

BN/Maas

1:	Otsen M, etal., Mamm Genome 1995 Sep;6(9):595-601.
2:	Bender K, etal., Immunogenetics 1984;19(3):257-66.
3:	Institute for Animal Experimentation University of Tokushima School of Medicine
4:	Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
5:	Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
6:	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

BN/Mol

1:	Institute for Animal Experimentation University of Tokushima School of Medicine
2:	Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
3:	Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
4:	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

BN/MolTac

1:	Personal Communication with Taconic

BN/NHsdCpb

1:	Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
2:	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

BN/NHsdMcwi

1:	Schlick NE, etal., Am J Physiol Cell Physiol. 2006 Dec;291(6):C1183-92. Epub 2006 Jul 19.
2:	PhysGen strains
3:	Baker JE, etal., Am J Physiol Heart Circ Physiol 2000 Apr;278(4):H1395-400.
4:	Saavedra JM J Hypertens. 2009 Jun;27(6):1129-33.
5:	Gilibert S, etal., J Hypertens. 2009 Jun;27(6):1186-93.
6:	Wiessner JH, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F301-6. Epub 2009 Jun 3.
7:	Mattson DL, etal., Am J Physiol Renal Physiol. 2008 Sep;295(3):F837-42. Epub 2008 Jul 23.
8:	Stadnicka A, etal., J Pharmacol Exp Ther. 2009 Sep;330(3):727-35. Epub 2009 Jun 18.
9:	Adamovic T, etal., Cancer Genet Cytogenet. 2008 Oct;186(1):41-8.
10:	Kunert MP, etal., Am J Physiol Regul Integr Comp Physiol. 2008 May 28;.
11:	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
12:	Moreno C, etal., Physiol Genomics 2003 Nov 11;15(3):243-57. Epub 2003 Oct 07.

BN/OlaHsd

1:	Institute for Animal Experimentation University of Tokushima School of Medicine
2:	Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
3:	Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
4:	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

BN/Orl

1:	Bender K, etal., Immunogenetics 1984;19(3):257-66.
2:	Institute for Animal Experimentation University of Tokushima School of Medicine
3:	Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
4:	Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
5:	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

BN/OrlCrlf

1:	Marissal-Arvy N, etal., J Biol Chem 2004 Sep 17;279(38):39232-9. Epub 2004 Jul 12.

BN/RijHfr

1:	Behmoaras J, etal., Am J Physiol Heart Circ Physiol 2005 Feb;288(2):H769-77. Epub 2004 Oct 7.

BN/RijKun

1:	Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
2:	Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
3:	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

BN/RijN

1:	Bender K, etal., Immunogenetics 1984;19(3):257-66.
2:	Institute for Animal Experimentation University of Tokushima School of Medicine
3:	Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
4:	Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
5:	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

BN/Rj

1:	Mas M, etal., Eur J Immunol 2000 Jun;30(6):1698-705.
2:	Kota L, etal., Physiol Genomics. 2008 Jul 15;34(2):215-24. Epub 2008 Jun 3.
3:	Kota LT, etal., Physiol Genomics. 2008 Jun 3;.
4:	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.

BN/Sea

1:	Yamashita S, etal., Invest Ophthalmol Vis Sci 2002 Oct;43(10):3153-9.

BN/Seac

1:	Asahina M, etal., J Lipid Res 2005 Aug 1;.
2:	Asahina M, etal., J Lipid Res. 2008 Aug 27.

BN/SsN

1:	Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
2:	NIH Rat Strain Data
3:	Institute for Animal Experimentation University of Tokushima School of Medicine
4:	Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
5:	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

BN/SsNHsd

1:	Joe B, etal., Immunogenetics 2000 Sep;51(11):930-44.
2:	Shull JD, etal., Mamm Genome. 2006 Jul;17(7):751-9. Epub 2006 Jul 14.
3:	Gould KA, etal., Mamm Genome. 2006 May;17(5):451-64.
4:	Stoll M, etal., Science 2001 Nov 23;294(5547):1723-6.
5:	Gould KA, etal., Mamm Genome. 2005 Nov;16(11):854-64. Epub 2005 Nov 11.
6:	Shull JD, etal., Mamm Genome. 2007 Sep 18;.
7:	Schaffer BS, etal., Cancer Res. 2006 Aug 1;66(15):7793-800.
8:	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
9:	Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
10:	Festing, MFW, Personal Communication Update, Feb-2000
11:	Gu L, etal., J Clin Invest 1996 Feb 1;97(3):777-88
12:	Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
13:	Wendell DL and Gorski J, Mamm Genome 1997;8(11):823-9
14:	Palmer AA, etal., Psychopharmacology (Berl) 2003 Jan;165(3):270-9.
15:	Wendell DL, etal., Mamm Genome 2002 Nov;13(11):664-6.

BN/SsNSlc

1:	Personal Communication with Dr. Takashi Kuramoto and Dr. Tomoji Mashimo
2:	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.

BN/Ztm

1:	Weiss H, etal., Mamm Genome 2005 Jun;16(6):432-41.
2:	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.

BN/fMaiHok

1:	Personal Communication with Dr. Takashi Kuramoto and Dr. Tomoji Mashimo

Database Information (?)