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Strain Report
Basic details
Annotations:
General
| 80-100% of male and female BB/OK rats develop spontaneously insulin-dependent type 1 diabetes mellitus at an age of about 90 days; first autoantobodies are detectable at an age of 10 days; first sign of insulitis at an age of 30 days; all animals develop insulitis up to an age of 30 weeks. | 1549690 |
Reproduction
| Average litter size at weaning 6.5 pups for diabetic-prone and 7.2 pups for the diabetic-resistant colonies. | 61077 |
Lifespan and Spontaneous Disease
| These animals develop insulin-dependent diabetes. | 619667, 619684 |
Ontology (?)
| Term | Qualifier | Evidence | With | Reference | Notes | Source |
Disease
Phenotype
Strain SSLP data (?)
Strain QTL data
| BB/OK |
| Chr | Symbol | Name | Trait | Subtrait |
| X | Iddm5 | Insulin dependent diabetes mellitus QTL 5 | Insulin level | |
| 1 | Bw18 | Body weight QTL 18 | Body weight | |
| 1 | Scl5 | Serum cholesterol level QTL 5 | Lipid level | cholesterol |
| 1 | Bp43 | Blood pressure QTL 43 | Blood pressure | |
| 1 | Stl3 | Serum triglyceride level QTL 3 | Lipid level | triglyceride |
| 1 | Bw39 | Body weight QTL 39 | Body weight | |
| 1 | Bp42 | Blood pressure QTL 42 | Blood pressure | |
| 1 | Bp44 | Blood pressure QTL 44 | Blood pressure | |
| 1 | Iddm10 | Insulin dependent diabetes mellitus QTL 10 | Insulin level | |
| 1 | Iddm9 | Insulin dependent diabetes mellitus QTL 9 | Insulin level | |
| 1 | Bw20 | Body weight QTL 20 | Body weight | |
| 1 | Iddm6 | Insulin dependent diabetes mellitus QTL 6 | Insulin level | |
| 4 | Bp79 | Blood pressure QTL 79 | Blood pressure | systolic |
| 4 | Bw22 | Body weight QTL 22 | Body weight | |
| 4 | Stl2 | Serum triglyceride level QTL 2 | Lipid level | triglyceride |
| 4 | Scl4 | Serum cholesterol level QTL 4 | Lipid level | cholesterol |
| 4 | Bw40 | Body weight QTL 40 | Body weight | |
| 6 | Iddm8 | Insulin dependent diabetes mellitus QTL 8 | Insulin level | |
| 6 | Iddm16 | Insulin dependent diabetes mellitus QTL 16 | Insulin level | |
| 10 | Bp45 | Blood pressure QTL 45 | Blood pressure | |
| 13 | Bp80 | Blood pressure QTL 80 | Blood pressure | systolic |
| 18 | Bp47 | Blood pressure QTL 47 | Blood pressure | |
| 18 | Iddm4 | Insulin dependent diabetes mellitus QTL 4 | Glucose level | insulin-dependent |
| 18 | Scl22 | Serum cholesterol level QTL 22 | Lipid level | cholesterol |
| 18 | Bp48 | Blood pressure QTL 48 | Blood pressure | |
| 18 | Bp46 | Blood pressure QTL 46 | Blood pressure | |
| 18 | Spl3 | Serum phospholipid level QTL 3 | Protein level | |
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Associated References (?)
| 1: | Jacob HJ, etal., Nat Genet 1992 Sep;2(1):56-60 |
| 2: | Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8 |
| 3: | Kloting I, etal., Ann N Y Acad Sci 1997 Sep 20;827:64-84. |
| 4: | Kovacs P and Kloting I, Arch Biochem Biophys 1998 Jun 1;354(1):139-43. |
| 5: | Jackerott M, etal., J Autoimmun 1997 Feb;10(1):35-41. |
| 6: | Kloting I, etal., Biochem Biophys Res Commun 1998 Apr 17;245(2):483-6 |
| 7: | Saar K, etal., Nat Genet. 2008 May;40(5):560-6. |
Database Information (?)
| RGD ID | 61107 | | History | No Nomenclature events are recorded for this object | | Created | 05-JAN-01 |
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